Science and Research

Tuberculostearic Acid-Containing Phosphatidylinositols as Markers of Bacterial Burden in Tuberculosis

One-fourth of the global human population is estimated to be infected with strains of the Mycobacterium tuberculosis complex (MTBC), the causative agent of tuberculosis (TB). Using lipidomic approaches, we show that tuberculostearic acid (TSA)-containing phosphatidylinositols (PIs) are molecular markers for infection with clinically relevant MTBC strains and signify bacterial burden. For the most abundant lipid marker, detection limits of

  • Brandenburg, J.
  • Heyckendorf, J.
  • Marwitz, F.
  • Zehethofer, N.
  • Linnemann, L.
  • Gisch, N.
  • Karaköse, H.
  • Reimann, M.
  • Kranzer, K.
  • Kalsdorf, B.
  • Sanchez-Carballo, P.
  • Weinkauf, M.
  • Scholz, V.
  • Malm, S.
  • Homolka, S.
  • Gaede, K. I.
  • Herzmann, C.
  • Schaible, U. E.
  • Hölscher, C.
  • Reiling, N.
  • Schwudke, D.

Keywords

  • Mtbc
  • markers
  • mycobacteria
  • tuberculosis
Publication details
DOI: 10.1021/acsinfecdis.2c00075
Journal: ACS Infect Dis
Pages: 1303-1315 
Number: 7
Work Type: Original
Location: ARCN
Disease Area: PALI, PLB
Partner / Member: FZB
Access-Number: 35763439

DZL Engagements

chevron-down