Sarcoidosis-Associated Pulmonary Hypertension

Pulmonary hypertension is a life-threatening complication of advanced sarcoidosis. Many mechanisms can cause an elevation of pulmonary pressure in sarcoidosis, leading to precapillary or postcapillary pulmonary hypertension. Sarcoidosis-associated pulmonary hypertension contributes to severe exertional dyspnea, reduced exercise capacity, and notably compromised the survival. Despite the critical functional and prognostic implications of pulmonary hypertension in sarcoidosis, there is a scarcity of specific guidelines on the management of these patients due to a lack of evidence. Hence, further research is required to identify subgroups of patients who may benefit from pulmonary arterial hypertension-targeted therapies and/or immunosuppressive therapies.

• Savale, L.
• Dorfmüller, P.
• Boucly, A.
• Jaïs, X.
• Lacoste-Palasset, T.
• Jevnikar, M.
• Seferian, A.
• Humbert, M.
• Sitbon, O.
• Montani, D.