BACKGROUND: Residing in greener places may be protective against diabetes mellitus (DM) but evidence is scarce and comes mainly from developed countries. OBJECTIVES: To investigate associations of residential greenness with DM prevalence and glucose-homeostasis markers in Chinese adults and whether these associations were mediated by air pollution, physical activity, and body mass index. METHODS: In 2009, a total of 15,477 adults from the cross-sectional 33 Communities Chinese Health Study provided blood samples and completed a questionnaire. We considered fasting and 2-h glucose and insulin concentrations, as well as the homoeostasis model assessment of insulin resistance and beta-cell function, as glucose-homeostasis markers. DM was defined according to the American Diabetes Association's recommendations. Residential greenness was estimated by two satellite-derived vegetation indexes - Normalized Difference Vegetation Index (NDVI) and Soil Adjusted Vegetation Index (SAVI). Nitrogen dioxide and particulate matter =2.5mum were used as air pollution proxies. Associations were assessed by two-level adjusted logistic and linear regression models. RESULTS: A 0.1-unit increase in NDVI500 m and SAVI500 m was significantly associated with lower odds of DM by factors of 0.88 (95% Confidence Interval 0.82-0.94) and 0.80 (0.72-0.90), respectively. Higher greenness was also significantly associated with lower fasting and 2-h glucose levels, 2-h insulin level, as well as lower insulin resistance and higher beta-cell function. Air pollution and body mass index significantly mediated 6.9-51.1% and 8.6-78.7% these associations, respectively, while no mediation role was observed for physical activity. CONCLUSIONS: Higher residential greenness appears to be associated with a lower prevalence of DM. This association might be due to glucose and insulin metabolism and pancreatic beta-cell function. Lower levels of air pollution and body mass index can be pathways linking greenspace to diabetes.
- Yang, B. Y.
- Markevych, I.
- Heinrich, J.
- Bowatte, G.
- Bloom, M. S.
- Guo, Y.
- Dharmage, S. C.
- Jalaludin, B.
- Knibbs, L. D.
- Morawska, L.
- Qian, Z. M.
- Chen, D. H.
- Ma, H.
- Chen, D.
- Lin, S.
- Yang, M.
- Liu, K. K.
- Zeng, X. W.
- Hu, L. W.
- Dong, G. H.
Keywords
- Adult
- Air Pollutants/analysis
- Blood Glucose/analysis
- China/epidemiology
- Diabetes Mellitus/blood/*epidemiology
- Female
- Homeostasis
- Humans
- Insulin/blood
- Male
- Middle Aged
- Nitrogen Dioxide/analysis
- Particulate Matter/analysis
- *Plants
- *Residence Characteristics
- Satellite Imagery
- *Cross-sectional
- *Diabetes mellitus
- *Glucose
- *Greenness
- *Insulin resistance
- *Mediation