Prof. Dr. Norbert Krug (Chair, BREATH), Prof. Dr. Jürgen Behr (CPC-M), Prof. Dr. H. Ardeschir Ghofrani (UGMLC), Prof. Dr. Michael Thomas (TLRC), PD Dr. Henrik Watz (ARCN)

(Administr. Coordinator: Dr. Annegret Zurawski (BREATH)))


The ultimate goal in translational medicine is to test and validate new therapeutic options in humans to advance appropriate tools for tailored treatment.  To that end, a major aim of the DZL is to promote and enable the progress of  innovative early clinical trials. In order to allow the best and most promising studies to be supported, an excellence-based selection process is in place within the DZL.  The studies currently funded by the DZL are:

  • Randomized, double-blind, controlled pilot study on the safety of hypertonic saline as a preventative inhalation therapy in newborn patients with cystic fibrosis
    • Coordinating Investigator:  M.A. Mall (TLRC)
  • Comprehensive characterization of Non Small Cell Lung Cancer (NSCLC) by integrated clinical and molecular analysis
    • Coordinating Investigators:  M. Thomas (TLRC), R.M. Huber (CPC-M)
  • Clinical validation of the iNOS-EMAPII axis as biomarkers, predictors and novel targets in COPD
    • Coordinating investigators:  R. Voswinckel, C. Vogelmeier (UGMLC)
  • Clinical study to investigate safety, tolerability, efficacy, pharmacokinetics and pharmacodynamics of multiple doses of the human GATA-3-specific DNAzyme solution SB010 in patients with moderate to severe DOPD - A randomised, double-blind, parallel, multicentre, pilot study
    • Coordinating Investigator:  C. Vogelmeier (UGMLC)
  • Exploratory Efficacy and Safety Study of oral pirfenidone for progressive, non-IPF lung fibrosis (RELIEF in lung fibrosis)
    • Coordinating Investigators:  J. Behr (CPC-M), A. Günther (UGMLC)
  • Impact of de-novo donor-specific antibodies on short- and long-term survival following single and double lung transplantation
    • Coordinating Investigators:  T. Kauke, H. Winter (CPC-M)
  • Promotion of host defense and alveolar barrier regeneration by inhaled GM-CSF in patients with pneumonia-associated ARDS
    • Coordinating Investigators:  S. Herold, J. Lohmeyer (UGMLC)
  • Phase II study of pleurectomy/decortication and hyperthermic intrathoracic cehmotehrapy (HITHOC) or hyperthermic saline lavage for mesenthelioma
    • Coordinating Investigator:  M. Lindner (CPC-M)