Science and Research

Recent advances in mouse models for systemic sclerosis

SSc is a complex rheumatoid disease characterized by autoimmunity, fibrosis and vasculopathy. Mouse models provide powerful research tools for exploring the pathogenesis of the human diseases. Each mouse model can represent a specific way leading to the development of disease. Moreover, mouse models can be used to investigate the role of candidate molecule in the pathogenesis of disease. So far, more than twenty mouse models for SSc have been established and provide new insights in the understanding of the pathogenesis of SSc. In this review, we provide an overview on recent advances in the field of experimental SSc. We introduce novel mouse models generated in the recent years and discuss their relevance to the SSc pathogenesis. Moreover, we summarize and discuss recent findings in the pathogenesis of classical SSc mouse models.

  • Yue, X.
  • Yu, X.
  • Petersen, F.
  • Riemekasten, G.
Publication details
DOI: 10.1016/j.autrev.2018.06.013
Journal: Autoimmunity reviews
Pages: 1225-1234 
Number: 12
Work Type: Review
Location: ARCN
Disease Area: General Lung and Other
Partner / Member: FZB
Access-Number: 30316997
See publication on PubMed

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