Intranasal Administration of Bedaquiline-Loaded Fucosylated Liposomes Provides Anti-Tubercular Activity while Reducing the Potential for Systemic Side Effects

Liposomal formulations of antibiotics for inhalation offer the potential for the delivery of high drug doses, controlled drug release kinetics in the lung, and an excellent safety profile. In this study, we evaluated the in vivo performance of a liposomal formulation for the poorly soluble, antituberculosis agent, bedaquiline. Bedaquiline was encapsulated within monodisperse liposomes of

• Marwitz, F.
• Hädrich, G.
• Redinger, N.
• Besecke, K. F. W.
• Li, F.
• Aboutara, N.
• Thomsen, S.
• Cohrs, M.
• Neumann, P. R.
• Lucas, H.
• Kollan, J.
• Hozsa, C.
• Gieseler, R. K.
• Schwudke, D.
• Furch, M.
• Schaible, U.
• Dailey, L. A.