Publikationen Oktober 2017

Publikationen September 2017

Publikationen August 2017

Publikationen Juli 2017

Publikationen Juni 2017
Publikationen Mai 2017
Publikationen April 2017
Publikationen März 2017
Publikationen Februar 2017
Publikationen Januar 2017

Publikationen Dezember 2016
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Publikationen Oktober 2016
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Publikationen Dezember 2015
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Publikationen Oktober 2015
Publikationen September 2015
Publikationen August 2015
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Publikationen-Archiv (Mai 2015 und älter)

 

Oktober 2017

New in PubMed from DZL Faculty / Neu von der DZL-Fakultät in der Woche bis 22. Oktober 2017:

Gotschke J., Mertsch P., Bischof M., Kneidinger N., Matthes S., Renner E. D., Schultz K., Traidl-Hoffmann C., Duchna H. W., Behr J., Schmude J., Huber R. M., Milger K.; Perception of climate change in patients with chronic lung disease; PloS one; 2017; e0186632; doi: 10.1371/journal.pone.0186632; Epub; https://www.ncbi.nlm.nih.gov/pubmed/29045479

Landgraf-Rauf K., Boeck A., Raedler D., Klucker E., Vogelsang V., Schmidt S., Kunze S., Weissenbacher C., Graessel A., Schmidt-Weber C., Von Mutius E., Schedel M., Schaub B.; IRF-1 SNPs influence the risk for childhood allergic asthma: a critical role for pro-inflammatory immune regulation; Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology; Oct 19 2017; 10.1111/pai.12821; Epub; https://www.ncbi.nlm.nih.gov/pubmed/29047170

Leichsenring J., Volckmar A. L., Kirchner M., Kazdal D., Kriegsmann M., Stogbauer F., Bockmayr T., Klauschen F., Herth F. J. F., Penzel R., Warth A., Schirmacher P., Endris V., Stenzinger A.; Targeted Deep Sequencing of Effusion Cytology Samples is Feasible, informs Spatiotemporal Tumor Evolution, and has Clinical and Diagnostic Utility; Genes, chromosomes & cancer; Oct 16 2017; 10.1002/gcc.22509; Epub; https://www.ncbi.nlm.nih.gov/pubmed/29044880

Liu R., Fan W., Kruger K., Xiao Y. U., Pilat C., Seimetz M., Ringseis R., Baumgart-Vogt E., Eder K., Weissmann N., Mooren F. C.; Exercise Affects T-Cell Function by Modifying Intracellular Calcium Homeostasis; Medicine and science in sports and exercise; Jan 2017; 29-39; doi: 10.1249/MSS.0000000000001080; Epub; https://www.ncbi.nlm.nih.gov/pubmed/27525377

Ntokou A., Szibor M., Rodriguez-Castillo J. A., Quantius J., Herold S., El Agha E., Bellusci S., Salwig I., Braun T., Voswinckel R., Seeger W., Morty R. E., Ahlbrecht K.; A novel mouse Cre-driver line targeting Perilipin 2-expressing cells in the neonatal lung; Genesis (New York, N.Y. : 2000); Oct 16 2017; 10.1002/dvg.23080; Epub; https://www.ncbi.nlm.nih.gov/pubmed/29045046

Pak O., Sydykov A., Kosanovic D., Schermuly R. T., Dietrich A., Schroder K., Brandes R. P., Gudermann T., Sommer N., Weissmann N.; Lung Ischaemia-Reperfusion Injury: The Role of Reactive Oxygen Species; Advances in experimental medicine and biology; 2017; 195-225; doi: 10.1007/978-3-319-63245-2_12; Epub; https://www.ncbi.nlm.nih.gov/pubmed/29047088

Polke M., Oelmann-Avendano J., Warth A., Heussel C. P., Herth F. J. F., Eberhardt R.; Successful treatment of a recurrent granulation polyp in the airways with high-dose-rate brachytherapy: a case report; Journal of medical case reports; Oct 18 2017; 289; doi: 10.1186/s13256-017-1465-2; Epub; https://www.ncbi.nlm.nih.gov/pubmed/29047403

Richter M. J., Milger K., Tello K., Stille P., Seeger W., Mayer E., Ghofrani H. A., Gall H.; Heart rate response during 6-minute walking testing predicts outcome in operable chronic thromboembolic pulmonary hypertension; BMC pulmonary medicine; Jul 04 2016; 96; doi: 10.1186/s12890-016-0260-y; Epub; PMC4932688; https://www.ncbi.nlm.nih.gov/pubmed/27377832

Schmidt K., Damm K., Vogel A., Golpon H., Manns M. P., Welte T., Graf Von Der Schulenburg J. M.; Therapy preferences of patients with lung and colon cancer: a discrete choice experiment; Patient preference and adherence; 2017; 1647-1656; doi: 10.2147/PPA.S138863; Epub; PMC5630067; https://www.ncbi.nlm.nih.gov/pubmed/29033552

Shi L., Kojonazarov B., Elgheznawy A., Popp R., Dahal B. K., Bohm M., Pullamsetti S. S., Ghofrani H. A., Godecke A., Jungmann A., Katus H. A., Muller O. J., Schermuly R. T., Fisslthaler B., Seeger W., Fleming I.; miR-223-IGF-IR signalling in hypoxia- and load-induced right-ventricular failure: a novel therapeutic approach; Cardiovascular research; Aug 01 2016; 184-193; doi: 10.1093/cvr/cvw065; Epub; https://www.ncbi.nlm.nih.gov/pubmed/27013635

Wiskemann J., Hummler S., Diepold C., Keil M., Abel U., Steindorf K., Beckhove P., Ulrich C. M., Steins M., Thomas M.; POSITIVE study: physical exercise program in non-operable lung cancer patients undergoing palliative treatment; BMC cancer; Jul 19 2016; 499; doi: 10.1186/s12885-016-2561-1; Epub; PMC4949758; https://www.ncbi.nlm.nih.gov/pubmed/27430336

Forster K., Sass S., Ehrhardt H., Mous D. S., Rottier R. J., Oak P., Schulze A., Flemmer A. W., Gronbach J., Hubener C., Desai T., Eickelberg O., Theis F. J., Hilgendorff A.; Early Identification of Bronchopulmonary Dysplasia Using Novel Biomarkers by Proteomic Screening; American journal of respiratory and critical care medicine; Oct 20 2017; 10.1164/rccm.201706-1218LE; Epub; https://www.ncbi.nlm.nih.gov/pubmed/29053024

Agusti A., Bafadhel M., Beasley R., Bel E. H., Faner R., Gibson P. G., Louis R., Mcdonald V. M., Sterk P. J., Thomas M., Vogelmeier C., Pavord I. D., On Behalf of All Participants in The Seminar; Precision medicine in airway diseases: moving to clinical practice; The European respiratory journal; Oct 2017; 10.1183/13993003.01655-2017; Epub; https://www.ncbi.nlm.nih.gov/pubmed/29051276

New in PubMed from DZL Faculty / Neu von der DZL-Fakultät in der Woche bis 15. Oktober 2017:

Vogelmeier C., Worth H., Buhl R., Criee C. P., Lossi N. S., Mailander C., Kardos P.; "Real-life" inhaled corticosteroid withdrawal in COPD: a subgroup analysis of DACCORD; International journal of chronic obstructive pulmonary disease; 2017; 487-494; doi: 10.2147/COPD.S125616; Epub; PMC5295250; https://www.ncbi.nlm.nih.gov/pubmed/28203072

Tiede S. L., Wassenberg M., Christ K., Schermuly R. T., Seeger W., Grimminger F., Ghofrani H. A., Gall H.; Biomarkers of tissue remodeling predict survival in patients with pulmonary hypertension; International journal of cardiology; Nov 15 2016; 821-826; doi: 10.1016/j.ijcard.2016.08.240; Epub; https://www.ncbi.nlm.nih.gov/pubmed/27575785

Muller J., Lim H. J., Eichinger M., Jobst B. J., Eberhardt R., Gompelmann D., Koenigkam-Santos M., Puderbach M., Kauczor H. U., Heussel C. P., Wielputz M. O.; Influence of fissure integrity on quantitative CT and emphysema distribution in emphysema-type COPD using a dedicated COPD software; European journal of radiology; Oct 2017; 293-299; doi: 10.1016/j.ejrad.2017.08.015; Epub; https://www.ncbi.nlm.nih.gov/pubmed/28987683

Flechsig P., Frank P., Kratochwil C., Antoch G., Rath D., Moltz J., Rieser M., Warth A., Kauczor H. U., Schwartz L. H., Haberkorn U., Giesel F. L.; Radiomic Analysis using Density Threshold for FDG-PET/CT-Based N-Staging in Lung Cancer Patients; Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging; Apr 2017; 315-322; doi: 10.1007/s11307-016-0996-z; Epub; https://www.ncbi.nlm.nih.gov/pubmed/27539308

Wittmann T., Schindlbeck U., Hoppner S., Kinting S., Frixel S., Kroner C., Liebisch G., Hegermann J., Aslanidis C., Brasch F., Reu S., Lasch P., Zarbock R., Griese M.; Tools to explore ABCA3 mutations causing interstitial lung disease; Pediatric pulmonology; Dec 2016; 1284-1294; doi: 10.1002/ppul.23471; Epub; https://www.ncbi.nlm.nih.gov/pubmed/27177387

Cilloniz C., Torres A., Niederman M., Van Der Eerden M., Chalmers J., Welte T., Blasi F.; Community-acquired pneumonia related to intracellular pathogens; Intensive care medicine; Sep 2016; 1374-1386; doi: 10.1007/s00134-016-4394-4; Epub; https://www.ncbi.nlm.nih.gov/pubmed/27276986

Carleo A., Chorostowska-Wynimko J., Koeck T., Mischak H., Czajkowska-Malinowska M., Rozy A., Welte T., Janciauskiene S.; Does urinary peptide content differ between COPD patients with and without inherited alpha-1 antitrypsin deficiency?; International journal of chronic obstructive pulmonary disease; 2017; 829-837; doi: 10.2147/COPD.S125240; Epub; PMC5352160; https://www.ncbi.nlm.nih.gov/pubmed/28331304

Richeldi L., Kreuter M., Selman M., Crestani B., Kirsten A. M., Wuyts W. A., Xu Z., Bernois K., Stowasser S., Quaresma M., Costabel U.; Long-term treatment of patients with idiopathic pulmonary fibrosis with nintedanib: results from the TOMORROW trial and its open-label extension; Thorax; Oct 09 2017; 10.1136/thoraxjnl-2016-209701; Epub; https://www.ncbi.nlm.nih.gov/pubmed/28993537

Waschki B., Watz H., Holz O., Magnussen H., Olejnicka B., Welte T., Rabe K. F., Janciauskiene S.; Plasminogen activator inhibitor-1 is elevated in patients with COPD independent of metabolic and cardiovascular function; International journal of chronic obstructive pulmonary disease; 2017; 981-987; doi: 10.2147/COPD.S128689; Epub; PMC5367764; https://www.ncbi.nlm.nih.gov/pubmed/28356730

New in PubMed from DZL Faculty / Neu von der DZL-Fakultät in der Woche bis 08. Oktober 2017:

Yamauchi Y., Safi S., Orschiedt L., Gardyan A., Brons S., Rieber J., Nicolay N. H., Huber P. E., Eichhorn M., Dienemann H., Herth F. J. F., Weber K. J., Debus J., Hoffmann H., Rieken S.; Low-dose photon irradiation induces invasiveness through the SDF-1alpha/CXCR4 pathway in malignant mesothelioma cells; Oncotarget; Sep 15 2017; 68001-68011; doi: 10.18632/oncotarget.19134; Epub; PMC5620231; https://www.ncbi.nlm.nih.gov/pubmed/28978091

Von Stackelberg O., Kauczor H. U.; [Lung cancer screening with thoracic Xray and CT : Current situation]; Der Radiologe; Sep 2016; 793-797; doi: 10.1007/s00117-016-0141-7; Epub; https://www.ncbi.nlm.nih.gov/pubmed/27411917

Tufman A., Huber R. M., Volk S., Aigner F., Edelmann M., Gamarra F., Kiefl R., Kahnert K., Tian F., Boulesteix A. L., Endres S., Kobold S.; Interleukin-22 is elevated in lavage from patients with lung cancer and other pulmonary diseases; BMC cancer; Jul 07 2016; 409; doi: 10.1186/s12885-016-2471-2; Epub; PMC4936283; https://www.ncbi.nlm.nih.gov/pubmed/27388918

Surate Solaligue D. E., Rodriguez-Castillo J. A., Ahlbrecht K., Morty R. E.; Recent advances in our understanding of the mechanisms of late lung development and bronchopulmonary dysplasia; American journal of physiology. Lung cellular and molecular physiology; Sep 28 2017; ajplung 00343 02017; doi: 10.1152/ajplung.00343.2017; Epub; https://www.ncbi.nlm.nih.gov/pubmed/28971976

Solyanik O., Gaass T., Hellbach K., Dinkel J.; [Pneumonia in immunosuppressed patients]; Der Radiologe; Jan 2017; 22-28; doi: 10.1007/s00117-016-0197-4; Epub; https://www.ncbi.nlm.nih.gov/pubmed/28058476

Kolditz M., Scherag A., Rohde G., Ewig S., Welte T., Pletz M., Group Capnetz Study; Comparison of the qSOFA and CRB-65 for risk prediction in patients with community-acquired pneumonia; Intensive care medicine; Dec 2016; 2108-2110; doi: 10.1007/s00134-016-4517-y; Epub; https://www.ncbi.nlm.nih.gov/pubmed/27647332

Horner-Rieber J., Dern J., Bernhardt D., Konig L., Adeberg S., Verma V., Paul A., Kappes J., Hoffmann H., Debus J., Heussel C. P., Rieken S.; Parenchymal and Functional Lung Changes after Stereotactic Body Radiotherapy for Early-Stage Non-Small Cell Lung Cancer-Experiences from a Single Institution; Frontiers in oncology; 2017; 215; doi: 10.3389/fonc.2017.00215; Epub; PMC5610686; https://www.ncbi.nlm.nih.gov/pubmed/28975083

Hecker M., Hecker A., Kramm T., Askevold I., Kuhnert S., Reichert M., Mayer E., Seeger W., Padberg W., Mayer K.; Use of very old donors for lung transplantation: a dual-centre retrospective analysis; European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery; Jul 17 2017; 10.1093/ejcts/ezx202; Epub; https://www.ncbi.nlm.nih.gov/pubmed/28977370

Gutberlet M., Kaireit T. F., Voskrebenzev A., Lasch F., Freise J., Welte T., Wacker F., Hohlfeld J. M., Vogel-Claussen J.; Free-breathing Dynamic 19F Gas MR Imaging for Mapping of Regional Lung Ventilation in Patients with COPD; Radiology; Oct 03 2017; 170591; doi: 10.1148/radiol.2017170591; Epub; https://www.ncbi.nlm.nih.gov/pubmed/28972817

Didiasova M., Singh R., Wilhelm J., Kwapiszewska G., Wujak L., Zakrzewicz D., Schaefer L., Markart P., Seeger W., Lauth M., Wygrecka M.; Pirfenidone exerts antifibrotic effects through inhibition of GLI transcription factors; FASEB journal : official publication of the Federation of American Societies for Experimental Biology; May 2017; 1916-1928; doi: 10.1096/fj.201600892RR; Epub; https://www.ncbi.nlm.nih.gov/pubmed/28148565

Boutin S., Graeber S. Y., Stahl M., Dittrich A. S., Mall M. A., Dalpke A. H.; Chronic but not intermittent infection with Pseudomonas aeruginosa is associated with global changes of the lung microbiome in cystic fibrosis; The European respiratory journal; Oct 2017; 10.1183/13993003.01086-2017; Epub; https://www.ncbi.nlm.nih.gov/pubmed/28982777

New in PubMed from DZL Faculty / Neu von der DZL-Fakultät in der Woche bis 01. Oktober 2017:

Zhao J., Dinkel J., Warth A., Penzel R., Reinmuth N., Schnabel P., Muley T., Meister M., Zabeck H., Steins M., Yang J. Y., Zhou Q., Schlemmer H. P., Herth F. J. F., Kauczor H. U., Heussel C. P.; CT characteristics in pulmonary adenocarcinoma with epidermal growth factor receptor mutation; PloS one; 2017; e0182741; doi: 10.1371/journal.pone.0182741; Epub; https://www.ncbi.nlm.nih.gov/pubmed/28949965

Worth H., Buhl R., Criee C. P., Kardos P., Lossi N. S., Vogelmeier C. F.; GOLD 2017 treatment pathways in 'real life': An analysis of the DACCORD observational study; Respiratory medicine; Oct 2017; 77-84; doi: 10.1016/j.rmed.2017.08.008; Epub; https://www.ncbi.nlm.nih.gov/pubmed/28947047

Sommer W., Buechler G., Jansson K., Avsar M., Knofel A. K., Salman J., Hoeffler K., Siemeni T., Gottlieb J., Karstens J. H., Jonigk D., Reising A., Haverich A., Struber M., Warnecke G.; Irradiation before and donor splenocyte infusion immediately after transplantation induce tolerance to lung, but not heart allografts in miniature swine; Transplant international : official journal of the European Society for Organ Transplantation; Apr 2017; 420-431; doi: 10.1111/tri.12916; Epub; https://www.ncbi.nlm.nih.gov/pubmed/28095640

Lykhmus O., Voytenko L. P., Lips K. S., Bergen I., Krasteva-Christ G., Vetter D. E., Kummer W., Skok M.; Nicotinic Acetylcholine Receptor alpha9 and alpha10 Subunits Are Expressed in the Brain of Mice; Frontiers in cellular neuroscience; 2017; 282; doi: 10.3389/fncel.2017.00282; Epub; PMC5601054; https://www.ncbi.nlm.nih.gov/pubmed/28955208

Leutz-Schmidt P., Weinheimer O., Jobst B. J., Dinkel J., Biederer J., Kauczor H. U., Puderbach M. U., Wielputz M. O.; Influence of exposure parameters and iterative reconstruction on automatic airway segmentation and analysis on MDCT-An ex vivo phantom study; PloS one; 2017; e0182268; doi: 10.1371/journal.pone.0182268; Epub; PMC5540604; https://www.ncbi.nlm.nih.gov/pubmed/28767732

Kreuter M., Cottin V.; The threat in chronic lung diseases: acute exacerbations; European respiratory review : an official journal of the European Respiratory Society; Sep 30 2017; 10.1183/16000617.0075-2017; Epub; https://www.ncbi.nlm.nih.gov/pubmed/28954770

Kallenberger S. M., Unger A. L., Legewie S., Lymperopoulos K., Klingmuller U., Eils R., Herten D. P.; Correlated receptor transport processes buffer single-cell heterogeneity; PLoS computational biology; Sep 25 2017; e1005779; doi: 10.1371/journal.pcbi.1005779; Epub; https://www.ncbi.nlm.nih.gov/pubmed/28945754

Herbig B., Jorres R. A., Schierl R., Simon M., Langner J., Seeger S., Nowak D., Karrasch S.; Psychological and cognitive effects of laser printer emissions: a controlled exposure study; Indoor air; Sep 28 2017; 10.1111/ina.12429; Epub; https://www.ncbi.nlm.nih.gov/pubmed/28960517

Guo M., Tomoshige K., Meister M., Muley T., Fukazawa T., Tsuchiya T., Karns R., Warth A., Fink-Baldauf I. M., Nagayasu T., Naomoto Y., Xu Y., Mall M. A., Maeda Y.; Gene signature driving invasive mucinous adenocarcinoma of the lung; EMBO molecular medicine; Apr 2017; 462-481; doi: 10.15252/emmm.201606711; Epub; PMC5376761; https://www.ncbi.nlm.nih.gov/pubmed/28255028

Brinker T. J., Enk A., Gatzka M., Nakamura Y., Sondermann W., Omlor A. J., Petri M. P., Karoglan A., Seeger W., Klode J., Von Kalle C., Schadendorf D.; A Dermatologist's Ammunition in the War Against Smoking: A Photoaging App; Journal of medical Internet research; Sep 21 2017; e326; doi: 10.2196/jmir.8743; Epub; https://www.ncbi.nlm.nih.gov/pubmed/28935619

September 2017

New in PubMed from DZL Faculty / Neu von der DZL-Fakultät in der Woche bis 24. September 2017:

Wentker P., Eberhardt M., Dreyer F. S., Bertrams W., Cantone M., Griss K., Schmeck B., Vera J.; An Interactive Macrophage Signal Transduction Map Facilitates Comparative Analyses of High-Throughput Data; Journal of immunology (Baltimore, Md. : 1950); Mar 01 2017; 2191-2201; doi: 10.4049/jimmunol.1502513; Epub; https://www.ncbi.nlm.nih.gov/pubmed/28137890

Schulz C., Lai X., Bertrams W., Jung A. L., Sittka-Stark A., Herkt C. E., Janga H., Zscheppang K., Stielow C., Schulte L., Hippenstiel S., Vera J., Schmeck B.; THP-1-derived macrophages render lung epithelial cells hypo-responsive to Legionella pneumophila - a systems biology study; Scientific reports; Sep 20 2017; 11988; doi: 10.1038/s41598-017-12154-4; Epub; PMC5607273; https://www.ncbi.nlm.nih.gov/pubmed/28931863

Kahnert K., Lucke T., Huber R. M., Behr J., Biertz F., Vogt A., Watz H., Alter P., Fahndrich S., Bals R., Holle R., Karrasch S., Sohler S., Wacker M., Ficker J. H., Parhofer K. G., Vogelmeier C., Jorres R. A., Consortium Cosyconet; Relationship of hyperlipidemia to comorbidities and lung function in COPD: Results of the COSYCONET cohort; PloS one; 2017; e0177501; doi: 10.1371/journal.pone.0177501; Epub; PMC5432186; https://www.ncbi.nlm.nih.gov/pubmed/28505167

Horner-Rieber J., Bernhardt D., Dern J., Konig L., Adeberg S., Paul A., Heussel C. P., Kappes J., Hoffmann H., Herth F. J. P., Debus J., Warth A., Rieken S.; Histology of non-small cell lung cancer predicts the response to stereotactic body radiotherapy; Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology; Sep 14 2017; 10.1016/j.radonc.2017.08.029; Epub; https://www.ncbi.nlm.nih.gov/pubmed/28919006

Hoegl S., Zwissler B.; Preventing ventilator-induced lung injury-what does the evidence say?; Journal of thoracic disease; Aug 2017; 2259-2263; doi: 10.21037/jtd.2017.06.135; Epub; PMC5594202; https://www.ncbi.nlm.nih.gov/pubmed/28932519

Ghofrani H. A., Simonneau G., D'armini A. M., Fedullo P., Howard L. S., Jais X., Jenkins D. P., Jing Z. C., Madani M. M., Martin N., Mayer E., Papadakis K., Richard D., Kim N. H., Investigators Merit Study; Macitentan for the treatment of inoperable chronic thromboembolic pulmonary hypertension (MERIT-1): results from the multicentre, phase 2, randomised, double-blind, placebo-controlled study; The Lancet. Respiratory medicine; Sep 08 2017; 10.1016/S2213-2600(17)30305-3; Epub; https://www.ncbi.nlm.nih.gov/pubmed/28919201

New in PubMed from DZL Faculty / Neu von der DZL-Fakultät in der Woche bis 17. September 2017:

Ackermann M., Gaumann A., Mentzer S. J., Hinrichs J. B., Warnecke G., Hoeper M. M., Braubach P., Kuehnel M., Maegel L., Jonigk D.; Plexiform Vasculopathy in Chronic Thromboembolic Pulmonary Hypertension; American journal of respiratory and critical care medicine; Sep 11 2017; 10.1164/rccm.201703-0591IM; Epub; https://www.ncbi.nlm.nih.gov/pubmed/28892403

Bahmer T., Kirsten A. M., Waschki B., Rabe K. F., Magnussen H., Kirsten D., Gramm M., Hummler S., Brunnemer E., Kreuter M., Watz H.; Clinical Correlates of Reduced Physical Activity in Idiopathic Pulmonary Fibrosis; Respiration; international review of thoracic diseases; 2016; 497-502; doi: 10.1159/000446607; Epub; https://www.ncbi.nlm.nih.gov/pubmed/27240427

Brinker T. J., Seeger W., Buslaff F.; Photoaging Mobile Apps in School-Based Tobacco Prevention: The Mirroring Approach; Journal of medical Internet research; Jun 28 2016; e183; doi: 10.2196/jmir.6016; Epub; PMC4942683; https://www.ncbi.nlm.nih.gov/pubmed/27352819

Budas G. R., Boehm M., Kojonazarov B., Viswanathan G., Tian X., Veeroju S., Novoyatleva T., Grimminger F., Hinojosa-Kirschenbaum F., Ghofrani H. A., Weissmann N., Seeger W., Liles J. T., Schermuly R. T.; ASK1 Inhibition Halts Disease Progression in Preclinical Models of Pulmonary Arterial Hypertension; American journal of respiratory and critical care medicine; Sep 14 2017; 10.1164/rccm.201703-0502OC; Epub; https://www.ncbi.nlm.nih.gov/pubmed/28910144

Ciuleanu T. E., Ahmed S., Kim J. H., Mezger J., Park K., Thomas M., Chen J., Poondru S., Vantornout J. M., Whitcomb D., Blackhall F.; Randomised Phase 2 study of maintenance linsitinib (OSI-906) in combination with erlotinib compared with placebo plus erlotinib after platinum-based chemotherapy in patients with advanced non-small cell lung cancer; British journal of cancer; Sep 05 2017; 757-766; doi: 10.1038/bjc.2017.226; Epub; PMC5589984; https://www.ncbi.nlm.nih.gov/pubmed/28772281

Conrad A., Janciauskiene S., Kohnlein T., Fuge J., Ivanyi P., Tudorache I., Gottlieb J., Welte T., Fuehner T.; Impact of alpha 1-antitrypsin deficiency and prior augmentation therapy on patients' survival after lung transplantation; The European respiratory journal; Sep 2017; 10.1183/13993003.00962-2017; Epub; https://www.ncbi.nlm.nih.gov/pubmed/28890438

Fahndrich S., Biertz F., Karch A., Kleibrink B., Koch A., Teschler H., Welte T., Kauczor H. U., Janciauskiene S., Jorres R. A., Greulich T., Vogelmeier C. F., Bals R., Investigators Cosyconet; Cardiovascular risk in patients with alpha-1-antitrypsin deficiency; Respiratory research; Sep 15 2017; 171; doi: 10.1186/s12931-017-0655-1; Epub; https://www.ncbi.nlm.nih.gov/pubmed/28915894

Hattar K., Reinert C. P., Sibelius U., Gokyildirim M. Y., Subtil F. S. B., Wilhelm J., Eul B., Dahlem G., Grimminger F., Seeger W., Grandel U.; Lipoteichoic acids from Staphylococcus aureus stimulate proliferation of human non-small-cell lung cancer cells in vitro; Cancer immunology, immunotherapy : CII; Jun 2017; 799-809; doi: 10.1007/s00262-017-1980-4; Epub; PMC5445152; https://www.ncbi.nlm.nih.gov/pubmed/28314957

Lang S., Popp T., Kriegs C. S., Schmidt A., Balszuweit F., Menacher G., Kehe K., Thiermann H., Gudermann T., Steinritz D.; Anti-apoptotic and moderate anti-inflammatory effects of berberine in sulfur mustard exposed keratinocytes; Toxicology letters; Sep 12 2017; 10.1016/j.toxlet.2017.09.004; Epub; https://www.ncbi.nlm.nih.gov/pubmed/28916288

Op Den Winkel J., Eichhorn F., Rieken S., Dienemann H.; [Local treatment of solitary intrapulmonary, malignant nodules]; Der Radiologe; Feb 2017; 97-104; doi: 10.1007/s00117-016-0200-0; Epub; https://www.ncbi.nlm.nih.gov/pubmed/28054137

Torres A., Niederman M. S., Chastre J., Ewig S., Fernandez-Vandellos P., Hanberger H., Kollef M., Li Bassi G., Luna C. M., Martin-Loeches I., Paiva J. A., Read R. C., Rigau D., Timsit J. F., Welte T., Wunderink R.; International ERS/ESICM/ESCMID/ALAT guidelines for the management of hospital-acquired pneumonia and ventilator-associated pneumonia: Guidelines for the management of hospital-acquired pneumonia (HAP)/ventilator-associated pneumonia (VAP) of the European Respiratory Society (ERS), European Society of Intensive Care Medicine (ESICM), European Society of Clinical Microbiology and Infectious Diseases (ESCMID) and Asociacion Latinoamericana del Torax (ALAT); The European respiratory journal; Sep 2017; 10.1183/13993003.00582-2017; Epub; https://www.ncbi.nlm.nih.gov/pubmed/28890434

New in PubMed from DZL Faculty / Neu von der DZL-Fakultät in der Woche bis 10. September 2017:

Behr J., Neuser P., Prasse A., Kreuter M., Rabe K., Schade-Brittinger C., Wagner J., Gunther A.; Exploring efficacy and safety of oral Pirfenidone for progressive, non-IPF lung fibrosis (RELIEF) - a randomized, double-blind, placebo-controlled, parallel group, multi-center, phase II trial; BMC pulmonary medicine; Sep 06 2017; 122; doi: 10.1186/s12890-017-0462-y; Epub; https://www.ncbi.nlm.nih.gov/pubmed/28877715

Hautefort A., Chesne J., Preussner J., Pullamsetti S. S., Tost J., Looso M., Antigny F., Girerd B., Riou M., Eddahibi S., Deleuze J. F., Seeger W., Fadel E., Simonneau G., Montani D., Humbert M., Perros F.; Pulmonary endothelial cell DNA methylation signature in pulmonary arterial hypertension; Oncotarget; Aug 08 2017; 52995-53016; doi: 10.18632/oncotarget.18031; Epub; PMC5581088; https://www.ncbi.nlm.nih.gov/pubmed/28881789

Hoppner S., Kinting S., Torrano A. A., Schindlbeck U., Brauchle C., Zarbock R., Wittman T., Griese M.; Quantification of volume and lipid filling of intracellular vesicles carrying the ABCA3 transporter; Biochimica et biophysica acta; Sep 05 2017; 10.1016/j.bbamcr.2017.08.013; Epub; https://www.ncbi.nlm.nih.gov/pubmed/28887056

Jentho E., Bodden M., Schulz C., Jung A. L., Seidel K., Schmeck B., Bertrams W.; microRNA-125a-3p is regulated by MyD88 in Legionella pneumophila infection and targets NTAN1; PloS one; 2017; e0176204; doi: 10.1371/journal.pone.0176204; Epub; PMC5406027; https://www.ncbi.nlm.nih.gov/pubmed/28445535

Jobst B. J., Weinheimer O., Trauth M., Becker N., Motsch E., Gross M. L., Tremper J., Delorme S., Eigentopf A., Eichinger M., Kauczor H. U., Wielputz M. O.; Effect of smoking cessation on quantitative computed tomography in smokers at risk in a lung cancer screening population; European radiology; Sep 07 2017; 10.1007/s00330-017-5030-6; Epub; https://www.ncbi.nlm.nih.gov/pubmed/28884215

Kauffmann-Guerrero D., Kahnert K., Pratschke S., Angstwurm M., Tufman A., Huber R. M.; Black and Blue; Respiration; international review of thoracic diseases; Sep 07 2017; 10.1159/000479703; Epub; https://www.ncbi.nlm.nih.gov/pubmed/28877530

Kemp S. V., Slebos D. J., Kirk A., Kornaszewska M., Carron K., Ek L., Broman G., Hillerdal G., Mal H., Pison C., Briault A., Downer N., Darwiche K., Rao J., Hubner R. H., Ruwwe-Glosenkamp C., Trosini-Desert V., Eberhardt R., Herth F. J., Derom E., Malfait T., Shah P. L., Garner J. L., Ten Hacken N. H., Fallouh H., Leroy S., Marquette C. H., Team Transform Study; A Multicenter RCT of Zephyr(R) Endobronchial Valve Treatment in Heterogeneous Emphysema (TRANSFORM); American journal of respiratory and critical care medicine; Sep 08 2017; 10.1164/rccm.201707-1327OC; Epub; https://www.ncbi.nlm.nih.gov/pubmed/28885054

Murtaza G., Mermer P., Goldenberg A., Pfeil U., Paddenberg R., Weissmann N., Lochnit G., Kummer W.; TASK-1 potassium channel is not critically involved in mediating hypoxic pulmonary vasoconstriction of murine intra-pulmonary arteries; PloS one; 2017; e0174071; doi: 10.1371/journal.pone.0174071; Epub; PMC5354433; https://www.ncbi.nlm.nih.gov/pubmed/28301582

Orth M., Unger K., Schoetz U., Belka C., Lauber K.; Taxane-mediated radiosensitization derives from chromosomal missegregation on tripolar mitotic spindles orchestrated by AURKA and TPX2; Oncogene; Sep 04 2017; 10.1038/onc.2017.304; Epub; https://www.ncbi.nlm.nih.gov/pubmed/28869599

Schumer E., Hoffler K., Kuehn C., Slaughter M., Haverich A., Wiegmann B.; In-vitro evaluation of limitations and possibilities for the future use of intracorporeal gas exchangers placed in the upper lobe position; Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs; Sep 06 2017; 10.1007/s10047-017-0987-0; Epub; https://www.ncbi.nlm.nih.gov/pubmed/28879605

Wain L. V., Shrine N., Artigas M. S., Erzurumluoglu A. M., Noyvert B., Bossini-Castillo L., Obeidat M., Henry A. P., Portelli M. A., Hall R. J., Billington C. K., Rimington T. L., Fenech A. G., John C., Blake T., Jackson V. E., Allen R. J., Prins B. P., Understanding Society Scientific Group, Campbell A., Porteous D. J., Jarvelin M. R., Wielscher M., James A. L., Hui J., Wareham N. J., Zhao J. H., Wilson J. F., Joshi P. K., Stubbe B., Rawal R., Schulz H., Imboden M., Probst-Hensch N. M., Karrasch S., Gieger C., Deary I. J., Harris S. E., Marten J., Rudan I., Enroth S., Gyllensten U., Kerr S. M., Polasek O., Kahonen M., Surakka I., Vitart V., Hayward C., Lehtimaki T., Raitakari O. T., Evans D. M., Henderson A. J., Pennell C. E., Wang C. A., Sly P. D., Wan E. S., Busch R., Hobbs B. D., Litonjua A. A., Sparrow D. W., Gulsvik A., Bakke P. S., Crapo J. D., Beaty T. H., Hansel N. N., Mathias R. A., Ruczinski I., Barnes K. C., Bosse Y., Joubert P., Van Den Berge M., Brandsma C. A., Pare P. D., Sin D. D., Nickle D. C., Hao K., Gottesman O., Dewey F. E., Bruse S. E., Carey D. J., Kirchner H. L., Geisinger-Regeneron Discov E. H. R. Collaboration, Jonsson S., Thorleifsson G., Jonsdottir I., Gislason T., Stefansson K., Schurmann C., Nadkarni G., Bottinger E. P., Loos R. J., Walters R. G., Chen Z., Millwood I. Y., Vaucher J., Kurmi O. P., Li L., Hansell A. L., Brightling C., Zeggini E., Cho M. H., Silverman E. K., Sayers I., Trynka G., Morris A. P., Strachan D. P., Hall I. P., Tobin M. D.; Genome-wide association analyses for lung function and chronic obstructive pulmonary disease identify new loci and potential druggable targets; Nature genetics; Mar 2017; 416-425; doi: 10.1038/ng.3787; Epub; PMC5326681; https://www.ncbi.nlm.nih.gov/pubmed/28166213

Wiedenroth C. B., Liebetrau C., Gall H., Risch T., Arlt M., Mayer E., Guth S.; The effective systematic heparin pre-treatment on thrombus formation on pulmonary artery catheter tips during pulmonary endarterectomy for chronic thromboembolic pulmonary hypertension: a randomized, double-blind study; Journal of thrombosis and thrombolysis; Sep 05 2017; 10.1007/s11239-017-1547-4; Epub; https://www.ncbi.nlm.nih.gov/pubmed/28875371

Yin J., Liu H., Liu Z., Owzar K., Han Y., Su L., Wei Y., Hung R. J., Brhane Y., Mclaughlin J., Brennan P., Bickeboeller H., Rosenberger A., Houlston R. S., Caporaso N., Landi M. T., Heinrich J., Risch A., Christiani D. C., Amos C. I., Wei Q.; Pathway-analysis of published genome-wide association studies of lung cancer: A potential role for the CYP4F3 locus; Molecular carcinogenesis; Jun 2017; 1663-1672; doi: 10.1002/mc.22622; Epub; PMC5423820; https://www.ncbi.nlm.nih.gov/pubmed/28150878

New in PubMed from DZL Faculty / Neu von der DZL-Fakultät in der Woche bis 03. September 2017:

Baarsma H. A., Konigshoff M.; 'WNT-er is coming': WNT signalling in chronic lung diseases; Thorax; Aug 2017; 746-759; doi: 10.1136/thoraxjnl-2016-209753; Epub; PMC5537530; https://www.ncbi.nlm.nih.gov/pubmed/28416592

Brick T., Ege M., Boeren S., Bock A., Von Mutius E., Vervoort J., Hettinga K.; Effect of Processing Intensity on Immunologically Active Bovine Milk Serum Proteins; Nutrients; Aug 31 2017; 10.3390/nu9090963; Epub; https://www.ncbi.nlm.nih.gov/pubmed/28858242

Gompelmann D., Herth F. J.; [Endoscopic interventions in pulmonology]; Der Internist; Aug 2016; 763-772; doi: 10.1007/s00108-016-0090-2; Epub; https://www.ncbi.nlm.nih.gov/pubmed/27351790

Haberkorn U., Mier W., Kopka K., Herold-Mende C., Altmann A., Babich J.; Identification of Ligands and Translation to Clinical Applications; Journal of nuclear medicine : official publication, Society of Nuclear Medicine; Sep 2017; 27S-33S; doi: 10.2967/jnumed.116.186791; Epub; https://www.ncbi.nlm.nih.gov/pubmed/28864609

