The newly described severe acute respiratory syndrome corona virus 2 (SARS-CoV-2) is responsible for a pandemic (Corona virus-induced disease -19, COVID-19). It is now well established that certain comorbidities define high risk patients. They include hypertension, diabetes, and coronary artery disease. In contrast, the context with bronchial asthma is controversial and shows marked regional differences. Since asthma is the most prevalent chronic inflammatory lung disease worldwide and SARS-CoV-2 primarily affects the upper and lower airways leading to marked inflammation, the question arises about the possible clinical and pathophysiological association between asthma and SARS-CoV-2/COVID-19. Here we analyze the global epidemiology of asthma among COVID-19 patients and propose the concept that patients suffering from different asthma endotypes (type 2 asthma versus non-type 2 asthma) present with a different risk profile in terms of SARS-CoV-2 infection, development of COVID-19 and progression to severe COVID-19 outcomes. This concept may have important implications for future COVID-19 diagnostics and immune-based therapy developments.
- Skevaki, C.
- Karsonova, A.
- Karaulov, A.
- Xie, M.
- Renz, H.
Keywords
- Covid 19
- SARS-CoV-2
- asthma
- endotypes
- non-type 2 asthma
- type 2 asthma
