Natural and hybrid immunity after SARS-CoV-2 infection in children and adolescents

PURPOSE: In contrast to adults, immune protection against SARS-CoV-2 in children and adolescents with natural or hybrid immunity is still poorly understood. The aim of this study was to analyze different immune compartments in different age groups and whether humoral immune reactions correlate with a cellular immune response. METHODS: 72 children and adolescents with a preceding SARS-CoV-2 infection were recruited. 37 were vaccinated with an RNA vaccine (BNT162b2). Humoral immunity was analyzed 3-26 months (median 10 months) after infection by measuring Spike protein (S), nucleocapsid (NCP), and neutralizing antibodies (nAB). Cellular immunity was analyzed using a SARS-CoV-2-specific interferon-

• Rothoeft, T.
• Maier, C.
• Talarico, A.
• Hoffmann, A.
• Schlegtendal, A.
• Lange, B.
• Petersmann, A.
• Denz, R.
• Timmesfeld, N.
• Toepfner, N.
• Vidal-Blanco, E.
• Pfaender, S.
• Lücke, T.
• Brinkmann, F.