Hose A. J., Depner M., Illi S., Lau S., Keil T., Wahn U., Fuchs O., Pfefferle P. I., Schmausser-Hechfellner E., Genuneit J., Lauener R., Karvonen A. M., Roduit C., Dalphin J. C., Riedler J., Pekkanen J., Von Mutius E., Ege M. J., Mas, Groups Pasture Study; Latent class analysis reveals clinically relevant atopy phenotypes in 2 birth cohorts; The Journal of allergy and clinical immunology; Jun 2017; 1935-1945 e1912; doi: 10.1016/j.jaci.2016.08.046; Epub; https://www.ncbi.nlm.nih.gov/pubmed/27771325

Leisegang M. S., Fork C., Josipovic I., Richter F. M., Preussner J., Hu J., Miller M. J., Epah J., Hofmann P., Gunther S., Moll F., Valasarajan C., Heidler J., Ponomareva Y., Freiman T. M., Maegdefessel L., Plate K. H., Mittelbronn M., Uchida S., Kunne C., Stellos K., Schermuly R. T., Weissmann N., Devraj K., Wittig I., Boon R. A., Dimmeler S., Pullamsetti S. S., Looso M., Miller F. J., Jr., Brandes R. P.; Long Noncoding RNA MANTIS Facilitates Endothelial Angiogenic Function; Circulation; Jul 04 2017; 65-79; doi: 10.1161/CIRCULATIONAHA.116.026991; Epub; PMC5491227; https://www.ncbi.nlm.nih.gov/pubmed/28351900

Rodriguez-Gil A., Ritter O., Hornung J., Stekman H., Kruger M., Braun T., Kremmer E., Kracht M., Schmitz M. L.; HIPK family kinases bind and regulate the function of the CCR4-NOT complex; Molecular biology of the cell; Jun 15 2016; 1969-1980; doi: 10.1091/mbc.E15-09-0629; Epub; PMC4907730; https://www.ncbi.nlm.nih.gov/pubmed/27122605

Schmidt M. O., Garman K. A., Lee Y. G., Zuo C., Beck P. J., Tan M., Aguilar-Pimentel J. A., Ollert M., Schmidt-Weber C., Fuchs H., Gailus-Durner V., Hrabe De Angelis M., German Mouse Clinic Consortium, Tassi E., Riegel A. T., Wellstein A.; The Role of Fibroblast Growth Factor Binding Protein 1 in Skin Carcinogenesis and Inflammation; The Journal of investigative dermatology; Aug 29 2017; 10.1016/j.jid.2017.07.847; Epub; https://www.ncbi.nlm.nih.gov/pubmed/28864076

Triphan S. M., Jobst B. J., Anjorin A., Sedlaczek O., Wolf U., Terekhov M., Hoffmann C., Ley S., Duber C., Biederer J., Kauczor H. U., Jakob P. M., Wielputz M. O.; Reproducibility and comparison of oxygen-enhanced T1 quantification in COPD and asthma patients; PloS one; 2017; e0172479; doi: 10.1371/journal.pone.0172479; Epub; PMC5312969; https://www.ncbi.nlm.nih.gov/pubmed/28207845

Voskrebenzev A., Gutberlet M., Klimes F., Kaireit T. F., Schonfeld C., Rotarmel A., Wacker F., Vogel-Claussen J.; Feasibility of quantitative regional ventilation and perfusion mapping with phase-resolved functional lung (PREFUL) MRI in healthy volunteers and COPD, CTEPH, and CF patients; Magnetic resonance in medicine; Aug 30 2017; 10.1002/mrm.26893; Epub; https://www.ncbi.nlm.nih.gov/pubmed/28856715

Walsh S. L. F., Maher T. M., Kolb M., Poletti V., Nusser R., Richeldi L., Vancheri C., Wilsher M. L., Antoniou K. M., Behr J., Bendstrup E., Brown K., Calandriello L., Corte T. J., Cottin V., Crestani B., Flaherty K., Glaspole I., Grutters J., Inoue Y., Kokosi M., Kondoh Y., Kouranos V., Kreuter M., Johannson K., Judge E., Ley B., Margaritopoulos G., Martinez F. J., Molina-Molina M., Morais A., Nunes H., Raghu G., Ryerson C. J., Selman M., Spagnolo P., Taniguchi H., Tomassetti S., Valeyre D., Wijsenbeek M., Wuyts W., Hansell D., Wells A., Consortium I. P. F. Project; Diagnostic accuracy of a clinical diagnosis of idiopathic pulmonary fibrosis: an international case-cohort study; The European respiratory journal; Aug 2017; 10.1183/13993003.00936-2017; Epub; https://www.ncbi.nlm.nih.gov/pubmed/28860269

Zscheppang K., Berg J., Hedtrich S., Verheyen L., Wagner D. E., Suttorp N., Hippenstiel S., Hocke A. C.; Human pulmonary 3D models for translational research; Biotechnology journal; Sep 02 2017; 10.1002/biot.201700341; Epub; https://www.ncbi.nlm.nih.gov/pubmed/28865134

August 2017

New in PubMed from DZL Faculty / Neu von der DZL-Fakultät in der Woche bis 28. August 2017:

Coyle K., Coyle D., Lester-George A., West R., Nemeth B., Hiligsmann M., Trapero-Bertran M., Leidl R., Pokhrel S., Group Equipt Study; Development and Application of an Economic Model (EQUIPTMOD) to assess the Impact of Smoking Cessation; Addiction (Abingdon, England); Aug 18 2017; 10.1111/add.14001; Epub; https://www.ncbi.nlm.nih.gov/pubmed/28833765

Kontogianni K., Gerovasili V., Gompelmann D., Schuhmann M., Hoffmann H., Heussel C. P., Herth F. J., Eberhardt R.; Coil therapy for patients with severe emphysema and bilateral incomplete fissures - effectiveness and complications after 1-year follow-up: a single-center experience; International journal of chronic obstructive pulmonary disease; 2017; 383-394; doi: 10.2147/COPD.S117655; Epub; PMC5271380; https://www.ncbi.nlm.nih.gov/pubmed/28176954

Treskova M., Aumann I., Golpon H., Vogel-Claussen J., Welte T., Kuhlmann A.; Trade-off between benefits, harms and economic efficiency of low-dose CT lung cancer screening: a microsimulation analysis of nodule management strategies in a population-based setting; BMC medicine; Aug 25 2017; 162; doi: 10.1186/s12916-017-0924-3; Epub; https://www.ncbi.nlm.nih.gov/pubmed/28838313

Uhl F. E., Wagner D. E., Weiss D. J.; Preparation of Decellularized Lung Matrices for Cell Culture and Protein Analysis; Methods in molecular biology (Clifton, N.J.); 2017; 253-283; doi: 10.1007/978-1-4939-7113-8_18; Epub; https://www.ncbi.nlm.nih.gov/pubmed/28836208

Juli 2017

New in PubMed from DZL Faculty / Neu von der DZL-Fakultät in der Woche bis 30. Juli 2017:

Bahmer T., Kirsten A. M., Waschki B., Rabe K. F., Magnussen H., Kirsten D., Gramm M., Hummler S., Brunnemer E., Kreuter M., Watz H., Prognosis and longitudinal changes of physical activity in idiopathic pulmonary fibrosis, BMC Pulm Med, Jul 25 2017, 104, doi: 10.1186/s12890-017-0444-0, Epub, https://www.ncbi.nlm.nih.gov/pubmed/28743305

De Castro J., Tagliaferri P., De Lima V. C. C., Ng S., Thomas M., Arunachalam A., Cao X., Kothari S., Burke T., Myeong H., Grattan A., Lee D. H., Systemic therapy treatment patterns in patients with advanced non-small cell lung cancer (NSCLC): PIvOTAL study, European journal of cancer care, Jul 27 2017, 10.1111/ecc.12734, Epub, https://www.ncbi.nlm.nih.gov/pubmed/28748556

Fahndrich S., Bernhard N., Lepper P. M., Vogelmeier C., Seibert M., Wagenpfeil S., Bals R., Exacerbations and duration of smoking abstinence are associated with the annual loss of FEV1 in individuals with PiZZ alpha-1-antitrypsin deficiency, Respir Med, Aug 2017, 8-15, doi: 10.1016/j.rmed.2017.05.011, Epub, https://www.ncbi.nlm.nih.gov/pubmed/28732839

Fehringer G., Kraft P., Pharoah P. D., Eeles R. A., Chatterjee N., Schumacher F. R., Schildkraut J. M., Lindstrom S., Brennan P., Bickeboller H., Houlston R. S., Landi M. T., Caporaso N., Risch A., Amin Al Olama A., Berndt S. I., Giovannucci E. L., Gronberg H., Kote-Jarai Z., Ma J., Muir K., Stampfer M. J., Stevens V. L., Wiklund F., Willett W. C., Goode E. L., Permuth J. B., Risch H. A., Reid B. M., Bezieau S., Brenner H., Chan A. T., Chang-Claude J., Hudson T. J., Kocarnik J. K., Newcomb P. A., Schoen R. E., Slattery M. L., White E., Adank M. A., Ahsan H., Aittomaki K., Baglietto L., Blomquist C., Canzian F., Czene K., Dos-Santos-Silva I., Eliassen A. H., Figueroa J. D., Flesch-Janys D., Fletcher O., Garcia-Closas M., Gaudet M. M., Johnson N., Hall P., Hazra A., Hein R., Hofman A., Hopper J. L., Irwanto A., Johansson M., Kaaks R., Kibriya M. G., Lichtner P., Liu J., Lund E., Makalic E., Meindl A., Muller-Myhsok B., Muranen T. A., Nevanlinna H., Peeters P. H., Peto J., Prentice R. L., Rahman N., Sanchez M., Schmidt D. F., Schmutzler R. K., Southey M. C., Tamimi R., Travis R. C., Turnbull C., Uitterlinden A. G., Wang Z., Whittemore A. S., Yang X. R., Zheng W., Buchanan D. D., Casey G., Conti D. V., Edlund C. K., Gallinger S., Haile R. W., Jenkins M., Le Marchand L., Li L., Lindor N. M., Schmit S. L., Thibodeau S. N., Woods M. O., Rafnar T., Gudmundsson J., Stacey S. N., Stefansson K., Sulem P., Chen Y. A., Tyrer J. P., Christiani D. C., Wei Y., Shen H., Hu Z., Shu X. O., Shiraishi K., Takahashi A., Bosse Y., Obeidat M., Nickle D., Timens W., Freedman M. L., Li Q., Seminara D., Chanock S. J., Gong J., Peters U., Gruber S. B., Amos C. I., Sellers T. A., Easton D. F., Hunter D. J., Haiman C. A., Henderson B. E., Hung R. J., Ovarian Cancer Association Consortium, Consortium Practical, Hereditary Breast, Ovarian Cancer Research Group Netherlands, Colorectal Transdisciplinary Study, African American Breast Cancer Consortium, African Ancestry Prostate Cancer Consortium, Cross-Cancer Genome-Wide Analysis of Lung, Ovary, Breast, Prostate, and Colorectal Cancer Reveals Novel Pleiotropic Associations, Cancer Res, Sep 01 2016, 5103-5114, doi: 10.1158/0008-5472.CAN-15-2980, Epub, PMC5010493, https://www.ncbi.nlm.nih.gov/pubmed/27197191

Jung A. L., Herkt C. E., Schulz C., Bolte K., Seidel K., Scheller N., Sittka-Stark A., Bertrams W., Schmeck B., Legionella pneumophila infection activates bystander cells differentially by bacterial and host cell vesicles, Scientific reports, Jul 24 2017, 6301, doi: 10.1038/s41598-017-06443-1, Epub, PMC5524687, https://www.ncbi.nlm.nih.gov/pubmed/28740179

Leuschner G., Stocker F., Veit T., Kneidinger N., Winter H., Schramm R., Weig T., Matthes S., Ceelen F., Arnold P., Munker D., Klenner F., Hatz R., Frankenberger M., Behr J., Neurohr C., Outcome of lung transplantation in idiopathic pulmonary fibrosis with previous anti-fibrotic therapy, J Heart Lung Transplant, Jul 05 2017, 10.1016/j.healun.2017.07.002, Epub, https://www.ncbi.nlm.nih.gov/pubmed/28734935

Marwitz S., Depner S., Dvornikov D., Merkle R., Szczygiel M., Muller-Decker K., Lucarelli P., Wasch M., Mairbaurl H., Rabe K. F., Kugler C., Vollmer E., Reck M., Scheufele S., Kroger M., Ammerpohl O., Siebert R., Goldmann T., Klingmuller U., Downregulation of the TGFbeta Pseudoreceptor BAMBI in Non-Small Cell Lung Cancer Enhances TGFbeta Signaling and Invasion, Cancer Res, Jul 01 2016, 3785-3801, doi: 10.1158/0008-5472.CAN-15-1326, Epub, https://www.ncbi.nlm.nih.gov/pubmed/27197161

Schmitt D., Nill S., Roeder F., Gompelmann D., Herth F., Oelfke U., Motion monitoring during a course of lung radiotherapy with anchored electromagnetic transponders: Quantification of inter- and intrafraction motion and variability of relative transponder positions, Strahlentherapie und Onkologie: Organ der Deutschen Rontgengesellschaft ... [et al], Jul 21 2017, 10.1007/s00066-017-1183-0, Epub, https://www.ncbi.nlm.nih.gov/pubmed/28733724

Strielkov I., Pak O., Sommer N., Weissmann N., Recent advances in oxygen sensing and signal transduction in hypoxic pulmonary vasoconstriction, Journal of applied physiology (Bethesda, Md. : 1985), Jul 27 2017, jap 00103 02017, doi: 10.1152/japplphysiol.00103.2017, Epub, https://www.ncbi.nlm.nih.gov/pubmed/28751366

Weichand B., Popp R., Dziumbla S., Mora J., Strack E., Elwakeel E., Frank A. C., Scholich K., Pierre S., Syed S. N., Olesch C., Ringleb J., Oren B., Doring C., Savai R., Jung M., Von Knethen A., Levkau B., Fleming I., Weigert A., Brune B., S1PR1 on tumor-associated macrophages promotes lymphangiogenesis and metastasis via NLRP3/IL-1beta, J Exp Med, Jul 24 2017, 10.1084/jem.20160392, Epub, https://www.ncbi.nlm.nih.gov/pubmed/28739604

Yamauchi Y., Safi S., Orschiedt L., Gardyan A., Brons S., Rieber J., Nicolay N. H., Huber P. E., Eichhorn M., Dienemann H., Herth F. J. F., Weber K. J., Debus J., Hoffmann H., Rieken S., Low-dose photon irradiation induces invasiveness through the SDF-1alpha/CXCR4 pathway in malignant mesothelioma cells, Oncotarget, Jul 10 2017, 10.18632/oncotarget.19134, Epub, https://www.ncbi.nlm.nih.gov/pubmed/28754849

New in PubMed from DZL Faculty / Neu von der DZL-Fakultät in der Woche bis 23. Juli 2017:

Depner M., Ege M. J., Cox M. J., Dwyer S., Walker A. W., Birzele L. T., Genuneit J., Horak E., Braun-Fahrlander C., Danielewicz H., Maier R. M., Moffatt M. F., Cookson W. O., Heederik D., Von Mutius E., Legatzki A., Bacterial microbiota of the upper respiratory tract and childhood asthma, J Allergy Clin Immunol, Mar 2017, 826-834 e813, doi: 10.1016/j.jaci.2016.05.050, Epub, https://www.ncbi.nlm.nih.gov/pubmed/27576124

Dommaschk A., Ding N., Tort Tarres M., Bittersohl L. F., Maus R., Stolper J., Jonigk D., Braubach P., Lippmann T., Welte T., Maus U. A., Nasopharyngeal colonization with Streptococcus pneumoniae triggers dendritic cell dependent antibody responses against invasive disease in mice, European journal of immunology, Mar 2017, 540-551, doi: 10.1002/eji.201646700, Epub, https://www.ncbi.nlm.nih.gov/pubmed/28101913

Grimminger J., Ghofrani H. A., Weissmann N., Klose H., Grimminger F., COPD-associated pulmonary hypertension: clinical implications and current methods for treatment, Expert review of respiratory medicine, Jul 2016, 755-766, doi: 10.1080/17476348.2016.1190275, Epub, https://www.ncbi.nlm.nih.gov/pubmed/27212458

Herth F. J., Eberhardt R., Schuhmann M., Bronchoscopy in lung cancer: navigational modalities and their clinical use, Expert review of respiratory medicine, Aug 2016, 901-906, doi: 10.1080/17476348.2016.1191354, Epub, https://www.ncbi.nlm.nih.gov/pubmed/27196405

Herth F. J. F., Bronchoscopy and bleeding risk, European respiratory review : an official journal of the European Respiratory Society, Sep 30 2017, 10.1183/16000617.0052-2017, Epub, https://www.ncbi.nlm.nih.gov/pubmed/28724564

Janciauskiene S., Tumpara S., Wiese M., Wrenger S., Vijayan V., Gueler F., Chen R., Madyaningrana K., Mahadeva R., Welte T., Immenschuh S., Chorostowska-Wynimko J., Alpha1-antitrypsin binds hemin and prevents oxidative activation of human neutrophils: putative pathophysiological significance, Journal of leukocyte biology, Jul 17 2017, 10.1189/jlb.3A0317-124R, Epub, https://www.ncbi.nlm.nih.gov/pubmed/28716864

Kerkhof M., Sonnappa S., Postma D. S., Brusselle G., Agusti A., Anzueto A., Jones R., Papi A., Pavord I., Pizzichini E., Popov T., Roche N., Ryan D., Thomas M., Vogelmeier C., Chisholm A., Freeman D., Bafadhel M., Hillyer E. V., Price D. B., Blood eosinophil count and exacerbation risk in patients with COPD, Eur Respir J, Jul 2017, 10.1183/13993003.00761-2017, Epub, https://www.ncbi.nlm.nih.gov/pubmed/28729477

Leichsenring J., Volckmar A. L., Magios N., Morais De Oliveira C. M., Penzel R., Brandt R., Kirchner M., Bozorgmehr F., Thomas M., Schirmacher P., Warth A., Endris V., Stenzinger A., Synonymous EGFR variant p.Q787Q is neither prognostic nor predictive in patients with lung adenocarcinoma, Genes, chromosomes & cancer, Mar 2017, 214-220, doi: 10.1002/gcc.22427, Epub, https://www.ncbi.nlm.nih.gov/pubmed/27750395

Liu X. Q., Kiefl R., Roskopf C., Tian F., Huber R. M., Interactions among Lung Cancer Cells, Fibroblasts, and Macrophages in 3D Co-Cultures and the Impact on MMP-1 and VEGF Expression, PLoS One, 2016, e0156268, doi: 10.1371/journal.pone.0156268, Epub, PMC4883750, https://www.ncbi.nlm.nih.gov/pubmed/27232698

Rath P., Nardiello C., Morty R. E., A new target for caffeine in the developing lung: endoplasmic reticulum stress?, Am J Physiol Lung Cell Mol Physiol, Jul 20 2017, ajplung 00251 02017, doi: 10.1152/ajplung.00251.2017, Epub, https://www.ncbi.nlm.nih.gov/pubmed/28729348

Schierhorn K. L., Jolmes F., Bespalowa J., Saenger S., Peteranderl C., Dzieciolowski J., Mielke M., Budt M., Pleschka S., Herrmann A., Herold S., Wolff T., Influenza A Virus Virulence Depends on Two Amino Acids in the N-Terminal Domain of Its NS1 Protein To Facilitate Inhibition of the RNA-Dependent Protein Kinase PKR, Journal of virology, May 15 2017, 10.1128/JVI.00198-17, Epub, PMC5411612, https://www.ncbi.nlm.nih.gov/pubmed/28250123

Welte T., Pletz M., Pneumonia and the Risk of Cardiovascular Death - Time to Change Our Strategy, Am J Respir Crit Care Med, Jul 19 2017, 10.1164/rccm.201707-1421ED, Epub, https://www.ncbi.nlm.nih.gov/pubmed/28723315

Yuan X., Braun T., Multimodal Regulation of Cardiac Myocyte Proliferation, Circulation research, Jul 21 2017, 293-309, doi: 10.1161/CIRCRESAHA.117.308428, Epub, https://www.ncbi.nlm.nih.gov/pubmed/28729454

Zakrzewicz A., Richter K., Agne A., Wilker S., Siebers K., Fink B., Krasteva-Christ G., Althaus M., Padberg W., Hone A. J., Mcintosh J. M., Grau V., Canonical and Novel Non-Canonical Cholinergic Agonists Inhibit ATP-Induced Release of Monocytic Interleukin-1beta via Different Combinations of Nicotinic Acetylcholine Receptor Subunits alpha7, alpha9 and alpha10, Frontiers in cellular neuroscience, 2017, 189, doi: 10.3389/fncel.2017.00189, Epub, PMC5496965, https://www.ncbi.nlm.nih.gov/pubmed/28725182

Zuber V., Marconett C. N., Shi J., Hua X., Wheeler W., Yang C., Song L., Dale A. M., Laplana M., Risch A., Witoelar A., Thompson W. K., Schork A. J., Bettella F., Wang Y., Djurovic S., Zhou B., Borok Z., Van Der Heijden H. F., De Graaf J., Swinkels D., Aben K. K., Mckay J., Hung R. J., Bikeboller H., Stevens V. L., Albanes D., Caporaso N. E., Han Y., Wei Y., Panadero M. A., Mayordomo J. I., Christiani D. C., Kiemeney L., Andreassen O. A., Houlston R., Amos C. I., Chatterjee N., Laird-Offringa I. A., Mills I. G., Landi M. T., Pleiotropic Analysis of Lung Cancer and Blood Triglycerides, Journal of the National Cancer Institute, Dec 2016, 10.1093/jnci/djw167, Epub, PMC5241892, https://www.ncbi.nlm.nih.gov/pubmed/27565901

New in PubMed from DZL Faculty / Neu von der DZL-Fakultät in der Woche bis 16. Juli 2017:

Dietz S., Harms A., Endris V., Eichhorn F., Kriegsmann M., Longuespee R., Stenzinger A., Sultmann H., Warth A., Kazdal D., Spatial distribution of EGFR and KRAS mutation frequencies correlates with histological growth patterns of lung adenocarcinomas, International journal of cancer, Jul 12 2017, 10.1002/ijc.30881, Epub, https://www.ncbi.nlm.nih.gov/pubmed/28699162

Engel M., Endesfelder D., Schloter-Hai B., Kublik S., Granitsiotis M. S., Boschetto P., Stendardo M., Barta I., Dome B., Deleuze J. F., Boland A., Muller-Quernheim J., Prasse A., Welte T., Hohlfeld J., Subramanian D., Parr D., Gut I. G., Greulich T., Koczulla A. R., Nowinski A., Gorecka D., Singh D., Gupta S., Brightling C. E., Hoffmann H., Frankenberger M., Hofer T. P., Burggraf D., Heiss-Neumann M., Ziegler-Heitbrock L., Schloter M., Zu Castell W., Influence of lung CT changes in chronic obstructive pulmonary disease (COPD) on the human lung microbiome, PLoS One, 2017, e0180859, doi: 10.1371/journal.pone.0180859, Epub, https://www.ncbi.nlm.nih.gov/pubmed/28704452

Garrett L., Becker L., Rozman J., Puk O., Stoeger T., Yildirim A. O., Bohla A., Eickelberg O., Hans W., Prehn C., Adamski J., Klopstock T., Racz I., Zimmer A., Klingenspor M., Fuchs H., Gailus-Durner V., Wurst W., Hrabe De Angelis M., Graw J., Holter S. M., Fgf9 Y162C Mutation Alters Information Processing and Social Memory in Mice, Molecular neurobiology, Jul 10 2017, 10.1007/s12035-017-0659-3, Epub, https://www.ncbi.nlm.nih.gov/pubmed/28695538

Gu F., Zhang H., Hyland P. L., Berndt S., Gapstur S. M., Wheeler W., Consortium Ellipse, Amos C. I., Bezieau S., Bickeboller H., Brenner H., Brennan P., Chang-Claude J., Conti D. V., Ann Doherty J., Gruber S. B., Harrison T. A., Hayes R. B., Hoffmeister M., Houlston R. S., Hung R. J., Jenkins M. A., Kraft P., Lawrenson K., Mckay J., Markt S., Mucci L., Phelan C. M., Qu C., Risch A., Rossing M. A., Wichmann H. E., Shi J., Schernhammer E., Yu K., Landi M. T., Caporaso N. E., Inherited variation in circadian rhythm genes and risks of prostate cancer and three other cancer sites in combined cancer consortia, International journal of cancer, Jul 12 2017, 10.1002/ijc.30883, Epub, https://www.ncbi.nlm.nih.gov/pubmed/28699174

Jansson K., Dreckmann K., Sommer W., Avsar M., Salman J., Siemeni T., Knofel A. K., Pauksch L., Gottlieb J., Fruhauf J., Werner M., Jonigk D., Struber M., Haverich A., Warnecke G., Splenocyte Infusion and Whole-Body Irradiation for Induction of Peripheral Tolerance in Porcine Lung Transplantation: Modifications of the Preconditioning Regime for Improved Clinical Feasibility, Transplantation direct, Jul 2017, e170, doi: 10.1097/TXD.0000000000000689, Epub, PMC5498011, https://www.ncbi.nlm.nih.gov/pubmed/28706973

Kreuter M., Swigris J., Pittrow D., Geier S., Klotsche J., Prasse A., Wirtz H., Koschel D., Andreas S., Claussen M., Grohe C., Wilkens H., Hagmeyer L., Skowasch D., Meyer J. F., Kirschner J., Glaser S., Herth F. J. F., Welte T., Neurohr C., Schwaiblmair M., Held M., Bahmer T., Frankenberger M., Behr J., Health related quality of life in patients with idiopathic pulmonary fibrosis in clinical practice: insights-IPF registry, Respir Res, Jul 14 2017, 139, doi: 10.1186/s12931-017-0621-y, Epub, https://www.ncbi.nlm.nih.gov/pubmed/28709421

Lingner H., Aumann I., Wacker M., Kreuter M., Leidl R., Von Der Schulenburg J. G., Welte T., [Health Science Research with Primary Care Routine Data From Electronic Patient Records: the BeoNet Registry], Gesundheitswesen (Bundesverband der Arzte des Offentlichen Gesundheitsdienstes (Germany)), Jul 11 2017, 10.1055/s-0043-108544, Epub, https://www.ncbi.nlm.nih.gov/pubmed/28697524

Luzak A., Fuertes E., Flexeder C., Standl M., Von Berg A., Berdel D., Koletzko S., Heinrich J., Nowak D., Schulz H., Which early life events or current environmental and lifestyle factors influence lung function in adolescents? - results from the GINIplus & LISAplus studies, Respir Res, Jul 12 2017, 138, doi: 10.1186/s12931-017-0619-5, Epub, https://www.ncbi.nlm.nih.gov/pubmed/28701166

Mizikova I., Palumbo F., Tabi T., Herold S., Vadasz I., Mayer K., Seeger W., Morty R. E., Perturbations to lysyl oxidase expression broadly influence the transcriptome of lung fibroblasts, Physiological genomics, Jul 10 2017, physiolgenomics 00026 02017, doi: 10.1152/physiolgenomics.00026.2017, Epub, https://www.ncbi.nlm.nih.gov/pubmed/28698228

Von Der Beck D., Seeger W., Herold S., Gunther A., Loh B., Characteristics and outcomes of a cohort hospitalized for pandemic and seasonal influenza in Germany based on nationwide inpatient data, PLoS One, 2017, e0180920, doi: 10.1371/journal.pone.0180920, Epub, https://www.ncbi.nlm.nih.gov/pubmed/28708896

New in PubMed from DZL Faculty / Neu von der DZL-Fakultät in der Woche bis 09. Juli 2017:

Behr J., Gunther A., Bonella F., Geissler K., Koschel D., Kreuter M., Prasse A., Schonfeld N., Sitter H., Muller-Quernheim J., Costabel U., [German Guideline for Idiopathic Pulmonary Fibrosis - Update on Pharmacological Therapies 2017], Pneumologie (Stuttgart, Germany), Jul 05 2017, 10.1055/s-0043-115504, Epub

Burgstaller G., Oehrle B., Gerckens M., White E. S., Schiller H. B., Eickelberg O., The instructive extracellular matrix of the lung: basic composition and alterations in chronic lung disease, Eur Respir J, Jul 2017, 10.1183/13993003.01805-2016, Epub

De Wijs-Meijler D. P., Duncker D. J., Tibboel D., Schermuly R. T., Weissmann N., Merkus D., Reiss I. K. M., Oxidative injury of the pulmonary circulation in the perinatal period: Short- and long-term consequences for the human cardiopulmonary system, Pulm Circ, Mar 2017, 55-66, doi: 10.1086/689748, Epub, PMC5448552

Hector A., Chotirmall S. H., Lavelle G. M., Mirkovic B., Horan D., Eichler L., Mezger M., Singh A., Ralhan A., Berenbrinker S., Mack I., Ensenauer R., Riethmuller J., Graepler-Mainka U., Murray M. A., Griese M., Mcelvaney N. G., Hartl D., Chitinase activation in patients with fungus-associated cystic fibrosis lung disease, J Allergy Clin Immunol, Oct 2016, 1183-1189.e1184, doi: 10.1016/j.jaci.2016.01.031, Epub

Houben-Wilke S., Jorres R. A., Bals R., Franssen F. M., Glaser S., Holle R., Karch A., Koch A., Magnussen H., Obst A., Schulz H., Spruit M. A., Wacker M. E., Welte T., Wouters E. F., Vogelmeier C., Watz H., Peripheral Artery Disease and Its Clinical Relevance in Patients with Chronic Obstructive Pulmonary Disease in the COPD and Systemic Consequences-Comorbidities Network Study, Am J Respir Crit Care Med, Jan 15 2017, 189-197, doi: 10.1164/rccm.201602-0354OC, Epub

Malczyk M., Erb A., Veith C., Ghofrani H. A., Schermuly R. T., Gudermann T., Dietrich A., Weissmann N., Sydykov A., The Role of Transient Receptor Potential Channel 6 Channels in the Pulmonary Vasculature, Front Immunol, 2017, 707, doi: 10.3389/fimmu.2017.00707, Epub, PMC5472666

Richter M. J., Grimminger J., Kruger B., Ghofrani H. A., Mooren F. C., Gall H., Pilat C., Kruger K., Effects of exercise training on pulmonary hemodynamics, functional capacity and inflammation in pulmonary hypertension, Pulm Circ, Mar 2017, 20-37, doi: 10.1086/690553, Epub, PMC5448538

Rodriguez-Roisin R., Rabe K. F., Vestbo J., Vogelmeier C., Agusti A., Global Initiative for Chronic Obstructive Lung Disease (GOLD) 20th Anniversary: a brief history of time, Eur Respir J, Jul 2017, 10.1183/13993003.00671-2017, Epub

Sarnowski C., Sugier P. E., Granell R., Jarvis D., Dizier M. H., Ege M., Imboden M., Laprise C., Khusnutdinova E. K., Freidin M. B., Cookson W. O., Moffatt M., Lathrop M., Siroux V., Ogorodova L. M., Karunas A. S., James A., Probst-Hensch N. M., Von Mutius E., Pin I., Kogevinas M., Henderson A. J., Demenais F., Bouzigon E., Identification of a new locus at 16q12 associated with time to asthma onset, J Allergy Clin Immunol, Oct 2016, 1071-1080, doi: 10.1016/j.jaci.2016.03.018, Epub

Song J., Eichstaedt C. A., Viales R. R., Benjamin N., Harutyunova S., Fischer C., Grunig E., Hinderhofer K., Identification of genetic defects in pulmonary arterial hypertension by a new gene panel diagnostic tool, Clinical science (London, England : 1979), Nov 01 2016, 2043-2052, doi: 10.1042/cs20160531, Epub

Vohwinkel C. U., Buchackert Y., Al-Tamari H. M., Mazzocchi L. C., Eltzschig H. K., Mayer K., Morty R. E., Herold S., Seeger W., Pullamsetti S. S., Vadasz I., Restoration of Megalin-mediated Clearance of Alveolar Protein as a Novel Therapeutic Approach for Acute Lung Injury, Am J Respir Cell Mol Biol, Jul 05 2017, 10.1165/rcmb.2016-0358OC, Epub

New in PubMed from DZL Faculty / Neu von der DZL-Fakultät in der Woche bis 02. Juli 2017:

Dettmer S., Shin H. O., Vogel-Claussen J., Westphal M., Haverich A., Warnecke G., Welte T., Wacker F., Gottlieb J., Suhling H., CT at onset of chronic lung allograft dysfunction in lung transplant patients predicts development of the restrictive phenotype and survival, European journal of radiology, Jun 15 2017, 10.1016/j.ejrad.2017.06.008, Epub

Herth F. J. F., Schuhmann M., Vocal cord dysfunction or inducible laryngeal obstruction: whatever it is, it exists, Lancet Respir Med, Jul 2017, 548-549, doi: 10.1016/s2213-2600(17)30222-9, Epub

Johannson K. A., Strambu I., Ravaglia C., Grutters J. C., Valenzuela C., Mogulkoc N., Luppi F., Richeldi L., Wells A. U., Vancheri C., Kreuter M., Antacid therapy in idiopathic pulmonary fibrosis: more questions than answers?, Lancet Respir Med, Jul 2017, 591-598, doi: 10.1016/s2213-2600(17)30219-9, Epub

Kojonazarov B., Novoyatleva T., Boehm M., Happe C., Sibinska Z., Tian X., Sajjad A., Luitel H., Posern G., Evans S. M., Grimminger F., Ghofrani H. A., Weissmann N., Bogaard H. J., Seeger W., Schermuly R. T., p38 MAPK Inhibition Improves Heart Function in Pressure Loaded Right Ventricular Hypertrophy, Am J Respir Cell Mol Biol, Jun 28 2017, 10.1165/rcmb.2016-0374OC, Epub

Opitz C. F., Hoeper M. M., Gibbs J. S., Kaemmerer H., Pepke-Zaba J., Coghlan J. G., Scelsi L., D'alto M., Olsson K. M., Ulrich S., Scholtz W., Schulz U., Grunig E., Vizza C. D., Staehler G., Bruch L., Huscher D., Pittrow D., Rosenkranz S., Pre-Capillary, Combined, and Post-Capillary Pulmonary Hypertension: A Pathophysiological Continuum, Journal of the American College of Cardiology, Jul 26 2016, 368-378, doi: 10.1016/j.jacc.2016.05.047, Epub

Pfarr N., Penzel R., Klauschen F., Heim D., Brandt R., Kazdal D., Jesinghaus M., Herpel E., Schirmacher P., Warth A., Weichert W., Endris V., Stenzinger A., Copy number changes of clinically actionable genes in melanoma, non-small cell lung cancer and colorectal cancer-A survey across 822 routine diagnostic cases, Genes, chromosomes & cancer, Nov 2016, 821-833, doi: 10.1002/gcc.22378, Epub

Richter M. J., Tiede S. L., Sommer N., Schmidt T., Seeger W., Ghofrani H. A., Schermuly R., Gall H., Circulating Angiopoietin-1 Is Not a Biomarker of Disease Severity or Prognosis in Pulmonary Hypertension, PLoS One, 2016, e0165982, doi: 10.1371/journal.pone.0165982, Epub, PMC5089726

Schiller H. B., Mayr C. H., Leuschner G., Strunz M., Staab-Weijnitz C., Preisendorfer S., Eckes B., Moinzadeh P., Krieg T., Schwartz D. A., Hatz R. A., Behr J., Mann M., Eickelberg O., Deep Proteome Profiling Reveals Common Prevalence of MZB1-positive Plasma B Cells in Human Lung and Skin Fibrosis, Am J Respir Crit Care Med, Jun 27 2017, 10.1164/rccm.201611-2263OC, Epub

Stephan A. J., Strobl R., Holle R., Meisinger C., Schulz H., Ladwig K. H., Thorand B., Peters A., Grill E., Male sex and poverty predict abrupt health decline: Deficit accumulation patterns and trajectories in the KORA-Age cohort study, Preventive medicine, Jun 26 2017, 10.1016/j.ypmed.2017.06.032, Epub

Van Geffen W. H., Herth F. J., Deslee G., Slebos D. J., Shah P. L., Lung volume reduction for emphysema - Authors' reply, Lancet Respir Med, Jul 2017, e24, doi: 10.1016/s2213-2600(17)30232-1, Epub

Juni 2017

New in PubMed from DZL Faculty / Neu von der DZL-Fakultät in der Woche bis 25. Juni 2017:

Schrom E., Huber M., Aneja M., Dohmen C., Emrich D., Geiger J., Hasenpusch G., Herrmann-Janson A., Kretzschmann V., Mykhailyk O., Pasewald T., Oak P., Hilgendorff A., Wohlleber D., Hoymann H. G., Schaudien D., Plank C., Rudolph C., Kubisch-Dohmen R., Translation of Angiotensin-Converting Enzyme 2 upon Liver- and Lung-Targeted Delivery of Optimized Chemically Modified mRNA, Molecular therapy. Nucleic acids, Jun 16 2017, 350-365, doi: 10.1016/j.omtn.2017.04.006, Epub, PMC5423349

Frei R., Ferstl R., Roduit C., Dipl-Ing M. Z., Schiavi E., Barcik W., Rodriguez-Perez N., Wirz O. F., Wawrzyniak M., Pugin B., Nehrbass D., Jutel M., Smolinska S., Konieczna P., Bieli C., Loeliger S., Waser M., Pershagen G., Riedler J., Depner M., Schaub B., Genuneit J., Renz H., Pekkanen J., Karvonen A. M., Dalphin J. C., Van Hage M., Doekes G., Akdis M., Braun-Fahrlander C., Akdis C. A., Von Mutius E., O'mahony L., Lauener R. P., Exposure to non-microbial N-Glycolylneuraminic acid protects farmers' children against airway inflammation and colitis, J Allergy Clin Immunol, Jun 16 2017, 10.1016/j.jaci.2017.04.051, Epub

Kiehl S., Zimmermann T., Savai R., Pullamsetti S. S., Seeger W., Bartkuhn M., Dammann R. H., Epigenetic silencing of downstream genes mediated by tandem orientation in lung cancer, Scientific reports, Jun 20 2017, 3896, doi: 10.1038/s41598-017-04248-w, Epub, PMC5478622

Magnussen H., Arzt M., Andreas S., Plate T., Ribera A., Seoane B., Watz H., Kirsten A. M., Aclidinium bromide improves symptoms and sleep quality in COPD: a pilot study, Eur Respir J, Jun 2017, 10.1183/13993003.00485-2017, Epub

