Our objective was to examine the brain biopsies by histopathology and investigate the prognosis of patients with myelin oligodendrocyte glycoprotein antibody-associated demyelinating pseudotumor. The clinical, MRI, and histological features of two patients with myelin oligodendrocyte glycoprotein antibody-associated demyelinating pseudotumor were reviewed. Both patients were treated with steroid plus rituximab and followed up. The brain biopsies of both cases revealed T cells, macrophages, and complement-mediated demyelination, which was in accord with multiple sclerosis-like pathology. Moreover, both cases showed favorable response to steroid plus rituximab therapy. Our cases add a new variant to the myelin oligodendrocyte glycoprotein-encephalomyelitis spectrum, which favorably responds to immunotherapy.
- Shu, Y.
- Long, Y.
- Wang, S.
- Hu, W.
- Zhou, J.
- Xu, H.
- Chen, C.
- Ou, Y.
- Lu, Z.
- Lau, A. Y.
- Yu, X.
- Kermode, A. G.
- Qiu, W.
Keywords
- Autoantibodies/*adverse effects
- Demyelinating Diseases/*chemically induced/diagnosis/pathology
- Encephalomyelitis/drug therapy/pathology
- Humans
- Immunologic Factors/metabolism
- Male
- Middle Aged
- Multiple Sclerosis/drug therapy/pathology
- Myelin-Associated Glycoprotein/metabolism
- Myelin-Oligodendrocyte Glycoprotein/*metabolism
- Nervous System Malformations/drug therapy/*pathology
- Oligodendroglia/drug effects/metabolism