A distinct monocyte transcriptional state links systemic immune dysregulation to pulmonary impairment in long COVID

The mechanisms driving immune dysregulation in long COVID disease remain elusive. Here we integrated single-cell multiome data, immunological profiling and functional assays to investigate immune alterations across multiple cohorts. A transcriptional state in circulating monocytes (LC-Mo) was enriched in individuals with mild-moderate acute infection and accompanied by persistent elevations of plasma CCL2, CXCL11 and TNF. LC-Mo showed TGF

• Kumar, S.
• Li, C.
• Zhou, L.
• Zhan, Q.
• Alaswad, A.
• Volland, S.
• Costa, B.
• Krooss, S. A.
• Klefenz, I.
• Schmaus, H.
• Zeuzem, A.
• von Witzendorff, D.
• Lickei, H.
• Pueschel, L.
• Kraft, A. R. M.
• Cornberg, M.
• Koczulla, A. R.
• Pink, I.
• Hoeper, M. M.
• Xu, C. J.
• Häussler, S.
• Wiestler, M.
• Netea, M. G.
• Illig, T.
• Sun, J.
• Li, Y.