New in PubMed from DZL Faculty / Neu von der DZL-Fakultät in der Woche bis 18. Juni 2017:

Barcena-Varela S., Martinez-De-Tejada G., Martin L., Schuerholz T., Gil-Royo A. G., Fukuoka S., Goldmann T., Droemann D., Correa W., Gutsmann T., Brandenburg K., Heinbockel L., Coupling killing to neutralization: combined therapy with ceftriaxone/Pep19-2.5 counteracts sepsis in rabbits, Experimental & molecular medicine, Jun 16 2017, e345, doi: 10.1038/emm.2017.75, Epub

Halank M., Hoeper M. M., Ghofrani H. A., Meyer F. J., Stahler G., Behr J., Ewert R., Fletcher M., Colorado P., Nikkho S., Grimminger F., Riociguat for pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension: Results from a phase II long-term extension study, Respir Med, Jul 2017, 50-56, doi: 10.1016/j.rmed.2017.05.008, Epub

Happle C., Jirmo A. C., Meyer-Bahlburg A., Habener A., Hoymann H. G., Hennig C., Skuljec J., Hansen G., B cells control maternofetal priming of allergy and tolerance in a murine model of allergic airway inflammation, J Allergy Clin Immunol, Jun 07 2017, 10.1016/j.jaci.2017.03.051, Epub

Harkness L. M., Weckmann M., Kopp M., Becker T., Ashton A. W., Burgess J. K., Tumstatin regulates the angiogenic and inflammatory potential of airway smooth muscle extracellular matrix, Journal of cellular and molecular medicine, Jun 13 2017, 10.1111/jcmm.13232, Epub

Kaestle M., Bartel S., Geillinger-Kastle K., Irmler M., Beckers J., Ryffel B., Eickelberg O., Krauss-Etschmann S., microRNA cluster 106a~363 is involved in T-Helper 17 (Th17) cell differentiation, Immunology, Jun 15 2017, 10.1111/imm.12775, Epub

Kreuter M., Walscher J., Behr J., Antifibrotic drugs as treatment of nonidiopathic pulmonary fibrosis interstitial pneumonias: the time is now (?), Current opinion in pulmonary medicine, Jun 15 2017, 10.1097/mcp.0000000000000408, Epub

Mckay J. D., Hung R. J., Han Y., Zong X., Carreras-Torres R., Christiani D. C., Caporaso N. E., Johansson M., Xiao X., Li Y., Byun J., Dunning A., Pooley K. A., Qian D. C., Ji X., Liu G., Timofeeva M. N., Bojesen S. E., Wu X., Le Marchand L., Albanes D., Bickeboller H., Aldrich M. C., Bush W. S., Tardon A., Rennert G., Teare M. D., Field J. K., Kiemeney L. A., Lazarus P., Haugen A., Lam S., Schabath M. B., Andrew A. S., Shen H., Hong Y. C., Yuan J. M., Bertazzi P. A., Pesatori A. C., Ye Y., Diao N., Su L., Zhang R., Brhane Y., Leighl N., Johansen J. S., Mellemgaard A., Saliba W., Haiman C. A., Wilkens L. R., Fernandez-Somoano A., Fernandez-Tardon G., Van Der Heijden H. F. M., Kim J. H., Dai J., Hu Z., Davies M. P. A., Marcus M. W., Brunnstrom H., Manjer J., Melander O., Muller D. C., Overvad K., Trichopoulou A., Tumino R., Doherty J. A., Barnett M. P., Chen C., Goodman G. E., Cox A., Taylor F., Woll P., Bruske I., Wichmann H. E., Manz J., Muley T. R., Risch A., Rosenberger A., Grankvist K., Johansson M., Shepherd F. A., Tsao M. S., Arnold S. M., Haura E. B., Bolca C., Holcatova I., Janout V., Kontic M., Lissowska J., Mukeria A., Ognjanovic S., Orlowski T. M., Scelo G., Swiatkowska B., Zaridze D., Bakke P., Skaug V., Zienolddiny S., Duell E. J., Butler L. M., Koh W. P., Gao Y. T., Houlston R. S., Mclaughlin J., Stevens V. L., Joubert P., Lamontagne M., Nickle D. C., Obeidat M., Timens W., Zhu B., Song L., Kachuri L., Artigas M. S., Tobin M. D., Wain L. V., Rafnar T., Thorgeirsson T. E., Reginsson G. W., Stefansson K., Hancock D. B., Bierut L. J., Spitz M. R., Gaddis N. C., Lutz S. M., Gu F., Johnson E. O., Kamal A., Pikielny C., Zhu D., Lindstroem S., Jiang X., Tyndale R. F., Chenevix-Trench G., Beesley J., Bosse Y., Chanock S., Brennan P., Landi M. T., Amos C. I., Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes, Nature genetics, Jun 12 2017, 10.1038/ng.3892, Epub

Peters S., Gettinger S., Johnson M. L., Janne P. A., Garassino M. C., Christoph D., Toh C. K., Rizvi N. A., Chaft J. E., Carcereny Costa E., Patel J. D., Chow L. Q. M., Koczywas M., Ho C., Fruh M., Van Den Heuvel M., Rothenstein J., Reck M., Paz-Ares L., Shepherd F. A., Kurata T., Li Z., Qiu J., Kowanetz M., Mocci S., Shankar G., Sandler A., Felip E., Phase II Trial of Atezolizumab As First-Line or Subsequent Therapy for Patients With Programmed Death-Ligand 1-Selected Advanced Non-Small-Cell Lung Cancer (BIRCH), J Clin Oncol, Jun 13 2017, Jco2016719476, doi: 10.1200/jco.2016.71.9476, Epub

Schiener M., Graessel A., Ollert M., Schmidt-Weber C. B., Blank S., Allergen-specific immunotherapy of Hymenoptera venom allergy - also a matter of diagnosis, Hum Vaccin Immunother, Jun 12 2017, 0, doi: 10.1080/21645515.2017.1334745, Epub

Schneeberger T., Gloeckl R., Welte T., Kenn K., Pulmonary Rehabilitation Outcomes after Single or Double Lung Transplantation in Patients with Chronic Obstructive Pulmonary Disease or Interstitial Lung Disease, Respiration, Jun 10 2017, 10.1159/000477351, Epub

New in PubMed from DZL Faculty / Neu von der DZL-Fakultät in der Woche bis 11. Juni 2017:

Brinker T. J., Owczarek A. D., Seeger W., Groneberg D. A., Brieske C. M., Jansen P., Klode J., Stoffels I., Schadendorf D., Izar B., Fries F. N., Hofmann F. J., A Medical Student-Delivered Smoking Prevention Program, Education Against Tobacco, for Secondary Schools in Germany: Randomized Controlled Trial, Journal of medical Internet research, Jun 06 2017, e199, doi: 10.2196/jmir.7906, Epub

Gessler T., Ghofrani H. A., Held M., Klose H., Leuchte H., Olschewski H., Rosenkranz S., Fels L., Li N., Ren D., Kaiser A., Schultze-Mosgau M. H., Mullinger B., Rohde B., Seeger W., The safety and pharmacokinetics of rapid iloprost aerosol delivery via the BREELIB nebulizer in pulmonary arterial hypertension, Pulm Circ, Apr-Jun 2017, 505-513, doi: 10.1177/2045893217706691, Epub

Gwozdzinska P., Buchbinder B. A., Mayer K., Herold S., Morty R. E., Seeger W., Vadasz I., Hypercapnia Impairs ENaC Cell Surface Stability by Promoting Phosphorylation, Polyubiquitination and Endocytosis of beta-ENaC in a Human Alveolar Epithelial Cell Line, Front Immunol, 2017, 591, doi: 10.3389/fimmu.2017.00591, Epub, PMC5440515

Hill A. T., Haworth C. S., Aliberti S., Barker A., Blasi F., Boersma W., Chalmers J. D., De Soyza A., Dimakou K., Elborn J. S., Feldman C., Flume P., Goeminne P. C., Loebinger M. R., Menendez R., Morgan L., Murris M., Polverino E., Quittner A., Ringshausen F. C., Tino G., Torres A., Vendrell M., Welte T., Wilson R., Wong C., O'donnell A., Aksamit T., Pulmonary exacerbation in adults with bronchiectasis: a consensus definition for clinical research, Eur Respir J, Jun 2017, 10.1183/13993003.00051-2017, Epub, http://erj.ersjournals.com/content/49/6/1700051

Jatzlauk G., Bartel S., Heine H., Schloter M., Krauss-Etschmann S., Influences of environmental bacteria and their metabolites on allergies, asthma and host microbiota, Allergy, Jun 10 2017, 10.1111/all.13220, Epub, http://onlinelibrary.wiley.com/store/10.1111/all.13220/asset/all13220.pdf?v=1&t=j3ucck7q&s=ae2ea3cd2b1008ac2ba849a14e98c3e130158682

Jimenez A. P., Traum A., Boettger T., Hackstein H., Richter A. M., Dammann R. H., The tumor suppressor RASSF1A induces the YAP1 target gene ANKRD1 that is epigenetically inactivated in human cancers and inhibits tumor growth, Oncotarget, May 23 2017, 10.18632/oncotarget.18177, Epub, http://www.impactjournals.com/oncotarget/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=18177&path%5B%5D=58276

Olsson K. M., Wiedenroth C. B., Kamp J. C., Breithecker A., Fuge J., Krombach G. A., Haas M., Hamm C., Kramm T., Guth S., Ghofrani H. A., Hinrichs J. B., Cebotari S., Meyer K., Hoeper M. M., Mayer E., Liebetrau C., Meyer B. C., Balloon pulmonary angioplasty for inoperable patients with chronic thromboembolic pulmonary hypertension: the initial German experience, Eur Respir J, Jun 2017, 10.1183/13993003.02409-2016, Epub, http://erj.ersjournals.com/content/49/6/1602409

Richter A. M., Kiehl S., Koger N., Breuer J., Stiewe T., Dammann R. H., ZAR1 is a novel epigenetically inactivated tumour suppressor in lung cancer, Clinical epigenetics, 2017, 60, doi: 10.1186/s13148-017-0360-4, Epub, PMC5457737, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5457737/pdf/13148_2017_Article_360.pdf

Schupp J. C., Vukmirovic M., Kaminski N., Prasse A., Transcriptome profiles in sarcoidosis and their potential role in disease prediction, Current opinion in pulmonary medicine, Jun 05 2017, 10.1097/mcp.0000000000000403, Epub

Wujak L., Hesse C., Sewald K., Jonigk D., Braubach P., Warnecke G., Fieguth H. G., Braun A., Lochnit G., Markart P., Schaefer L., Wygrecka M., FXII promotes proteolytic processing of the LRP1 ectodomain, Biochimica et biophysica acta, May 25 2017, 10.1016/j.bbagen.2017.05.023, Epub, http://www.sciencedirect.com/science/article/pii/S0304416517301757

New in PubMed from DZL Faculty / Neu von der DZL-Fakultät in der Woche bis 05. Juni 2017:

A. Aguilar-Pimentel, A. Graessel, F. Alessandrini, H. Fuchs, V. Gailus-Durner, M. Hrabe de Angelis, D. Russkamp, A. Chaker, M. Ollert, S. Blank, J. Gutermuth, C.B. Schmidt-Weber, Improved efficacy of allergen-specific immunotherapy by JAK inhibition in a murine model of allergic asthma, PLoS One, 12 (2017) e0178563.

N. Bernhard, P.M. Lepper, C. Vogelmeier, M. Seibert, S. Wagenpfeil, R. Bals, S. Fahndrich, Deterioration of quality of life is associated with the exacerbation frequency in individuals with alpha-1-antitrypsin deficiency - analysis from the German Registry, International journal of chronic obstructive pulmonary disease, 12 (2017) 1427-1437.

B.A. Bollmann, B. Seeliger, N. Drick, T. Welte, J.T. Gottlieb, M. Greer, Cellular analysis in bronchoalveolar lavage: inherent limitations of current standard procedure, Eur Respir J, 49 (2017).

K. Brown, A. Filuta, M.G. Ludwig, K. Seuwen, J. Jaros, S. Vidal, K. Arora, A.P. Naren, K. Kandasamy, K. Parthasarathi, S. Offermanns, R.J. Mason, W.E. Miller, J.A. Whitsett, J.P. Bridges, Epithelial Gpr116 regulates pulmonary alveolar homeostasis via Gq/11 signaling, JCI insight, 2 (2017).

A. Hautefort, J. Chesne, J. Preussner, S.S. Pullamsetti, J. Tost, M. Looso, F. Antigny, B. Girerd, M. Riou, S. Eddahibi, J.F. Deleuze, W. Seeger, E. Fadel, G. Simonneau, D. Montani, M. Humbert, F. Perros, Pulmonary endothelial cell DNA methylation signature in pulmonary arterial hypertension, Oncotarget, (2017).

M. Keshavarz, H. Schwarz, P. Hartmann, S. Wiegand, M. Skill, M. Althaus, W. Kummer, G. Krasteva-Christ, Caveolin-1: Functional Insights into Its Role in Muscarine- and Serotonin-Induced Smooth Muscle Constriction in Murine Airways, Frontiers in physiology, 8 (2017) 295.

M. Kondili, A. Fust, J. Preussner, C. Kuenne, T. Braun, M. Looso, UROPA: a tool for Universal RObust Peak Annotation, Scientific reports, 7 (2017) 2593.

V. Neuhaus, D. Schaudien, T. Golovina, U.A. Temann, C. Thompson, T. Lippmann, C. Bersch, O. Pfennig, D. Jonigk, P. Braubach, H.G. Fieguth, G. Warnecke, V. Yusibov, K. Sewald, A. Braun, Assessment of long-term cultivated human precision-cut lung slices as an ex vivo system for evaluation of chronic cytotoxicity and functionality, Journal of occupational medicine and toxicology (London, England), 12 (2017) 13.

M.W. Pletz, E. Tacconelli, T. Welte, [Antiobiotic Stewardship 2.0 : Individualization of therapy], Internist (Berl), (2017).

Mai 2017

New in PubMed from DZL Faculty / Neu von der DZL-Fakultät in der Woche bis 28. Mai 2017:

Skaaby T., Taylor A. E., Jacobsen R. K., Paternoster L., Thuesen B. H., Ahluwalia T. S., Larsen S. C., Zhou A., Wong A., Gabrielsen M. E., Bjorngaard J. H., Flexeder C., Mannisto S., Hardy R., Kuh D., Barry S. J., Tang Mollehave L., Cerqueira C., Friedrich N., Bonten T. N., Noordam R., Mook-Kanamori D. O., Taube C., Jessen L. E., Mcconnachie A., Sattar N., Upton M. N., Mcsharry C., Bonnelykke K., Bisgaard H., Schulz H., Strauch K., Meitinger T., Peters A., Grallert H., Nohr E. A., Kivimaki M., Kumari M., Volker U., Nauck M., Volzke H., Power C., Hypponen E., Hansen T., Jorgensen T., Pedersen O., Salomaa V., Grarup N., Langhammer A., Romundstad P. R., Skorpen F., Kaprio J., M R. Munafo, Linneberg A., Investigating the causal effect of smoking on hay fever and asthma: a Mendelian randomization meta-analysis in the CARTA consortium, Scientific reports, May 22 2017, 2224, doi: 10.1038/s41598-017-01977-w, Epub, PMC5440386

Tan X. H., Zheng X. M., Yu L. X., He J., Zhu H. M., Ge X. P., Ren X. L., Ye F. Q., Bellusci S., Xiao J., Li X. K., Zhang J. S., Fibroblast growth factor 2 protects against renal ischaemia/reperfusion injury by attenuating mitochondrial damage and proinflammatory signalling, Journal of cellular and molecular medicine, May 24 2017, 10.1111/jcmm.13203, Epub

Watz H., Uddin M., Pedersen F., Kirsten A., Goldmann T., Stellmacher F., Groth E., Larsson B., Bottcher G., Malmgren A., Kraan M., Rabe K. F., Effects of the CXCR2 antagonist AZD5069 on lung neutrophil recruitment in asthma, Pulmonary pharmacology & therapeutics, May 23 2017, 10.1016/j.pupt.2017.05.012, Epub

Weckmann M., Becker T., Nissen G., Pech M., Kopp M. V., SiMA: A simplified migration assay for analyzing neutrophil migration, Cytometry. Part A : the journal of the International Society for Analytical Cytology, May 19 2017, 10.1002/cyto.a.23114, Epub

New in PubMed from DZL Faculty/ Neu von der DZL-Fakultät in der Woche bis 21. Mai 2017:

Grimminger J, Richter M, Tello K, Sommer N, Gall H, Ghofrani HA. Thin Air Resulting in High Pressure: Mountain Sickness and Hypoxia-Induced Pulmonary Hypertension. Can Respir J. 2017;2017:8381653. doi: 10.1155/2017/8381653. Epub 2017 Mar 27. Review. PubMed PMID: 28522921; PubMed Central PMCID: PMC5385916.

Buzan MTA, Wetscherek A, Heussel CP, Kreuter M, Herth FJ, Warth A, Kauczor HU, Pop CM, Dinkel J. Texture analysis using proton density and T2 relaxation in patients with histological usual interstitial pneumonia (UIP) or nonspecific interstitial pneumonia (NSIP). PLoS One. 2017 May 16;12(5):e0177689. doi: 10.1371/journal.pone.0177689. eCollection 2017. PubMed PMID: 28520778.

van den Bruck R, Weil PP, Ziegenhals T, Schreiner P, Juranek S, Gödde D, Vogel S, Schuster F, Orth V, Dörner J, Pembaur D, Röper M, Störkel S, Zirngibl H, Wirth S, Jenke ACW, Postberg J, Boy N, Heringer J, Haege G, Glahn EM, Hoffmann GF, Garbade SF, Burgard P, Kölker S, Chao CM, Yahya F, Moiseenko A, Shrestha A, Ahmadvand N, Quantius J, Wilhelm J, El-Agha E, Zimmer KP, Bellusci S, Staufner C, Kölker S, Prokisch H, Hoffmann GF, Seeliger S, Müller M, Hippe A, Steinkraus H, Wauer R, Lachmann B, Hofmann SR, Hedrich CM, Zierk J, Arzideh F, Haeckel R, Rascher W, Rauh M, Metzler M, Thieme S, Bandola J, Richter C, Ryser M, Jamal A, Ashton MP, von Bonin M, Kuhn M, Hedrich CM, Bonifacio E, Berner R, Brenner S, Hammersen J, Has C, Naumann-Bartsch N, Stachel D, Kiritsi D, Söder S, Tardieu M,  Metzler M, Bruckner-Tuderman L, Schneider H, Bohne F, Langer D, Cencic R, Eggermann T, Zechner U, Pelletier J, Zepp F, Enklaar T, Prawitt D, Pech M, Weckmann M, Heinsen FA, Franke A, Happle C, Dittrich AM, Hansen G, Fuchs O, von Mutius E, Oliver BG, Kopp MV, Paret C, Russo A, Theruvath J, Keller B, El Malki K, Lehmann N, Wingerter A, Neu MA, Aslihan GA, Wagner W, Sommer C, Pietsch T, Seidmann L, Faber J, Schreiner F, Ackermann M, Michalik M, Rother E, Bilkei-Gorzo A, Racz I, Bindila L, Lutz B, Dötsch J, Zimmer A, Woelfle J, Fischer HS, Ullrich TL, Bührer C, Czernik C, Schmalisch G, Stein R, Hofmann SR, Hagenbuchner J, Kiechl-Kohlendorfer U, Obexer P, Ausserlechner MJ, Loges NT, Frommer AT, Wallmeier J, Omran H, Öner-Sieben S, Gimpfl M, Rozman J, Irmler M, Beckers J, De Angelis MH, Roscher A, Wolf E, Ensenauer R, Nemes K, Frühwald M, Hasselblatt M, Siebert R, Kordes U, Kool M, Wang H, Hardy H, Refai O, Barwick KES, Zimmerman HH, Weis J, Baple EL, Crosby AH, Cirak S, Hellmuth C, Uhl O, Standl M, Heinrich J, Thiering E, Koletzko B, Blümel L, Kerl K, Picard D, Frühwald MC, Liebau MC, Reifenberger G, Borkhardt A, Hasselblatt M, Remke M, Tews D, Wabitsch M, Fischer-Posovszky P, Westhoff MA, Nonnenmacher L, Langhans J, Schneele L, Trenkler N, Debatin KM. Abstracts of the 52nd Workshop for Pediatric Research: Frankfurt, Germany. 27-28 October 2016. Mol Cell Pediatr. 2017 May;4(Suppl 1):5. doi: 10.1186/s40348-017-0071-0. PubMed PMID: 28516419.

New in PubMed from DZL Faculty / Neu von der DZL-Fakultät in der Woche bis 14. Mai 2017:

Neves J, Leitz D, Kraut S, Brandenberger C, Agrawal R, Weissmann N, Mühlfeld C, Mall MA, Altamura S, Muckenthaler MU. Disruption of the Hepcidin/Ferroportin Regulatory System Causes Pulmonary Iron Overload and Restrictive Lung Disease. EBioMedicine. 2017 Apr 29. pii: S2352-3964(17)30191-3. doi: 10.1016/j.ebiom.2017.04.036. [Epub ahead of print] PubMed PMID: 28499927.

Dietrich A, Steinritz D, Gudermann T. Transient receptor potential (TRP) channels as molecular targets in lung toxicology and associated diseases. Cell Calcium. 2017 Apr 26. pii: S0143-4160(17)30072-6. doi: 10.1016/j.ceca.2017.04.005. [Epub ahead of print] Review. PubMed PMID: 28499580.

Budinger GS, Kohanski RA, Gan W, Kobor MS, Amaral LA, Armanios M, Kelsey KT, Pardo A, Tuder R, Macian F, Chandel N, Vaughan D, Rojas M, Mora AL, Kovacs E, Duncan SR, Finkel T, Choi A, Eickelberg O, Chen D, Agusti A, Selman M, Balch WE,  Busse P, Lin A, Morimoto R, Sznajder JI, Thannickal VJ. The Intersection Of Aging Biology and The Pathobiology of Lung Diseases: A Joint NHLBI/NIA Workshop. J Gerontol A Biol Sci Med Sci. 2017 May 12. doi: 10.1093/gerona/glx090. [Epub ahead of print] PubMed PMID: 28498894.

Blank S, Etzold S, Darsow U, Schiener M, Eberlein B, Russkamp D, Wolf S, Graessel A, Biedermann T, Ollert M, Schmidt-Weber CB. Component-resolved evaluation of the content of major allergens in therapeutic extracts for specific immunotherapy of honeybee venom allergy. Hum Vaccin Immunother. 2017 May 11:0. doi: 10.1080/21645515.2017.1323603. [Epub ahead of print] PubMed PMID: 28494206.

Karadagi A, Johansson H, Zemack H, Salipalli S, Mörk LM, Kannisto K, Jorns C, Gramignoli R, Strom S, Stokkeland K, Ericzon BG, Jonigk D, Janciauskiene S, Nowak G, Ellis ECS. Exogenous alpha 1-antitrypsin down-regulates SERPINA1 expression. PLoS One. 2017 May 9;12(5):e0177279. doi: 10.1371/journal.pone.0177279. eCollection 2017. PubMed PMID: 28486562.

Homann A, Schramm G, Jappe U. Glycans and Glycan-specific IgE in Clinical and Molecular Allergology - Sensitization, Diagnostics and Clinical Symptoms. J Allergy Clin Immunol. 2017 May 4. pii: S0091-6749(17)30740-6. doi: 10.1016/j.jaci.2017.04.019. [Epub ahead of print] PubMed PMID: 28479330.

Granitzny A, Knebel J, Schaudien D, Braun A, Steinberg P, Dasenbrock C, Hansen T. Maintenance of high quality rat precision cut liver slices during culture to study hepatotoxic responses: Acetaminophen as a model compound. Toxicol In Vitro. 2017 May 2;42:200-213. doi: 10.1016/j.tiv.2017.05.001. [Epub ahead of print] PubMed PMID: 28476500.

Zmora P, Molau-Blazejewska P, Bertram S, Walendy-Gnirß K, Nehlmeier I, Hartleib A, Moldenhauer AS, Konzok S, Dehmel S, Sewald K, Brinkmann C, Curths C, Knauf S, Gruber J, Mätz-Rensing K, Dahlmann F, Braun A, Pöhlmann S. Non-human primate orthologues of TMPRSS2 cleave and activate the influenza virus hemagglutinin. PLoS One. 2017 May 11;12(5):e0176597. doi: 10.1371/journal.pone.0176597. eCollection 2017. PubMed PMID: 28493964.

New in PubMed from DZL Faculty / Neu von der DZL-Fakultät in der Woche bis 08. Mai 2017:

Storch U, Straub J, Erdogmus S, Gudermann T, Mederos Y Schnitzler M. Erratum to: Dynamic monitoring of G(i/o)-protein-mediated decreases of intracellular cAMP by FRET-based Epac sensors. Pflugers Arch. 2017 May 4. doi: 10.1007/s00424-017-1985-z. [Epub ahead of print] PubMed PMID: 28474133.

Zheng X, Turkowski K, Mora J, Brüne B, Seeger W, Weigert A, Savai R. Redirecting tumor-associated macrophages to become tumoricidal effectors as a novel strategy for cancer therapy. Oncotarget. 2017 Apr 12. doi: 10.18632/oncotarget.17061. [Epub ahead of print] Review. PubMed PMID: 28467800.

Kastaun S, Brown J, Brose LS, Ratschen E, Raupach T, Nowak D, Cholmakow-Bodechtel C, Shahab L, West R, Kotz D. Study protocol of the German Study on Tobacco Use (DEBRA): a national household survey of smoking behaviour and cessation. BMC Public Health. 2017 May 2;17(1):378. doi: 10.1186/s12889-017-4328-2. PubMed PMID: 28464934; PubMed Central PMCID: PMC5414339.

Kahn N, Fregonese L, Barrecheguren M, Franssen FME, Grgic A, Gompelmann D, Bibaki E, Antoniou KM, Kocks JWH, Pinnock H, Herth F. Clinical highlights from the 2016 European Respiratory Society International Congress. ERJ Open Res. 2017 Apr 12;3(2). pii: 00147-2016. doi: 10.1183/23120541.00147-2016. eCollection 2017 Apr. PubMed PMID: 28462234; PubMed Central PMCID: PMC5406227.

Reck M, Blais N, Juhasz E, Gorbunova V, Jones CM, Urban L, Orlov S, Barlesi F, Kio E, Keilholz U, Qin Q, Qian J, Nickner C, Dziubinski J, Xiong H, Mittapalli RK, Dunbar M, Ansell P, He L, McKee M, Giranda V, Ramalingam SS. Smoking History Predicts Sensitivity to PARP Inhibitor Veliparib in Patients with Advanced Non-small Cell Lung Cancer. J Thorac Oncol. 2017 Apr 28. pii: S1556-0864(17)30338-6. doi: 10.1016/j.jtho.2017.04.010. [Epub ahead of print] PubMed PMID: 28461256.

Diel R, Ringshausen FC, Richter E, Welker L, Schmitz J, Nienhaus A. Microbiological and clinical outcomes of treating non-MAC NTM pulmonary disease: A systematic review and meta-analysis. Chest. 2017 Apr 28. pii: S0012-3692(17)30794-8. doi: 10.1016/j.chest.2017.04.166. [Epub ahead of print] PubMed PMID: 28461147.

Pullamsetti SS, Savai R. Macrophage Regulation during Vascular Remodeling: Implications for Pulmonary Hypertension Therapy. Am J Respir Cell Mol Biol. 2017 May;56(5):556-558. doi: 10.1165/rcmb.2017-0033ED. PubMed PMID: 28459385.

Peteranderl C, Sznajder JI, Herold S, Lecuona E. Inflammatory Responses Regulating Alveolar Ion Transport during Pulmonary Infections. Front Immunol. 2017 Apr 18;8:446. doi: 10.3389/fimmu.2017.00446. eCollection 2017. Review. PubMed PMID: 28458673; PubMed Central PMCID: PMC5394420.

Costa R, Königshoff M. Linking Wnt Signaling to Mucosal Inflammation. Am J Respir Cell Mol Biol. 2017 May;56(5):551-552. doi: 10.1165/rcmb.2017-0054ED. PubMed PMID: 28459386.

April 2017

New in PubMed from DZL Faculty/ Neu von der DZL-Fakultät in der Woche bis 30. April 2017:

Steffen L, Ruppert C, Hoymann HG, Funke M, Ebener S, Kloth C, Mühlfeld C, Ochs M, Knudsen L, Lopez-Rodriguez E. Surfactant replacement therapy reduces acute lung injury and collapse induration related lung remodeling in the bleomycin model. Am J Physiol Lung Cell Mol Physiol. 2017 Apr 27:ajplung.00033.2017. doi: 10.1152/ajplung.00033.2017. [Epub ahead of print] PubMed PMID: 28450283.

Diel R, Jacob J, Lampenius N, Loebinger M, Nienhaus A, Rabe KF, Ringshausen FC. Burden of non-tuberculous mycobacterial pulmonary disease in Germany. Eur Respir J. 2017 Apr 26;49(4). pii: 1602109. doi: 10.1183/13993003.02109-2016. Print 2017 Apr. PubMed PMID: 28446559.

Sommerburg O, Stahl M, Hammermann J, Okun JG, Kulozik A, Hoffmann G, Mall M. [Newborn Screening on Cystic Fibrosis in Germany: Comparison of the new Screening Protocol with an Alternative Protocol]. Klin Padiatr. 2017 Mar;229(2):59-66. doi: 10.1055/s-0042-124187. Epub 2017 Apr 25. German. PubMed PMID: 28444650.

Richter MJ, Gall H, Wittkaemper G, Seeger W, Mayer E, Ghofrani A, Guth S, Reichenberger F. EXPRESS: Inspiratory capacity is not altered in operable chronic thromboembolic pulmonary hypertension. Pulm Circ. 2017 Jan 1:2045893217709763. doi: 10.1177/2045893217709763. [Epub ahead of print] PubMed PMID: 28440730.

Helbig AK, Stöckl D, Heier M, Thorand B, Schulz H, Peters A, Ladwig KH, Meisinger C. Relationship between sleep disturbances and multimorbidity among community-dwelling men and women aged 65-93 years: results from the KORA Age Study. Sleep Med. 2017 May;33:151-159. doi: 10.1016/j.sleep.2017.01.016. Epub 2017 Feb 20. PubMed PMID: 28449896.

Gautschi O, Milia J, Filleron T, Wolf J, Carbone DP, Owen D, Camidge R, Narayanan V, Doebele RC, Besse B, Remon-Masip J, Janne PA, Awad MM, Peled N, Byoung CC, Karp DD, Van Den Heuvel M, Wakelee HA, Neal JW, Mok TSK, Yang JCH, Ou SI, Pall G, Froesch P, Zalcman G, Gandara DR, Riess JW, Velcheti V, Zeidler K, Diebold J, Früh M, Michels S, Monnet I, Popat S, Rosell R, Karachaliou N, Rothschild SI, Shih JY, Warth A, Muley T, Cabillic F, Mazières J, Drilon A. Targeting RET in Patients With RET-Rearranged Lung Cancers: Results From the Global, Multicenter RET Registry. J Clin Oncol. 2017 May 1;35(13):1403-1410. doi: 10.1200/JCO.2016.70.9352. Epub 2017 Mar 13. PubMed PMID: 28447912.

Flexeder C, Thiering E, Koletzko S, Berdel D, Lehmann I, von Berg A, Hoffmann B, Bauer CP, Heinrich J, Schulz H. Higher serum 25(OH)D concentrations are associated with improved FEV(1) and FVC in adolescence. Eur Respir J. 2017 Apr 26;49(4). pii: 1601804. doi: 10.1183/13993003.01804-2016. Print 2017 Apr. PubMed PMID: 28446555.

New in PubMed from DZL Faculty/ Neu von der DZL-Fakultät in der Woche bis 23. April 2017:

Warth A. cR and pR: The Residual Tumor Classification Revisited. Pathol Oncol Res. 2017 Apr 21. doi: 10.1007/s12253-017-0221-7. [Epub ahead of print] PubMed PMID: 28432651.

Karl FM, Holle R, Bals R, Greulich T, Jörres RA, Karch A, Koch A, Karrasch S, Leidl R, Schulz H, Vogelmeier C, Wacker ME; COSYCONET Study Group. Costs and health-related quality of life in Alpha-1-Antitrypsin Deficient COPD patients. Respir Res. 2017 Apr 17;18(1):60. doi: 10.1186/s12931-017-0543-8. PubMed PMID: 28416015; PubMed Central PMCID: PMC5392996.

Ewert R, Richter MJ, Steringer-Mascherbauer R, Grünig E, Lange TJ, Opitz CF, Warnke C, Ghofrani HA. Intravenous treprostinil infusion via a fully implantable pump for pulmonary arterial hypertension. Clin Res Cardiol. 2017 Apr 20. doi: 10.1007/s00392-017-1114-1. [Epub ahead of print] PubMed PMID: 28429083.

Baarsma HA, Königshoff M. 'WNT-er is coming': WNT signalling in chronic lung diseases. Thorax. 2017 Apr 17. pii: thoraxjnl-2016-209753. doi: 10.1136/thoraxjnl-2016-209753. [Epub ahead of print] PubMed PMID: 28416592.

Röcken C, Baretton GB, Kreipe HH, Kirchner T. [University Pathology in Germany]. Pathologe. 2017 Apr 21. doi: 10.1007/s00292-017-0285-x. [Epub ahead of print] German. PubMed PMID: 28432389.

Störmann S, Gutt B, Roemmler-Zehrer J, Bidlingmaier M, Huber RM, Schopohl J, Angstwurm M. Assessment of lung function in a large cohort of patients with acromegaly. Eur J Endocrinol. 2017 Apr 21. pii: EJE-16-1080. doi: 10.1530/EJE-16-1080. [Epub ahead of print] PubMed PMID: 28432267.

Kahnert K, Kauffmann-Guerrero D, Tufman A, Borgmeier A, Huber RM, Berger F. Cancer vaccination causes prolonged FDG accumulation in subcutaneous tissue. Nuklearmedizin. 2017 Apr 21. doi: 10.3413/Nukmed-0868-16-12. [Epub ahead of print] PubMed PMID: 28429815.

Egelund GB, Jensen AV, Andersen SB, Petersen PT, Lindhardt BØ, von Plessen C, Rohde G, Ravn P. Penicillin treatment for patients with Community-Acquired Pneumonia in Denmark: a retrospective cohort study. BMC Pulm Med. 2017 Apr 20;17(1):66. doi: 10.1186/s12890-017-0404-8. PubMed PMID: 28427381; PubMed Central PMCID: PMC5397671.

Aaron CP, Hoffman EA, Lima JAC, Kawut SM, Bertoni AG, Vogel-Claussen J, Habibi M, Hueper K, Jacobs DR Jr, Kalhan R, Michos ED, Post WS, Prince MR, Smith BM, Ambale-Venkatesh B, Liu CY, Zemrak F, Watson KE, Budoff M, Bluemke DA, Barr RG. Pulmonary vascular volume, impaired left ventricular filling and dyspnea: The MESA Lung Study. PLoS One. 2017 Apr 20;12(4):e0176180. doi: 10.1371/journal.pone.0176180. eCollection 2017. PubMed PMID: 28426728.

Watz H. Chronic obstructive pulmonary disease: inhale deeply and start to exercise. Eur Respir J. 2017 Apr 19;49(4). pii: 1700424. doi: 10.1183/13993003.00424-2017. Print 2017 Apr. PubMed PMID: 28424367.

Kauczor HU, Heussel CP, von Stackelberg O. Time to take CT screening to the next level? Eur Respir J. 2017 Apr 19;49(4). pii: 1700064. doi: 10.1183/13993003.00064-2017. Print 2017 Apr. PubMed PMID: 28424364.

Zhou Y, Hu LW, Qian ZM, Geiger SD, Parrish KL, Dharmage SC, Campbell B, Roponen M, Jalava P, Hirvonen MR, Heinrich J, Zeng XW, Yang BY, Qin XD, Lee YL, Dong GH. Interaction effects of polyfluoroalkyl substances and sex steroid hormones on asthma among children. Sci Rep. 2017 Apr 18;7(1):899. doi: 10.1038/s41598-017-01140-5. PubMed PMID: 28420867.

Müller T, Fay S, Vieira RP, Karmouty-Quintana H, Cicko S, Ayata K, Zissel G, Goldmann T, Lungarella G, Ferrari D, Di Virgilio F, Robaye B, Boeynaems JM, Blackburn MR, Idzko M. The purinergic receptor subtype P2Y2 mediates chemotaxis of neutrophils and fibroblasts in fibrotic lung disease. Oncotarget. 2017 Mar 21. doi: 10.18632/oncotarget.16414. [Epub ahead of print] PubMed PMID: 28415591.

Ryerson CJ, Corte TJ, Lee JS, Richeldi L, Walsh SLF, Myers JL, Behr J, Cottin V, Danoff SK, Flaherty KR, Lederer DJ, Lynch DA, Martinez FJ, Raghu G, Travis WD, Udwadia Z, Wells AU, Collard HR. A Standardized Diagnostic Ontology for Fibrotic Interstitial Lung Disease: An International Working Group Perspective. Am J Respir Crit Care Med. 2017 Apr 17. doi: 10.1164/rccm.201702-0400PP. [Epub ahead of print] PubMed PMID: 28414524.

Rello J, Solé-Lleonart C, Rouby JJ, Chastre J, Blot S, Poulakou G, Luyt CE, Riera J, Palmer LB, Pereira JM, Felton T, Dhanani J, Bassetti M, Welte T, Roberts JA. Use of Nebulized Antimicrobials for the Treatment of Respiratory Infections in Invasively Mechanically Ventilated Adults: A Position Paper from the European Society of Clinical Microbiology and Infectious Diseases. Clin Microbiol Infect. 2017 Apr 13. pii: S1198-743X(17)30219-7. doi: 10.1016/j.cmi.2017.04.011. [Epub ahead of print] PubMed PMID: 28412382.

New in PubMed from DZL Faculty/ Neu von der DZL-Fakultät in der Woche bis 16. April 2017: 

Kneidinger N, Milger K, Janitza S, Ceelen F, Leuschner G, Dinkel J, Königshoff M, Weig T, Schramm R, Winter H, Behr J, Neurohr C. Lung volumes predict survival in patients with chronic lung allograft dysfunction. Eur Respir J. 2017 Apr 12;49(4). pii: 1601315. doi: 10.1183/13993003.01315-2016. Print 2017 Apr. PubMed PMID: 28404648.

