Science and Research

LRP1: A chameleon receptor of lung inflammation and repair

The lung displays a remarkable capability to regenerate following injury. Considerable effort has been made thus far to understand the cardinal processes underpinning inflammation and reconstruction of lung tissue. However, the factors determining the resolution or persistence of inflammation and efficient wound healing or aberrant remodeling remain largely unknown. Low density lipoprotein receptor-related protein 1 (LRP1) is an endocytic/signaling cell surface receptor which controls cellular and molecular mechanisms driving the physiological and pathological inflammatory reactions and tissue remodeling in several organs. In this review, we will discuss the impact of LRP1 on the consecutive steps of the inflammatory response and its role in the balanced tissue repair and aberrant remodeling in the lung.

  • Wujak, L.
  • Schnieder, J.
  • Schaefer, L.
  • Wygrecka, M.

Keywords

  • Fibrosis
  • Inflammation
  • Lrp1
  • Lung
  • Repair
Publication details
DOI: 10.1016/j.matbio.2017.12.007
Journal: Matrix biology : journal of the International Society for Matrix Biology
Work Type: Review
Location: UGMLC
Disease Area: PALI
Partner / Member: JLU
Access-Number: 29262309

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