Science and Research

Current concepts in chronic inflammatory diseases: Interactions between microbes, cellular metabolism, and inflammation

Recent research indicates that chronic inflammatory diseases, including allergies and autoimmune and neuropsychiatric diseases, share common pathways of cellular and molecular dysregulation. It was the aim of the International von-Behring-Rontgen Symposium (October 16-18, 2014, in Marburg, Germany) to discuss recent developments in this field. These include a concept of biodiversity; the contribution of urbanization, lifestyle factors, and nutrition (eg, vitamin D); and new mechanisms of metabolic and immune dysregulation, such as extracellular and intracellular RNAs and cellular and mitochondrial stress. Epigenetic mechanisms contribute further to altered gene expression and therefore to the development of chronic inflammation. These novel findings provide the foundation for further development of preventive and therapeutic strategies.

  • Garn, H.; Bahn, S.; Baune, B. T.; Binder, E. B.; Bisgaard, H.; Chatila, T. A.; Chavakis, T.; Culmsee, C.; Dannlowski, U.; Gay, S.; Gern, J.; Haahtela, T.; Kircher, T.; Muller-Ladner, U.; Neurath, M. F.; Preissner, K. T.; Reinhardt, C.; Rook, G.; Russell, S.; Schmeck, B.; Stappenbeck, T.; Steinhoff, U.; van Os, J.; Weiss, S.; Zemlin, M.; Renz, H.

Keywords

  • Animals
  • Chronic Disease
  • Energy Metabolism
  • Environment
  • Genetic Predisposition to Disease
  • Host-Pathogen Interactions/genetics/immunology
  • Humans
  • Immunity
  • Inflammation/*etiology/*metabolism
  • Microbiota/immunology
  • Chronic inflammation
  • biodiversity
  • epigenetics
  • immune dysregulation
  • metabolism
  • stress
Publication details
DOI: 10.1016/j.jaci.2016.02.046
Journal: The Journal of allergy and clinical immunology
Pages: 47-56 
Number: 1
Work Type: Review
Location: UGMLC
Disease Area: AA, COPD
Partner / Member: JLU, UMR
Access-Number: 27373325
See publication on PubMed

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