Jahreis S, Trump S, Bauer M, Bauer T, Thürmann L, Feltens R, Wang Q, Gu L, Grützmann K, Röder S, Averbeck M, Weichenhan D, Plass C, Sack U, Borte M, Dubourg V, Schüürmann G, Simon JC, von Bergen M, Hackermüller J, Eils R, Lehmann I, Polte T. Maternal Phthalate Exposure Promotes Allergic Airway Inflammation over Two Generations Via Epigenetic Modifications. J Allergy Clin Immunol. 2017 Apr 6. pii: S0091-6749(17)30570-5. doi: 10.1016/j.jaci.2017.03.017. [Epub ahead of print] PubMed PMID: 28392331.

Petersen F, Yue X, Riemekasten G, Yu X. Dysregulated homeostasis of target tissues or autoantigens - A novel principle in autoimmunity. Autoimmun Rev. 2017 Apr 11. pii: S1568-9972(17)30101-5. doi: 10.1016/j.autrev.2017.04.006. [Epub ahead of print] Review. PubMed PMID: 28411168.

Resch AF, Landry G, Kamp F, Cabal G, Belka C, Wilkens JJ, Parodi K, Dedes G. Quantification of the uncertainties of a biological model and their impact on variable RBE proton treatment plan optimization. Phys Med. 2017 Apr;36:91-102. doi: 10.1016/j.ejmp.2017.03.013. Epub 2017 Mar 30. PubMed PMID: 28410691.

Amirjanians M, Egemnazarov B, Sydykov A, Kojonazarov B, Brandes R, Luitel H, Pradhan K, Stasch JP, Redlich G, Weissmann N, Grimminger F, Seeger W, Ghofrani H, Schermuly R. Chronic intratracheal application of the soluble guanylyl cyclase stimulator BAY 41-8543 ameliorates experimental pulmonary hypertension. Oncotarget. 2017 Mar 31. doi: 10.18632/oncotarget.16769. [Epub ahead of print] PubMed PMID: 28410199.

Rosell R, Dafni U, Felip E, Curioni-Fontecedro A, Gautschi O, Peters S, Massutí B, Palmero R, Aix SP, Carcereny E, Früh M, Pless M, Popat S, Kotsakis A, Cuffe S, Bidoli P, Favaretto A, Froesch P, Reguart N, Puente J, Coate L, Barlesi F, Rauch D, Thomas M, Camps C, Gómez-Codina J, Majem M, Porta R, Shah R, Hanrahan E, Kammler R, Ruepp B, Rabaglio M, Kassapian M, Karachaliou N, Tam R, Shames DS, Molina-Vila MA, Stahel RA; BELIEF collaborative group. Erlotinib and bevacizumab in patients with advanced non-small-cell lung cancer and activating EGFR mutations (BELIEF): an international, multicentre, single-arm, phase 2 trial. Lancet Respir Med. 2017 Apr 10. pii: S2213-2600(17)30129-7. doi: 10.1016/S2213-2600(17)30129-7. [Epub ahead of print] PubMed PMID: 28408243.

Hoffman O, Burns N, Vadász I, Eltzschig HK, Edwards MG, Vohwinkel CU. Correction: Detrimental ELAVL-1/HuR-dependent GSK3β mRNA stabilization impairs resolution in acute respiratory distress syndrome. PLoS One. 2017 Apr 13;12(4):e0176134. doi: 10.1371/journal.pone.0176134. eCollection 2017. PubMed PMID: 28407018.

Backhaus S, Zakrzewicz A, Richter K, Damm J, Wilker S, Fuchs-Moll G, Kuellmar M, Hecker A, Manzini I, Ruppert C, McIntosh JM, Padberg W, Grau V. Surfactant inhibits ATP-induced release of interleukin-1β; via nicotinic acetylcholine receptors. J Lipid Res. 2017 Apr 12. pii: jlr.M071506. doi: 10.1194/jlr.M071506. [Epub ahead of print] PubMed PMID: 28404637.

Timofeev O, Stiewe T. p53 gain-of-function mutations promote metastasis via ENTPD5 upregulation and enhanced N-glycoprotein folding. Mol Cell Oncol. 2017 Feb 3;4(2):e1288678. doi: 10.1080/23723556.2017.1288678. eCollection 2017. PubMed PMID: 28401189; PubMed Central PMCID: PMC5383355.

Feng Y, Wang Y, Liu H, Liu Z, Mills C, Han Y, Hung RJ, Brhane Y, McLaughlin J, Brennan P, Bickeboeller H, Rosenberger A, Houlston RS, Caporaso NE, Teresa Landi M, Brueske I, Risch A, Ye Y, Wu X, Christiani DC, Amos CI, Wei Q. Genetic variants of PTPN2 are associated with lung cancer risk: a re-analysis of eight GWASs in the TRICL-ILCCO consortium. Sci Rep. 2017 Apr 11;7(1):825. doi: 10.1038/s41598-017-00850-0. PubMed PMID: 28400551.

Renz H. Autophagy - Nobel Prize 2016 and Allergy and Asthma Research. J Allergy Clin Immunol. 2017 Apr 8. pii: S0091-6749(17)30577-8. doi: 10.1016/j.jaci.2017.03.021. [Epub ahead of print] PubMed PMID: 28400114.

Flemmer AW, Thio M, Wallace MJ, Lee K, Kitchen KM, Kerr L, Roehr CC, Fouras A, Carnibella R, Jani JJ, DeKoninck P, tePas AB, Pearson JT, Hooper SB. Lung hypoplasia in newborn rabbits with a diaphragmatic hernia affects pulmonary ventilation but not perfusion. Pediatr Res. 2017 Apr 11. doi: 10.1038/pr.2017.91. [Epub ahead of print] PubMed PMID: 28399114.

Merkus D, Schermuly RT. Farnesylation of RhoB: the cancer hypothesis of pulmonary hypertension revisited. Cardiovasc Res. 2017 Mar 1;113(3):249-250. doi: 10.1093/cvr/cvx010. PubMed PMID: 28395024.

Kreuter M, Spagnolo P, Wuyts W, Renzoni E, Koschel D, Bonella F, Maher TM, Kolb M, Weycker D, Kirchgässler KU, Costabel U. Antacid Therapy and Disease Progression in Patients with Idiopathic Pulmonary Fibrosis Who Received Pirfenidone. Respiration. 2017 Apr 12. doi: 10.1159/000468546. [Epub ahead of print] PubMed PMID: 28399537.

New in PubMed from DZL Faculty/ Neu von der DZL-Fakultät in der Woche bis 9. April 2017: 

Tichy D, Anna Pickl JM, Benner A, Sültmann H. Experimental design and data analysis of Ago-RIP-Seq experiments for the identification of microRNA targets. Brief Bioinform. 2017 Mar 31. doi: 10.1093/bib/bbx032. [Epub ahead of print] PubMed PMID: 28379479.

Domingues PH, Nanduri LS, Seget K, Venkateswaran SV, Agorku D, Viganó C, von Schubert C, Nigg EA, Swanton C, Sotillo R, Bosio A, Storchová Z, Hardt O. Cellular prion protein PRPC and ecto-5'-nucleotidase are markers of the cellular stress response to aneuploidy. Cancer Res. 2017 Apr 4. pii: canres.3052.2016. doi: 10.1158/0008-5472.CAN-16-3052. [Epub ahead of print] PubMed PMID: 28377454.

Gottlieb J, Smits J, Schramm R, Langer F, Buhl R, Witt C, Strueber M, Reichenspurner H. Lung Transplantation in Germany Since the Introduction of the Lung Allocation Score. Dtsch Arztebl Int. 2017 Mar 17;114(11):179-185. doi: 10.3238/arztebl.2017.0179. PubMed PMID: 28382903.

Hinske LC, Hoechter DJ, Schröeer E, Kneidinger N, Schramm R, Preissler G, Tomasi R, Sisic A, Frey L, von Dossow V, Scheiermann P. Predicting the Necessity for Extracorporeal Circulation During Lung Transplantation: A Feasibility Study. J Cardiothorac Vasc Anesth. 2017 Feb 3. pii: S1053-0770(17)30055-1. doi: 10.1053/j.jvca.2017.02.005. [Epub ahead of print] PubMed PMID: 28366711.

New in PubMed from DZL Faculty/ Neu von der DZL-Fakultät in der Woche bis 2. April 2017: 

Welte T, Bodmann KF. [Infectiology in intensive care medicine]. Med Klin Intensivmed Notfmed. 2017 Apr;112(3):184-185. doi: 10.1007/s00063-017-0274-0. German. PubMed PMID: 28361231.

Maschke SK, Renne J, Werncke T, Olsson KM, Hoeper MM, Wacker FK, Meyer BC, Hinrichs JB. Chronic thromboembolic pulmonary hypertension: Evaluation of 2D-perfusion angiography in patients who undergo balloon pulmonary angioplasty. Eur Radiol. 2017 Mar 30. doi: 10.1007/s00330-017-4806-z. [Epub ahead of print] PubMed PMID: 28361177.

Wang Y, McKay JD, Rafnar T, Wang Z, Timofeeva MN, Broderick P, Zong X, Laplana M, Wei Y, Han Y, Lloyd A, Delahaye-Sourdeix M, Chubb D, Gaborieau V, Wheeler W, Chatterjee N, Thorleifsson G, Sulem P, Liu G, Kaaks R, Henrion M, Kinnersley B, Vallée M, Le Calvez-Kelm F, Stevens VL, Gapstur SM, Chen WV, Zaridze D, Szeszenia-Dabrowska N, Lissowska J, Rudnai P, Fabianova E, Mates D, Bencko V, Foretova L, Janout V, Krokan HE, Gabrielsen ME, Skorpen F, Vatten L, Njølstad I, Chen C, Goodman G, Benhamou S, Vooder T, Välk K, Nelis M, Metspalu A, Lener M, Lubiński J, Johansson M, Vineis P, Agudo A, Clavel-Chapelon F, Bueno-de-Mesquita HB, Trichopoulos D, Khaw KT, Johansson M, Weiderpass E, Tjønneland A, Riboli E, Lathrop M, Scelo G, Albanes D, Caporaso NE, Ye Y, Gu J, Wu X, Spitz MR, Dienemann H, Rosenberger A, Su L, Matakidou A, Eisen T, Stefansson K, Risch A, Chanock SJ, Christiani DC, Hung RJ, Brennan P, Landi MT, Houlston RS, Amos CI. Corrigendum: Rare variants of large effect in BRCA2 and CHEK2 affect risk of lung cancer. Nat Genet. 2017 Mar 30;49(4):651. doi: 10.1038/ng0417-651a. PubMed PMID: 28358128.

Waschki B, Watz H, Holz O, Magnussen H, Olejnicka B, Welte T, Rabe KF, Janciauskiene S. Plasminogen activator inhibitor-1 is elevated in patients with COPD independent of metabolic and cardiovascular function. Int J Chron Obstruct Pulmon Dis. 2017 Mar 22;12:981-987. doi: 10.2147/COPD.S128689. eCollection 2017. PubMed PMID: 28356730; PubMed Central PMCID: PMC5367764.

Gerlach T, Hensen L, Matrosovich T, Bergmann J, Winkler M, Peteranderl C, Klenk HD, Weber F, Herold S, Pöhlmann S, Matrosovich M. pH-optimum of hemagglutinin-mediated membrane fusion determines sensitivity of influenza A viruses to the interferon-induced antiviral state and IFITMs. J Virol. 2017 Mar 29. pii: JVI.00246-17. doi: 10.1128/JVI.00246-17. [Epub ahead of print] PubMed PMID: 28356532.

Gall H, Hoeper MM, Richter MJ, Cacheris W, Hinzmann B, Mayer E. An epidemiological analysis of the burden of chronic thromboembolic pulmonary hypertension in the USA, Europe and Japan. Eur Respir Rev. 2017 Mar 29;26(143). pii: 160121. doi: 10.1183/16000617.0121-2016. Print 2017 Mar 31. Review. PubMed PMID: 28356407.

Lang I, Meyer BC, Ogo T, Matsubara H, Kurzyna M, Ghofrani HA, Mayer E, Brenot P. Balloon pulmonary angioplasty in chronic thromboembolic pulmonary hypertension. Eur Respir Rev. 2017 Mar 29;26(143). pii: 160119. doi: 10.1183/16000617.0119-2016. Print 2017 Mar 31. Review. PubMed PMID: 28356406.

Pepke-Zaba J, Ghofrani HA, Hoeper MM. Medical management of chronic thromboembolic pulmonary hypertension. Eur Respir Rev. 2017 Mar 29;26(143). pii: 160107. doi: 10.1183/16000617.0107-2016. Print 2017 Mar 31. Review. PubMed PMID: 28356404.

Chubanov V, Ferioli S, Gudermann T. Assessment of TRPM7 functions by drug-like small molecules. Cell Calcium. 2017 Mar 14. pii: S0143-4160(17)30051-9. doi: 10.1016/j.ceca.2017.03.004. [Epub ahead of print] Review. PubMed PMID: 28356194.

Nold P, Hartmann R, Feliu N, Kantner K, Gamal M, Pelaz B, Hühn J, Sun X, Jungebluth P, Del Pino P, Hackstein H, Macchiarini P, Parak WJ, Brendel C. Optimizing conditions for labeling of mesenchymal stromal cells (MSCs) with gold nanoparticles: a prerequisite for in vivo tracking of MSCs. J Nanobiotechnology. 2017 Mar 29;15(1):24. doi: 10.1186/s12951-017-0258-5. PubMed PMID: 28356160; PubMed Central PMCID: PMC5372278.

Poppe M, Wittig S, Jurida L, Bartkuhn M, Wilhelm J, Müller H, Beuerlein K, Karl N, Bhuju S, Ziebuhr J, Schmitz ML, Kracht M. The NF-κB-dependent and -independent transcriptome and chromatin landscapes of human coronavirus 229E-infected cells. PLoS Pathog. 2017 Mar 29;13(3):e1006286. doi: 10.1371/journal.ppat.1006286. eCollection 2017 Mar. PubMed PMID: 28355270.

Leisegang MS, Fork C, Josipovic I, Richter F, Preussner J, Hu J, Miller MJ, Epah JN, Hofmann P, Günther S, Moll F, Valasarajan C, Heidler J, Ponomareva Y, Freiman TM, Maegdefessel L, Plate KH, Mittelbronn M, Uchida S, Künne C, Stellos K, Schermuly RT, Weissmann N, Devraj K, Wittig I, Boon RA, Dimmeler S, Pullamsetti SS, Looso M, Miller FJ, Brandes RP. Long Noncoding RNA MANTIS Facilitates Endothelial Angiogenic Function. Circulation. 2017 Mar 28. pii: CIRCULATIONAHA.116.026991. doi: 10.1161/CIRCULATIONAHA.116.026991. [Epub ahead of print] PubMed PMID: 28351900.

Einecke G, Beutel G, Hoeper MM, Kielstein JT. The answer is blowing in the wind: an uncommon cause for severe ARDS accompanied by circulatory insufficiency requiring extracorporeal membrane oxygenation. BMJ Case Rep. 2017 Mar 24;2017. pii: bcr2016218079. doi: 10.1136/bcr-2016-218079. PubMed PMID: 28343152.

Krug N, Hohlfeld JM, Buhl R, Renz J, Garn H, Renz H. Blood eosinophils predict therapeutic effects of a GATA3-specific DNAzyme in asthma patients. J Allergy Clin Immunol. 2017 Mar 22. pii: S0091-6749(17)30421-9. doi: 10.1016/j.jaci.2017.02.024. [Epub ahead of print] PubMed PMID: 28342914.

Schwager C, Kull S, Behrends J, Röckendorf N, Schocker F, Frey A, Homann A, Becker WM, Jappe U. Peanut oleosins associated with severe peanut allergy - Importance of lipophilic allergens for comprehensive allergy diagnostics. J Allergy Clin Immunol. 2017 Mar 22. pii: S0091-6749(17)30417-7. doi: 10.1016/j.jaci.2017.02.020. [Epub ahead of print] PubMed PMID: 28342912.

Rieth A, Richter MJ, Gall H, Seeger W, Ghofrani HA, Mitrovic V, Hamm CW. Hemodynamic phenotyping based on exercise catheterization predicts outcome in patients with heart failure and reduced ejection fraction. J Heart Lung Transplant. 2017 Feb 28. pii: S1053-2498(17)31673-X. doi: 10.1016/j.healun.2017.02.022. [Epub ahead of print] PubMed PMID: 28342708.

Scherer K, Yaroshenko A, Bölükbas DA, Gromann LB, Hellbach K, Meinel FG, Braunagel M, Berg JV, Eickelberg O, Reiser MF, Pfeiffer F, Meiners S, Herzen J. X-ray Dark-field Radiography - In-Vivo Diagnosis of Lung Cancer in Mice. Sci Rep. 2017 Mar 24;7(1):402. doi: 10.1038/s41598-017-00489-x. PubMed PMID: 28341830.

Remon J, Menis J, Hasan B, Peric A, De Maio E, Novello S, Reck M, Berghmans T, Wasag B, Besse B, Dziadziuszko R. The APPLE Trial: Feasibility and Activity of AZD9291 (Osimertinib) Treatment on Positive PLasma T790M in EGFR-mutant NSCLC Patients. EORTC 1613. Clin Lung Cancer. 2017 Mar 1. pii: S1525-7304(17)30048-7. doi: 10.1016/j.cllc.2017.02.005. [Epub ahead of print] PubMed PMID: 28341106.

März 2017

New in PubMed from DZL Faculty/ Neu von der DZL-Fakultät in der Woche bis 26. März 2017: 

Gao JW, Rizzo S, Ma LH, Qiu XY, Warth A, Seki N, Hasegawa M, Zou JW, Li Q, Femia M, Lv TF, Song Y; written on behalf of the AME Lung Cancer Collaborative Group. Pulmonary ground-glass opacity: computed tomography features, histopathology and molecular pathology. Transl Lung Cancer Res. 2017 Feb;6(1):68-75. doi: 10.21037/tlcr.2017.01.02. Review. PubMed PMID: 28331826; PubMed Central PMCID: PMC5344841.

Volaklis KA, Thorand B, Peters A, Halle M, Heier M, Strasser B, Amann U, Ladwig KH, Schulz H, Koenig W, Meisinger C. Physical activity, muscular strength, and polypharmacy among older multimorbid persons: Results from the KORA-Age study. Scand J Med Sci Sports. 2017 Mar 22. doi: 10.1111/sms.12884. [Epub ahead of print] PubMed PMID: 28329413.

Salman J, Ius F, Sommer W, Siemeni T, Kuehn C, Avsar M, Boethig D, Molitoris U, Bara C, Gottlieb J, Welte T, Haverich A, Hoeper MM, Warnecke G, Tudorache I. Mid-term results of bilateral lung transplant with postoperatively extended intraoperative extracorporeal membrane oxygenation for severe pulmonary hypertension†. Eur J Cardiothorac Surg. 2017 Mar 2. doi: 10.1093/ejcts/ezx047. [Epub ahead of print] PubMed PMID: 28329232.

Lindner K, Ströbele M, Schlick S, Webering S, Jenckel A, Kopf J, Danov O, Sewald K, Buj C, Creutzenberg O, Tillmann T, Pohlmann G, Ernst H, Ziemann C, Hüttmann G, Heine H, Bockhorn H, Hansen T, König P, Fehrenbach H. Biological effects of carbon black nanoparticles are changed by surface coating with polycyclic aromatic hydrocarbons. Part Fibre Toxicol. 2017 Mar 21;14(1):8. doi: 10.1186/s12989-017-0189-1. PubMed PMID: 28327162; PubMed Central PMCID: PMC5361723.

Buccitelli C, Salgueiro L, Rowald K, Sotillo R, Mardin BR, Korbel JO. Pan-cancer analysis distinguishes transcriptional changes of aneuploidy from proliferation. Genome Res. 2017 Apr;27(4):501-511. doi: 10.1101/gr.212225.116. Epub 2017 Mar 20. PubMed PMID: 28320919; PubMed Central PMCID: PMC5378169.

Alsafadi HN, Staab-Weijnitz CA, Lehmann M, Lindner M, Peschel B, Königshoff M, Wagner DE. An ex vivo model to induce early fibrosis-like changes in human precision-cut lung slices. Am J Physiol Lung Cell Mol Physiol. 2017 Mar 17:ajplung.00084.2017. doi: 10.1152/ajplung.00084.2017. [Epub ahead of print] PubMed PMID: 28314802.

Gupta SK, Thum T. MiR-142-3p is a paracrine mediator between T cells and endothelium during allograft rejection. Cardiovasc Res. 2017 Apr 1;113(5):431-433. doi: 10.1093/cvr/cvx031. PubMed PMID: 28339725.

Hellbach K, Yaroshenko A, Willer K, Conlon TM, Braunagel MB, Auweter S, Yildirim AÖ, Eickelberg O, Pfeiffer F, Reiser MF, Meinel FG. X-ray dark-field radiography facilitates the diagnosis of pulmonary fibrosis in a mouse model. Sci Rep. 2017 Mar 23;7(1):340. doi: 10.1038/s41598-017-00475-3. PubMed PMID: 28336945.

Schröder K, Weissmann N, Brandes RP. Organizers and activators: Cytosolic Nox proteins impacting on vascular function. Free Radic Biol Med. 2017 Mar 21. pii: S0891-5849(17)30150-8. doi: 10.1016/j.freeradbiomed.2017.03.017. [Epub ahead of print] Review. PubMed PMID: 28336130.

Carleo A, Chorostowska-Wynimko J, Koeck T, Mischak H, Czajkowska-Malinowska M, Rozy A, Welte T, Janciauskiene S. Does urinary peptide content differ between COPD patients with and without inherited alpha-1 antitrypsin deficiency? Int J Chron Obstruct Pulmon Dis. 2017 Mar 8;12:829-837. doi: 10.2147/COPD.S125240. eCollection 2017. PubMed PMID: 28331304; PubMed Central PMCID: PMC5352160.

Luitel H, Sydykov A, Schymura Y, Mamazhakypov A, Janssen W, Pradhan K, Wietelmann A, Kosanovic D, Dahal BK, Weissmann N, Seeger W, Grimminger F, Ghofrani HA, Schermuly RT. Pressure overload leads to an increased accumulation and activity of mast cells in the right ventricle. Physiol Rep. 2017 Mar;5(6). pii: e13146. doi: 10.14814/phy2.13146. PubMed PMID: 28330950; PubMed Central PMCID: PMC5371552.

Wolf Y, Shemer A, Polonsky M, Gross M, Mildner A, Yona S, David E, Kim KW, Goldmann T, Amit I, Heikenwalder M, Nedospasov S, Prinz M, Friedman N, Jung S. Autonomous TNF is critical for in vivo monocyte survival in steady state and inflammation. J Exp Med. 2017 Apr 3;214(4):905-917. doi: 10.1084/jem.20160499. Epub 2017 Mar 22. PubMed PMID: 28330904; PubMed Central PMCID: PMC5379969.

Boeselt T, Nell C, Lütteken L, Kehr K, Koepke J, Apelt S, Veith M, Beutel B, Spielmanns M, Greulich T, Vogelmeier CF, Kenn K, Janciauskiene S, Alter P, Koczulla AR. Benefits of High-Intensity Exercise Training to Patients with Chronic Obstructive Pulmonary Disease: A Controlled Study. Respiration. 2017;93(5):301-310. doi: 10.1159/000464139. Epub 2017 Mar 23. PubMed PMID: 28329753.

Popat S, Mellemgaard A, Reck M, Hastedt C, Griebsch I. Nintedanib plus docetaxel as second-line therapy in patients with non-small-cell lung cancer of adenocarcinoma histology: a network meta-analysis vs new therapeutic options. Future Oncol. 2017 Feb 27. doi: 10.2217/fon-2016-0493. [Epub ahead of print] PubMed PMID: 28326832.

Hoppe J, Ünal CM, Thiem S, Grimpe L, Goldmann T, Gaßler N, Richter M, Shevchuk O, Steinert M. PilY1 Promotes Legionella pneumophila Infection of Human Lung Tissue Explants and Contributes to Bacterial Adhesion, Host Cell Invasion, and Twitching Motility. Front Cell Infect Microbiol. 2017 Mar 7;7:63. doi: 10.3389/fcimb.2017.00063. eCollection 2017. PubMed PMID: 28326293; PubMed Central PMCID: PMC5339237.

Gayathri Vegesna NV, Ronchi P, Durdu S, Terjung S, Pepperkok R. Targeted Ablation Using Laser Nanosurgery. Methods Mol Biol. 2017;1563:107-125. doi: 10.1007/978-1-4939-6810-7_8. PubMed PMID: 28324605.

Potaczek DP, Harb H, Michel S, Alhamwe BA, Renz H, Tost J. Epigenetics and allergy: from basic mechanisms to clinical applications. Epigenomics. 2017 Apr;9(4):539-571. doi: 10.2217/epi-2016-0162. Epub 2017 Mar 21. PubMed PMID: 28322581.

Dettmer S, Grünwald V, Fuehner T, Ganser A, Wacker F, Ivanyi P, Rodt T. CT patterns of organizing pneumonia in patients treated with VEGF/mTOR inhibitors for metastatic renal cell cancer: an observational study. Acta Radiol Open. 2017 Feb 1;6(2):2058460117694216. doi: 10.1177/2058460117694216. eCollection 2017 Feb. PubMed PMID: 28321331; PubMed Central PMCID: PMC5347262.

Hattar K, Reinert CP, Sibelius U, Gökyildirim MY, Subtil FS, Wilhelm J, Eul B, Dahlem G, Grimminger F, Seeger W, Grandel U. Lipoteichoic acids from Staphylococcus aureus stimulate proliferation of human non-small-cell lung cancer cells in vitro. Cancer Immunol Immunother. 2017 Mar 17. doi: 10.1007/s00262-017-1980-4. [Epub ahead of print] PubMed PMID: 28314957.

Rademacher J, Welte T. [New antibiotics - standstill or progress]. Med Klin Intensivmed Notfmed. 2017 Apr;112(3):206-213. doi: 10.1007/s00063-017-0271-3. Epub 2017 Mar 17. German. PubMed PMID: 28314920.

Pozarska A, Rodríguez-Castillo JA, Surate Solaligue DE, Ntokou A, Rath P, Mižíková I, Madurga A, Mayer K, Vadász I, Herold S, Ahlbrecht K, Seeger W, Morty RE. Stereological monitoring of mouse lung alveolarization from the early post-natal period to adulthood. Am J Physiol Lung Cell Mol Physiol. 2017 Mar 17:ajplung.00492.2016. doi: 10.1152/ajplung.00492.2016. [Epub ahead of print] PubMed PMID: 28314804.

New in PubMed from DZL Faculty/ Neu von der DZL-Fakultät in der Woche bis 19. März 2017: 

Prasse A. In Reply. Dtsch Arztebl Int. 2017 Feb 17;114(7):120. doi: 10.3238/arztebl.2017.0120c. PubMed PMID: 28302260; PubMed Central PMCID: PMC5359469.

Schepkin VD, Neubauer A, Nagel AM, Budinger TF. Comparison of potassium and sodium binding in vivo and in agarose samples using TQTPPI pulse sequence. J Magn Reson. 2017 Apr;277:162-168. doi: 10.1016/j.jmr.2017.03.003. Epub 2017 Mar 6. PubMed PMID: 28314206.

Pfaff N, Liebhaber S, Möbus S, Beh-Pajooh A, Fiedler J, Pfanne A, Schambach A, Thum T, Cantz T, Moritz T. Inhibition of miRNA-212/132 improves the reprogramming of fibroblasts into induced pluripotent stem cells by de-repressing important epigenetic remodelling factors. Stem Cell Res. 2017 Apr;20:70-75. doi: 10.1016/j.scr.2017.03.003. Epub 2017 Mar 7. PubMed PMID: 28314201.

Calverley PM, Tetzlaff K, Vogelmeier C, Fabbri LM, Magnussen H, Wouters EF, Mezzanotte W, Disse B, Finnigan H, Asijee G, Hallmann C, Watz H. Eosinophilia, Frequent Exacerbations, and Steroid Response in Chronic Obstructive Pulmonary Disease. Am J Respir Crit Care Med. 2017 Mar 17. doi: 10.1164/rccm.201612-2525LE. [Epub ahead of print] PubMed PMID: 28306321.

Thomas M, Sadjadian P, Kollmeier J, Lowe J, Mattson P, Trout JR, Gargano M, Patchen ML, Walsh R, Beliveau M, Marier JF, Bose N, Gorden K, Schneller F 3rd. A randomized, open-label, multicenter, phase II study evaluating the efficacy and safety of BTH1677 (1,3-1,6 beta glucan; Imprime PGG) in combination with cetuximab and chemotherapy in patients with advanced non-small cell lung cancer. Invest New Drugs. 2017 Mar 16. doi: 10.1007/s10637-017-0450-3. [Epub ahead of print] PubMed PMID: 28303530.

Neubauer A. [Immunotherapy of cancer with checkpoint inhibitors : Not only in malignant melanoma]. Internist (Berl). 2017 Apr;58(4):409-423. doi: 10.1007/s00108-017-0208-1. German. PubMed PMID: 28303311.

Gall H, Felix JF, Schneck FK, Milger K, Sommer N, Voswinckel R, Franco OH, Hofman A, Schermuly RT, Weissmann N, Grimminger F, Seeger W, Ghofrani HA. The Giessen Pulmonary Hypertension Registry: Survival in pulmonary hypertension subgroups. J Heart Lung Transplant. 2017 Feb 17. pii: S1053-2498(17)31625-X. doi: 10.1016/j.healun.2017.02.016. [Epub ahead of print] PubMed PMID: 28302503.

Loktev A, Haberkorn U, Mier W. Multicyclic Peptides as Scaffolds for the Development of Tumor Targeting Agents. Curr Med Chem. 2017 Mar 16. doi: 10.2174/0929867324666170316120304. [Epub ahead of print] PubMed PMID: 28302013.

Murtaza G, Mermer P, Goldenberg A, Pfeil U, Paddenberg R, Weissmann N, Lochnit G, Kummer W. TASK-1 potassium channel is not critically involved in mediating hypoxic pulmonary vasoconstriction of murine intra-pulmonary arteries. PLoS One. 2017 Mar 16;12(3):e0174071. doi: 10.1371/journal.pone.0174071. eCollection 2017. PubMed PMID: 28301582; PubMed Central PMCID: PMC5354433.

Wedzicha JA Ers Co-Chair, Miravitlles M, Hurst JR, Calverley PM, Albert RK, Anzueto A, Criner GJ, Papi A, Rabe KF, Rigau D, Sliwinski P, Tonia T, Vestbo J, Wilson KC, Krishnan JA Ats Co-Chair. Management of COPD exacerbations: a European Respiratory Society/American Thoracic Society guideline. Eur Respir J. 2017 Mar 15;49(3). pii: 1600791. doi: 10.1183/13993003.00791-2016. Print 2017 Mar. PubMed PMID: 28298398.

Jenkins D, Madani M, Fadel E, D'Armini AM, Mayer E. Pulmonary endarterectomy in the management of chronic thromboembolic pulmonary hypertension. Eur Respir Rev. 2017 Mar 15;26(143). pii: 160111. doi: 10.1183/16000617.0111-2016. Print 2017 Jan. Review. PubMed PMID: 28298388.

Buschle LR, Kurz FT, Kampf T, Wagner WL, Duerr J, Stiller W, Konietzke P, Wünnemann F, Mall MA, Wielpütz MO, Schlemmer HP, Ziener CH. Dephasing and diffusion on the alveolar surface. Phys Rev E. 2017 Feb;95(2-1):022415. doi: 10.1103/PhysRevE.95.022415. Epub 2017 Feb 24. PubMed PMID: 28297921.

Verleden SE, Gottlieb J, Dubbeldam A, Verleden GM, Suhling H, Welte T, Vos R, Greer M. "White-Out" After Lung Transplantation: A Multicenter Cohort Description of Late Acute Graft Failure. Am J Transplant. 2017 Mar 12. doi: 10.1111/ajt.14268. [Epub ahead of print] PubMed PMID: 28296181.

Jappe U. [Molecular-allergological aspects of allergen-specific immunotherapy]. Hautarzt. 2017 Apr;68(4):271-281. doi: 10.1007/s00105-017-3958-8. Review. German. PubMed PMID: 28293695.

Hoogendoorn M, Feenstra TL, Asukai Y, Briggs AH, Hansen RN, Leidl R, Risebrough N, Samyshkin Y, Wacker M, Rutten-van Mölken MP. External Validation of Health Economic Decision Models for Chronic Obstructive Pulmonary Disease (COPD): Report of the Third COPD Modeling Meeting. Value Health. 2017 Mar;20(3):397-403. doi: 10.1016/j.jval.2016.10.016. Epub 2017 Jan 3. PubMed PMID: 28292484.

Doyle MF, Tracy RP, Parikh MA, Hoffman EA, Shimbo D, Austin JH, Smith BM, Hueper K, Vogel-Claussen J, Lima J, Gomes A, Watson K, Kawut S, Barr RG. Endothelial progenitor cells in chronic obstructive pulmonary disease and emphysema. PLoS One. 2017 Mar 14;12(3):e0173446. doi: 10.1371/journal.pone.0173446. eCollection 2017. PubMed PMID: 28291826; PubMed Central PMCID: PMC5349667.

Lehmann C, Berner R, Bogner JR, Cornely OA, de With K, Herold S, Kern WV, Lemmen S, Pletz MW, Ruf B, Salzberger B, Stellbrink HJ, Suttorp N, Ullmann AJ, Fätkenheuer G, Jung N. The "Choosing Wisely" initiative in infectious diseases. Infection. 2017 Mar 13. doi: 10.1007/s15010-017-0997-0. [Epub ahead of print] Review. PubMed PMID: 28290130.

Mitchell S, Riha RL, Rohde G, Simonds AK. Continuing professional development: introducing the ERS International Certificate in Respiratory Sleep Medicine. Breathe (Sheff). 2017 Mar;13(1):11-14. doi: 10.1183/20734735.001617. PubMed PMID: 28289446; PubMed Central PMCID: PMC5343602.

Jung AL, Hoffmann K, Herkt CE, Schulz C, Bertrams W, Schmeck B. Legionella pneumophila Outer Membrane Vesicles: Isolation and Analysis of Their Pro-inflammatory Potential on Macrophages. J Vis Exp. 2017 Feb 22;(120). doi: 10.3791/55146. PubMed PMID: 28287548.

Badorrek P, Müller M, Koch W, Hohlfeld JM, Krug N. Specificity and reproducibility of nasal biomarkers in patients with allergic rhinitis after allergen challenge chamber exposure. Ann Allergy Asthma Immunol. 2017 Mar;118(3):290-297. doi: 10.1016/j.anai.2017.01.018. PubMed PMID: 28284536.

Kardos P, Vogelmeier C, Worth H, Buhl R, Lossi NS, Mailänder C, Criée CP. A two-year evaluation of the 'real life' impact of COPD on patients in Germany: The DACCORD observational study. Respir Med. 2017 Mar;124:57-64. doi: 10.1016/j.rmed.2017.02.007. Epub 2017 Feb 16. PubMed PMID: 28284322.

Boutin S, Hagenfeld D, Zimmermann H, El Sayed N, Höpker T, Greiser HK, Becher H, Kim TS, Dalpke AH. Clustering of Subgingival Microbiota Reveals Microbial Disease Ecotypes Associated with Clinical Stages of Periodontitis in a Cross-Sectional Study. Front Microbiol. 2017 Mar 1;8:340. doi: 10.3389/fmicb.2017.00340. eCollection 2017. PubMed PMID: 28298910; PubMed Central PMCID: PMC5331054.

New in PubMed from DZL Faculty/ Neu von der DZL-Fakultät in der Woche bis 12. März 2017: 

Wielpütz MO, Kauczor HU, Weckbach S. [Incidental findings in chest X‑rays]. Radiologe. 2017 Apr;57(4):263-269. doi: 10.1007/s00117-017-0230-2. German. PubMed PMID: 28283729.

Hsieh LT, Nastase MV, Roedig H, Zeng-Brouwers J, Poluzzi C, Schwalm S, Fork C, Tredup C, Brandes RP, Wygrecka M, Huwiler A, Pfeilschifter J, Schaefer L. Biglycan- and Sphingosine Kinase-1 Signaling Crosstalk Regulates the Synthesis of Macrophage Chemoattractants. Int J Mol Sci. 2017 Mar 9;18(3). pii: E595. doi: 10.3390/ijms18030595. PubMed PMID: 28282921; PubMed Central PMCID: PMC5372611.

Stelzer D, Weber A, Ihle F, Matthes S, Ceelen F, Zimmermann G, Kneidinger N, Schramm R, Winter H, Zoller M, Vogeser M, Behr J, Neurohr C. Comparing Azole Plasma Trough Levels in Lung Transplant Recipients: Percentage of Therapeutic Levels and Intrapatient Variability. Ther Drug Monit. 2017 Apr;39(2):93-101. doi: 10.1097/FTD.0000000000000371. PubMed PMID: 28282366; PubMed Central PMCID: PMC5348107.

Roche N, Chapman KR, Vogelmeier CF, Herth FJ, Thach C, Fogel R, Olsson P, Patalano F, Banerji D, Wedzicha JA. Blood Eosinophils and Response to Maintenance COPD Treatment: Data from the FLAME Trial. Am J Respir Crit Care Med. 2017 Mar 9. doi: 10.1164/rccm.201701-0193OC. [Epub ahead of print] PubMed PMID: 28278391.

Effner R, Hiller J, Eyerich S, Traidl-Hoffmann C, Brockow K, Triggiani M, Behrendt H, Schmidt-Weber CB, Buters JT. Cytochrome P450s in human immune cells regulate IL-22 and c-Kit via an AHR feedback loop. Sci Rep. 2017 Mar 9;7:44005. doi: 10.1038/srep44005. PubMed PMID: 28276465; PubMed Central PMCID: PMC5343665.

Schultz K, Seidl H, Jelusic D, Wagner R, Wittmann M, Faller H, Nowak D, Schuler M. Effectiveness of pulmonary rehabilitation for patients with asthma: study protocol of a randomized controlled trial (EPRA). BMC Pulm Med. 2017 Mar 9;17(1):49. doi: 10.1186/s12890-017-0389-3. PubMed PMID: 28274210; PubMed Central PMCID: PMC5343403.

