Rev-erb-

Circadian rhythms control the diurnal nature of many physiological, metabolic, and immune processes. We hypothesized that age-related impairments in circadian rhythms are associated with high susceptibility to bacterial respiratory tract infections. Our data show that the time-of-day difference in the control of Streptococcus pneumoniae infection is altered in elderly mice. A lung circadian transcriptome analysis revealed that aging alters the daily oscillations in the expression of a specific set of genes and that some pathways that are rhythmic in young-adult mice are non-rhythmic or time shifted in elderly mice. In particular, the circadian expression of the clock component Rev-erb-

• Silva Angulo, F.
• Joseph, C. V.
• Delval, L.
• Deruyter, L.
• Heumel, S.
• Bicharel, M.
• Rodrigues, P. B.
• Sencio, V.
• Bourguignon, T.
• Machado, M. G.
• Fourcot, M.
• Delhaye, S.
• Salomé-Desnoulez, S.
• Valet, P.
• Adnot, S.
• Wolowczuk, I.
• Sirard, J. C.
• Pichavant, M.
• Staels, B.
• Haas, J. T.
• Gref, R.
• Vandel, J.
• Machelart, A.
• Duez, H.
• Pourcet, B.
• Trottein, F.