Translational Research to Combat Widespread Lung Diseases

Translational research is the process of transforming scientific discoveries arising from the laboratory into practical applications that directly impact human health and well-being.  For each of the diseases studied by DZL scientists, the entire “bench-to-bedside” translational research chain runs the gamut from investigation of molecular signatures and pathways of disease in animal and laboratory models to the use of those data to drive the design and implementation of clinical trials and patient care.  This process is achieved by the close integration of basic scientists and clinicians and is facilitated by regular meetings, symposia, and access to common infrastructure.

The DZL program follows a unified scientific strategy and is focused on eight disease areas:

Lung diseases are multi-dimensional, affecting the airways, lung tissue, and pulmonary vasculature.  Nevertheless, there is substantial mechanistic overlap as to disease initiation and progression among all disease areas studied by the DZL.  The integrated scientific approach being put into practice explores the dynamic relations among 1) lung generation, regeneration, repair; 2) inflammation and its resolution; and 3) hyperproliferation and its control across all DZL disease areas.  Findings in one disease area may thus be applicable across several disease areas, and the DZL scientific approach and infrastructure allow for rapid translation of findings across diseases.