Reck M, Brahmer JR. Pembrolizumab in Non-Small-Cell Lung Cancer. N Engl J Med. 2017 Mar 9;376(10):997. doi: 10.1056/NEJMc1615559. PubMed PMID: 28273022.

von Mutius E. The shape of the microbiome in early life. Nat Med. 2017 Mar 7;23(3):274-275. doi: 10.1038/nm.4299. PubMed PMID: 28267714.

Guetz S, Tufman A, von Pawel J, Rittmeyer A, Borgmeier A, Ferré P, Edlich B, Huber RM. Metronomic treatment of advanced non-small-cell lung cancer with daily oral vinorelbine - a Phase I trial. Onco Targets Ther. 2017 Feb 21;10:1081-1089. doi: 10.2147/OTT.S122106. eCollection 2017. PubMed PMID: 28260922; PubMed Central PMCID: PMC5328303.

Winter M, Thürmann L, Gu Z, Schüürmann G, Herberth G, Hinz D, von Bergen M, Harms H, Olek S, Röder S, Borte M, Eils R, Lehmann I, Trump S. The benzene metabolite 1,4-benzoquinone reduces regulatory T-cell function: A potential mechanism for tobacco smoke-associated atopic dermatitis. J Allergy Clin Immunol. 2017 Mar 6. pii: S0091-6749(17)30339-1. doi: 10.1016/j.jaci.2017.01.034. [Epub ahead of print] PubMed PMID: 28274748.

Niehof M, Hildebrandt T, Danov O, Arndt K, Koschmann J, Dahlmann F, Hansen T, Sewald K. RNA isolation from precision-cut lung slices (PCLS) from different species. BMC Res Notes. 2017 Mar 9;10(1):121. doi: 10.1186/s13104-017-2447-6. PubMed PMID: 28274266; PubMed Central PMCID: PMC5343379.

González-Avalos P, Mürnseer M, Deeg J, Bachmann A, Spatz J, Dooley S, Eils R, Gladilin E. Quantification of substrate and cellular strains in stretchable 3D cell cultures: an experimental and computational framework. J Microsc. 2017 May;266(2):115-125. doi: 10.1111/jmi.12520. Epub 2017 Mar 7. PubMed PMID: 28267878.

Sabel BO, Plum JL, Kneidinger N, Leuschner G, Koletzko L, Raziorrouh B, Schinner R, Kunz WG, Schoeppe F, Thierfelder KM, Sommer WH, Meinel FG. Structured reporting of CT examinations in acute pulmonary embolism. J Cardiovasc Comput Tomogr. 2017 Feb 22. pii: S1934-5925(17)30042-4. doi: 10.1016/j.jcct.2017.02.008. [Epub ahead of print] PubMed PMID: 28259629.

New in PubMed from DZL Faculty/ Neu von der DZL-Fakultät in der Woche bis 5. März 2017:

Guo M, Tomoshige K, Meister M, Muley T, Fukazawa T, Tsuchiya T, Karns R, Warth A, Fink-Baldauf IM, Nagayasu T, Naomoto Y, Xu Y, Mall MA, Maeda Y. Gene signature driving invasive mucinous adenocarcinoma of the lung. EMBO Mol Med. 2017 Mar 2. pii: e201606711. doi: 10.15252/emmm.201606711. [Epub ahead of print] PubMed PMID: 28255028.

Skronska-Wasek W, Mutze K, Baarsma HA, Bracke KR, Alsafadi HN, Lehmann M, Costa R, Stornaiuolo M, Novellino E, Brusselle GG, Wagner DE, Yildirim AÖ, Königshoff M. Reduced Frizzled Receptor 4 Expression Prevents WNT/β-catenin-driven Alveolar Lung Repair in COPD. Am J Respir Crit Care Med. 2017 Feb 28. doi: 10.1164/rccm.201605-0904OC. [Epub ahead of print] PubMed PMID: 28245136.

Hoeper MM, Ghofrani HA, Grünig E, Klose H, Olschewski H, Rosenkranz S. Pulmonary Hypertension. Dtsch Arztebl Int. 2017 Feb 3;114(5):73-84. doi: 10.3238/arztebl.2017.0073. PubMed PMID: 28241922.

Poobalasingam T, Yates LL, Walker SA, Pereira M, Gross NY, Ali A, Kolatsi-Joannou M, Jarvelin MR, Pekkanen J, Papakrivopoulou E, Long DA, Griffiths M, Wagner D, Königshoff M, Hind M, Minelli C, Lloyd CM, Dean CH. Heterozygous Vangl2(Looptail) mice reveal novel roles for the planar cell polarity pathway in adult lung homeostasis and repair. Dis Model Mech. 2017 Feb 24. pii: dmm.028175. doi: 10.1242/dmm.028175. [Epub ahead of print] PubMed PMID: 28237967.

Knüppel L, Ishikawa Y, Aichler M, Heinzelmann K, Hatz R, Behr J, Walch A, Bächinger HP, Eickelberg O, Staab-Weijnitz CA. A Novel Antifibrotic Mechanism of Nintedanib and Pirfenidone: Inhibition of Collagen Fibril Assembly. Am J Respir Cell Mol Biol. 2017 Mar 3. doi: 10.1165/rcmb.2016-0217OC. [Epub ahead of print] PubMed PMID: 28257580.

Sparla A, Flach-Vorgang S, Villalobos M, Krug K, Kamradt M, Coulibaly K, Szecsenyi J, Thomas M, Gusset-Bährer S, Ose D. Reflection of illness and strategies for handling advanced lung cancer - a qualitative analysis in patients and their relatives. BMC Health Serv Res. 2017 Mar 2;17(1):173. doi: 10.1186/s12913-017-2110-x. PubMed PMID: 28253884.

Schierhorn KL, Jolmes F, Bespalowa J, Saenger S, Peteranderl C, Dzieciolowski J, Budt M, Pleschka S, Herrmann A, Herold S, Wolff T. Influenza A virus virulence depends on two amino acids in the N-terminal domain of its NS1 protein facilitating inhibition of PKR. J Virol. 2017 Mar 1. pii: JVI.00198-17. doi: 10.1128/JVI.00198-17. [Epub ahead of print] PubMed PMID: 28250123.

Solé-Lleonart C, Rouby JJ, Blot S, Poulakou G, Chastre J, Palmer LB, Bassetti M, Luyt CE, Pereira JM, Riera J, Felton T, Dhanani J, Welte T, Garcia-Alamino JM, Roberts JA, Rello J. Nebulization of Antiinfective Agents in Invasively Mechanically Ventilated Adults: A Systematic Review and Meta-analysis. Anesthesiology. 2017 Mar 1. doi: 10.1097/ALN.0000000000001570. [Epub ahead of print] PubMed PMID: 28248714.

Herth FJ. To Remember and to Motivate: The Chris Bolliger Award. Respiration. 2017 Mar 1. doi: 10.1159/000462010. [Epub ahead of print] PubMed PMID: 28245477.

Skronska-Wasek W, Mutze K, Baarsma HA, Bracke KR, Alsafadi HN, Lehmann M, Costa R, Stornaiuolo M, Novellino E, Brusselle GG, Wagner DE, Yildirim AÖ, Königshoff M. Reduced Frizzled Receptor 4 Expression Prevents WNT/β-catenin-driven Alveolar Lung Repair in COPD. Am J Respir Crit Care Med. 2017 Feb 28. doi: 10.1164/rccm.201605-0904OC. [Epub ahead of print] PubMed PMID: 28245136.

Bousquet J, …, Rabe KF et al. Erratum to: Scaling up strategies of the chronic respiratory disease programme of the European Innovation Partnership on Active and Healthy Ageing (Action Plan B3: Area 5). Clin Transl Allergy. 2017 Feb 20;7:5. doi: 10.1186/s13601-016-0135-6. PubMed PMID: 28239450; PubMed Central PMCID: PMC5319069.

Februar 2017

New in PubMed from DZL Faculty/ Neu von der DZL-Fakultät in der Woche bis 26. Februar 2017:

Gaass T, Schneider MJ, Dietrich O, Ingrisch M, Dinkel J. Technical Note: Quantitative Dynamic Contrast-Enhanced MRI of a 3-Dimensional Artificial Capillary Network. Med Phys. 2017 Feb 24. doi: 10.1002/mp.12162. [Epub ahead of print] PubMed PMID: 28235128.

Kreuter M, Cottin V. The yin and yang of idiopathic pulmonary fibrosis. Eur Respir J. 2017 Feb 23;49(2). pii: 1602316. doi: 10.1183/13993003.02316-2016. PubMed PMID: 28232416.

van Manen MJ, Kreuter M, van den Blink B, Oltmanns U, Palmowski K, Brunnemer E, Hummler S, Tak NC, van den Toorn L, Miedema J, Hoogsteden HC, Wijsenbeek MS. What patients with pulmonary fibrosis and their partners think: a live, educative survey in the Netherlands and Germany. ERJ Open Res. 2017 Feb 14;3(1). pii: 00065-2016. doi: 10.1183/23120541.00065-2016. PubMed PMID: 28229083; PubMed Central PMCID: PMC5308412.

Thimraj TA, Birru RL, Mitra A, Schulz H, Leikauf GD, Ganguly K. Homeobox, Wnt, and Fibroblast Growth Factor Signaling is Augmented During Alveogenesis in Mice Lacking Superoxide Dismutase 3, Extracellular. Lung. 2017 Feb 20. doi: 10.1007/s00408-017-9980-x. [Epub ahead of print] PubMed PMID: 28220305.

Heigener DF, Hoeffken G, Wuerflein D, Feurer M, Rittmeyer A, Huber RM, Pietsch M, Ring A, Deppermann KM. Chemotherapy in the Elderly with Non-Small Cell Lung Cancer: A Non-Interventional, Prospective, Multicentric Observational Study. Dtsch Med Wochenschr. 2017 Feb;142(4):e21-e27. doi: 10.1055/s-0042-121785. German. PubMed PMID: 28235221.

Chauveau A, Dalphin ML, Mauny F, Kaulek V, Schmausser-Hechfellner E, Renz H, Riedler J, Pekkanen J, Karvonen AM, Lauener R, Roduit C, Vuitton DA, von Mutius E, Dalphin JC; PASTURE study group.. Skin prick tests and specific IgE in 10 year old children: agreement and association with allergic diseases. Allergy. 2017 Feb 24. doi: 10.1111/all.13148. [Epub ahead of print] PubMed PMID: 28235151.

Braeken DC, Franssen FM, von Baum H, Schütte H, Pletz MW, Rupp J, Stassen F, Mooij MJ, Rohde GG. Bacterial aetiology and mortality in COPD patients with CAP:  results from the German Competence Network, CAPNETZ. Int J Tuberc Lung Dis. 2017 Feb 1;21(2):236-243. doi: 10.5588/ijtld.16.0567. PubMed PMID: 28234091.

Bosch B, Bilton D, Sosnay P, Raraigh KS, Mak DY, Ishiguro H, Gulmans V, Thomas M, Cuppens H, Amaral M, De Boeck K. Ethnicity impacts the cystic fibrosis diagnosis: A note of caution. J Cyst Fibros. 2017 Feb 20. pii: S1569-1993(17)30023-1. doi: 10.1016/j.jcf.2017.01.016. [Epub ahead of print] PubMed PMID: 28233695.

Simonneau G, Hoeper MM. Evaluation of the incidence of rare diseases: difficulties and uncertainties, the example of chronic thromboembolic pulmonary hypertension. Eur Respir J. 2017 Feb 23;49(2). pii: 1602522. doi: 10.1183/13993003.02522-2016. PubMed PMID: 28232419.

Gompelmann D, Sarmand N, Herth FJ. Interventional pulmonology in chronic obstructive pulmonary disease. Curr Opin Pulm Med. 2017 Feb 17. doi: 10.1097/MCP.0000000000000373. [Epub ahead of print] PubMed PMID: 28221172.

Gottlieb J, Fuehner T, Greer M. Biodegradable stent for vanishing bronchus syndrome after lung transplantation. J Heart Lung Transplant. 2017 Jan 5. pii: S1053-2498(17)30013-X. doi: 10.1016/j.healun.2017.01.006. [Epub ahead of print] PubMed PMID: 28215478.

New in PubMed from DZL Faculty/ Neu von der DZL-Fakultät in der Woche bis 19. Februar 2017:

Magnussen C, Ojeda FM, Rzayeva N, Zeller T, Sinning CR, Pfeiffer N, Beutel M, Blettner M, Lackner KJ, Blankenberg S, Münzel T, Rabe KF, Wild PS, Schnabel RB; Gutenberg Health Study investigators. FEV1 and FVC predict all-cause mortality independent of cardiac function - Results from the population-based Gutenberg Health Study. Int J Cardiol. 2017 Feb 3. pii: S0167-5273(17)30689-7. doi: 10.1016/j.ijcard.2017.02.012. [Epub ahead of print] PubMed PMID: 28214081.

Farr A, Clementsen P, Herth F, Konge L, Rohde G, Dowsland S, Schuhmann M, Annema J. Endobronchial ultrasound: launch of an ERS structured training programme. Breathe (Sheff). 2016 Sep;12(3):217-220. doi: 10.1183/20734735.013116. PubMed PMID: 28210294; PubMed Central PMCID: PMC5298157.

Triphan SM, Jobst BJ, Anjorin A, Sedlaczek O, Wolf U, Terekhov M, Hoffmann C, Ley S, Düber C, Biederer J, Kauczor HU, Jakob PM, Wielpütz MO. Reproducibility and comparison of oxygen-enhanced T1 quantification in COPD and asthma patients. PLoS One. 2017 Feb 16;12(2): e0172479. doi: 10.1371/journal.pone.0172479. PubMed PMID: 28207845.

Hecker M, Sommer N, Hecker A, Bandorski D, Weigand MA, Krombach GA, Mayer E, Walmrath D. Pulmonary embolism. Anaesthesist. 2017 Feb 15. doi: 10.1007/s00101-017-0282-8. [Epub ahead of print] German. PubMed PMID: 28204834.

Vogelmeier C, Worth H, Buhl R, Criée CP, Lossi NS, Mailänder C, Kardos P. "Real-life" inhaled corticosteroid withdrawal in COPD: a subgroup analysis of DACCORD. Int J Chron Obstruct Pulmon Dis. 2017 Feb 1;12: 487-494. doi: 10.2147/COPD.S125616. PubMed PMID: 28203072; PubMed Central PMCID: PMC5295250.

Hoffman O, Burns N, Vadász I, Eltzschig HK, Edwards MG, Vohwinkel CU. Detrimental ELAVL-1/HuR-dependent GSK3β mRNA stabilization impairs resolution in acute respiratory distress syndrome. PLoS One. 2017 Feb 14;12(2): e0172116. doi: 10.1371/journal.pone.0172116. PubMed PMID: 28196122.

Guarino C, Hamon Y, Croix C, Lamort AS, Dallet-Choisy S, Marchand-Adam S, Lesner A, Baranek T, Viaud-Massuard MC, Lauritzen C, Pedersen J, Heuzé-Vourc'h N, Si-Tahar M, Fıratlı E, Jenne DE, Gauthier F, Horwitz MS, Borregaard N, Korkmaz B. Prolonged pharmacological inhibition of cathepsin C results in elimination of neutrophil serine proteases. Biochem Pharmacol. 2017 Feb 10. pii: S0006-2952(17)30086-2. doi: 10.1016/j.bcp.2017.02.009. [Epub ahead of print] PubMed PMID: 28193451.

Galiè N, Grimminger F, Grünig E, Hoeper MM, Humbert M, Jing ZC, Keogh AM, Langleben D, Rubin LJ, Fritsch A, Davie N, Ghofrani HA. Comparison of hemodynamic parameters in treatment-naïve and pre-treated patients with pulmonary arterial hypertension in the randomized phase III PATENT-1 study. J Heart Lung Transplant. 2016 Dec 24. pii: S1053-2498(16)30472-7. doi: 10.1016/j.healun.2016.12.012. [Epub ahead of print] PubMed PMID: 28190787.

Fehrenbach H, Wagner C, Wegmann M. Airway remodeling in asthma: what really matters. Cell Tissue Res. 2017 Feb 11. doi: 10.1007/s00441-016-2566-8. [Epub ahead of print] Review. PubMed PMID: 28190087.

Kreuter M, Zeynel S, Mishra DR. Interstitial lung diseases: course report. Breathe (Sheff). 2016 Sep;12(3):213-215. doi: 10.1183/20734735.011516. PubMed PMID: 28210293; PubMed Central PMCID: PMC5298150.

Ng Kuet Leong N, Brombacher F, Dalpke AH, Weitnauer M. Crosstalk between glucocorticoids and IL-4 modulates Ym1 expression in alternatively activated myeloid cells. Immunobiology. 2017 Feb 9. pii: S0171-2985(17)30019-0. doi: 10.1016/j.imbio.2017.02.003. [Epub ahead of print] PubMed PMID: 28209270.

New in PubMed from DZL Faculty/ Neu von der DZL-Fakultät in der Woche bis 12. Februar 2017:

. Genome-wide association analyses for lung function and chronic obstructive pulmonary disease identify new loci and potential druggable targets. Nat Genet. 2017 Feb 6. doi: 10.1038/ng.3787. [Epub ahead of print] PubMed PMID: 28166213.

Harms A, Kriegsmann M, Fink L, Länger F, Warth A. The new TNM classification for lung tumors: Changes and the assessment of multiple tumor foci. Pathologe. 2017 Feb;38(1):11-20. doi: 10.1007/s00292-017-0268-y. German. PubMed PMID: 28154917.

Eichstaedt CA, Song J, Rodríguez Viales R, Pan Z, Benjamin N, Fischer C, Hoeper M, Ulrich S, Hinderhofer K, Grünig E. First identification of Krüppel-like factor 2 mutation in heritable pulmonary arterial hypertension. Clin Sci (Lond). 2017 Feb 10. pii: CS20160930. doi: 10.1042/CS20160930. [Epub ahead of print] PubMed PMID: 28188237.

Schneider JP, Arkenau M, Knudsen L, Wedekind D, Ochs M. Lung remodeling in aging surfactant protein D deficient mice. Ann Anat. 2017 Feb 6. pii: S0940-9602(17)30015-8. doi: 10.1016/j.aanat.2017.01.013. [Epub ahead of print] PubMed PMID: 28185902.

Kontogianni K, Gerovasili V, Gompelmann D, Schuhmann M, Hoffmann H, Heussel CP, Herth FJ, Eberhardt R. Coil therapy for patients with severe emphysema and bilateral incomplete fissures - effectiveness and complications after 1-year follow-up: a single-center experience. Int J Chron Obstruct Pulmon Dis. 2017 Jan 23;12:383-394. doi: 10.2147/COPD.S117655. PubMed PMID: 28176954; PubMed Central PMCID: PMC5271380.

Fuehner T, Kuehn C, Welte T, Gottlieb J. Response. Chest. 2017 Feb;151(2):517-518. doi: 10.1016/j.chest.2016.11.048. PubMed PMID: 28183495.

Sibinska Z, Tian X, Korfei M, Kojonazarov B, Kolb JS, Klepetko W, Kosanovic D, Wygrecka M, Ghofrani HA, Weissmann N, Grimminger F, Seeger W, Guenther A, Schermuly RT. Amplified canonical transforming growth factor-β signalling via heat shock protein 90 in pulmonary fibrosis. Eur Respir J. 2016 Dec 19. pii: 1501941. doi: 10.1183/13993003.01941-2015. [Epub ahead of print] PubMed PMID: 28182573.

Vogelmeier CF, Criner GJ, Martinez FJ, Anzueto A, Barnes PJ, Bourbeau J, Celli BR, Chen R, Decramer M, Fabbri LM, Frith P, Halpin DM, López Varela MV, Nishimura M, Roche N, Rodriguez-Roisin R, Sin DD, Singh D, Stockley R, Vestbo J, Wedzicha JA, Agusti A. Global Strategy for the Diagnosis, Management, and Prevention of Chronic Obstructive Lung Disease 2017 Report: GOLD Executive Summary. Eur Respir J. 2017 Jan 30. pii: 1700214. doi: 10.1183/13993003.00214-2017. [Epub ahead of print] PubMed PMID: 28182564.

Taggart C, Mall MA, Lalmanach G, Cataldo D, Ludwig A, Janciauskiene S, Heath N, Meiners S, Overall CM, Schultz C, Turk B, Borensztajn KS. Protean proteases: at the cutting edge of lung diseases. Eur Respir J. 2017 Feb 8;49(2). pii: 1501200. doi: 10.1183/13993003.01200-2015. PubMed PMID: 28179435.

Kontogianni K, Gerovasili V, Gompelmann D, Schuhmann M, Hoffmann H, Heussel CP, Herth FJ, Eberhardt R. Coil therapy for patients with severe emphysema and bilateral incomplete fissures - effectiveness and complications after 1-year follow-up: a single-center experience. Int J Chron Obstruct Pulmon Dis. 2017 Jan 23;12:383-394. doi: 10.2147/COPD.S117655. PubMed PMID: 28176954; PubMed Central PMCID: PMC5271380.

Ochs MM, Siepen FA, Fritz T, Andre F, Gitsioudis G, Korosoglou G, Seitz S, Bogomazov Y, Schlett CL, Sokiranski R, Sommer A, Gückel F, Brado M, Kauczor HU, Görich J, Friedrich MG, Katus HA, Buss SJ. Limits of the possible: diagnostic image quality in coronary angiography with third-generation dual-source CT. Clin Res Cardiol. 2017 Feb 6. doi: 10.1007/s00392-017-1077-2. [Epub ahead of print] PubMed PMID: 28168514.

Hämmerling S, Becker S, Mall MA. Rare cause for hemoptysis in an adolescent: Bronchial capillary hemangioma. Pediatr Pulmonol. 2017 Feb 6. doi: 10.1002/ppul.23673. [Epub ahead of print] PubMed PMID: 28165678.

Kollef MH, Bassetti M, Francois B, Burnham J, Dimopoulos G, Garnacho-Montero J, Lipman J, Luyt CE, Nicolau DP, Postma MJ, Torres A, Welte T, Wunderink RG. The intensive care medicine research agenda on multidrug-resistant bacteria, antibiotics, and stewardship. Intensive Care Med. 2017 Feb 4. doi: 10.1007/s00134-017-4682-7. [Epub ahead of print] Review. PubMed PMID: 28160023.

Rello J, Krenn CG, Locker G, Pilger E, Madl C, Balica L, Dugernier T, Laterre PF, Spapen H, Depuydt P, Vincent JL, Bogár L, Szabó Z, Völgyes B, Máñez R, Cakar N, Ramazanoglu A, Topeli A, Mastruzzo MA, Jasovich A, Remolif CG, Del Carmen Soria L, Andresen Hernandez MA, Ruiz Balart C, Krémer I, Molnár Z, von Sonnenburg F, Lyons A, Joannidis M, Burgmann H, Welte T, Klingler A, Hochreiter R, Westritschnig K. A randomized placebo-controlled phase II study of a Pseudomonas vaccine in ventilated ICU patients. Crit Care. 2017 Feb 4;21(1):22. doi: 10.1186/s13054-017-1601-9. PubMed PMID: 28159015; PubMed Central PMCID: PMC5291979.

Kindler E, Gil-Cruz C, Spanier J, Li Y, Wilhelm J, Rabouw HH, Züst R, Hwang M, V'kovski P, Stalder H, Marti S, Habjan M, Cervantes-Barragan L, Elliot R, Karl N, Gaughan C, van Kuppeveld FJ, Silverman RH, Keller M, Ludewig B, Bergmann CC, Ziebuhr J, Weiss SR, Kalinke U, Thiel V. Early endonuclease-mediated evasion of RNA sensing ensures efficient coronavirus replication. PLoS Pathog. 2017 Feb 3;13(2):e1006195. doi: 10.1371/journal.ppat.1006195. [Epub ahead of print] PubMed PMID: 28158275.

Harms A, Kriegsmann M, Fink L, Länger F, Warth A. The new TNM classification for lung tumors : Changes and the assessment of multiple tumor foci. Pathologe. 2017 Feb;38(1):11-20. doi: 10.1007/s00292-017-0268-y. German. PubMed PMID: 28154917.

Lingner M, Herrmann S, Tümmler B. Adherence of Pseudomonas aeruginosa to cystic fibrosis buccal epithelial cells. ERJ Open Res. 2017 Jan 17;3(1). pii: 00095-2016. doi: 10.1183/23120541.00095-2016. PubMed PMID: 28154819; PubMed Central PMCID: PMC5279068.

Yin J, Liu H, Liu Z, Owzar K, Han Y, Su L, Wei Y, Hung RJ, Brhane Y, McLaughlin J, Brennan P, Bickeboeller H, Rosenberger A, Houlston RS, Caporaso N, Landi MT, Heinrich J, Risch A, Christiani DC, Amos CI, Wei Q. Pathway-analysis of published genome-wide association studies of lung cancer: A potential role for the CYP4F3 locus. Mol Carcinog. 2017 Feb 2. doi: 10.1002/mc.22622. [Epub ahead of print] PubMed PMID: 28150878.

Didiasova M, Singh R, Wilhelm J, Kwapiszewska G, Wujak L, Zakrzewicz D, Schaefer L, Markart P, Seeger W, Lauth M, Wygrecka M. Pirfenidone exerts antifibrotic effects through inhibition of GLI transcription factors. FASEB J. 2017 Feb 1. pii: fj.201600892RR. doi: 10.1096/fj.201600892RR. [Epub ahead of print] PubMed PMID: 28148565.

New in PubMed from DZL Faculty/ Neu von der DZL-Fakultät in der Woche bis 6. Februar 2017:

Jonigk D, Rath B, Borchert P, Braubach P, Maegel L, Izykowski N, Warnecke G, Sommer W, Kreipe H, Blach R, Anklamm A, Haverich A, Eder M, Stadler M, Welte T, Gottlieb J, Kuehnel M, Laenger F. Comparative analysis of morphological and molecular motifs in bronchiolitis obliterans and alveolar fibroelastosis after lung and stem cell transplantation. J Pathol Clin Res. 2016 Dec 10;3(1):17-28. doi: 10.1002/cjp2.60. PubMed PMID: 28138398; PubMed Central PMCID: PMC5259562.

Singh D, Miravitlles M, Vogelmeier C. Erratum to: Chronic Obstructive Pulmonary Disease Individualized Therapy: Tailored Approach to Symptom Management. Adv Ther. 2017 Jan 31. doi: 10.1007/s12325-017-0481-3. [Epub ahead of print] PubMed PMID: 28144919.

Welte T. Acute life-threatening hemorrhage: Diagnostic workup and treatment possibilities are constantly improving. Internist (Berl). 2017 Jan 31. doi: 10.1007/s00108-017-0198-z. [Epub ahead of print] German. PubMed PMID: 28144688.

Rath P, Nardiello C, Solaligue DE, Agius R, Mižíková I, Hühn S, Mayer K, Vadász I, Herold S, Runkel F, Seeger W, Morty RE. Caffeine administration modulates TGF-β signaling but does not attenuate blunted alveolarization in a hyperoxia-based mouse model of bronchopulmonary dysplasia. Pediatr Res. 2017 Jan 31. doi: 10.1038/pr.2017.21. [Epub ahead of print] PubMed PMID: 28141790.

Steiert SA, Zissler UM, Chaker AM, Esser-von-Bieren J, Dittlein D, Guerth F, Jakwerth CA, Piontek G, Zahner C, Drewe J, Traidl-Hoffmann C, Schmidt-Weber CB, Gilles S. Anti-inflammatory effects of the petasin phyto drug Ze339 are mediated by inhibition of the STAT pathway. Biofactors. 2017 Jan 31. doi: 10.1002/biof.1349. [Epub ahead of print] PubMed PMID: 28139053.

Wentker P, Eberhardt M, Dreyer FS, Bertrams W, Cantone M, Griss K, Schmeck B, Vera J. An Interactive Macrophage Signal Transduction Map Facilitates Comparative Analyses of High-Throughput Data. J Immunol. 2017 Jan 30. pii: 1502513. doi: 10.4049/jimmunol.1502513. [Epub ahead of print] PubMed PMID: 28137890.

Xavier LE, Bernardes-Souza B, Lisboa OC, Seeger W, Groneberg DA, Tran TA, Fries FN, Corrêa PC, Brinker TJ. A Medical Student-Delivered Smoking Prevention Program, Education Against Tobacco, for Secondary Schools in Brazil: Study Protocol for a Randomized Trial. JMIR Res Protoc. 2017 Jan 30;6(1):e16. doi: 10.2196/resprot.7134. PubMed PMID: 28137703.

January 2017

New in PubMed from DZL Faculty/ Neu von der DZL-Fakultät in der Woche bis 29. Januar 2017:

Boxberg M, Jesinghaus M, Dorfner C, Mogler C, Drecoll E, Warth A, Steiger K, Bollwein C, Meyer P, Wolff KD, Kolk A, Weichert W. Tumor budding activity and cell nest size determine patient outcome in oral squamous cell carcinoma: Proposal for an adjusted grading system. Histopathology. 2017 Jan 25. doi: 10.1111/his.13173. [Epub ahead of print] PubMed PMID: 28122134.

 Warth A, Beasley MB, Mino-Kenudson M. Breaking New Ground: The Evolving Concept of Spread through Air Spaces (STAS). J Thorac Oncol. 2017 Feb;12(2):176-178. doi: 10.1016/j.jtho.2016.10.020. PubMed PMID: 28115109.

 Fuchs O, Gorlanova O, Latzin P, Schmidt A, Schieck M, Toncheva AA, Michel S, Gaertner VD, Kabesch M, Frey U. 6q12 and 11p14 variants are associated with postnatal exhaled nitric oxide and respiratory symptoms. J Allergy Clin Immunol. 2017 Jan 18. pii: S0091-6749(17)30046-5. doi: 10.1016/j.jaci.2016.11.048. [Epub ahead of print] PubMed PMID: 28109725.

Farrell PM, White TB, Howenstine MS, Munck A, Parad RB, Rosenfeld M, Sommerburg O, Accurso FJ, Davies JC, Rock MJ, Sanders DB, Wilschanski M, Sermet-Gaudelus I, Blau H, Gartner S, McColley SA. Diagnosis of Cystic Fibrosis in Screened Populations. J Pediatr. 2017 Feb;181S:S33-S44.e2. doi: 10.1016/j.jpeds.2016.09.065. PubMed PMID: 28129810.

Vogelmeier CF, Criner GJ, Martinez FJ, Anzueto A, Barnes PJ, Bourbeau J, Celli BR, Chen R, Decramer M, Fabbri LM, Frith P, Halpin DM, López Varela MV, Nishimura M, Roche N, Rodriguez-Roisin R, Sin DD, Singh D, Stockley R, Vestbo J, Wedzicha JA, Agusti A. Global Strategy for the Diagnosis, Management, and Prevention of Chronic Obstructive Lung Disease 2017 Report: GOLD Executive Summary. Am J Respir Crit Care Med. 2017 Jan 27. doi: 10.1164/rccm.201701-0218PP. [Epub ahead of print] PubMed PMID: 28128970.

Pletz MW, Kamradt T, Welte T. Time to follow up when comparing studies of pneumococcal vaccines. Lancet Infect Dis. 2017 Jan 23. pii: S1473-3099(17)30051-8. doi: 10.1016/S1473-3099(17)30051-8. [Epub ahead of print] PubMed PMID: 28126328.

 Altmäe S, Segura MT, Esteban FJ, Bartel S, Brandi P, Irmler M, Beckers J, Demmelmair H, López-Sabater C, Koletzko B, Krauss-Etschmann S, Campoy C. Maternal Pre-Pregnancy Obesity Is Associated with Altered Placental Transcriptome. PLoS One. 2017 Jan 26;12(1):e0169223. doi: 10.1371/journal.pone.0169223. PubMed PMID: 28125591; PubMed Central PMCID: PMC5268451.

Adlung L, Kar S, Wagner MC, She B, Chakraborty S, Bao J, Lattermann S, Boerries M, Busch H, Wuchter P, Ho AD, Timmer J, Schilling M, Höfer T, Klingmüller U. Protein abundance of AKT and ERK pathway components governs cell type-specific regulation of proliferation. Mol Syst Biol. 2017 Jan 24;13(1):904. doi: 10.15252/msb.20167258. PubMed PMID: 28123004; PubMed Central PMCID: PMC5293153.

Wiehlmann L, Pienkowska K, Hedtfeld S, Dorda M, Tümmler B. Impact of sample processing on human airways microbial metagenomes. J Biotechnol. 2017 Jan 23. pii: S0168-1656(17)30012-3. doi: 10.1016/j.jbiotec.2017.01.001. [Epub ahead of print] PubMed PMID: 28119120.

Price D, Østrem A, Thomas M, Welte T. Dual bronchodilation in COPD: lung function and patient-reported outcomes - a review. Int J Chron Obstruct Pulmon Dis. 2016 Dec 30;12:141-168. doi: 10.2147/COPD.S116719. Review. PubMed PMID: 28115839; PubMed Central PMCID: PMC5221557.

50: Heigener DF, Reck M. J Thorac Oncol. 2017 Feb;12(2):171-172. doi: 10.1016/j.jtho.2016.12.013. PubMed PMID: 28115107.

Hecker M, Weigand MA, Mayer K. Adjunctive pharmacotherapy for acute respiratory distress syndrome. Dtsch Med Wochenschr. 2017 Jan;142(2):96-101. doi: 10.1055/s-0042-105943. German. PubMed PMID: 28114714.

Fuchs O, Gorlanova O, Latzin P, Schmidt A, Schieck M, Toncheva AA, Michel S, Gaertner VD, Kabesch M, Frey U. 6q12 and 11p14 variants are associated with postnatal exhaled nitric oxide and respiratory symptoms. J Allergy Clin Immunol. 2017 Jan 18. pii: S0091-6749(17)30046-5. doi: 10.1016/j.jaci.2016.11.048. [Epub ahead of print] PubMed PMID: 28109725.

New in PubMed from DZL Faculty/ Neu von der DZL-Fakultät in der Woche bis 23. Januar 2017:

Zhou-Suckow Z, Duerr J, Hagner M, Agrawal R, Mall MA. Airway mucus, inflammation and remodeling: emerging links in the pathogenesis of chronic lung diseases. Cell Tissue Res. 2017 Jan 20. doi: 10.1007/s00441-016-2562-z. [Epub ahead of print] Review. PubMed PMID: 28108847.

Matamala N, Aggarwal N, Iadarola P, Fumagalli M, Gomez-Mariano G, Lara B, Martinez MT, Cuesta I, Stolk J, Janciauskiene S, Martinez-Delgado B. Identification of Novel Short C-Terminal Transcripts of Human SERPINA1 Gene. PLoS One. 2017 Jan 20;12(1):e0170533. doi: 0.1371/journal.pone.0170533. PubMed PMID: 28107454; PubMed Central PMCID: PMC5249162.

Nattenmüller J, Wochner R, Muley T, Steins M, Hummler S, Teucher B, Wiskemann J, Kauczor HU, Wielpütz MO, Heussel CP. Prognostic Impact of CT-Quantified Muscle and Fat Distribution before and after First-Line-Chemotherapy in Lung Cancer Patients. PLoS One. 2017 Jan 20;12(1):e0169136. doi: 10.1371/journal.pone.0169136. PubMed PMID: 28107410; PubMed Central PMCID: PMC5249228.

Dommaschk A, Ding N, Tort Tarres M, Bittersohl LF, Maus R, Stolper J, Jonigk D, Braubach P, Lippmann T, Welte T, Maus UA. Nasopharyngeal colonization with Streptococcus pneumoniae triggers dendritic cell dependent antibody responses against invasive disease in mice. Eur J Immunol. 2017 Jan 19. doi: 10.1002/eji.201646700. [Epub ahead of print] PubMed PMID: 28101913.

Schneider MA, Christopoulos P, Muley T, Warth A, Klingmueller U, Thomas M, Herth FJ, Dienemann H, Mueller NS, Theis F, Meister M. AURKA, DLGAP5, TPX2, KIF11 and CKAP5: Five specific mitosis-associated genes correlate with poor prognosis for non-small cell lung cancer patients. Int J Oncol. 2017 Feb;50(2):365-372. doi: 10.3892/ijo.2017.3834. PubMed PMID: 28101582; PubMed Central PMCID: PMC5238780.

Maarman GJ, Schulz R, Sliwa K, Schermuly R, Lecour S. Novel putative pharmacologic therapies to protect the right ventricle in pulmonary hypertension: A review of current literature. Br J Pharmacol. 2017 Jan 18. doi: 10.1111/bph.13721. [Epub ahead of print] Review. PubMed PMID: 28099680.

Berliner D, Schneider N, Welte T, Bauersachs J. The Differential Diagnosis of Dyspnea. Dtsch Arztebl Int. 2016 Dec 9;113(49):834-845. doi: 10.3238/arztebl.2016.0834. PubMed PMID: 28098068; PubMed Central PMCID: PMC5247680.

Sommer W, Buechler G, Jansson K, Avsar M, Knöfel AK, Salman J, Hoeffler K, Siemeni T, Gottlieb J, Karstens JH, Jonigk D, Reising A, Haverich A, Strüber M, Warnecke G. Irradiation before and donor splenocyte infusion immediately after transplantation induce tolerance to lung, but not heart allografts in miniature swine. Transpl Int. 2017 Jan 17. doi: 10.1111/tri.12916. [Epub ahead of print] PubMed PMID: 28095640.

Mühlfeld C, Ochs M. Development, remodeling and regeneration of the lung: coping with the structural and functional challenges of breathing. Cell Tissue Res. 2017 Jan 16. doi: 10.1007/s00441-016-2568-6. [Epub ahead of print] PubMed PMID: 28091774.

Audrit KJ, Delventhal L, Aydin Ö, Nassenstein C. The nervous system of airways and its remodeling in inflammatory lung diseases. Cell Tissue Res. 2017 Jan 14. doi: 10.1007/s00441-016-2559-7. [Epub ahead of print] Review. PubMed PMID: 28091773.

Bandorski D, Bogossian H, Stempfl J, Seeger W, Hecker M, Ghofrani A, Hoeltgen R, Gall H. Prognostic Relevance of Nonsustained Ventricular Tachycardia in Patients with Pulmonary Hypertension. Biomed Res Int. 2016;2016:1327265. doi: 10.1155/2016/1327265. PubMed PMID: 28090536; PubMed Central PMCID: PMC5206408.

