Science and Research

Dominant immune tolerance in the intestinal tract imposed by RelB-dependent migratory dendritic cells regulates protective type 2 immunity

Dendritic cells (DCs) are crucial for initiating protective immune responses and have also been implicated in the generation and regulation of Foxp3(+) regulatory T cells (Treg cells). Here, we show that in the lamina propria of the small intestine, the alternative NF-

  • Geiselhöringer, A. L.
  • Kolland, D.
  • Patt, A. J.
  • Hammann, L.
  • Köhler, A.
  • Kreft, L.
  • Wichmann, N.
  • Hils, M.
  • Ruedl, C.
  • Riemann, M.
  • Biedermann, T.
  • Anz, D.
  • Diefenbach, A.
  • Voehringer, D.
  • Schmidt-Weber, C. B.
  • Straub, T.
  • Pasztoi, M.
  • Ohnmacht, C.

Keywords

  • Animals
  • *Transcription Factor RelB/metabolism/genetics
  • *Dendritic Cells/immunology/metabolism
  • *T-Lymphocytes, Regulatory/immunology
  • *Immune Tolerance
  • *Mice, Knockout
  • Mice
  • *Mice, Inbred C57BL
  • Cell Movement
  • Forkhead Transcription Factors/metabolism/genetics
  • Chemokine CCL22/metabolism/genetics
  • Intestinal Mucosa/immunology/metabolism
  • Intestine, Small/immunology/metabolism
  • Strongylida Infections/immunology/parasitology
  • Cell Differentiation
  • Th2 Cells/immunology
Publication details
DOI: 10.1038/s41467-024-53112-9
Journal: Nat Commun
Pages: 9143 
Number: 1
Work Type: Original
Location: CPC-M
Disease Area: AA
Partner / Member: HMGU, KUM
Access-Number: 39443450

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