In the DZL more than 240 principal investigators and their research groups are working together to combat lung disease. These scientists are located at 28 top research institutes throughout Germany, and their activities are managed by five coordinating centers

The DZL is overseen by a five member Board of Directors, and an  International Advisory Board provides input on scientific strategy. The scientific and administrative activities of the DZL are coodinated by the Central Office in Giessen in conjunction with the local Managers. Financial administration is managed by the Funding Management Office based at the Helmholtz Center in Munich.