Prediction of the individual risk for the development of brain metastases in patients with non-oncogene-addicted non-small cell lung cancer: Real-world data from the German prospective CRISP registry (AIO-TRK-0315)

Brain metastases (BM) from non-small cell lung cancer (NSCLC) are a relevant cause of morbidity and mortality. This study aims to identify a population at high risk for BM in order to inform personalized follow-up strategies in the future. We have therefore developed and validated a point-based risk classifier for the risk of BM1 in patients with metastatic non-oncogene-addicted NSCLC without BM at disease onset. A total of 3139 patients were included from the German CRISP lung cancer registry and randomly assigned to a derivation and validation set (2:1). In the derivation set, a Fine and Gray model was developed considering BM and death competing risks. A point-based risk classifier was derived and evaluated in the validation set. Of the baseline variables included in the risk model,

• Acker, F.
• Wenger, K.
• Reck, M.
• Waller, C. F.
• Hoffknecht, P.
• Bethge, A.
• Nusch, A.
• Reiser, M.
• Bernhardt, C.
• Bendel, M.
• Lennartz, C.
• Fleitz, A.
• Jänicke, M.
• Ludwig, P.
• Groth, A.
• Griesinger, F.
• Thomas, M.
• Eberhardt, W. E. E.
• Sebastian, M.