One-fourth of the global human population is estimated to be infected with strains of the Mycobacterium tuberculosis complex (MTBC), the causative agent of tuberculosis (TB). Using lipidomic approaches, we show that tuberculostearic acid (TSA)-containing phosphatidylinositols (PIs) are molecular markers for infection with clinically relevant MTBC strains and signify bacterial burden. For the most abundant lipid marker, detection limits of
- Brandenburg, J.
- Heyckendorf, J.
- Marwitz, F.
- Zehethofer, N.
- Linnemann, L.
- Gisch, N.
- Karaköse, H.
- Reimann, M.
- Kranzer, K.
- Kalsdorf, B.
- Sanchez-Carballo, P.
- Weinkauf, M.
- Scholz, V.
- Malm, S.
- Homolka, S.
- Gaede, K. I.
- Herzmann, C.
- Schaible, U. E.
- Hölscher, C.
- Reiling, N.
- Schwudke, D.
Keywords
- Mtbc
- markers
- mycobacteria
- tuberculosis