Cerebral microcirculatory pulse wave propagation and pulse wave amplitude mapping in retrospectively gated MRI

To analyze cerebral arteriovenous pulse propagation and to generate phase-resolved pulse amplitude maps from a fast gradient-echo sequence offering flow-related enhancement (FREE). Brain MRI was performed using a balanced steady-state free precession sequence at 3T followed by retrospective k-space gating. The time interval of the pulse wave between anterior-, middle- and posterior cerebral artery territories and the superior sagittal sinus were calculated and compared between and older and younger groups within 24 healthy volunteers. Pulse amplitude maps were generated and compared to pseudo-Continuous Arterial Spin Labeling (pCASL) MRI maps by voxel-wise Pearson correlation, Sørensen-Dice maps and in regards to signal contrast. The arteriovenous delays between all vascular territories and the superior sagittal sinus were significantly shorter in the older age group (11 individuals, 

• Kornemann, N.
• Klime
• Kern, A. L.
• Behrendt, L.
• Voskrebenzev, A.
• Gutberlet, M.
• Wattjes, M. P.
• Wacker, F.
• Vogel-Claussen, J.
• Glandorf, J.