Effects of Elexacaftor/Tezacaftor/Ivacaftor on cough frequency, physical activity patterns, and sleep quality in adolescents and adults with cystic fibrosis

BACKGROUND: Cystic fibrosis (CF) transmembrane conductance regulator modulators improve lung function, however, effects on cough frequency, physical activity, and sleep have not been assessed in clinical studies. METHODS: After a 12-week, phase 4 pilot feasibility study, we conducted a 13-week, phase 3b, open-label study in participants with CF aged

• Van Braeckel, E.
• Braun, A. T.
• Simmonds, N. J.
• Barry, P. J.
• Davies, J. C.
• Egan, M. E.
• Lapey, A.
• Mall, M. A.
• McKone, E. F.
• Peckham, D.
• Proesmans, M.
• Ramsey, B.
• Santamaria, S. V.
• Smith, D.
• Taylor-Cousar, J. L.
• Tullis, E.
• De Wachter, E.
• Withers, N.
• Ahluwalia, N.
• Conner, S.
• Jennings, M.
• Lou, Y.
• Weinstock, T. G.
• Keating, D.