Science and Research

Diabetes impairs IFN

Diabetes mellitus is associated with an increased risk of pneumonia, often caused by so-called typical and atypical pathogens including Streptoccocus pneumoniae and Legionella pneumophila, respectively. Here, we employed a variety of mouse models to investigate how diabetes influences pulmonary antibacterial immunity. Following intranasal infection with S. pneumoniae or L. pneumophila, type 2 diabetic and prediabetic mice exhibited higher bacterial loads in their lungs compared to control animals. Single cell RNA sequencing, flow cytometry, and functional analyses revealed a compromised IFN

  • Fiocca Vernengo, F.
  • Röwekamp, I.
  • Boillot, L.
  • Caesar, S.
  • Dörner, P. J.
  • Tarnowski, B.
  • Gutbier, B.
  • Nouailles, G.
  • Fatykhova, D.
  • Hellwig, K.
  • Witzenrath, M.
  • Hocke, A. C.
  • Klatt, A. B.
  • Opitz, B.

Keywords

  • Diabetes
  • Innate immunity
  • Legionella pneumophila
  • Pneumonia
  • Streptococcus pneumoniae
Publication details
DOI: 10.1016/j.mucimm.2024.12.015
Journal: Mucosal Immunol
Work Type: Original
Location: Assoziierter Partner
Disease Area: PALI
Partner / Member: BIH
Access-Number: 39746547

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