Science and Research

Brain histopathological study and prognosis in MOG antibody-associated demyelinating pseudotumor

Our objective was to examine the brain biopsies by histopathology and investigate the prognosis of patients with myelin oligodendrocyte glycoprotein antibody-associated demyelinating pseudotumor. The clinical, MRI, and histological features of two patients with myelin oligodendrocyte glycoprotein antibody-associated demyelinating pseudotumor were reviewed. Both patients were treated with steroid plus rituximab and followed up. The brain biopsies of both cases revealed T cells, macrophages, and complement-mediated demyelination, which was in accord with multiple sclerosis-like pathology. Moreover, both cases showed favorable response to steroid plus rituximab therapy. Our cases add a new variant to the myelin oligodendrocyte glycoprotein-encephalomyelitis spectrum, which favorably responds to immunotherapy.

  • Shu, Y.
  • Long, Y.
  • Wang, S.
  • Hu, W.
  • Zhou, J.
  • Xu, H.
  • Chen, C.
  • Ou, Y.
  • Lu, Z.
  • Lau, A. Y.
  • Yu, X.
  • Kermode, A. G.
  • Qiu, W.

Keywords

  • Autoantibodies/*adverse effects
  • Demyelinating Diseases/*chemically induced/diagnosis/pathology
  • Encephalomyelitis/drug therapy/pathology
  • Humans
  • Immunologic Factors/metabolism
  • Male
  • Middle Aged
  • Multiple Sclerosis/drug therapy/pathology
  • Myelin-Associated Glycoprotein/metabolism
  • Myelin-Oligodendrocyte Glycoprotein/*metabolism
  • Nervous System Malformations/drug therapy/*pathology
  • Oligodendroglia/drug effects/metabolism
Publication details
DOI: 10.1002/acn3.712
Journal: Ann Clin Transl Neurol
Pages: 392-396 
Number: 2
Work Type: Original
Location: ARCN
Disease Area: General Lung and Other
Partner / Member: FZB
Access-Number: 30847372
See publication on PubMed

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