Differentiation-induced reduction in functional diversity restricts the ability of cytomegalovirus-specific CD8 T cells to eliminate virus-infected cells

BACKGROUND: Human cytomegalovirus (HCMV) is one of the pathogens with the most significant impact on the immune system's composition, including the expansion of virus-specific CD8 T cells. Nevertheless, it remains unclear why individuals with expanded CD8 T cells recognising the pp65-HLA-A(

• Fritz, L.
• Hassan, A.
• Riemann, L.
• Čuvalo, B.
• Costa, B.
• Wieland, B.
• Eiz-Vesper, B.
• Falk, C.
• Roesner, L. M.
• Werfel, T.
• Kalinke, U.
• Georgiev, H.
• F
• Bo