Bridging therapy-induced phenotypes and genetic immune dysregulation to study interleukin-2-induced immunotoxicology

Interleukin-2 (IL-2) holds promise for the treatment of cancer and autoimmune diseases, but its high-dose usage is associated with systemic immunotoxicity. Differential IL-2 receptor (IL-2R) regulation might impact function of cells upon IL-2 stimulation, possibly inducing cellular changes similar to patients with hypomorphic IL2RB mutations, presenting with multiorgan autoimmunity. Here, we show that sustained high-dose IL-2 stimulation of human lymphocytes drastically reduces IL-2R

• Sommer, C.
• Jacob, S.
• Bargmann, T.
• Shoaib, M.
• Alshaikhdeeb, B.
• Satagopam, V. P.
• Dehmel, S.
• Neuhaus, V.
• Braun, A.
• Sewald, K.