Richter MJ, Schermuly R, Seeger W, Rao Y, Ghofrani HA, Gall H. Relevance of angiopoietin-2 and soluble P-selectin levels in patients with pulmonary arterial hypertension receiving combination therapy with oral treprostinil: a FREEDOM-C2 biomarker substudy. Pulm Circ. 2016 Dec;6(4):516-523. doi: 10.1086/688671. PubMed PMID: 28090293; PubMed Central PMCID: PMC5210055.

Pullamsetti SS, Perros F, Chelladurai P, Yuan J, Stenmark K. Transcription factors, transcriptional coregulators, and epigenetic modulation in the control of pulmonary vascular cell phenotype: therapeutic implications for pulmonary hypertension (2015 Grover Conference series). Pulm Circ. 2016 Dec;6(4):448-464. doi: 10.1086/688908. Review. PubMed PMID: 28090287; PubMed Central PMCID: PMC5210074.

Albrecht M, Stichel D, Müller B, Merkle R, Sticht C, Gretz N, Klingmüller U, Breuhahn K, Matthäus F. TTCA: an R package for the identification of differentially expressed genes in time course microarray data. BMC Bioinformatics. 2017 Jan 14;18(1):33. doi: 10.1186/s12859-016-1440-8. PubMed PMID: 28088176; PubMed Central PMCID: PMC5237546.

Boutin S, Dalpke AH. Acquisition and adaptation of the airway microbiota in the early life of cystic fibrosis patients. Mol Cell Pediatr. 2017 Dec;4(1):1. doi: 10.1186/s40348-016-0067-1. Review. PubMed PMID: 28097632; PubMed Central PMCID: PMC5241261.

New in PubMed from DZL Faculty/ Neu von der DZL-Fakultät in der Woche bis 16. Januar 2017:

Offermanns S. Hydroxy-Carboxylic Acid Receptor Actions in Metabolism. Trends Endocrinol Metab. 2017 Jan 10. pii: S1043-2760(16)30167-9. doi: 10.1016/j.tem.2016.11.007. [Epub ahead of print] Review. PubMed PMID: 28087125.

Kahnert K, Lucke T, Biertz F, Lechner A, Watz H, Alter P, Bals R, Behr J, Holle R, Huber RM, Karrasch S, Stubbe B, Wacker M, Söhler S, Wouters EF, Vogelmeier C, Jörres RA; COSYCONET study group.. Transfer factor for carbon monoxide in patients with COPD and diabetes: results from the German COSYCONET cohort. Respir Res. 2017 Jan 13;18(1):14. doi: 10.1186/s12931-016-0499-0. PubMed PMID: 28086884; PubMed Central PMCID: PMC5237203.

Vehreschild JJ, Heussel CP, Groll AH, Vehreschild MJ, Silling G, Würthwein G, Brecht M, Cornely OA. Serial assessment of pulmonary lesion volume by computed tomography allows survival prediction in invasive pulmonary aspergillosis. Eur Radiol. 2017 Jan 12. doi: 10.1007/s00330-016-4717-4. [Epub ahead of print] PubMed PMID: 28083695.

Spina G, Spruit MA, Alison J, Benzo RP, Calverley PM, Clarenbach CF, Costello RW, Donaire-Gonzalez D, Dürr S, Garcia-Aymerich J, van Gestel AJ, Gramm M, Hernandes NA, Hill K, Hopkinson NS, Jarreta D, Kohler M, Kirsten AM, Leuppi JD, Magnussen H, Maltais F, Man WD, McKeough ZJ, Mesquita R, Miedinger D, Pitta F, Singh SJ, Smeenk FW, Tal-Singer R, Vagaggini B, Waschki B, Watz H, Wouters EF, Zogg S, den Brinker AC. Analysis of nocturnal actigraphic sleep measures in patients with COPD and their association with daytime physical activity. Thorax. 2017 Jan 12. pii: thoraxjnl-2016-208900. doi: 10.1136/thoraxjnl-2016-208900. [Epub ahead of print] PubMed PMID: 28082529.

Lingner H, Burger B, Kardos P, Criée CP, Worth H, Hummers-Pradier E. What patients really think about asthma guidelines: barriers to guideline implementation from the patients' perspective. BMC Pulm Med. 2017 Jan 11;17(1):13. doi: 10.1186/s12890-016-0346-6. PubMed PMID: 28077097; PubMed Central PMCID: PMC5225589.

Greulich T, Regner W, Branscheidt M, Herr C, Koczulla AR, Vogelmeier CF, Bals R. Altered blood levels of vitamin D, cathelicidin and parathyroid hormone in patients with sepsis-a pilot study. Anaesth Intensive Care. 2017 Jan;45(1):36-45. PubMed PMID: 28072933.

Baarsma HA, Skronska-Wasek W, Mutze K, Ciolek F, Wagner DE, John-Schuster G, Heinzelmann K, Günther A, Bracke KR, Dagouassat M, Boczkowski J, Brusselle GG, Smits R, Eickelberg O, Yildirim AÖ, Königshoff M. Correction: Noncanonical WNT-5A signaling impairs endogenous lung repair in COPD. J Exp Med. 2017 Feb;214(2):565. doi: 10.1084/jem.2016067501052017c. PubMed PMID: 28069639; PubMed Central PMCID: PMC5294856.

Sattler C, Moritz F, Chen S, Steer B, Kutschke D, Irmler M, Beckers J, Eickelberg O, Schmitt-Kopplin P, Adler H, Stoeger T. Nanoparticle exposure reactivates latent herpesvirus and restores a signature of acute infection. Part Fibre Toxicol. 2017 Jan 10;14(1):2. doi: 10.1186/s12989-016-0181-1. PubMed PMID: 28069010; PubMed Central PMCID: PMC5223553.

Nardiello C, Mižíková I, Silva DM, Ruiz-Camp J, Mayer K, Vadász I, Herold S, Seeger W, Morty RE. Standardisation of oxygen exposure in the development of mouse models for bronchopulmonary dysplasia. Dis Model Mech. 2017 Feb 1;10(2):185-196. doi: 10.1242/dmm.027086. PubMed PMID: 28067624.

Wang XB, Yin Y, Miao Y, Eberhardt R, Hou G, Herth FJ, Kang J. Flex-rigid pleuroscopic biopsy with the SB knife Jr is a novel technique for diagnosis of malignant or benign fibrothorax. J Thorac Dis. 2016 Nov;8(11):E1555-E1559. doi: 10.21037/jtd.2016.11.92. PubMed PMID: 28066660; PubMed Central PMCID: PMC5179399.

Eze C, Roengvoraphoj O, Niyazi M, Hildebrandt G, Fietkau R, Belka C, Manapov F. Treatment Response and Prophylactic Cranial Irradiation Are Prognostic Factors in a Real-life Limited-disease Small-cell Lung Cancer Patient Cohort Comprehensively Staged With Cranial Magnetic Resonance Imaging. Clin Lung Cancer. 2016 Nov 21. pii: S1525-7304(16)30359-X. doi: 10.1016/j.cllc.2016.11.005. [Epub ahead of print] PubMed PMID: 28065620.

Aschard H, Tobin MD, Hancock DB, Skurnik D, Sood A, James A, Vernon Smith A, Manichaikul AW, Campbell A, Prins BP, Hayward C, Loth DW, Porteous DJ, Strachan DP, Zeggini E, O'Connor GT, Brusselle GG, Boezen HM, Schulz H, Deary IJ, Hall IP, Rudan I, Kaprio J, Wilson JF, Wilk JB, Huffman JE, Hua Zhao J, de Jong K, Lyytikäinen LP, Wain LV, Jarvelin MR, Kähönen M, Fornage M, Polasek O, Cassano PA, Barr RG, Rawal R, Harris SE, Gharib SA, Enroth S, Heckbert SR, Lehtimäki T, Gyllensten U, Society Scientific Group U, Jackson VE, Gudnason V, Tang W, Dupuis J, Soler Artigas M, Joshi AD, London SJ, Kraft P. Evidence for large-scale gene-by-smoking interaction effects on pulmonary function. Int J Epidemiol. 2017 Jan 12. pii: dyw318. doi: 10.1093/ije/dyw318. [Epub ahead of print] PMID: 28082375 [PubMed - as supplied by publisher]

New in PubMed from DZL Faculty/ Neu von der DZL-Fakultät in der Woche bis 9. Januar 2017:

Reisner C, Fabbri LM, Kerwin EM, Fogarty C, Spangenthal S, Rabe KF, Ferguson GT, Martinez FJ, Donohue JF, Darken P, St Rose E, Orevillo C, Strom S, Fischer T, Golden M, Dwivedi S. A randomized, seven-day study to assess the efficacy and safety of a glycopyrrolate/formoterol fumarate fixed-dose combination metered dose inhaler using novel Co-Suspension™ Delivery Technology in patients with moderate-to-very severe chronic obstructive pulmonary disease. Respir Res. 2017 Jan 6;18(1):8. doi: 10.1186/s12931-016-0491-8. PubMed PMID: 28061907; PubMed Central PMCID: PMC5216561.

Biasin V, Wygrecka M, Marsh LM, Becker-Pauly C, Brcic L, Ghanim B, Klepetko W, Olschewski A, Kwapiszewska G. Meprin β contributes to collagen deposition in lung fibrosis. Sci Rep. 2017 Jan 6;7: 39969. doi: 10.1038/srep39969. PubMed PMID: 28059112; PubMed Central PMCID: PMC5216360.

Welte T, Vogelmeier CF. Chest pain : Possible sign of a life-threatening condition. Internist (Berl). 2017 Jan;58(1):1-2. doi: 10.1007/s00108-016-0176-x. German. PubMed PMID: 28058457.

Op den Winkel J, Eichhorn F, Rieken S, Dienemann H. Local treatment of solitary intrapulmonary, malignant nodules. Radiologe. 2017 Feb;57(2):97-104. doi: 10.1007/s00117-016-0200-0. German. PubMed PMID: 28054137.

Bahmer T, Waschki B, Schatz F, Herzmann C, Zabel P, Kirsten AM, Rabe KF, Watz H; ERA-Study Group.. Physical activity, airway resistance and small airway dysfunction in severe asthma. Eur Respir J. 2017 Jan 4;49(1). pii: 1601827. doi: 10.1183/13993003.01827-2016. PubMed PMID: 28052957.

Montgomery ST, Mall MA, Kicic A, Stick SM; AREST CF.. Hypoxia and sterile inflammation in cystic fibrosis airways: mechanisms and potential therapies. Eur Respir J. 2017 Jan 4;49(1). pii: 1600903. doi: 10.1183/13993003.00903-2016. Review. PubMed PMID: 28052955.

Bousquet J, … Rabe KF, et al ARIA 2016: Care pathways implementing emerging technologies for predictive medicine in rhinitis and asthma across the life cycle. Clin Transl Allergy. 2016 Dec 30;6:47. doi: 10.1186/s13601-016-0137-4. Review. PubMed PMID: 28050247; PubMed Central PMCID: PMC5203711.

Stelzer D, Weber A, Ihle F, Matthes S, Ceelen F, Zimmermann G, Kneidinger N, Schramm R, Winter H, Zoller M, Vogeser M, Behr J, Neurohr C. Comparing Azole Plasma Trough Levels In Lung Transplant Recipients: Percentage Of Therapeutic Levels And Intra-Patient Variability. Ther Drug Monit. 2016 Dec 29. doi: 10.1097/FTD.0000000000000371. [Epub ahead of print] PubMed PMID: 28045862.

Barben J, Castellani C, Dankert-Roelse J, Gartner S, Kashirskaya N, Linnane B, Mayell S, Munck A, Sands D, Sommerburg O, Pybus S, Winters V, Southern KW. The expansion and performance of national newborn screening programmes for cystic fibrosis in Europe. J Cyst Fibros. 2016 Dec 30. pii: S1569-1993(16)30681-6. doi: 10.1016/j.jcf.2016.12.012. [Epub ahead of print] PubMed PMID: 28043799.

Schneider T, Hoffmann H, Dienemann H, Herpel E, Heussel CP, Enk AH, Ring S, Mahnke K. Immune Response After Radiofrequency Ablation and Surgical Resection in Nonsmall Cell Lung Cancer. Semin Thorac Cardiovasc Surg. 2016 Summer;28(2):585-592. doi: 10.1053/j.semtcvs.2016.02.008. PubMed PMID: 28043482.

Solyanik O, Gaass T, Hellbach K, Dinkel J. Pneumonia in immunosuppressed patients. Radiologe. 2017 Jan;57(1):22-28. doi: 10.1007/s00117-016-0197-4. German. PubMed PMID: 28058476.

Weinrich JM, Diel R, Sauer M, Henes FO, Meywald-Walter K, Adam G, Schön G, Bannas P. Yield of chest X-ray tuberculosis screening of immigrants during the European refugee crisis of 2015: a single-centre experience. Eur Radiol. 2017 Jan 3. doi: 10.1007/s00330-016-4684-9. [Epub ahead of print] PubMed PMID: 28050691.

New in PubMed from DZL Faculty/ Neu von der DZL-Fakultät in der Woche bis 2. Januar 2017:

Coghlan JG, Galiè N, Barberà JA, Frost AE, Ghofrani HA, Hoeper MM, Kuwana M, McLaughlin VV, Peacock AJ, Simonneau G, Vachiéry JL, Blair C, Gillies H, Miller KL, Harris JH, Langley J, Rubin LJ; AMBITION investigators.. Initial combination therapy with ambrisentan and tadalafil in connective tissue disease-associated pulmonary arterial hypertension (CTD-PAH): subgroup analysis from the AMBITION trial. Ann Rheum Dis. 2016 Dec 30. pii: annrheumdis-2016-210236. doi: 10.1136/annrheumdis-2016-210236. [Epub ahead of print] PubMed PMID: 28039187.

Herpel E, Rieker RJ, Dienemann H, Muley T, Meister M, Hartmann A, Warth A, Agaimy A. SMARCA4 and SMARCA2 deficiency in non-small cell lung cancer: immunohistochemical survey of 316 consecutive specimens. Ann Diagn Pathol. 2017 Feb;26:47-51. doi: 10.1016/j.anndiagpath.2016.10.006. PubMed PMID: 28038711.

Rezende F, Schürmann C, Schütz S, Harenkamp S, Herrmann E, Seimetz M, Weißmann N, Schröder K. Knock out of the NADPH oxidase Nox4 has no impact on life span in mice. Redox Biol. 2017 Apr;11:312-314. doi: 10.1016/j.redox.2016.12.012. PubMed PMID: 28038425; PubMed Central PMCID: PMC5196091.

Beers MF, Knudsen L, Tomer Y, Maronn J, Zhao M, Ochs M, Mulugeta S. Aberrant lung remodeling in a mouse model of surfactant dysregulation induced by modulation of the Abca3 gene. Ann Anat. 2017 Mar;210:135-146. doi: 10.1016/j.aanat.2016.11.015. PubMed PMID: 28034695.

Mann P, Witte M, Moser T, Lang C, Runz A, Johnen W, Berger M, Biederer J, Karger CP. 3D dosimetric validation of motion compensation concepts in radiotherapy using an anthropomorphic dynamic lung phantom. Phys Med Biol. 2017 Jan 21;62(2):573-595. doi: 10.1088/1361-6560/aa51b1. PubMed PMID: 28033114.

Michelfelder M, Becker M, Riedlinger A, Siegert E, Drömann D, Yu X, Petersen F, Riemekasten G. Interstitial lung disease increases mortality in systemic sclerosis patients with pulmonary arterial hypertension without affecting hemodynamics and exercise capacity. Clin Rheumatol. 2017 Feb;36(2):381-390. doi: 10.1007/s10067-016-3504-6. PubMed PMID: 28028682.

Bernhardt D, Adeberg S, Bozorgmehr F, Opfermann N, Hoerner-Rieber J, Repka MC, Kappes J, Thomas M, Bischoff H, Herth F, Heußel CP, Debus J, Steins M, Rieken S. Nine-year Experience: Prophylactic Cranial Irradiation in Extensive Disease Small-cell Lung Cancer. Clin Lung Cancer. 2016 Dec 2. pii: S1525-7304(16)30366-7. doi: 10.1016/j.cllc.2016.11.012. [Epub ahead of print] PubMed PMID: 28027850.

Dietrich O, Gaass T, Reiser MF. T1 relaxation time constants, influence of oxygen, and the oxygen transfer function of the human lung at 1.5T-A meta-analysis. Eur J Radiol. 2017 Jan; 86:252-260. doi: 10.1016/j.ejrad.2016.11.027. PubMed PMID: 28027756.

von Laffert M, Schirmacher P, Warth A, Weichert W, Büttner R, Huber RM, Wolf J, Griesinger F, Dietel M, Grohé C. ALK-Testing in non-small cell lung cancer (NSCLC): Immunohistochemistry (IHC) and/or fluorescence in-situ Hybridisation (FISH)?: Statement of the Germany Society for Pathology (DGP) and the Working Group Thoracic Oncology (AIO) of the German Cancer Society e.V. (Stellungnahme der Deutschen Gesellschaft für Pathologie und der AG Thorakale Onkologie der Arbeitsgemeinschaft Onkologie/Deutsche Krebsgesellschaft e.V.). Lung Cancer. 2017 Jan;103:1-5. doi: 10.1016/j.lungcan.2016.11.008. PubMed PMID: 28024689.

Bandorski D, Kurniawan N, Baltes P, Hoeltgen R, Hecker M, Stunder D, Keuchel M. Contraindications for video capsule endoscopy. World J Gastroenterol. 2016 Dec 7;22(45):9898-9908. doi: 10.3748/wjg.v22.i45.9898. Review. PubMed PMID: 28018097; PubMed Central PMCID: PMC5143757.

Chen F, Wang Y, Rafikov R, Haigh S, Zhi WB, Kumar S, Doulias PT, Rafikova O, Pillich H, Chakraborty T, Lucas R, Verin AD, Catravas JD, She JX, Black SM, Fulton DJ. RhoA S-nitrosylation as a regulatory mechanism influencing endothelial barrier function in response to G(+)-bacterial toxins. Biochem Pharmacol. 2017 Mar 1;127:34-45. doi: 10.1016/j.bcp.2016.12.014. PubMed PMID: 28017778.

December 2016

New in PubMed from DZL Faculty/ Neu von der DZL-Fakultät in der Woche bis 25. Dezember 2016:

Kim NH, D'Armini AM, Grimminger F, Grünig E, Hoeper MM, Jansa P, Mayer E, Neurohr C, Simonneau G, Torbicki A, Wang C, Fritsch A, Davie N, Ghofrani HA. Haemodynamic effects of riociguat in inoperable/recurrent chronic thromboembolic pulmonary hypertension. Heart. 2017 Apr;103(8):599-606. doi: 10.1136/heartjnl-2016-309621. Epub 2016 Dec 23. PubMed PMID: 28011757.

Hoeper MM, Lam CS, Vachiery JL, Bauersachs J, Gerges C, Lang IM, Bonderman D, Olsson KM, Gibbs JS, Dorfmuller P, Guazzi M, Galiè N, Manes A, Handoko ML, Vonk-Noordegraaf A, Lankeit M, Konstantinides S, Wachter R, Opitz C, Rosenkranz S. Pulmonary hypertension in heart failure with preserved ejection fraction: a plea for proper phenotyping and further research. Eur Heart J. 2016 Dec 23. pii: ehw597. doi: 10.1093/eurheartj/ehw597. [Epub ahead of print] PubMed PMID: 28011705.

Vogelmeier C, Zhong N, Humphries MJ, Mezzi K, Fogel R, Bader G, Patalano F, Banerji D. Indacaterol/glycopyrronium in symptomatic patients with COPD (GOLD B and GOLD D) versus salmeterol/fluticasone: ILLUMINATE/LANTERN pooled analysis. Int J Chron Obstruct Pulmon Dis. 2016 Dec 14;11:3189-3197. doi: 10.2147/COPD.S116786. eCollection 2016. PubMed PMID: 28008244; PubMed Central PMCID: PMC5167461.

Sun T, Yang L, Kaur H, Pestel J, Looso M, Nolte H, Krasel C, Heil D, Krishnan RK, Santoni MJ, Borg JP, Bünemann M, Offermanns S, Swiercz JM, Worzfeld T. A reverse signaling pathway downstream of Sema4A controls cell migration via Scrib. J Cell Biol. 2017 Jan 2;216(1):199-215. doi: 10.1083/jcb.201602002. Epub 2016 Dec 22. PubMed PMID: 28007914; PubMed Central PMCID: PMC5223600.

Wielpütz MO, Mall MA. MRI accelerating progress in functional assessment of cystic fibrosis lung disease. J Cyst Fibros. 2017 Mar;16(2):165-167. doi: 10.1016/j.jcf.2016.12.010. Epub 2016 Dec 20. PubMed PMID: 28007460.

Wygrecka M, Kosanovic D, Wujak L, Reppe K, Henneke I, Frey H, Didiasova M, Kwapiszewska G, Marsh LM, Baal N, Hackstein H, Zakrzewicz D, Müller-Redetzky HC, de Maat S, Maas C, Nolte MW, Panousis C, Schermuly RT, Seeger W, Witzenrath M, Schaefer L, Markart P. Anti-histone Properties of C1 Esterase Inhibitor Protect Against Lung Injury. Am J Respir Crit Care Med. 2016 Dec 22. doi: 10.1164/rccm.201604-0712OC. [Epub ahead of print] PubMed PMID: 28005404.

Rizvanov AA, Persson J, Şahin F, Bellusci S, Oliveira PJ. Hematopoietic and Mesenchymal Stem Cells in Biomedical and Clinical Applications. Stem Cells Int. 2016;2016:3157365. doi: 10.1155/2016/3157365. Epub 2016 Nov 24. PubMed PMID: 27999598; PubMed Central PMCID: PMC5143730.

Habener A, Behrendt AK, Skuljec J, Jirmo AC, Meyer-Bahlburg A, Hansen G. B cell subsets are modulated during allergic airway inflammation but are not required for the development of respiratory tolerance in a murine model. Eur J Immunol. 2017 Mar;47(3):552-562. doi: 10.1002/eji.201646518. Epub 2017 Jan 17. PubMed PMID: 27995616.

Gompelmann D, Benjamin N, Kontogianni K, Herth F, Heussel CP, Hoffmann H, Eberhardt R. Clinical and radiological outcome following pneumothorax after endoscopic lung volume reduction with valves. Int J Chron Obstruct Pulmon Dis. 2016 Dec 7;11:3093-3099. eCollection 2016. PubMed PMID: 27994448; PubMed Central PMCID: PMC5153254.

Buhl R, Magder S, Bothner U, Tetzlaff K, Voß F, Loaiza L, Vogelmeier CF, McGarvey L. Long-term general and cardiovascular safety of tiotropium/olodaterol in patients with moderate to very severe chronic obstructive pulmonary disease. Respir Med. 2017 Jan;122:58-66. doi: 10.1016/j.rmed.2016.11.011. Epub 2016 Nov 14. PubMed PMID: 27993292.

Chubanov V, Ferioli S, Wisnowsky A, Simmons DG, Leitzinger C, Einer C, Jonas W, Shymkiv Y, Bartsch H, Braun A, Akdogan B, Mittermeier L, Sytik L, Torben F, Jurinovic V, van der Vorst EP, Weber C, Yildirim ÖA, Sotlar K, Schürmann A, Zierler S, Zischka H, Ryazanov AG, Gudermann T. Epithelial magnesium transport by TRPM6 is essential for prenatal development and adult survival. Elife. 2016 Dec 19;5. pii: e20914. doi: 10.7554/eLife.20914. PubMed PMID: 27991852; PubMed Central PMCID: PMC5218537.

Boehm M, Lawrie A, Wilhelm J, Ghofrani HA, Grimminger F, Weissmann N, Seeger W, Schermuly RT, Kojonazarov B. Maintained right ventricular pressure overload induces ventricular-arterial decoupling in mice. Exp Physiol. 2017 Feb 1;102(2):180-189. doi: 10.1113/EP085963. PubMed PMID: 27990701.

Lehmann M, Baarsma HA, Königshoff M. WNT Signaling in Lung Aging and Disease. Ann Am Thorac Soc. 2016 Dec;13(Supplement_5):S411-S416. doi: 10.1513/AnnalsATS.201608-586AW. PubMed PMID: 28005418.

New in PubMed from DZL Faculty/ Neu von der DZL-Fakultät in der Woche bis 18. Dezember 2016:

Elborn JS, Davies J, Mall MA, Flume PA, Plant B. Current strategies for the long-term assessment, monitoring, and management of cystic fibrosis patients treated with CFTR modulator therapy. J Cyst Fibros. 2017 Jan;16(1):163-164. doi: 10.1016/j.jcf.2016.11.009. Epub 2016 Dec 13. PubMed PMID: 27986495.

Kriegsmann M, Longuespée R, Wandernoth P, Mohanu C, Lisenko K, Weichert W, Warth A, Dienemann H, De Pauw E, Katzenberger T, Aust D, Baretton G, Kriegsmann J, Casadonte R. Typing of colon and lung adenocarcinoma by high throughput imaging mass spectrometry. Biochim Biophys Acta. 2016 Dec 8. pii: S1570-9639(16)30257-6. doi: 10.1016/j.bbapap.2016.11.018. [Epub ahead of print] PubMed PMID: 27939606.

Knudsen L, Ruppert C, Ochs M. Tissue remodelling in pulmonary fibrosis. Cell Tissue Res. 2017 Mar;367(3):607-626. doi: 10.1007/s00441-016-2543-2. Epub 2016 Dec 16. Review. PubMed PMID: 27981380.

New in PubMed from DZL Faculty/ Neu von der DZL-Fakultät in der Woche bis 11. Dezember 2016:

Salman J, Ius F, Knoefel AK, Sommer W, Siemeni T, Kuehn C, Tudorache I, Avsar M, Nakagiri T, Preissler G, Hatz R, Greer M, Welte T, Haverich A, Warnecke G. Association of Higher CD4(+) CD25(high) CD127(low) , FoxP3(+) , and IL-2(+) T Cell Frequencies Early After Lung Transplantation With Less Chronic Lung Allograft Dysfunction at Two Years. Am J Transplant. 2016 Dec 8. doi: 10.1111/ajt.14148. [Epub ahead of print] PubMed PMID: 27931084.

Sommer W, Hallensleben M, Ius F, Kühn C, Tudorache I, Avsar M, Salman J, Siemeni T, Greer M, Gottlieb J, Boethig D, Blasczyk R, Haverich A, Warnecke G. Repeated human leukocyte antigen mismatches in lung re-transplantation. Transpl Immunol. 2017 Feb;40:1-7. doi: 10.1016/j.trim.2016.12.001. Epub 2016 Dec 5. PubMed PMID: 27923603.

Zimmer J, Weitnauer M, Boutin S, Küblbeck G, Thiele S, Walker P, Lasitschka F, Lunding L, Orinska Z, Vock C, Arnold B, Wegmann M, Dalpke A. Nuclear Localization of Suppressor of Cytokine Signaling-1 Regulates Local Immunity in the Lung. Front Immunol. 2016 Nov 18;7:514. eCollection 2016. PubMed PMID: 27917175; PubMed Central PMCID: PMC5114302.

Kempf H, Olmer R, Haase A, Franke A, Bolesani E, Schwanke K, Robles-Diaz D, Coffee M, Göhring G, Dräger G, Pötz O, Joos T, Martinez-Hackert E, Haverich A, Buettner FF, Martin U, Zweigerdt R. Bulk cell density and Wnt/TGFbeta signalling regulate mesendodermal patterning of human pluripotent stem cells. Nat Commun. 2016 Dec 9;7:13602. doi: 10.1038/ncomms13602. PubMed PMID: 27934856; PubMed Central PMCID: PMC5155150.

Waschki B, Kirsten AM, Holz O, Meyer T, Lichtinghagen R, Rabe KF, Magnussen H, Welte T, Watz H, Janciauskiene S. Angiopoietin-like protein 4 and cardiovascular function in COPD. BMJ Open Respir Res. 2016 Oct 31;3(1):e000161. eCollection 2016. PubMed PMID: 27933182; PubMed Central PMCID: PMC5133419.

Hofmann K, Fiedler S, Vierkotten S, Weber J, Klee S, Jia J, Zwickenpflug W, Flockerzi V, Storch U, Yildirim AÖ, Gudermann T, Königshoff M, Dietrich A. Classical transient receptor potential 6 (TRPC6) channels support myofibroblast differentiation and development of experimental pulmonary fibrosis. Biochim Biophys Acta. 2017 Feb;1863(2):560-568. doi: 10.1016/j.bbadis.2016.12.002. Epub 2016 Dec 6. PubMed PMID: 27932059.

Murtaza G, Mermer P, Pfeil U, Kummer W. Avertin®, but Not Volatile Anesthetics Addressing the Two-Pore Domain K+ Channel, TASK-1, Slows Down Cilia-Driven Particle Transport in the Mouse Trachea. PLoS One. 2016 Dec 8;11(12):e0167919. doi: 10.1371/journal.pone.0167919. eCollection 2016. PubMed PMID: 27930725; PubMed Central PMCID: PMC5145217.

Behler-Janbeck F, Takano T, Maus R, Stolper J, Jonigk D, Tort Tarrés M, Fuehner T, Prasse A, Welte T, Timmer MS, Stocker BL, Nakanishi Y, Miyamoto T, Yamasaki S, Maus UA. C-type Lectin Mincle Recognizes Glucosyl-diacylglycerol of Streptococcus pneumoniae and Plays a Protective Role in Pneumococcal Pneumonia. PLoS Pathog. 2016 Dec 6;12(12):e1006038. doi: 10.1371/journal.ppat.1006038. eCollection 2016 Dec. PubMed PMID: 27923071; PubMed Central PMCID: PMC5140071.

Yin Y, Hou G, Herth FJ, Wang XB, Wang QY, Kang J. Significant lung volume reduction with endobronchial valves in a patient despite the presence of microcollaterals masked by low-flow Chartis phenotype. Int J Chron Obstruct Pulmon Dis. 2016 Nov 24;11:2913-2917. eCollection 2016. PubMed PMID: 27920518; PubMed Central PMCID: PMC5125985.

Nardiello C, Mižíková I, Morty RE. Looking ahead: where to next for animal models of bronchopulmonary dysplasia? Cell Tissue Res. 2017 Mar;367(3):457-468. doi: 10.1007/s00441-016-2534-3. Epub 2016 Dec 5. Review. PubMed PMID: 27917436; PubMed Central PMCID: PMC5320021.

Rajagopal K, Hoeper MM. State of the Art: Bridging to lung transplantation using artificial organ support technologies. J Heart Lung Transplant. 2016 Dec;35(12):1385-1398. doi: 10.1016/j.healun.2016.10.005. Epub 2016 Oct 17. PubMed PMID: 27916175.

Martinez FJ, Rabe KF, Ferguson GT, Fabbri LM, Rennard S, Feldman GJ, Sethi S, Spangenthal S, Gottschlich GM, Rodriguez-Roisin R, Arora S, Siler TM, Siddiqui S, Darken P, Fischer T, Maes A, Golden M, Orevillo C, Reisner C. Efficacy and Safety of Glycopyrrolate/Formoterol Metered Dose Inhaler Formulated Using Co-Suspension Delivery Technology in Patients With COPD. Chest. 2017 Feb;151(2):340-357. doi: 10.1016/j.chest.2016.11.028. Epub 2016 Dec 1. PubMed PMID: 27916620.

New in PubMed from DZL Faculty/ Neu von der DZL-Fakultät in der Woche bis 04. Dezember 2016:

Genuneit J, von Mutius E. Do farm-grown lungs breathe better? Thorax. 2017 Mar;72(3):202-203. doi: 10.1136/thoraxjnl-2016-209280. Epub 2016 Dec 2. PubMed PMID: 27913768.

Grothausmann R, Knudsen L, Ochs M, Mühlfeld C. Digital 3D reconstructions using histological serial sections of lung tissue including the alveolar capillary network. Am J Physiol Lung Cell Mol Physiol. 2017 Feb 1;312(2):L243-L257. doi: 10.1152/ajplung.00326.2016. Epub 2016 Dec 2. PubMed PMID: 27913424.

Krause T, Röckendorf N, Gaede KI, Ramaker K, Sinnecker H, Frey A. Validation of antibody reagents for mucin analysis in chronic inflammatory airway diseases. MAbs. 2017 Feb/Mar;9(2):333-341. doi: 10.1080/19420862.2016.1264551. Epub 2016 Dec 2. PubMed PMID: 27911216; PubMed Central PMCID: PMC5297535.

Simonneau G, Hoeper MM, McLaughlin V, Rubin L, Galiè N. Future perspectives in pulmonary arterial hypertension. Eur Respir Rev. 2016 Dec;25(142):381-389. doi: 10.1183/16000617.0084-2016. Review. PubMed PMID: 27903660.

Opitz C, Rosenkranz S, Ghofrani HA, Grünig E, Klose H, Olschewski H, Hoeper M. [ESC guidelines 2015 pulmonary hypertension: diagnosis and treatment]. Dtsch Med Wochenschr. 2016 Nov;141(24):1764-1769. Epub 2016 Nov 30. German. PubMed PMID: 27903027.

Vogelmeier CF. [International competitive clinical research]. Dtsch Med Wochenschr. 2016 Nov;141(24):1734. Epub 2016 Nov 30. German. PubMed PMID: 27903021.

Garon EB, Reck M, Paz-Ares L, Ponce S, Jaime JC, Juan O, Nadal E, Lee P, Dalal R, Liu J, He S, Treat J, Nakagawa K. Treatment Rationale and Study Design for the RELAY Study: A Multicenter, Randomized, Double-Blind Study of Erlotinib With Ramucirumab or Placebo in Patients With Epidermal Growth Factor Receptor Mutation-Positive Metastatic Non-Small-Cell Lung Cancer. Clin Lung Cancer. 2017Jan;18(1):96-99. doi: 10.1016/j.cllc.2016.05.023. Epub 2016 Jun 8. PubMed PMID: 27894601.

Zakrzewicz D, Bergmann S, Didiasova M, Giaimo BD, Borggrefe T, Mieth M, Hocke AC, Lochnit G, Schaefer L, Hammerschmidt S, Preissner KT, Wygrecka M. Host-derived extracellular RNA promotes adhesion of Streptococcus pneumoniae to endothelial and epithelial cells. Sci Rep. 2016 Nov 28;6:37758. doi: 10.1038/srep37758. PubMed PMID: 27892961; PubMed Central PMCID: PMC5125276.

Mossina A, Lukas C, Merl-Pham J, Uhl FE, Mutze K, Schamberger A, Staab-Weijnitz C, Jia J, Yildirim AÖ, Königshoff M, Hauck SM, Eickelberg O, Meiners S. Cigarette smoke alters the secretome of lung epithelial cells. Proteomics. 2017 Jan;17(1-2). doi: 10.1002/pmic.201600243. PubMed PMID: 27891773.

November 2016

New in PubMed from DZL Faculty/ Neu von der DZL-Fakultät in der Woche bis 27. November 2016:

Fritzsching B, Hagner M, Dai L, Christochowitz S, Agrawal R, van Bodegom C, Schmidt S, Schatterny J, Hirtz S, Brown R, Goritzka M, Duerr J, Zhou-Suckow Z, Mall MA. Impaired mucus clearance exacerbates allergen-induced type 2 airway inflammation in juvenile mice. J Allergy Clin Immunol. 2016 Nov 16. pii: S0091-6749(16)31296-9. doi: 10.1016/j.jaci.2016.09.045. [Epub ahead of print] PubMed PMID: 27865862.

Koczulla AR, Vogelmeier CF, Garn H, Renz H. New concepts in asthma: clinical phenotypes and pathophysiological mechanisms. Drug Discov Today. 2017 Feb;22(2):388-396. doi: 10.1016/j.drudis.2016.11.008. Epub 2016 Nov 17. Review. PubMed PMID: 27867084.

Jerrentrup L, Canisius S, Wilhelm S, Kesper K, Ploch T, Vogelmeier C, Greulich T, Becker HF. Work of Breathing in Fixed and Pressure Relief Continuous Positive Airway Pressure (C-Flex™): A post hoc Analysis. Respiration. 2017;93(1):23-31. Epub 2016 Nov 22. PubMed PMID: 27871083.

Hwang HJ, Hoffman EA, Lee CH, Goo JM, Levin DL, Kauczor HU, Seo JB. The role of dual-energy computed tomography in the assessment of pulmonary function. Eur J Radiol. 2017 Jan;86:320-334. doi: 10.1016/j.ejrad.2016.11.010. Epub 2016 Nov 8. Review. PubMed PMID: 27865580.

Herzmann C, Sotgiu G, Bellinger O, Diel R, Gerdes S, Goetsch U, Heykes-Uden H, Schaberg T, Lange C; TB or not TB consortium.. Risk for latent and active tuberculosis in Germany. Infection. 2016 Nov 19. [Epub ahead of print] PubMed PMID: 27866367.

New in PubMed from DZL Faculty/ Neu von der DZL-Fakultät in der Woche bis 20. November 2016:

Gompelmann D, Eberhardt R, Schuhmann M, Valipour A, Shah PL, Herth FJ, Kontogianni K. Lung Volume Reduction with Vapor Ablation in the Presence of Incomplete Fissures: 12-Month Results from the STEP-UP Randomized Controlled Study. Respiration. 2016;92(6):397-403. Epub 2016 Nov 12. PubMed PMID: 27838692.

Dhamija S, Doerrie A, Winzen R, Dittrich-Breiholz O, Taghipour A, Kuehne N, Kracht M, Holtmann H. IL-1-induced post-transcriptional mechanisms target overlapping translational silencing and destabilizing elements in IκBζ mRNA. J Biol Chem. 2016 Nov 18;291(47):24801. PubMed PMID: 27864527; PubMed Central PMCID: PMC5114428.

Rezende F, Prior KK, Löwe O, Wittig I, Strecker V, Moll F, Helfinger V, Schnütgen F, Kurrle N, Wempe F, Walter M, Zukunft S, Luck B, Fleming I, Weissmann N, Brandes RP, Schröder K. Cytochrome P450 enzymes but not NADPH oxidases are the source of the NADPH-dependent lucigenin chemiluminescence in membrane assays. Free Radic Biol Med. 2017 Jan;102:57-66. doi: 10.1016/j.freeradbiomed.2016.11.019. Epub 2016 Nov 15. PubMed PMID: 27863990.

