Science and Research

Chronic chromosome instability induced by Plk1 results in immune suppression in breast cancer

Chromosome instability (CIN) contributes to resistance to therapies and tumor evolution. Although natural killer (NK) cells can eliminate cells with complex karyotypes, high-CIN human tumors have an immunosuppressive phenotype. To understand which CIN-associated molecular features alter immune recognition during tumor evolution, we overexpress Polo-like kinase 1 (Plk1) in a Her2(+) breast cancer model. These high-CIN tumors activate a senescence-associated secretory phenotype (SASP), upregulate PD-L1 and CD206, and induce non-cell-autonomous nuclear factor

  • Kandala, S.
  • Ramos, M.
  • Voith von Voithenberg, L.
  • Diaz-Jimenez, A.
  • Chocarro, S.
  • Keding, J.
  • Brors, B.
  • Imbusch, C. D.
  • Sotillo, R.

Keywords

  • CP: Cancer
  • CP: Cell biology
  • Her2(+) breast cancer
  • NF-κβ signaling
  • chromosomal instability
  • immune evasion
  • senescence-associated secretory phenotype, SASP
  • single-cell sequencing
Publication details
DOI: 10.1016/j.celrep.2023.113266
Journal: Cell Rep
Pages: 113266 
Number: 12
Work Type: Original
Location: TLRC
Disease Area: LC
Partner / Member: DKFZ
Access-Number: 37979172

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