Transient receptor potential channel subfamily M member 7 (TRPM7) regulates cellular and systemic Mg(2+) homeostasis through its channel domain and induces protein phosphorylation via its kinase domain. We recently found that mice with selective deletion of Trpm7 in
- Boulassel, S.
- Schreier, P. C. F.
- Melyshi, A. M.
- Berger, J.
- Reinach, P. S.
- Jacob, K.
- Boekhoff, I.
- Breit, A.
- Müller, T. D.
- Zierler, S.
- Gudermann, T.
- Khajavi, N.
Keywords
- Animals
- *TRPM Cation Channels/genetics/metabolism/deficiency
- *Magnesium/pharmacology
- Insulin-Secreting Cells/metabolism/drug effects
- Mice
- Cell Proliferation/drug effects
- *Protein Serine-Threonine Kinases/genetics/metabolism
- Dietary Supplements
- Insulin/metabolism
- *Glucose Intolerance/genetics/metabolism/drug therapy
- Insulin Secretion/drug effects
- Male
- Insulin Resistance
- Mice, Knockout
- Diet, High-Fat
- Mice, Inbred C57BL
- Phosphorylation
- Homeodomain Proteins/metabolism/genetics
- Trans-Activators
- Mg2+ supplementation
- Trpm7
- glucose metabolism
- pancreatic β‐cell
- proliferation