Volckmar AL, Endris V, Bozorgmehr F, Lier C, Porcel C, Kirchner M, Leichsenring J, Penzel R, Thomas M, Schirmacher P, Warth A, Stenzinger A. Next-generation sequencing facilitates detection of the classic E13-A20 EML4-ALK fusion in an ALK-FISH/IHC inconclusive biopsy of a stage IV lung cancer patient: a case report. Diagn Pathol. 2016 Nov 18;11(1):133. PubMed PMID: 27863497; PubMed Central PMCID: PMC5116222.

Wuttke S, Zimpel A, Bein T, Braig S, Stoiber K, Vollmar A, Müller D, Haastert-Talini K, Schaeske J, Stiesch M, Zahn G, Mohmeyer A, Behrens P, Eickelberg O, Bölükbas DA, Meiners S. Validating Metal-Organic Framework Nanoparticles for Their Nanosafety in Diverse Biomedical Applications. Adv Healthc Mater. 2017 Jan;6(2). doi: 10.1002/adhm.201600818. Epub 2016 Nov 15. PubMed PMID: 27863166.

Voskrebenzev A, Gutberlet M, Kaireit TF, Wacker F, Vogel-Claussen J. Low-pass imaging of dynamic acquisitions (LIDA) with a group-oriented registration (GOREG) for proton MR imaging of lung ventilation. Magn Reson Med. 2016 Nov 18. doi: 10.1002/mrm.26526. [Epub ahead of print] PubMed PMID: 27859552.

Möller W, Feng S, Domanski U, Franke KJ, Celik G, Bartenstein P, Becker S, Meyer G, Schmid O, Eickelberg O, Tatkov S, Nilius G. Nasal high flow reduces dead space. J Appl Physiol (1985). 2017 Jan 1;122(1):191-197. doi: 10.1152/japplphysiol.00584.2016. Epub 2016 Nov 17. PubMed PMID: 27856714; PubMed Central PMCID: PMC5283847.

Lipps C, Badar M, Butueva M, Dubich T, Singh VV, Rau S, Weber A, Kracht M, Köster M, May T, Schulz TF, Hauser H, Wirth D. Proliferation status defines functional properties of endothelial cells. Cell Mol Life Sci. 2017 Apr;74(7):1319-1333. doi: 10.1007/s00018-016-2417-5. Epub 2016 Nov 16. PubMed PMID: 27853834.

Roengvoraphoj O, Eze C, Niyazi M, Li M, Hildebrandt G, Fietkau R, Belka C, Manapov F. Prognostic role of patient gender in limited-disease small-cell lung cancer treated with chemoradiotherapy. Strahlenther Onkol. 2017 Feb;193(2):150-155. doi: 10.1007/s00066-016-1073-x. Epub 2016 Nov 16. PubMed PMID: 27853828.

Athanazio R, Carvalho-Pinto R, Fernandes FL, Rached S, Rabe K, Cukier A, Stelmach R. Can severe asthmatic patients achieve asthma control? A systematic approach in patients with difficult to control asthma followed in a specialized clinic. BMC Pulm Med. 2016 Nov 16;16(1):153. PubMed PMID: 27852260; PubMed Central PMCID: PMC5112706.

Errea A, Cayet D, Marchetti P, Tang C, Kluza J, Offermanns S, Sirard JC, Rumbo M. Lactate Inhibits the Pro-Inflammatory Response and Metabolic Reprogramming in Murine Macrophages in a GPR81-Independent Manner. PLoS One. 2016 Nov 15;11(11):e0163694. doi: 10.1371/journal.pone.0163694. eCollection 2016. PubMed PMID: 27846210; PubMed Central PMCID: PMC5112849.

Yew MH, Fishman EK, Vogel-Claussen J, Spevak PJ. Assessment of Pentalogy of Cantrell using 3D Multidetector Computed Tomography. Radiol Case Rep. 2016 Oct 4;4(1):273. eCollection 2009. PubMed PMID: 27843529; PubMed Central PMCID: PMC5106532.

New in PubMed from DZL Faculty/ Neu von der DZL-Fakultät in der Woche bis 13. November 2016:

Harbaum L, Renk E, Yousef S, Glatzel A, Lüneburg N, Hennigs JK, Oqueka T, Baumann HJ, Atanackovic D, Grünig E, Böger RH, Bokemeyer C, Klose H. Acute effects of exercise on the inflammatory state in patients with idiopathic pulmonary arterial hypertension. BMC Pulm Med. 2016 Nov 11;16(1):145. PubMed PMID: 27835955; PubMed Central PMCID: PMC5106767.

Brinker TJ, Holzapfel J, Baudson TG, Sies K, Jakob L, Baumert HM, Heckl M, Cirac A, Suhre JL, Mathes V, Fries FN, Spielmann H, Rigotti N, Seeger W, Herth F, Groneberg DA, Raupach T, Gall H, Bauer C, Marek P, Batra A, Harrison CH, Taha L, Owczarek A, Hofmann FJ, Thomas R, Mons U, Kreuter M. Photoaging smartphone app promoting poster campaign to reduce smoking prevalence in secondary schools: the Smokerface Randomized Trial: design and baseline characteristics. BMJ Open. 2016 Nov 7;6(11):e014288. doi: 10.1136/bmjopen-2016-014288. PubMed PMID: 27821601; PubMed Central PMCID: PMC5128772.

Kuehnel M, Maegel L, Vogel-Claussen J, Robertus JL, Jonigk D. Airway emodelling in the transplanted lung. Cell Tissue Res. 2017 Mar;367(3):663-675.doi: 10.1007/s00441-016-2529-0. Epub 2016 Nov 12. Review. PubMed PMID: 27837271.

New in PubMed from DZL Faculty/ Neu von der DZL-Fakultät in der Woche bis 06. November 2016:

Schnerch J, Prasse A, Vlachakis D, Schuchardt KL, Pechkovsky DV, Goldmann T, Gaede KI, Müller-Quernheim J, Zissel G. Functional Toll-Like Receptor 9 Expression and CXCR3 Ligand Release in Pulmonary Sarcoidosis. Am J Respir Cell Mol Biol. 2016 Nov;55(5):749-757. PubMed PMID: 27390897.

Eichstaedt CA, Song J, Benjamin N, Harutyunova S, Fischer C, Grünig E, Hinderhofer K. EIF2AK4 mutation as "second hit" in hereditary pulmonary arterial hypertension. Respir Res. 2016 Nov 4;17(1):141. PubMed PMID: 27809840; PubMed Central PMCID: PMC5095976.

Richter MJ, Tiede SL, Sommer N, Schmidt T, Seeger W, Ghofrani HA, Schermuly R, Gall H. Circulating Angiopoietin-1 Is Not a Biomarker of Disease Severity or Prognosis in Pulmonary Hypertension. PLoS One. 2016 Nov 1;11(11):e0165982. doi: 10.1371/journal.pone.0165982. eCollection 2016. PubMed PMID: 27802345; PubMed Central PMCID: PMC5089726.

Kreuter M, Wijsenbeek MS, Vasakova M, Spagnolo P, Kolb M, Costabel U, Weycker D, Kirchgaessler KU, Maher TM. Unfavourable effects of medically indicated oral anticoagulants on survival in idiopathic pulmonary fibrosis: methodological concerns. Eur Respir J. 2016 Nov;48(5):1524-1526. doi: 10.1183/13993003.01482-2016. PubMed PMID: 27799399.

Valipour A, Slebos DJ, Herth F, Darwiche K, Wagner M, Ficker JH, Petermann C, Hubner RH, Stanzel F, Eberhardt R; IMPACT Study Team.. Endobronchial Valve Therapy in Patients with Homogeneous Emphysema. Results from the IMPACT Study. Am J Respir Crit Care Med. 2016 Nov 1;194(9):1073-1082. PubMed PMID: 27580428.

John AE, Wilson MR, Habgood A, Porte J, Tatler AL, Stavrou A, Miele G, Jolly L, Knox AJ, Takata M, Offermanns S, Jenkins RG. Loss of epithelial Gq and G11 signaling inhibits TGFβ production but promotes IL-33-mediated macrophage polarization and emphysema. Sci Signal. 2016 Oct 25;9(451):ra104. PubMed PMID: 27811142.

Diesner SC, Bergmayr C, Pfitzner B, Assmann V, Krishnamurthy D, Starkl P, Endesfelder D, Rothballer M, Welzl G, Rattei T, Eiwegger T, Szépfalusi Z, Fehrenbach H, Jensen-Jarolim E, Hartmann A, Pali-Schöll I, Untersmayr E. A distinct microbiota composition is associated with protection from food allergy in an oral mouse immunization model. Clin Immunol. 2016 Dec;173:10-18. doi: 10.1016/j.clim.2016.10.009. Epub 2016 Oct 24. PubMed PMID: 27789346.

Mueller-Rompa S, Janke T, Schwaiger K, Mayer M, Bauer J, Genuneit J, Braun-Fahrlaender C, Horak E, Boznanski A, von Mutius E, Ege MJ; GABRIELA study group.. Identification of fungal candidates for asthma protection in a large population-based study. Pediatr Allergy Immunol. 2017 Feb;28(1):72-78. doi: 10.1111/pai.12665. Epub 2016 Nov 3. PubMed PMID: 27711990.

Ramalingam SS, Blais N, Mazieres J, Reck M, Jones CM, Juhasz E, Urban L, Orlov S, Barlesi F, Kio E, Keiholz U, Qin Q, Qian J, Nickner C, Dziubinski J, Xiong H, Ansell P, McKee M, Giranda V, Gorbunova V. Randomized, Placebo-Controlled, Phase II Study of Veliparib in Combination with Carboplatin and Paclitaxel for Advanced/Metastatic Non-Small Cell Lung Cancer. Clin Cancer Res. 2017 Apr 15;23(8):1937-1944. doi: 10.1158/1078-0432.CCR-15-3069. Epub 2016 Oct 10. PubMed PMID: 27803064.

October 2016

New in PubMed from DZL Faculty/ Neu von der DZL-Fakultät in der Woche bis 30. Oktober 2016: 

Lucke T, Herrera R, Wacker M, Holle R, Biertz F, Nowak D, Huber RM, Söhler S, Vogelmeier C, Ficker JH, Mückter H, Jörres RA; COSYCONET-Consortium. Systematic Analysis of Self-Reported Comorbidities in Large Cohort Studies - A Novel Stepwise Approach by Evaluation of Medication. PLoS One. 2016 Oct 28;11(10):e0163408. doi: 10.1371/journal.pone.0163408. eCollection 2016. PubMed PMID: 27792735; PubMed Central PMCID: PMC5085029.

Hillmann D, Spahr H, Pfäffle C, Sudkamp H, Franke G, Hüttmann G. In vivo optical imaging of physiological responses to photostimulation in human photoreceptors. Proc Natl Acad Sci U S A. 2016 Nov 15;113(46):13138-13143. Epub 2016 Oct 11. PubMed PMID: 27729536; PubMed Central PMCID: PMC5135337.

Smits HH, van der Vlugt LE, von Mutius E, Hiemstra PS. Childhood allergies and asthma: New insights on environmental exposures and local immunity at the lung barrier. Curr Opin Immunol. 2016 Oct;42:41-47. doi: 10.1016/j.coi.2016.05.009. Epub 2016 May 30. Review. PubMed PMID: 27254380.

Welte T, Nitschmann S. [Cardiovascular outcome in patients with COPD : Study to Understand Mortality and Morbidity (SUMMIT)]. Internist (Berl). 2016 Nov;57(11):1139-1141. German. PubMed PMID: 27680739.

Cottin V, Bel E, Bottero P, Dalhoff K, Humbert M, Lazor R, Sinico RA, Sivasothy P, Wechsler ME, Groh M, Marchand-Adam S, Khouatra C, Wallaert B, Taillé C, Delaval P, Cadranel J, Bonniaud P, Prévot G, Hirschi S, Gondouin A, Dunogué B, Chatté G, Briault C, Pagnoux C, Jayne D, Guillevin L, Cordier JF; Groupe d’Etudes et de Recherche sur les Maladies Orphelines Pulmonaires (GERM“O”P). Revisiting the systemic vasculitis in eosinophilic granulomatosis with polyangiitis (Churg-Strauss): A study of 157 patients by the Groupe d'Etudes et de Recherche sur les Maladies Orphelines Pulmonaires and the European Respiratory Society Taskforce on eosinophilic granulomatosis with polyangiitis (Churg-Strauss). Autoimmun Rev. 2017 Jan;16(1):1-9. doi: 10.1016/j.autrev.2016.09.018. Epub 2016 Sep 23. PubMed PMID: 27671089.

Siemeni T, Knöfel AK, Madrahimov N, Sommer W, Avsar M, Salman J, Ius F, Frank N, Büchler G, Jonigk D, Jansson K, Maus U, Tudorache I, Falk CS, Haverich A, Warnecke G. In Vivo Development of Transplant Arteriosclerosis in Humanized Mice Reflects Alloantigen Recognition and Peripheral Treg Phenotype of Lung Transplant Recipients. Am J Transplant. 2016 Nov;16(11):3150-3162. doi: 10.1111/ajt.13905. Epub 2016 Jul 29. PubMed PMID: 27273729.

Suhling H, Dettmer S, Greer M, Fuehner T, Avsar M, Haverich A, Welte T, Gottlieb J. Phenotyping Chronic Lung Allograft Dysfunction Using Body Plethysmography and Computed Tomography. Am J Transplant. 2016 Nov;16(11):3163-3170. doi: 10.1111/ajt.13876. Epub 2016 Jun 27. PubMed PMID: 27203799.

Strueber M, Warnecke G, Fuge J, Simon AR, Zhang R, Welte T, Haverich A, Gottlieb J. Everolimus Versus Mycophenolate Mofetil De Novo After Lung Transplantation: A Prospective, Randomized, Open-Label Trial. Am J Transplant. 2016 Nov;16(11):3171-3180. doi: 10.1111/ajt.13835. Epub 2016 Jun 15. PubMed PMID: 27104933.

Aumann I, Rozanski K, Damm K, Graf von der Schulenburg JM. [Cost-Effectiveness of Pharmacological Smoking Cessation Therapies - A Systematic Literature Review]. Gesundheitswesen. 2016 Oct;78(10):660-671. Epub 2015 May 8. German. PubMed PMID: 27784123.

Hinrichs JB, Werncke T, Kaireit T, Hoeper MM, Olsson KM, Kamp JC, Wacker FK, Bengel F, von Falck C, Schatka I, Meyer BC. C-Arm Computed Tomography Adds Diagnostic Information in Patients with Chronic Thromboembolic Pulmonary Hypertension and a Positive V/Q SPECT. Rofo. 2017 Jan;189(1):49-56. doi: 10.1055/s-0042-116232. Epub 2016 Oct 26. PubMed PMID: 27784118.

Grünig E, Benjamin N, Lange TJ, Krueger U, Klose H, Neurohr C, Wilkens H, Halank M, Seyfarth HJ, Held M, Traube A, Pernow M, Grover ER, Egenlauf B, Gerhardt F, Viethen T, Rosenkranz S. Safety, Tolerability and Clinical Effects of a Rapid Dose Titration of Subcutaneous Treprostinil Therapy in Pulmonary Arterial Hypertension: A Prospective Multi-Centre Trial. Respiration. 2016;92(6):362-370. Epub 2016 Oct 27. PubMed PMID: 27784026.

El Agha E, Seeger W, Bellusci S. Therapeutic and pathological roles of fibroblast growth factors in pulmonary diseases. Dev Dyn. 2017 Apr;246(4):235-244. doi: 10.1002/dvdy.24468. Epub 2016 Dec 29. Review. PubMed PMID: 27783451.

Jarosch I, Gehlert S, Jacko D, Koczulla RA, Wencker M, Welte T, Bloch W, Janciauskiene S, Kenn K. Different Training-Induced Skeletal Muscle Adaptations in COPD Patients with and without Alpha-1 Antitrypsin Deficiency. Respiration. 2016;92(5):339-347. Epub 2016 Sep 30. PubMed PMID: 27686000.

Pils MC, Dreckmann K, Jansson K, Glage S, Held N, Sommer W, Länger F, Avsar M, Warnecke G, Bleich A. Mortality Due to Porcine Reproductive and Respiratory Syndrome Virus in Immunocompromised Göttingen Minipigs (Sus scrofa domestica). Comp Med. 2016;66(5):392-398. PubMed PMID: 27780006; PubMed Central PMCID: PMC5073064.

Kowalski ML, Ansotegui I, Aberer W, Al-Ahmad M, Akdis M, Ballmer-Weber BK, Beyer K, Blanca M, Brown S, Bunnag C, Hulett AC, Castells M, Chng HH, De Blay F, Ebisawa M, Fineman S, Golden DB, Haahtela T, Kaliner M, Katelaris C, Lee BW, Makowska J, Muller U, Mullol J, Oppenheimer J, Park HS, Parkerson J, Passalacqua G, Pawankar R, Renz H, Rueff F, Sanchez-Borges M, Sastre J, Scadding G, Sicherer S, Tantilipikorn P, Tracy J, van Kempen V, Bohle B, Canonica GW, Caraballo L, Gomez M, Ito K, Jensen-Jarolim E, Larche M, Melioli G, Poulsen LK, Valenta R, Zuberbier T. Risk and safety requirements for diagnostic and therapeutic procedures in allergology: World Allergy Organization Statement. World Allergy Organ J. 2016 Oct 12;9(1):33. eCollection 2016. Erratum in: World Allergy Organ J. 2017 Jan 11;10 (1):6. PubMed PMID: 27777642; PubMed Central PMCID: PMC5062928.

Pecqueux M, Liebetrau I, Werft W, Dienemann H, Muley T, Pfannschmidt J, Müssle B, Rahbari N, Schölch S, Büchler MW, Weitz J, Reissfelder C, Kahlert C. A Comprehensive MicroRNA Expression Profile of Liver and Lung Metastases of Colorectal Cancer with Their Corresponding Host Tissue and Its Prognostic Impact on Survival. Int J Mol Sci. 2016 Oct 21;17(10). pii: E1755. PubMed PMID: 27775664; PubMed Central PMCID: PMC5085780.

Pusterla O, Bauman G, Wielpütz MO, Nyilas S, Latzin P, Heussel CP, Bieri O. Rapid 3D in vivo 1H human lung respiratory imaging at 1.5 T using ultra-fast balanced steady-state free precession. Magn Reson Med. 2016 Oct 23. doi: 10.1002/mrm.26503. [Epub ahead of print] PubMed PMID: 27774645.

Haghikia A, Röntgen P, Vogel-Claussen J, Schwab J, Westenfeld R, Ehlermann P, Berliner D, Podewski E, Hilfiker-Kleiner D, Bauersachs J. Prognostic implication of right ventricular involvement in peripartum cardiomyopathy: a cardiovascular magnetic resonance study. ESC Heart Fail. 2015 Dec;2(4):139-149. Epub 2015 Sep 30. PubMed PMID: 27774259; PubMed Central PMCID: PMC5054874.

Lefaudeux D, De Meulder B, Loza MJ, Peffer N, Rowe A, Baribaud F, Bansal AT, Lutter R, Sousa AR, Corfield J, Pandis I, Bakke PS, Caruso M, Chanez P, Dahlén SE, Fleming LJ, Fowler SJ, Horvath I, Krug N, Montuschi P, Sanak M, Sandstrom T, Shaw DE, Singer F, Sterk PJ, Roberts G, Adcock IM, Djukanovic R, Auffray C, Chung KF; U-BIOPRED Study Group. U-BIOPRED clinical adult asthma clusters linked to a subset of sputum omics. J Allergy Clin Immunol. 2016 Oct 20. pii: S0091-6749(16)31185-X. doi: 10.1016/j.jaci.2016.08.048. [Epub ahead of print] PubMed PMID: 27773852.

Kubo T, Ohno Y, Seo JB, Yamashiro T, Kalender WA, Lee CH, Lynch DA, Kauczor HU, Hatabu H. Securing safe and informative thoracic CT examinations-Progress of radiation dose reduction techniques. Eur J Radiol. 2017 Jan;86:313-319. doi: 10.1016/j.ejrad.2016.10.012. Epub 2016 Oct 13. Review. PubMed PMID: 27773483.

Hose AJ, Depner M, Illi S, Lau S, Keil T, Wahn U, Fuchs O, Pfefferle PI, Schmaußer-Hechfellner E, Genuneit J, Lauener R, Karvonen AM, Roduit C, Dalphin JC, Riedler J, Pekkanen J, von Mutius E, Ege MJ; MAS.; PASTURE study groups. Latent class analysis reveals clinically relevant atopy phenotypes in 2 birth cohorts. J Allergy Clin Immunol. 2016 Oct 19. pii: S0091-6749(16)31135-6. doi: 10.1016/j.jaci.2016.08.046. [Epub ahead of print] PubMed PMID: 27771325.

Franzke K, Natanov R, Zinne N, Rajab TK, Biancosino C, Zander I, Lodziewski S, Ricklefs M, Kropivnitskaya I, Schmitto JD, Haverich A, Krüger M. Pulmonary metastasectomy - A retrospective comparison of surgical outcomes after laser-assisted and conventional resection. Eur J Surg Oncol. 2016 Sep 29. pii: S0748-7983(16)30887-3. doi: 10.1016/j.ejso.2016.09.001. [Epub ahead of print] PubMed PMID: 27771210.

Morán Losada P, Fischer S, Chouvarine P, Tümmler B. Three-base periodicity of sites of sequence variation in Pseudomonas aeruginosa and Staphylococcus aureus core genomes. FEBS Lett. 2016 Oct;590(20):3538-3543. doi: 10.1002/1873-3468.12431. Epub 2016 Oct 4. PubMed PMID: 27664047.

Bergroth E, Roponen M, Karvonen AM, Keski-Nisula L, Remes S, Riedler J, Roduit C, Dalphin JC, Kaulek V, Loss GJ, Lauener R, Hirvonen MR, Genuneit J, Schmaußer-Hechfellner E, Renz H, Pfefferle PI, Krauss-Etschmann S, Schaub B, von Mutius E, Pekkanen J; PASTURE Study Group. Enhanced T helper 1 and 2 cytokine responses at birth associate with lower risk of middle ear infections in infancy. Pediatr Allergy Immunol. 2017 Feb;28(1):53-59. doi: 10.1111/pai.12658. Epub 2016 Oct 24. PubMed PMID: 27633913.

Rosell R, Neninger E, Nicolson M, Huber RM, Thongprasert S, Parikh PM, D'Hondt E. Pathway Targeted Immunotherapy: Rationale and Evidence of Durable Clinical Responses with a Novel, EGF-directed Agent for Advanced NSCLC. J Thorac Oncol. 2016 Nov;11(11):1954-1961. doi: 10.1016/j.jtho.2016.08.132. Epub 2016 Aug 24. PubMed PMID: 27566188.

Vogl M, Warnecke G, Haverich A, Gottlieb J, Welte T, Hatz R, Hunger M, Leidl R, Lingner H, Behr J, Winter H, Schramm R, Zwissler B, Hagl C, Strobl N, Jaeger C, Preissler G. Lung transplantation in the spotlight: Reasons for high-cost procedures. J Heart Lung Transplant. 2016 Oct;35(10):1227-1236. doi: 10.1016/j.healun.2016.05.024. Epub 2016 Jun 7. PubMed PMID: 27377220.

Taudien S, Lausser L, Giamarellos-Bourboulis EJ, Sponholz C, Schöneweck F, Felder M, Schirra LR, Schmid F, Gogos C, Groth S, Petersen BS, Franke A, Lieb W, Huse K, Zipfel PF, Kurzai O, Moepps B, Gierschik P, Bauer M, Scherag A, Kestler HA, Platzer M. Genetic Factors of the Disease Course After Sepsis: Rare Deleterious Variants Are Predictive. EBioMedicine. 2016 Oct;12:227-238. doi: 10.1016/j.ebiom.2016.08.037. Epub 2016 Sep 15. PubMed PMID: 27639823; PubMed Central PMCID: PMC5078585.

Scheel AH, Dietel M, Heukamp LC, Jöhrens K, Kirchner T, Reu S, Rüschoff J, Schildhaus HU, Schirmacher P, Tiemann M, Warth A, Weichert W, Fischer RN, Wolf J, Büttner R. [Predictive PD-L1 immunohistochemistry for non-small cell lung cancer : Current state of the art and experiences of the first German harmonization study]. Pathologe. 2016 Nov;37(6):557-567. German. PMID: 27510417.

New in PubMed from DZL Faculty/ Neu von der DZL-Fakultät in der Woche bis 24. Oktober 2016:

Chao CM, Yahya F, Moiseenko A, Tiozzo C, Shrestha A, Ahmadvand N, El Agha E, Quantius J, Dilai S, Kheirollahi V, Jones M, Wilhem J, Carraro G, Ehrhardt H, Zimmer KP, Barreto G, Ahlbrecht K, Morty RE, Herold S, Abellar RG, Seeger W, Schermuly R, Zhang JS, Minoo P, Bellusci S. Fgf10 deficiency is causative for lethality in a mouse model of bronchopulmonary dysplasia. J Pathol. 2017 Jan;241(1):91-103. doi: 10.1002/path.4834. PubMed PMID: 27770432; PubMed Central PMCID: PMC5164852.

3: Haverich A. Chirurg. 2016 Nov;87(11):978-979. German. PubMed PMID: 27770140.

Csernus R, Wiebel M, Gődény M, Herth FJ, Kauczor HU, Heußel CP. Hypoxic respiratory failure in chronic lung disease. Med Klin Intensivmed Notfmed. 2016 Oct 20. [Epub ahead of print] German. PubMed PMID: 27766378.

Hillmann D, Spahr H, Hain C, Sudkamp H, Franke G, Pfäffle C, Winter C, Hüttmann G. Aberration-free volumetric high-speed imaging of in vivo retina. Sci Rep. 2016 Oct 20;6:35209. doi: 10.1038/srep35209. PubMed PMID: 27762314; PubMed Central PMCID: PMC5071870.

Hagenbucher J, Stekman H, Rodriguez-Gil A, Kracht M, Schmitz ML. Testing the Effects of SIAH Ubiquitin E3 Ligases on Lysine Acetyl Transferases. Methods Mol Biol. 2017; 1510:297-312. PubMed PMID: 27761830.

Wilkens H, Konstantinides S, Lang I, Bunck AC, Gerges M, Gerhardt F, Grgic A, Grohé C, Guth S, Held M, Hinrichs J, Hoeper MM, Klepetko W, Kramm T, Krüger U, Lankeit M, Meyer BC, Olsson KM, Schäfers HJ, Schmidt M, Seyfarth HJ, Ulrich S, Wiedenroth CB, Mayer E. Chronic thromboembolic pulmonary hypertension: Recommendations of the Cologne Consensus Conference 2016. Dtsch Med Wochenschr. 2016 Oct;141(S 01): S62-S69. German. PubMed PMID: 27760452.

Olschewski H, Behr J, Bremer H, Claussen M, Douschan P, Halank M, Held M, Hoeper MM, Holt S, Klose H, Krüger S, Lange TJ, Reichenberger F, Skowasch D, Ulrich S, Wilkens H, Seeger W. Pulmonary hypertension due to chronic lung disease: Recommendations of the Cologne Consensus Conference 2016. Dtsch Med Wochenschr. 2016 Oct;141(S 01):S57-S61. German. PubMed PMID: 27760451.

Olsson KM, Halank M, Egenlauf B, Fistera D, Gall H, Kaehler C, Kortmann K, Kramm T, Lichtblau M, Marra A, Nagel C, Sablotzki A, Seyfarth HJ, Schranz D, Ulrich S, Hoeper MM, Lange TJ. Decompensated right heart failure, intensive care and perioperative management in patients with pulmonary hypertension. Dtsch Med Wochenschr. 2016 Oct;141(S 01):S42-S47. German. PubMed PMID: 27760449.

Hoeper MM, Apitz C, Grünig E, Halank M, Ewert R, Kaemmerer H, Kabitz HJ, Kähler C, Klose H, Leuchte H, Ulrich S, Olsson KM, Distler O, Rosenkranz S, Ghofrani HA. Targeted therapy of pulmonary arterial hypertension: Recommendations of the Cologne Consensus Conference 2016. Dtsch Med Wochenschr. 2016 Oct;141(S 01): S33-S41. German. PubMed PMID: 27760448.

Grünig E, Benjamin N, Krüger U, Kaemmerer H, Harutyunova S, Olsson KM, Ulrich S, Gerhardt F, Neurohr C, Sablotzki A, Halank M, Kabitz HJ, Thimm G, Fliegel KG, Klose H. General and supportive therapy of pulmonary arterial hypertension. Dtsch Med Wochenschr. 2016 Oct;141(S 01): S26-S32. German. PubMed PMID: 27760447.

Leuchte HH, Ten Freyhaus H, Gall H, Halank M, Hoeper MM, Kaemmerer H, Kähler C, Riemekasten G, Ulrich S, Schwaiblmair M, Ewert R. Risk stratification and follow-up assessment of patients with pulmonary arterial hypertension: Recommendations of the Cologne Consensus Conference 2016. Dtsch Med Wochenschr. 2016 Oct;141(S 01): S19-S25. German. PubMed PMID: 27760446.

Olschewski A, Berghausen EM, Eichstaedt CA, Fleischmann BK, Grünig E, Grünig G, Hansmann G, Harbaum L, Hennigs JK, Jonigk D, Kübler WM, Kwapiszewska G, Pullamsetti SS, Stacher E, Weissmann N, Wenzel D, Schermuly RT. Pathobiology, pathology and genetics of pulmonary hypertension: Recommendations of the Cologne Consensus Conference 2016. Dtsch Med Wochenschr. 2016 Oct;141(S 01):S4-S9. German. PubMed PMID: 27760444.

Chouvarine P, Wiehlmann L, Moran Losada P, DeLuca DS, Tümmler B. Filtration and Normalization of Sequencing Read Data in Whole-Metagenome Shotgun Samples. PLoS One. 2016 Oct 19;11(10):e0165015. doi: 10.1371/journal.pone.0165015. PubMed PMID: 27760173; PubMed Central PMCID: PMC5070866.

Kellner M, Heidrich M, Lorbeer RA, Antonopoulos GC, Knudsen L, Wrede C, Izykowski N, Grothausmann R, Jonigk D, Ochs M, Ripken T, Kühnel MP, Meyer H. A combined method for correlative 3D imaging of biological samples from macro to nano scale. Sci Rep. 2016 Oct 19;6:35606. doi: 10.1038/srep35606. PubMed PMID: 27759114; PubMed Central PMCID: PMC5069670.

Tang C, Offermanns S. FFA2 and FFA3 in Metabolic Regulation. Handb Exp Pharmacol. 2016 Oct 19. [Epub ahead of print] PubMed PMID: 27757760.

Sparla A, Flach-Vorgang S, Villalobos M, Krug K, Kamradt M, Coulibaly K, Szecsenyi J, Thomas M, Gusset-Bährer S, Ose D. Individual difficulties and resources - a qualitative analysis in patients with advanced lung cancer and their relatives. Patient Prefer Adherence. 2016 Oct 3;10:2021-2029. PubMed PMID: 27757022; PubMed Central PMCID: PMC5055045.

Henkel M, Röckendorf N, Frey A. Selective and Efficient Cysteine Conjugation by Maleimides in the Presence of Phosphine Reductants. Bioconjug Chem. 2016 Oct 19;27(10):2260-2265. PubMed PMID: 27631603.

Awah CU, Tamm S, Hedtfeld S, Steinemann D, Tümmler B, Tsiavaliaris G, Stanke F. Mechanism of allele specific assembly and disruption of master regulator transcription factor complexes of NF-KBp50, NF-KBp65 and HIF1a on a non-coding FAS SNP. Biochim Biophys Acta. 2016 Nov;1859(11):1411-1428. doi: 10.1016/j.bbagrm.2016.09.002. PubMed PMID: 27616356.

Prior KK, Leisegang MS, Josipovic I, Löwe O, Shah AM, Weissmann N, Schröder K, Brandes RP. CRISPR/Cas9-mediated knockout of p22phox leads to loss of Nox1 and Nox4, but not Nox5 activity. Redox Biol. 2016 Oct;9:287-295. doi: 10.1016/j.redox.2016.08.013. PubMed PMID: 27614387; PubMed Central PMCID: PMC5021817.

Serpa Neto A, Schmidt M, Azevedo LC, Bein T, Brochard L, Beutel G, Combes A, Costa EL, Hodgson C, Lindskov C, Lubnow M, Lueck C, Michaels AJ, Paiva JA, Park M, Pesenti A, Pham T, Quintel M, Marco Ranieri V, Ried M, Roncon-Albuquerque R Jr, Slutsky AS, Takeda S, Terragni PP, Vejen M, Weber-Carstens S, Welte T, Gama de Abreu M, Pelosi P, Schultz MJ; ReVA Research Network and the PROVE Network Investigators.. Associations between ventilator settings during extracorporeal membrane oxygenation for refractory hypoxemia and outcome in patients with acute respiratory distress syndrome: a pooled individual patient data analysis : Mechanical ventilation during ECMO. Intensive Care Med. 2016 Nov;42(11):1672-1684. PubMed PMID: 27586996.

Schröder PC, Casaca VI, Illi S, Schieck M, Michel S, Böck A, Roduit C, Frei R, Lluis A, Genuneit J, Pfefferle P, Roponen M, Weber J, Braun-Fahrländer C, Riedler J, Lauener R, Vuitton DA, Dalphin JC, Pekkanen J, von Mutius E, Kabesch M, Schaub B; PASTURE Study group.. IL-33 polymorphisms are associated with increased risk of hay fever and reduced regulatory T cells in a birth cohort. Pediatr Allergy Immunol. 2016 Nov;27(7):687-695. doi: 10.1111/pai.12597. PubMed PMID: 27171815.

Heinrich J, Guo F, Trepka MJ. Brief Report: Low-level Mercury Exposure and Risk of Asthma in School-age Children. Epidemiology. 2017 Jan;28(1):116-118. PubMed PMID: 27755278.

Langer CJ, Obasaju C, Bunn P, Bonomi P, Gandara D, Hirsch FR, Kim ES, Natale RB, Novello S, Paz-Ares L, Pérol M, Reck M, Ramalingam SS, Reynolds CH, Socinski MA, Spigel DR, Wakelee H, Mayo C, Thatcher N. Incremental Innovation and Progress in Advanced Squamous Cell Lung Cancer: Current Status and Future Impact of Treatment. J Thorac Oncol. 2016 Dec;11(12):2066-2081. doi: 10.1016/j.jtho.2016.08.138. Review. PubMed PMID: 27575423.

Li M, Riddle S, Zhang H, D'Alessandro A, Flockton A, Serkova NJ, Hansen KC, Moldvan R, McKeon BA, Frid M, Kumar S, Li H, Liu H, Caánovas A, Medrano JF, Thomas MG, Iloska D, Plecitá-Hlavatá L, Ježek P, Pullamsetti S, Fini MA, El Kasmi KC, Zhang Q, Stenmark KR. Metabolic Reprogramming Regulates the Proliferative and Inflammatory Phenotype of Adventitial Fibroblasts in Pulmonary Hypertension Through the Transcriptional Corepressor C-Terminal Binding Protein-1. Circulation. 2016 Oct 11;134(15):1105-1121. PubMed PMID: 27562971; PubMed Central PMCID: PMC5069179.

Leichsenring J, Volckmar AL, Magios N, Morais de Oliveira CM, Penzel R, Brandt R, Kirchner M, Bozorgmehr F, Thomas M, Schirmacher P, Warth A, Endris V, Stenzinger A. Synonymous EGFR variant p.Q787Q is neither prognostic norpredictive in patients with lung adenocarcinoma. Genes Chromosomes Cancer. 2017 Mar;56(3):214-220. doi: 10.1002/gcc.22427. PubMed PMID: 27750395.

Liu X, Baarsma HA, Thiam CH, Montrone C, Brauner B, Fobo G, Heier JS, Duscha S, Königshoff M, Angeli V, Ruepp A, Campillos M. Systematic Identification of Pharmacological Targets from Small-Molecule Phenotypic Screens. Cell Chem Biol. 2016 Oct 20;23(10):1302-1313. doi: 10.1016/j.chembiol.2016.08.011. PubMed PMID: 27667560.

Leichsenring J, Volckmar AL, Magios N, Morais de Oliveira CM, Penzel R, Brandt R, Kirchner M, Bozorgmehr F, Thomas M, Schirmacher P, Warth A, Endris V, Stenzinger A. Synonymous EGFR variant p.Q787Q is neither prognostic nor predictive in patients with lung adenocarcinoma. Genes Chromosomes Cancer. 2017 Mar;56(3):214-220. doi: 10.1002/gcc.22427. PubMed PMID: 27750395.


New in PubMed from DZL Faculty/ Neu von der DZL-Fakultät in der Woche bis 17. Oktober 2016:

Brandenberger C, Mühlfeld C. Mechanisms of lung aging. Cell Tissue Res. 2016 Oct 14. [Epub ahead of print] Review. PubMed PMID: 27743206.

Dau T, Edeleva EV, Seidel SA, Stockley RA, Braun D, Jenne DE. Quantitative analysis of protease recognition by inhibitors in plasma using microscale thermophoresis. Sci Rep. 2016 Oct 14;6:35413. doi: 10.1038/srep35413. PubMed PMID: 27739542; PubMed Central PMCID: PMC5064372.

Stenger B, Popp T, John H, Siegert M, Tsoutsoulopoulos A, Schmidt A, Mückter H, Gudermann T, Thiermann H, Steinritz D. N-Acetyl-L-cysteine inhibits sulfur mustard-induced and TRPA1-dependent calcium influx. Arch Toxicol. 2016 Oct 13. [Epub ahead of print] PubMed PMID: 27738742.

Soultanova A, Mikulski Z, Pfeil U, Grau V, Kummer W. Calcitonin Peptide Family Members Are Differentially Regulated by LPS and Inhibit Functions of Rat Alveolar NR8383 Macrophages. PLoS One. 2016 Oct 13;11(10):e0163483. doi: 10.1371/journal.pone.0163483. PubMed PMID: 27737007; PubMed Central PMCID: PMC5063294.

