Murine Orthotopic Lung Transplant Models: A Comprehensive Overview of Genetic Mismatch Degrees and Histopathological Insights into Chronic Lung Allograft Dysfunction

Currently, lung transplantation outcome remains inferior compared to other solid organ transplantations. A major cause for limited survival after lung transplantation is chronic lung allograft dysfunction (CLAD). Numerous animal models have been developed to investigate CLAD in order to discover adequate treatments. The murine orthotopic lung transplant model has been further optimized over the last years. However, different degrees of genetic mismatch between donor and recipient mice have been used, applying a single, minor, moderate and major genetic mismatch. This review aims to reassess the existing murine mismatch models and to provide a comprehensive overview, with a specific focus on their eventual histopathologic presentation. This will be crucial to leverage this model and to tailor it according to specific research needs.

• Coppens, A.
• Verleden, S. E.
• Claes, E.
• Voet, H.
• Verleden, G. M.
• Lapperre, T. S.
• Yildirim, AÖ
• Jungraithmayr, W.
• Yamada, Y.
• Peeters, D. J.
• Hendriks, J. M.