Science and Research

NADPH oxidases-do they play a role in TRPC regulation under hypoxia?

In the lung, acute alveolar hypoxia causes hypoxic pulmonary vasoconstriction (HPV) to maintain ventilation perfusion matching and thus optimal oxygenation of blood. In contrast, global chronic hypoxia triggers a pathological thickening of pulmonary arterial walls, called pulmonary vascular remodelling, leading to persistence of pulmonary hypertension (PH). Moreover, ischaemia or hypoxia can lead to a damage of pulmonary endothelial cells with subsequent oedema formation. Alterations in reactive oxygen species (ROS) have been suggested as a crucial mediator of such responses. Among the various sources of cellular ROS production, NADPH oxidases (NOXs) have been found to contribute to these physiological and pathophysiological signalling processes. NOXs are the only known examples that generate ROS as the primary function of the enzyme system. However, the downstream targets of NOX-derived ROS signalling in hypoxia are still not known. Canonical transient receptor potential (TRPC) channels recently have been recognised as directly or indirectly ROS-activated channels and have been shown to be essential for hypoxia-dependent vascular regulatory processes in the lung. Against this background, we here summarise the current knowledge on NOX-mediated TRPC channel signalling during hypoxia in the pulmonary circulation.

  • Malczyk, M.
  • Veith, C.
  • Schermuly, R. T.
  • Gudermann, T.
  • Dietrich, A.
  • Sommer, N.
  • Weissmann, N.
  • Pak, O.


  • Animals
  • Humans
  • Hypoxia/*metabolism
  • NADPH Oxidases/*metabolism
  • Reactive Oxygen Species
  • Signal Transduction
  • TRPC Cation Channels/*metabolism
  • Hypoxic pulmonary vasoconstriction
  • NADPH oxidases
  • Pulmonary hypertension
  • Pulmonary vascular remodelling
  • Transient receptor potential channels
Publication details
DOI: 10.1007/s00424-015-1731-3
Journal: Pflugers Archiv : European journal of physiology
Pages: 23-41 
Number: 1
Work Type: Review
Location: CPC-M, UGMLC
Disease Area: PH
Partner / Member: JLU, LMU
Access-Number: 26424109
See publication on PubMed

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