Science and Research

Role of airway epithelial cells in the development of different asthma phenotypes

The term (bronchial) asthma describes a disorder syndrome that comprises several disease phenotypes, all characterized by chronic inflammation in the bronchial epithelium, with a variety of subsequent functional consequences. Thus, the epithelium in the conducting airways is the main localization of the complex pathological changes in the disease. In this regard, bronchial epithelial cells are not passively affected by inflammatory mechanisms induced by immunological processes but rather actively involved in all steps of disease development from initiation and perpetuation to chronification. In recent years it turned out that bronchial epithelial cells show a high level of structural and functional diversity and plasticity with epigenetic mechanisms playing a crucial role in the regulation of these processes. Thus, it is quite reasonable that differential functional activities of the bronchial epithelium are involved in the development of different asthma phenotypes and/or stages of disease. The current knowledge on this topic will be discussed in this review article.

  • Potaczek, D. P.
  • Miethe, S.
  • Schindler, V.
  • Alhamdan, F.
  • Garn, H.

Keywords

  • Asthma phenotypes
  • Barrier function
  • Bronchial epithelium
  • Epigenetics
  • Epithelial diversity and plasticity
  • Immune regulation
Publication details
DOI: 10.1016/j.cellsig.2019.109523
Journal: Cell Signal
Pages: 109523 
Work Type: Original
Location: UGMLC
Disease Area: AA
Partner / Member: UMR
Access-Number: 31904412
See publication on PubMed

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