Science and Research

Intravascular Survival and Extravasation of Tumor Cells

Most metastasizing tumor cells reach distant sites by entering the circulatory system. Within the bloodstream, they are exposed to severe stress due to loss of adhesion to extracellular matrix, hemodynamic shear forces, and attacks of the immune system, and only a few cells manage to extravasate and to form metastases. We review the current understanding of the cellular and molecular mechanisms that allow tumor cells to survive in the intravascular environment and that mediate and promote tumor cell extravasation. As these processes are critical for the metastatic spread of tumor cells, we discuss implications for potential therapeutic approaches and future research.

  • Strilic, B.
  • Offermanns, S.

Keywords

  • Animals
  • Anoikis
  • Cell Survival
  • Extravasation of Diagnostic and Therapeutic Materials/*pathology/therapy
  • Humans
  • Immune System/pathology
  • Neoplastic Cells, Circulating/*pathology
  • Stress, Mechanical
  • metastasis
  • tumor cell extravasation
  • tumor cell survival
Publication details
DOI: 10.1016/j.ccell.2017.07.001
Journal: Cancer cell
Pages: 282-293 
Number: 3
Work Type: Review
Location: UGMLC
Disease Area: LC
Partner / Member: MPI-BN
Access-Number: 28898694

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