Science and Research

Detection of SARS-CoV-2 by Mass Spectrometry

Amplification of viral ribonucleic acid by real-time reverse transcriptase polymerase chain reaction is the gold standard to detect severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). However, alternative reliable, fast, and cost-effective methods for the detection of SARS-CoV-2 are still needed. In this chapter, the mass spectrometry-based detection of amplified polymerase chain reaction products of SARS-CoV-2 genes from oral or nasopharyngeal swabs is described. The respective SARS-CoV-2 test has previously been shown to meet standard quality criteria and was therefore approved by the authorities in Europe and the USA.

  • Wandernoth, P.
  • Kriegsmann, K.
  • Kriegsmann, J.
  • Kriegsmann, M.

Keywords

  • Covid-19
  • Mass Spectrometry
  • MassARRAY
  • SARS-CoV-2
Publication details
DOI: 10.1007/978-1-0716-2111-0_12
Journal: Methods Mol Biol
Pages: 183-196 
Work Type: Original
Location: TLRC
Disease Area: PLI
Partner / Member: UKHD
Access-Number: 35554908

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