Science and Research

[Interstitial lung disease in infancy and early childhood]

Diffuse interstitial lung disease of infancy (chILD) shows a spectrum of disease substantially different from that of adults. Established classification systems divide chILD into conditions that are more prevalent in infancy and conditions that occur at any age. The classification is based on a multidisciplinary approach including clinical, radiological, genetic, and histological findings. Lung biopsies become necessary if other diagnostic investigations have not identified a precise chILD or if severe or refractory respiratory distress of unknown cause is present. As the majority of pediatric lung biopsies will be received first by pathologists outside of specialist centers this review summarizes relevant clinical and histological findings of chILD.

  • Länger, F.
  • Werlein, C.
  • Soudah, B.
  • Schwerk, N.
  • Jonigk, D.

Keywords

  • Classification
  • Genetics
  • Histology
  • Perinatal period
  • Surfactant deficiency
Publication details
DOI: 10.1007/s00292-020-00884-8
Journal: Pathologe
Work Type: Review
Location: BREATH
Disease Area: DPLD
Partner / Member: MHH
Access-Number: 33355705

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