Science and Research

Integrative deep immune profiling of the elderly reveals systems-level signatures of aging, sex, smoking, and clinical traits

BACKGROUND: Aging increases disease susceptibility and reduces vaccine responsiveness, highlighting the need to better understand the aging immune system and its clinical associations. Studying the human immune system, however, remains challenging due to its complexity and significant inter-individual variability. METHODS: We conducted an immune profiling study of 550 elderly participants (

  • Riemann, L.
  • Gutierrez, R.
  • Odak, I.
  • Barros-Martins, J.
  • Roesner, L. M.
  • Leon Lara, X.
  • Falk, C.
  • Schulz, T. F.
  • Hansen, G.
  • Werfel, T.
  • Förster, R.

Keywords

  • Aging
  • Cytokines
  • Deep immune phenotyping
  • Spectral flow cytometry
  • Systems biology
Publication details
DOI: 10.1016/j.ebiom.2025.105558
Journal: EBioMedicine
Pages: 105558 
Work Type: Original
Location: BREATH
Disease Area: PALI
Partner / Member: MHH
Access-Number: 39862806

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