Phenotyping of COPD with MRI in comparison to same-day CT in a multi-centre trial

OBJECTIVES: A prospective, multi-centre study to evaluate concordance of morphologic lung MRI and CT in chronic obstructive pulmonary disease (COPD) phenotyping for airway disease and emphysema. METHODS: A total of 601 participants with COPD from 15 sites underwent same-day morpho-functional chest MRI and paired inspiratory-expiratory CT. Two readers systematically scored bronchial wall thickening, bronchiectasis, centrilobular nodules, air trapping and lung parenchyma defects in each lung lobe and determined COPD phenotype. A third reader acted as adjudicator to establish consensus. Inter-modality and inter-reader agreement were assessed using Cohen's kappa (im-

• Nauck, S.
• Pohl, M.
• Jobst, B. J.
• Melzig, C.
• Meredig, H.
• Weinheimer, O.
• Triphan, S.
• von Stackelberg, O.
• Konietzke, P.
• Kauczor, H. U.
• Heußel, C. P.
• Wielpütz, M. O.
• Biederer, J.