Science and Research

A Phase I-III, Multicenter Study Evaluating the Efficacy and Safety of Multiple Therapies in Cohorts of Patients Selected According to Biomarker Status, With Locally Advanced, Unresectable, Stage III Non-Small Cell Lung Cancer (HORIZON 1 (BO42777))

A phase I-III multicenter study evaluating the efficacy and safety of multiple therapies in cohorts of patients selected according to biomarker status, with locally advanced, unresectable, stage III non-small cell lung cancer (ALK positive, ROS1 positive, RET fusion positive; TEST PRODUCTS: Alectinib (RO5424802), Entrectinib (RO7102122), Pralsetinib (RO7499790)). This study will evaluate the efficacy and safety of multiple therapies in participants with locally advanced, unresectable, Stage III NSCLC with eligible biomarker status as determined by Version 8 of the American Joint Committee on Cancer/Union for International Cancer Control NSCLC staging system.

Study details
Study-ID: NCT05170204, 2023-503920-14-00
Study-ID: NCT05170204, 2023-503920-14-00
DZL Disease Area: LC
DZL Disease Area: LC
Study Type: Interventional
Study Type: Interventional
DZL Role: DZL recruiting center
DZL Role: DZL recruiting center
Funding: Externally - industry
Funding: Externally - industry
DZL Participating Sites: CPC-M, TLRC
DZL Participating Sites: CPC-M, TLRC
Start Date: 01.11.2022
Completion Date: 01.09.2033
Status: Recruiting
Status: Recruiting
DZL recruiting center
Link to Study


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