Ventilatory capacity in CLAD is driven by dysfunctional airway structure

BACKGROUND: Chronic lung allograft dysfunction (CLAD) encompasses three main phenotypes: bronchiolitis obliterans syndrome (BOS), restrictive allograft syndrome (RAS) and a Mixed phenotype combining both pathologies. How the airway structure in its entirety is affected in these phenotypes is still poorly understood. METHODS: A detailed analysis of airway morphometry was applied to gain insights on the effects of airway remodelling on the distribution of alveolar ventilation in end-stage CLAD. Ex vivo whole lung

• Kerckhof, P.
• Ambrocio, G. P. L.
• Beeckmans, H.
• Kaes, J.
• Geudens, V.
• Bos, S.
• Willems, L.
• Vermaut, A.
• Vermant, M.
• Goos, T.
• De Fays, C.
• Aversa, L.
• Mohamady, Y.
• Vanstapel, A.
• Orlitová, M.
• Van Slambrouck, J.
• Jin, X.
• Varghese, V.
• Josipovic, I.
• Boone, M. N.
• Dupont, L. J.
• Weynand, B.
• Dubbeldam, A.
• Van Raemdonck, D. E.
• Ceulemans, L. J.
• Gayan-Ramirez, G.
• De Sadeleer, L. J.
• McDonough, J. E.
• Vanaudenaerde, B. M.
• Vos, R.