Since decades, model organisms have provided an important approach for understanding the mechanistic basis of human diseases. The German Mouse Clinic (GMC) was the first phenotyping facility that established a collaboration-based platform for phenotype characterization of mouse lines. In order to address individual projects by a tailor-made phenotyping strategy, the GMC advanced in developing a series of pipelines with tests for the analysis of specific disease areas. For a general broad analysis, there is a screening pipeline that covers the key parameters for the most relevant disease areas. For hypothesis-driven phenotypic analyses, there are thirteen additional pipelines with focus on neurological and behavioral disorders, metabolic dysfunction, respiratory system malfunctions, immune-system disorders and imaging techniques. In this article, we give an overview of the pipelines and describe the scientific rationale behind the different test combinations.
- Fuchs, H.
- Aguilar-Pimentel, J. A.
- Amarie, O. V.
- Becker, L.
- Calzada-Wack, J.
- Cho, Y. L.
- Garrett, L.
- Holter, S. M.
- Irmler, M.
- Kistler, M.
- Kraiger, M.
- Mayer-Kuckuk, P.
- Moreth, K.
- Rathkolb, B.
- Rozman, J.
- da Silva Buttkus, P.
- Treise, I.
- Zimprich, A.
- Gampe, K.
- Hutterer, C.
- Stoger, C.
- Leuchtenberger, S.
- Maier, H.
- Miller, M.
- Scheideler, A.
- Wu, M.
- Beckers, J.
- Bekeredjian, R.
- Brielmeier, M.
- Busch, D. H.
- Klingenspor, M.
- Klopstock, T.
- Ollert, M.
- Schmidt-Weber, C.
- Stoger, T.
- Wolf, E.
- Wurst, W.
- Yildirim, A. O.
- Zimmer, A.
- Gailus-Durner, V.
- Hrabe de Angelis, M.
Keywords
- *Gene function analysis
- *Mouse model
- *Mouse phenotyping
- *Phenotyping pipeline
