{"id":51825,"date":"2025-04-28T15:38:51","date_gmt":"2025-04-28T13:38:51","guid":{"rendered":"https:\/\/dzl.de\/news\/epigenetic-training-of-the-airways-how-rhinovirus-infections-imprint-the-bronchial-epithelium\/"},"modified":"2025-04-30T09:21:05","modified_gmt":"2025-04-30T07:21:05","slug":"epigenetic-training-of-the-airways-how-rhinovirus-infections-imprint-the-bronchial-epithelium","status":"publish","type":"post","link":"https:\/\/dzl.de\/en\/news\/epigenetic-training-of-the-airways-how-rhinovirus-infections-imprint-the-bronchial-epithelium\/","title":{"rendered":"Epigenetic Training of the Airways: How Rhinovirus Infections Imprint the Bronchial Epithelium"},"content":{"rendered":"<p class=\"\" data-start=\"207\" data-end=\"538\">Repeated infections with rhinoviruses can induce epigenetic changes in the human bronchial epithelium. Researchers from the German Center for Lung Research (DZL) have now demonstrated for the first time that structural airway cells can develop a form of \"trained immunity\". The results have been published in the journal <em data-start=\"528\" data-end=\"537\">Allergy<\/em>.<\/p>\n<p class=\"\" data-start=\"593\" data-end=\"973\">In their study, the scientists repeatedly infected bronchial epithelial cells (BEAS-2B) with rhinovirus type 16 and subsequently analyzed changes in gene expression and DNA methylation. They identified 77 genes whose activity systematically changed following repeated viral stimulation. These genes are associated with signal transduction, immune response, and cell communication.<\/p>\n<p class=\"\" data-start=\"975\" data-end=\"1016\"><strong data-start=\"975\" data-end=\"1016\">Focus on Altered Methylation Patterns<\/strong><\/p>\n<p class=\"\" data-start=\"1018\" data-end=\"1365\">Particular attention was given to the gene <em data-start=\"1061\" data-end=\"1069\">S100A8<\/em>, which plays a key role in the innate immune response. While in vitro experiments showed a progressive decrease in methylation with repeated infections, clinical samples from children with asthma\u2014based on data from the DZL\u2019s ALLIANCE cohort\u2014revealed an opposite trend with increased methylation.<\/p>\n<p class=\"\" data-start=\"1405\" data-end=\"1761\">The study provides important insights into how early viral infections may influence the risk of developing chronic airway diseases such as asthma. The results show that not only immune cells but also epithelial cells are capable of developing a kind of memory.<\/p>\n<p data-start=\"1405\" data-end=\"1761\"><strong>Original publication: <\/strong><span class=\"author\">Risha MA<\/span>, <span class=\"author\">Reddy KD<\/span>, <span class=\"author\">Nemani SSP<\/span>, et al. <span class=\"articleTitle\">Epigenetic training of human bronchial epithelium cells by repeated rhinovirus infections<\/span>. <i>Allergy<\/i>. <span class=\"pubYear\">2024<\/span>; <span class=\"vol\">79<\/span>: <span class=\"pageFirst\">3385<\/span>-<span class=\"pageLast\">3400<\/span>. doi:<a class=\"linkBehavior\" href=\"https:\/\/doi.org\/10.1111\/all.16388\">10.1111\/all.16388<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Repeated infections with rhinoviruses can induce epigenetic changes in the human bronchial epithelium. Researchers from the German Center for Lung Research (DZL) have now demonstrated for the first time that structural airway cells can develop a form of \"trained immunity\". The results have been published in the journal Allergy.<\/p>\n","protected":false},"author":26,"featured_media":51822,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_seopress_robots_primary_cat":"none","_seopress_titles_title":"Epigenetic Training of the Airways: How Rhinovirus Infections Imprint the Bronchial Epithelium","_seopress_titles_desc":"Repeated infections with rhinoviruses can induce epigenetic changes in the human bronchial epithelium. Researchers from the German Center for Lung Research (DZL) have now demonstrated for the first time that structural airway cells can develop a form of \"trained immunity\". The results have been published in the journal Allergy.","_seopress_robots_index":"","_seopress_analysis_target_kw":"","footnotes":""},"categories":[28],"tags":[312,248],"class_list":["post-51825","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news","tag-alliance-en","tag-asthma-allergy"],"acf":[],"_links":{"self":[{"href":"https:\/\/dzl.de\/en\/wp-json\/wp\/v2\/posts\/51825","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/dzl.de\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/dzl.de\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/dzl.de\/en\/wp-json\/wp\/v2\/users\/26"}],"replies":[{"embeddable":true,"href":"https:\/\/dzl.de\/en\/wp-json\/wp\/v2\/comments?post=51825"}],"version-history":[{"count":1,"href":"https:\/\/dzl.de\/en\/wp-json\/wp\/v2\/posts\/51825\/revisions"}],"predecessor-version":[{"id":51834,"href":"https:\/\/dzl.de\/en\/wp-json\/wp\/v2\/posts\/51825\/revisions\/51834"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/dzl.de\/en\/wp-json\/wp\/v2\/media\/51822"}],"wp:attachment":[{"href":"https:\/\/dzl.de\/en\/wp-json\/wp\/v2\/media?parent=51825"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/dzl.de\/en\/wp-json\/wp\/v2\/categories?post=51825"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/dzl.de\/en\/wp-json\/wp\/v2\/tags?post=51825"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}