Science and Research

New concepts in asthma: clinical phenotypes and pathophysiological mechanisms

Asthma is among the most common chronic inflammatory diseases worldwide. Recent evidence indicates that the pathogenesis shows a high degree of heterogeneity. Patient subsets have been identified that exhibit different cellular and molecular patterns of dysregulation. A prominent example is eosinophilic Th2-driven asthma. These unique and molecular patterns are termed endotypes. Characterization of endotypes has broad implications for therapeutic interventions. Although approximately 80% of asthmatic patients respond well to standard anti-inflammatory therapies, the remaining subset particularly consisting of severe patients requires a more specialized endotype-specific approach. This interrelationship between clinical phenotypes, molecular endotypes and endotype-specific therapies is the focus of this review.

  • Koczulla, A. R.; Vogelmeier, C. F.; Garn, H.; Renz, H.
Publication details
DOI: 10.1016/j.drudis.2016.11.008
Journal: Drug discovery today
Pages: 388-396 
Number: 2
Work Type: Review
Location: UGMLC
Disease Area: AA
Partner / Member: UMR
Access-Number: 27867084
See publication on PubMed

DZL Engagements

chevron-down