Science and Research

The nervous system of airways and its remodeling in inflammatory lung diseases

Inflammatory lung diseases are associated with bronchospasm, cough, dyspnea and airway hyperreactivity. The majority of these symptoms cannot be primarily explained by immune cell infiltration. Evidence has been provided that vagal efferent and afferent neurons play a pivotal role in this regard. Their functions can be altered by inflammatory mediators that induce long-lasting changes in vagal nerve activity and gene expression in both peripheral and central neurons, providing new targets for treatment of pulmonary inflammatory diseases.

  • Audrit, K. J.
  • Delventhal, L.
  • Aydin, O.
  • Nassenstein, C.

Keywords

  • *Airway Remodeling
  • Animals
  • Humans
  • Inflammation/complications/*pathology
  • Lung/*innervation/pathology/*physiopathology
  • Lung Diseases/complications/*pathology/*physiopathology
  • Neuronal Plasticity
  • Sensory Receptor Cells/pathology
  • Allergic asthma
  • Central sensitization
  • Chronic obstructive lung disease (COPD)
  • Nucleus tractus solitarii (NTS)
  • Peripheral sensitization
  • Transient receptor potential ankyrin 1 (TRPA1)
  • Transient receptor potential vanilloid 1 (TRPV1)
  • Vagal ganglia
Publication details
DOI: 10.1007/s00441-016-2559-7
Journal: Cell and tissue research
Pages: 571-590 
Number: 3
Work Type: Review
Location: UGMLC
Disease Area: AA
Partner / Member: JLU
Access-Number: 28091773

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