Schröder PC, Illi S, Casaca VI, Lluis A, Böck A, Roduit C, Depner M, Frei R, Genuneit J, Pfefferle PI, Roponen M, Weber J, Braun-Fahrländer C, Riedler J, Dalphin JC, Pekkanen J, Lauener R, von Mutius E, Schaub B; PASTURE study group. A switch in regulatory T cells through farm exposure during immune maturation in childhood. Allergy. 2016 Oct 12. doi: 10.1111/all.13069. [Epub ahead of print]

PubMed PMID: 27732759.

Ruiz-Camp J, Rodríguez-Castillo JA, Herold S, Mayer K, Vadász I, Tallquist MD, Seeger W, Ahlbrecht K, Morty RE. Tamoxifen dosing for Cre-mediated recombination in experimental bronchopulmonary dysplasia. Transgenic Res. 2016 Oct 11. [Epub ahead of print] PubMed PMID: 27730498.

Annema JT, Vogiatzis I, Grgic A, Antoniou K, Ställberg B, Herth FF. Clinical highlights from Amsterdam. ERJ Open Res. 2016 Jul 13;2(3). pii: 00031-2016. PubMed PMID: 27730202; PubMed Central PMCID: PMC5034595.

Moran Losada P, Chouvarine P, Dorda M, Hedtfeld S, Mielke S, Schulz A, Wiehlmann L, Tümmler B. The cystic fibrosis lower airways microbial metagenome. ERJ Open Res. 2016 May 9;2(2). pii: 00096-2015. PubMed PMID: 27730195; PubMed Central PMCID: PMC5005179.

Peters S, Kronseder A, Karrasch S, Neff PA, Haaks M, Koczulla AR, Reinhold P, Nowak D, Jörres RA. Hydrogen peroxide in exhaled air: a source of error, a paradox and its resolution. ERJ Open Res. 2016 Jun 17;2(2). pii: 00052-2015. PubMed PMID: 27730191; PubMed Central PMCID: PMC5005174.

Aggarwal N, Delgado BM, Salipalli S, Matamala N, Rademacher J, Schwerk N, Welte T, Janciauskiene S, Ringshausen FC. Why do some adults with PiMZ α(1)-antitrypsin develop bronchiectasis? ERJ Open Res. 2016 Jun 6;2(2). pii: 00021-2016. Erratum in: ERJ Open Res. 2016 Jul 11;2(3):. PubMed PMID: 27730187; PubMed Central PMCID: PMC5005170.

Chalmers JD, Aliberti S, Polverino E, Vendrell M, Crichton M, Loebinger M, Dimakou K, Clifton I, van der Eerden M, Rohde G, Murris-Espin M, Masefield S, Gerada E, Shteinberg M, Ringshausen F, Haworth C, Boersma W, Rademacher J, Hill AT, Aksamit T, O'Donnell A, Morgan L, Milenkovic B, Tramma L, Neves J, Menendez R, Paggiaro P, Botnaru V, Skrgat S, Wilson R, Goeminne P, De Soyza A, Welte T, Torres A, Elborn JS, Blasi F. The EMBARC European Bronchiectasis Registry: protocol for an international observational study. ERJ Open Res. 2016 Jan 20;2(1). pii: 00081-2015. PubMed PMID: 27730179; PubMed Central PMCID: PMC5005162.

Manegold C, Dingemans AC, Gray JE, Nakagawa K, Nicolson M, Peters S, Reck M, Wu YL, Brustugun OT, Crino L, Felip E, Fennell D, Garrido P, Huber RM, Marabelle  A, Moniuszko M, Mornex F, Novello S, Papotti M, Pérol M, Smit EF, Syrigos K, van Meerbeeck JP, van Zandwijk N, Chih-Hsin Yang J, Zhou C, Vokes E. The potential of combined immunotherapy and antiangiogenesis for the synergistic treatment of advanced NSCLC. J Thorac Oncol. 2016 Oct 8. pii: S1556-0864(16)31142-X. doi: 10.1016/j.jtho.2016.10.003. [Epub ahead of print] Review. PubMed PMID: 27729297.

Lorenz J, Bals R, Ewert R, Jany B, Koczulla AR, Köhnlein T, Randerath WJ, Steinkamp G, Watz H, Welte T. Expert Meeting on COPD: Personalized Treatment of COPD - Wishful Thinking or Reality?. Pneumologie. 2016 Oct;70(10):638-650. German. PubMed PMID: 27723914. 27723537.

Reck M, Rodríguez-Abreu D, Robinson AG, Hui R, Csőszi T, Fülöp A, Gottfried M, Peled N, Tafreshi A, Cuffe S, O'Brien M, Rao S, Hotta K, Leiby MA, Lubiniecki GM, Shentu Y, Rangwala R, Brahmer JR; KEYNOTE-024 Investigators.. Pembrolizumab versus Chemotherapy for PD-L1-Positive Non-Small-Cell Lung Cancer. N Engl J Med. 2016 Nov 10;375(19):1823-1833. PubMed PMID: 27718847.


New in PubMed from DZL Faculty/ Neu von der DZL-Fakultät in der Woche bis 10. Oktober 2016:

 Ota C, Baarsma HA, Wagner DE, Hilgendorff A, Königshoff M. Linking bronchopulmonary dysplasia to adult chronic lung diseases: role of WNT signaling. Mol Cell Pediatr. 2016 Dec;3(1):34. Review. PubMed PMID: 27718180; PubMed Central PMCID: PMC5055515.

 Yuan H, Liu H, Liu Z, Owzar K, Han Y, Su L, Wei Y, Hung RJ, McLaughlin J, Brhane Y, Brennan P, Bickeboeller H, Rosenberger A, Houlston RS, Caporaso N, Landi MT, Heinrich J, Risch A, Christiani DC, Gümüş ZH, Klein RJ, Amos CI, Wei Q. A Novel Genetic Variant in Long Non-coding RNA Gene NEXN-AS1 is Associated with Risk of Lung Cancer. Sci Rep. 2016 Oct 7;6:34234. doi: 10.1038/srep34234. PubMed PMID: 27713484; PubMed Central PMCID: PMC5054367.

 Schneider MA, Muley T, Kahn NC, Warth A, Thomas M, Herth FJ, Dienemann H, Meister M. Glycodelin is a potential novel follow-up biomarker for malignant pleural mesothelioma. Oncotarget. 2016 Oct 4. doi: 10.18632/oncotarget.12474. [Epub ahead of print] PubMed PMID: 27713145.

 Hoogendoorn M, Feenstra TL, Asukai Y, Briggs AH, Borg S, Dal Negro RW, Hansen RN, Jansson SA, Leidl R, Risebrough N, Samyshkin Y, Wacker ME, Rutten-van Mölken MP. Patient Heterogeneity in Health Economic Decision Models for Chronic Obstructive Pulmonary Disease: Are Current Models Suitable to Evaluate Personalized Medicine? Value Health. 2016 Sep - Oct;19(6):800-810. doi: 10.1016/j.jval.2016.04.002. PubMed PMID: 27712708.

 Ucar O, Li K, Dvornikov D, Kreutz C, Timmer J, Matt S, Brenner L, Smedley C, Travis MA, Hofmann TG, Klingmüller U, Kyewski B. A Thymic Epithelial Stem Cell Pool Persists throughout Ontogeny and Is Modulated by TGF-β. Cell Rep. 2016 Oct 4;17(2):448-457. doi: 10.1016/j.celrep.2016.09.027. PubMed PMID: 27705793; PubMed Central PMCID: PMC5067280.

 Losada PM, Tümmler B. SNP synteny analysis of Staphylococcus aureus and Pseudomonas aeruginosa population genomics. FEMS Microbiol Lett. 2016 Oct 3. pii: fnw229. [Epub ahead of print] PubMed PMID: 27702754.

 Welte T. Community-Acquired Pneumonia-an Underestimated Challenge. Dtsch Arztebl Int. 2016 Sep 16;113(37):605-606. doi: 10.3238/arztebl.2016.0607. PubMed PMID: 27697143.

 Shah PL, Herth FJ, van Geffen WH, Deslee G, Slebos DJ. Lung volume reduction for emphysema. Lancet Respir Med. 2016 Sep 29. pii: S2213-2600(16)30221-1. doi: 10.1016/S2213-2600(16)30221-1. [Epub ahead of print] Review. PubMed PMID: 27693408.

 Kreuter M, Bonella F, Maher TM, Costabel U, Spagnolo P, Weycker D, Kirchgaessler KU, Kolb M. Effect of statins on disease-related outcomes in patients with idiopathic pulmonary fibrosis. Thorax. 2016 Oct 5. pii: thoraxjnl-2016-208819. doi: 10.1136/thoraxjnl-2016-208819. [Epub ahead of print] PubMed PMID: 27708114.

 6: Federico G, Meister M, Mathow D, Heine GH, Moldenhauer G, Popovic ZV, Nordström V, Kopp-Schneider A, Hielscher T, Nelson PJ, Schaefer F, Porubsky S, Fliser D, Arnold B, Gröne HJ. Tubular Dickkopf-3 promotes the development of renal atrophy and fibrosis. JCI Insight. 2016 Jan 21;1(1):e84916. PubMed PMID: 27699213; PubMed Central PMCID: PMC5033928.


New in PubMed from DZL Faculty/ Neu von der DZL-Fakultät in der Woche bis 3. Oktober 2016:

Ochs M, Knudsen L, Hegermann J, Wrede C, Grothausmann R, Mühlfeld C. Using electron microscopes to look into the lung. Histochem Cell Biol. 2016 Dec;146(6):695-707. Review. PubMed PMID: 27688057.

Veith C, Kraut S, Wilhelm J, Sommer N, Quanz K, Seeger W, Brandes RP, Weissmann N, Schröder K. NADPH oxidase 4 is not involved in hypoxia-induced pulmonary hypertension. Pulm Circ. 2016 Sep;6(3):397-400. doi: 10.1086/687756. PubMed PMID: 27683617; PubMed Central PMCID: PMC5019094.

 Andrade-Sousa AS, Rogério Pereira P, MacKenzie B, Oliveira-Junior MC, Assumpção-Neto E, Brandão-Rangel MA, Damaceno-Rodrigues NR, Garcia Caldini E, Velosa AP, Teodoro WR, Ligeiro de Oliveira AP, Dolhnikoff M, Eickelberg O, Vieira RP. Aerobic Exercise Attenuated Bleomycin-Induced Lung Fibrosis in Th2-Dominant Mice. PLoS One. 2016 Sep 27;11(9):e0163420. doi: 10.1371/journal.pone.0163420. PubMed PMID: 27677175; PubMed Central PMCID: PMC5038953.

 Gralla RJ, Spigel D, Bennett B, Taylor F, Penrod JR, Derosa M, Dastani H, Orsini L, Mathias C, Reck M. P2.46 (also presented as PD1.01): LCSS as a Marker of Treatment Benefit With Nivolumab vs Docetaxel in Pts With Advanced Non-Squamous NSCLC From Checkmate 057: Track: Immunotherapy. J Thorac Oncol. 2016 Oct;11(10S):S247. doi: 10.1016/j.jtho.2016.08.117. PubMed PMID: 27676580.

 Borghaei H, Brahmer J, Horn L, Ready N, Steins M, Felip E, Paz-Ares L, Xx X, Barlesi F, Antonia S, Fayette J, Rizvi N, Crino L, Reck M, Erich Eberhardt WE, Hellmann M, Desai K, Li A, Healey D, Spigel D, Mathias C. P2.35: Nivolumab vs Docetaxel in Advanced NSCLC: CheckMate 017/057 2-Y Update and Exploratory Cytokine Profile Analysis: Track: Immunotherapy. J Thorac Oncol. 2016 Oct;11(10S):S237-S238. doi: 10.1016/j.jtho.2016.08.106. PubMed PMID: 27676569.

 Gralla RJ, Spigel D, Bennett B, Taylor F, Penrod JR, Derosa M, Dastani H, Orsini L, Mathias C, Reck M. PD1.01 (also presented as P2.46): LCSS as a Marker of Treatment Benefit With Nivolumab vs Docetaxel in Pts With Advanced Non-Squamous NSCLC From Checkmate 057. J Thorac Oncol. 2016 Oct;11(10S):S171. doi: 10.1016/j.jtho.2016.08.009. PubMed PMID: 27676476.

Campbell B, Raherison C, Lodge CJ, Lowe AJ, Gislason T, Heinrich J, Sunyer J, Gómez Real F, Norbäck D, Matheson MC, Wjst M, Dratva J, de Marco R, Jarvis D, Schlünssen V, Janson C, Leynaert B, Svanes C, Dharmage SC. The effects of growing up on a farm on adult lung function and allergic phenotypes: an international population-based study. Thorax. 2016 Sep 26. pii: thoraxjnl-2015-208154. doi: 10.1136/thoraxjnl-2015-208154. [Epub ahead of print] PubMed PMID: 27672121.

 Kolb M, Richeldi L, Behr J, Maher TM, Tang W, Stowasser S, Hallmann C, du Bois RM. Nintedanib in patients with idiopathic pulmonary fibrosis and preserved lung volume. Thorax. 2016 Sep 26. pii: thoraxjnl-2016-208710. doi: 10.1136/thoraxjnl-2016-208710. [Epub ahead of print] PubMed PMID: 27672117.

 Rawool DB, Doijad SP, Poharkar KV, Negi M, Kale SB, Malik SV, Kurkure NV, Chakraborty T, Barbuddhe SB. A multiplex PCR for detection of Listeria monocytogenes and its lineages. J Microbiol Methods. 2016 Nov;130:144-147. doi: 10.1016/j.mimet.2016.09.015. PubMed PMID: 27671346.

 Richter MJ, Ewert R, Warnke C, Gall H, Classen S, Grimminger F, Mayer E, Seeger W, Ghofrani HA. Procedural safety of a fully implantable intravenous prostanoid pump for pulmonary hypertension. Clin Res Cardiol. 2016 Sep 26. [Epub ahead of print] PubMed PMID: 27670656.

 Davieds B, Gross J, Berger MM, Baloğlu E, Bärtsch P, Mairbäurl H. Inhibition of alveolar Na transport and LPS causes hypoxemia and pulmonary arterialvasoconstriction in ventilated rats. Physiol Rep. 2016 Sep;4(18). pii: e12985. PubMed PMID: 27670411; PubMed Central PMCID: PMC5037927.

 Kepert I, Fonseca J, Müller C, Milger K, Hochwind K, Kostric M, Fedoseeva M, Ohnmacht C, Dehmel S, Nathan P, Bartel S, Eickelberg O, Schloter M, Hartmann A, Schmitt-Kopplin P, Krauss-Etschmann S. D-tryptophan from probiotic bacteria influences the gut microbiome and allergic airway disease. J Allergy Clin Immunol. 2016 Sep 23. pii: S0091-6749(16)31020-X. doi: 10.1016/j.jaci.2016.09.003. [Epub ahead of print] PubMed PMID: 27670239.

 Fuchs O, Bahmer T, Rabe KF, von Mutius E. Asthma transition from childhood into adulthood. Lancet Respir Med. 2016 Sep 22. pii: S2213-2600(16)30187-4. doi: 10.1016/S2213-2600(16)30187-4. [Epub ahead of print] Review. PubMed PMID: 27666650.

 Biederer J, Ohno Y, Hatabu H, Schiebler ML, van Beek EJ, Vogel-Claussen J, Kauczor HU. Screening for lung cancer: Does MRI have a role? Eur J Radiol. 2016 Sep 16. pii: S0720-048X(16)30285-6. doi: 10.1016/j.ejrad.2016.09.016. [Epub ahead of print] Review. PubMed PMID: 27665148.

 Wang Z, Monteiro CD, Jagodnik KM, Fernandez NF, Gundersen GW, Rouillard AD, Jenkins SL, Feldmann AS, Hu KS, McDermott MG, Duan Q, Clark NR, Jones MR, Kou Y, Goff T, Woodland H, Amaral FM, Szeto GL, Fuchs O, Schüssler-Fiorenza Rose SM, Sharma S, Schwartz U, Bausela XB, Szymkiewicz M, Maroulis V, Salykin A, Barra CM, Kruth CD, Bongio NJ, Mathur V, Todoric RD, Rubin UE, Malatras A, Fulp CT, Galindo JA, Motiejunaite R, Jüschke C, Dishuck PC, Lahl K, Jafari M, Aibar S, Zaravinos A, Steenhuizen LH, Allison LR, Gamallo P, de Andres Segura F, Dae Devlin T, Pérez-García V, Ma'ayan A. Extraction and analysis of signatures from the Gene Expression Omnibus by the crowd. Nat Commun. 2016 Sep 26;7:12846. doi: 10.1038/ncomms12846. PubMed PMID: 27667448; PubMed Central PMCID: PMC5052684.

September 2016

New in PubMed from DZL Faculty/ Neu von der DZL-Fakultät in der Woche bis 26. September 2016:

Novello S, Barlesi F, Califano R, Cufer T, Ekman S, Levra MG, Kerr K, Popat S, Reck M, Senan S, Simo GV, Vansteenkiste J, Peters S; ESMO Guidelines Committee. Metastatic non-small-cell lung cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol. 2016 Sep;27(suppl 5):v1-v27. PubMed PMID: 27664245.

 Tunaru S, Chennupati R, Nüsing RM, Offermanns S. PLoS One. 2016 Sep 23;11(9):e0163633. doi: 10.1371/journal.pone.0163633. PubMed PMID: 27662627; PubMed Central PMCID: PMC5035018.

 Mall MA, Stahl M, Graeber SY, Sommerburg O, Kauczor HU, Wielpütz MO. Early detection and sensitive monitoring of CF lung disease: Prospects of improved and safer imaging. Pediatr Pulmonol. 2016 Oct;51(S44):S49-S60. doi: 10.1002/ppul.23537. Review. PubMed PMID: 27662104.

 Giesel F, Schneider F, Kratochwil C, Rath D, Holland-Letz T, Moltz J, Kauczor HU, Schwartz L, Haberkorn U, Flechsig P. CT radiomic analysis using lymph-node-density profile in correlation to SUV-value for PET/CT based N-Staging. J Nucl Med. 2016 Sep 22. pii: jnumed.116.179648. [Epub ahead of print] PubMed PMID: 27660141.

 Vogel MN, Kreuter M, Kauczor HU, Heußel CP. Pulmonary manifestations in collagen vascular diseases. Radiologe. 2016 Oct;56(10):910-916. German. PubMed PMID: 27659711.

 Su C, Meyer M, Pirker R, Voigt W, Shi J, Pilz L, Huber RM, Wu Y, Wang J, He Y, Wang X, Zhang J, Zhi X, Shi M, Zhu B, Schoenberg SS, Henzler T, Manegold C, Zhou C, Roessner ED. From diagnosis to therapy in lung cancer: management of CT detected pulmonary nodules, a summary of the 2015 Chinese-German Lung Cancer Expert Panel. Transl Lung Cancer Res. 2016 Aug;5(4):377-88. doi: 10.21037/tlcr.2016.07.09. Review. PubMed PMID: 27652202; PubMed Central PMCID: PMC5009083.

 Roller FC, Wiedenroth C, Breithecker A, Liebetrau C, Mayer E, Schneider C, Rolf A, Hamm C, Krombach GA. Native T1 mapping and extracellular volume fraction measurement for assessment of right ventricular insertion point and septal fibrosis in chronic thromboembolic pulmonary hypertension. Eur Radiol. 2016 Sep 20. [Epub ahead of print] PubMed PMID: 27651142.

 Bonnet S, Provencher S, Guignabert C, Perros F, Boucherat O, Schermuly RT, Hassoun PM, Rabinovitch M, Nicolls MR, Humbert M. Translating Research into Improved Patient Care in Pulmonary Arterial Hypertension. Am J Respir Crit Care Med. 2016 Sep 20. [Epub ahead of print] PubMed PMID: 27649290.

 Kolditz M, Scherag A, Rohde G, Ewig S, Welte T, Pletz M; CAPNETZ Study Group.. Comparison of the qSOFA and CRB-65 for risk prediction in patients with community-acquired pneumonia. Intensive Care Med. 2016 Dec;42(12):2108-2110. PubMed PMID: 27647332.

 Lucas R, Yue Q, Alli A, Duke BJ, Al-Khalili O, Thai TL, Hamacher J, Sridhar S, Lebedyeva I, Su H, Tzotzos S, Fischer B, Gameiro AF, Loose M, Chakraborty T, Shabbir W, Aufy M, Lemmens-Gruber R, Eaton DC, Czikora I. J Biol Chem. 2016 Nov 4;291(45):23440-23451. PubMed PMID: 27645999; PubMed Central PMCID: PMC5095400.

 Tomasovic A, Kurrle N, Wempe F, De-Zolt S, Scheibe S, Koli K, Serchinger M, Schnütgen F, Sürün D, Sterner-Kock A, Weissmann N, von Melchner H. Ltbp4 regulates Pdgfrβ expression via TGFβ-dependent modulation of Nrf2 transcription factor function. Matrix Biol. 2016 Sep 17. pii: S0945-053X(16)30173-1. doi: 10.1016/j.matbio.2016.09.006. [Epub ahead of print] PubMed PMID: 27645114.

 Riediger AL, Dietz S, Schirmer U, Meister M, Heinzmann-Groth I, Schneider M, Muley T, Thomas M, Sültmann H. Mutation analysis of circulating plasma DNA to determine response to EGFR tyrosine kinase inhibitor therapy of lung adenocarcinoma patients. Sci Rep. 2016 Sep 19;6:33505. doi: 10.1038/srep33505. PubMed PMID: 27640882; PubMed Central PMCID: PMC5027592.

 Mall MA, Stahl M, Graeber SY, Sommerburg O, Kauczor HU, Wielpütz MO. Early detection and sensitive monitoring of CF lung disease: Prospects of improved and safer imaging. Pediatr Pulmonol. 2016 Oct;51(S44):S49-S60. doi: 10.1002/ppul.23537. Review. PubMed PMID: 27662104.

 Kreuter M, Birring SS, Wijsenbeek M, Wapenaar M, Oltmanns U, Costabel U, Bonella F. German Validation of the "King's Brief Interstitial Lung Disease (K-Bild) Health Status Questionnaire". Pneumologie. 2016 Nov;70(11):742-746. German. PubMed PMID: 27652583.

 Riediger AL, Dietz S, Schirmer U, Meister M, Heinzmann-Groth I, Schneider M, Muley T, Thomas M, Sültmann H. Mutation analysis of circulating plasma DNA to determine response to EGFR tyrosine kinase inhibitor therapy of lung adenocarcinoma patients. Sci Rep. 2016 Sep 19;6:33505. doi: 10.1038/srep33505. PubMed PMID: 27640882; PubMed Central PMCID: PMC5027592. 

New in PubMed from DZL Faculty/ Neu von der DZL-Fakultät in der Woche bis 19. September 2016:

Piel S, Kreuter M, Herth F, Kauczor HU, Heußel CP. [Pulmonary granulomatousdiseases and pulmonary manifestations of systemic granulomatous disease:Including tuberculosis and nontuberculous mycobacteriosis]. Radiologe. 2016 Sep15. [Epub ahead of print] German. PubMed PMID: 27638826.

 Warth A, Länger F. [Report of the working group Thoracic Pathology of theGerman Pathological Society 2016]. Pathologe. 2016 Sep 14. [Epub ahead of print] German. PubMed PMID: 27638525.

 Andrukhov O, Huber R, Shi B, Berner S, Rausch-Fan X, Moritz A, Spencer ND,Schedle A. Proliferation, behavior, and differentiation of osteoblasts onsurfaces of different microroughness. Dent Mater. 2016 Sep 13. pii:S0109-5641(16)30363-3. doi: 10.1016/j.dental.2016.08.217. [Epub ahead of print]PubMed PMID: 27637551.

Deák Z, Maertz F, Meurer F, Notohamiprodjo S, Mueck F, Geyer LL, Reiser MF,Wirth S. Submillisievert Computed Tomography of the Chest Using Model-BasedIterative Algorithm: Optimization of Tube Voltage With Regard to Patient Size. J Comput Assist Tomogr. 2016 Sep 16. [Epub ahead of print] PubMed PMID: 27636247.

Baglietto L, Ponzi E, Haycock P, Hodge A, Bianca Assumma M, Jung CH, Chung J, Fasanelli F, Guida F, Campanella G, Chadeau-Hyam M, Grankvist K, Johansson M, Ala U, Provero P, Ming Wong E, Joo J, English DR, Kazmi N, Lund E, Faltus C, Kaaks R, Risch A, Barrdahl M, Sandanger TM, Southey MC, Giles GG, Johansson M, Vineis P, Polidoro S, Relton CL, Severi G. DNA methylation changes measured in pre-diagnostic peripheral blood samples are associated with smoking and lung cancer risk. Int J Cancer. 2016 Sep 15. doi: 10.1002/ijc.30431. [Epub ahead of print] PubMed PMID: 27632354.

Henkel M, Röckendorf N, Frey A. Selective and Efficient Cysteine Conjugation by Maleimides in the Presence of Phosphine Reductants. Bioconjug Chem. 2016 Sep 22. [Epub ahead of print] PubMed PMID: 27631603.

Bolbat A, . Recent developments of genetically encoded optical sensors for cell biology. Biol Cell. 2016 Sep 15. doi: 10.1111/boc.201600040. [Epub ahead of print] Review. PubMed PMID: 27628952.

Rickert-Zacharias V, Schultz C, Mall MA. A Protease Inhibitor Tackles Epithelial Sodium Channels in Cystic Fibrosis. Am J Respir Crit Care Med. 2016 Sep 15;194(6):650-2. doi: 10.1164/rccm.201604-0781ED. PubMed PMID: 27628073.

Pullamsetti SS, Savai R, Seeger W, Goncharova EA. From Cancer Biology to New PAH Therapeutics: Targeting Cell Growth and Proliferation Signaling Hubs. Am J Respir Crit Care Med. 2016 Sep 14. [Epub ahead of print] PubMed PMID: 27627135.

Rengier F, Wörz S, Melzig C, Ley S, Fink C, Benjamin N, Partovi S, von Tengg-Kobligk H, Rohr K, Kauczor HU, Grünig E. Automated 3D Volumetry of the Pulmonary Arteries based on Magnetic Resonance Angiography Has Potential for Predicting Pulmonary Hypertension. PLoS One. 2016 Sep 14;11(9):e0162516. doi: 10.1371/journal.pone.0162516. eCollection 2016. PubMed PMID: 27626802.

Morty RE. The pluralization of septum. Am J Physiol Lung Cell Mol Physiol. 2016 Sep 1;311(3):L686. doi: 10.1152/ajplung.00359.2016. PubMed PMID: 27624409.

Zahedi F, Nazari-Jahantigh M, Zhou Z, Subramanian P, Wei Y, Grommes J, Gharaibeh M, Hagedorn M, Lilla S, Hauptmann M, Heine H, Fleischer B, Keller C. Toll-Like Receptor 2 recognizes Orientia tsutsugamushi and increases susceptibility to murine experimental scrub typhus. Infect Immun. 2016 Sep 12. pii: IAI.00185-16. [Epub ahead of print] PubMed PMID: 27620720.

Awah CU, Tamm S, Hedtfeld S, Steinemann D, Tümmler B, Tsiavaliaris G, Stanke F. Mechanism of allele specific assembly and disruption of master regulator transcription factor complexes of NF-KBp50, NF-KBp65 and HIF1a on a non-coding FAS SNP. Biochim Biophys Acta. 2016 Sep 9;1859(11):1411-1428. doi: 10.1016/j.bbagrm.2016.09.002. [Epub ahead of print] PubMed PMID: 27616356.

Reck M, Thomas M, Kropf-Sanchen C, Mezger J, Socinski MA, Depenbrock H, Soldatenkova V, Brown J, Krause T, Thatcher N. Necitumumab plus Gemcitabine and Cisplatin as First-Line Therapy in Patients with Stage IV EGFR- Expressing Squamous Non-Small-Cell Lung Cancer: German Subgroup Data from an Open-Label, Randomized Controlled Phase 3 Study (SQUIRE). Oncol Res Treat. 2016;39(9):539-47. doi: 10.1159/000448085. Epub 2016 Aug 2. PubMed PMID: 27614872.

Prior KK, Leisegang MS, Josipovic I, Löwe O, Shah AM, Weissmann N, Schröder K, Brandes RP. CRISPR/Cas9-mediated knockout of p22phox leads to loss of Nox1 and Nox4, but not Nox5 activity. Redox Biol. 2016 Aug 24;9:287-295. doi: 10.1016/j.redox.2016.08.013. [Epub ahead of print] PubMed PMID: 27614387; PubMed Central PMCID: PMC5021817.

Rengier F, Wörz S, Melzig C, Ley S, Fink C, Benjamin N, Partovi S, von Tengg-Kobligk H, Rohr K, Kauczor HU, Grünig E. Automated 3D Volumetry of the Pulmonary Arteries based on Magnetic Resonance Angiography Has Potential for Predicting Pulmonary Hypertension. PLoS One. 2016 Sep 14;11(9):e0162516. doi: 10.1371/journal.pone.0162516. eCollection 2016. PubMed PMID: 27626802.


New in PubMed from DZL Faculty/ Neu von der DZL-Fakultät in der Woche bis 12. September 2016:

Kirby M, van Beek EJ, Seo JB, Biederer J, Nakano Y, Coxson HO, Parraga G. Management of COPD: Is there a role for quantitative imaging? Eur J Radiol. 2016 Aug 28. pii: S0720-048X(16)30260-1. doi: 10.1016/j.ejrad.2016.08.022. [Epub ahead of print] PubMed PMID: 27592252.

Ardizzoni A, Tiseo M, Boni L, Di Maio M, Buffoni L, Belvedere O, Grossi F, D'Alessandro V, de Marinis F, Barbera S, Caroti C, Favaretto A, Cortinovis D, Morrica B, Tixi L, Ceschia T, Parisi S, Ricardi U, Grimaldi A, Loreggian L, Navarria P, Huber RM, Belani C, Bruswig PF, Scagliotti GV, Scolaro T. Randomized phase III PITCAP trial and meta-analysis of induction chemotherapy followed by thoracic irradiation with or without concurrent taxane-based chemotherapy in locally advanced NSCLC. Lung Cancer. 2016 Oct;100:30-7. doi: 10.1016/j.lungcan.2016.07.026. Epub 2016 Jul 27. PubMed PMID: 27597278.

Khankari NK, Shu XO, Wen W, Kraft P, Lindström S, Peters U, Schildkraut J, Schumacher F, Bofetta P, Risch A, Bickeböller H, Amos CI, Easton D, Eeles RA, Gruber SB, Haiman CA, Hunter DJ, Chanock SJ, Pierce BL, Zheng W; Colorectal Transdisciplinary Study (CORECT); Discovery, Biology, and Risk of Inherited Variants in Breast Cancer (DRIVE); Elucidating Loci Involved in Prostate Cancer Susceptibility (ELLIPSE); Transdisciplinary Research in Cancer of the Lung (TRICL). Association between Adult Height and Risk of Colorectal, Lung, and Prostate Cancer: Results from Meta-analyses of Prospective Studies and Mendelian Randomization Analyses. PLoS Med. 2016 Sep 6;13(9):e1002118. doi: 10.1371/journal.pmed.1002118. eCollection 2016 Sep. PubMed PMID: 27598322.

Schuette W, Eberhardt WE, Waller C, Schirmacher P, Dietel M, Zirrgiebel U, Radke S, Thomas M. [Subgroup Analysis of the Non-interventional REASON Study: PFS and OS According to Age, Smoking History, Gender, and Histology in NSCLC Patients Treated with Gefitinib or Chemotherapy]. Pneumologie. 2016 Sep;70(9):579-88. doi: 10.1055/s-0042-109760. Epub 2016 Sep 7. German. PubMed PMID: 27603946.

Reinmuth N, Gröschel A, Schumann C, Sebastian M, Wiewrodt R, Reck M. [Therapy of Metastatic Non-small Cell Lung Cancer]. Pneumologie. 2016 Sep;70(9):567-78. doi: 10.1055/s-0042-113087. Epub 2016 Sep 7. German. PubMed PMID: 27603945.

Trudzinski FC, Höink AJ, Leppert D, Fähndrich S, Wilkens H, Graeter TP, Langer F, Bals R, Minko P, Lepper PM. Endoscopic Lung Volume Reduction Using Endobronchial Valves in Patients with Severe Emphysema and Very Low FEV1. Respiration. 2016 Sep 8. [Epub ahead of print] PubMed PMID: 27603781.

Hellbach K, Yaroshenko A, Willer K, Pritzke T, Baumann A, Hesse N, Auweter S, Reiser MF, Eickelberg O, Pfeiffer F, Hilgendorff A, Meinel FG. Facilitated Diagnosis of Pneumothoraces in Newborn Mice Using X-ray Dark-Field Radiography. Invest Radiol. 2016 Oct;51(10):597-601. doi: 10.1097/RLI.0000000000000285. PubMed PMID: 27603110.

Kreuter M, Wuyts W, Renzoni E, Koschel D, Maher TM, Kolb M, Weycker D, Spagnolo P, Kirchgaessler KU, Herth FJ, Costabel U. Anti-acid treatment in patients with IPF: interpret results from post-hoc, subgroup, and exploratory analyses with great caution - Authors' reply. Lancet Respir Med. 2016 Sep;4(9):e48. doi: 10.1016/S2213-2600(16)30235-1. PubMed PMID: 27599251.

Neumann A, Sarikouch S, Bobylev D, Meschenmoser L, Breymann T, Westhoff-Bleck M, Scheid M, Tzanavaros I, Bertram H, Beerbaum P, Haverich A, Boethig D, Horke A. Long-term results after repair of anomalous origin of left coronary artery from the pulmonary artery: Takeuchi repair versus coronary transfer. Eur J Cardiothorac Surg. 2016 Sep 9. pii: ezw268. [Epub ahead of print] PubMed PMID: 27613425.

Hoffmann H, Gompelmann D, Heußel CP, Dienemann H, Eberhardt R. [Tracheobronchoplasty for Severe Diffuse Tracheomalacia]. Zentralbl Chir. 2016 Sep;141 Suppl 1: S35-42. doi: 10.1055/s-0042-113193. Epub 2016 Sep 8. German. PubMed PMID: 27607887.

Song J, Eichstaedt CA, Rodríguez Viales R, Benjamin N, Harutyunova S, Fischer C, Grünig E, Hinderhofer K. Identification of genetic defects in pulmonary arterial hypertension by a new panel diagnostic. Clin Sci (Lond). 2016 Sep 9. pii: CS20160531. [Epub ahead of print] PubMed PMID: 27613157.

Senís E, Mockenhaupt S, Rupp D, Bauer T, Paramasivam N, Knapp B, Gronych J, Grosse S, Windisch MP, Schmidt F, Theis FJ, Eils R, Lichter P, Schlesner M, Bartenschlager R, Grimm D. TALEN/CRISPR-mediated engineering of a promoterless anti-viral RNAi hairpin into an endogenous miRNA locus. Nucleic Acids Res. 2016 Sep 9. pii: gkw805. [Epub ahead of print] PubMed PMID: 27614072.

Prasse A. The Diagnosis, Differential Diagnosis, and Treatment of Sarcoidosis. Dtsch Arztebl Int. 2016 Aug 22;113(33-34):565-74. doi: 10.3238/arztebl.2016.0565. PubMed PMID: 27598883.

New in PubMed from DZL Faculty/ Neu von der DZL-Fakultät in der Woche bis 5. September 2016:

Madani M, Mayer E, Fadel E, Jenkins DP. Pulmonary Endarterectomy. Patient Selection, Technical Challenges, and Outcomes. Ann Am Thorac Soc. 2016 Jul;13 Suppl 3:S240-7. doi: 10.1513/AnnalsATS.201601-014AS. PubMed PMID: 27571005.

Greipel L, Fischer S, Klockgether J, Dorda M, Mielke S, Wiehlmann L, Cramer N, Tümmler B. Molecular epidemiology of mutations in antimicrobial resistance loci of Pseudomonas aeruginosa isolates from cystic fibrosis airways. Antimicrob Agents Chemother. 2016 Aug 29. pii: AAC.00724-16. [Epub ahead of print] PubMed PMID: 27572404.

Karrasch S, Brüske I, Smith MP, Thorand B, Huth C, Ladwig KH, Kronenberg F, Heinrich J, Holle R, Peters A, Schulz H. What is the impact of different spirometric criteria on the prevalence of spirometrically defined COPD and its comorbidities? Results from the population-based KORA study. Int J Chron Obstruct Pulmon Dis. 2016 Aug 16;11:1881-94. doi: 10.2147/COPD.S104529. eCollection 2016. PubMed PMID: 27574413; PubMed Central PMCID: PMC4993254.

Rennard SI, Martinez FJ, Rabe KF, Sethi S, Pizzichini E, McIvor A, Siddiqui S, Anzueto A, Zhu H. Effects of roflumilast in COPD patients receiving inhaled corticosteroid/long-acting β2-agonist fixed-dose combination: RE(2)SPOND rationale and study design. Int J Chron Obstruct Pulmon Dis. 2016 Aug 17;11:1921-8. doi: 10.2147/COPD.S109661. eCollection 2016. PubMed PMID: 27574416; PubMed Central PMCID: PMC4994799.

Welte T, Rosen JM, Zhang XH. Fatal attraction: TICs and MDSCs. Cell Cycle. 2016 Aug 30:1-3. [Epub ahead of print] PubMed PMID: 27574951.

Stolz D, Leeming DJ, Edfort Kristensen JH, Karsdal MA, Boersma W, Louis R, Milenkovic B, Kostikas K, Blasi F, Aerts J, Sand JM, Wouters EF, Rohde G, Prat C, Torres A, Welte T, Roth M, Papakonstantinou E, Tamm M. Systemic biomarkers of collagen and elastin turnover are associated with clinically relevant outcomes in COPD. Chest. 2016 Aug 26. pii: S0012-3692(16)57834-9. doi: 10.1016/j.chest.2016.08.1440. [Epub ahead of print] PubMed PMID: 27575358.

Langer CJ, Obasaju C, Bunn P, Bonomi P, Gandara D, Hirsch FR, Kim ES, Natalem RB, Novello S, Paz-Ares L, Pérol M, Reck M, Ramalingam SS, Reynolds CH, Socinski MA, Spigel DR, Wakelee H, Mayo C, Thatcher N. Incremental innovation and progress in advanced squamous cell lung cancer: current status and future impact of treatment. J Thorac Oncol. 2016 Aug 26. pii: S1556-0864(16)30905-4. doi: 10.1016/j.jtho.2016.08.138. [Epub ahead of print] Review. PubMed PMID: 27575423.

Rodriguez-Roisin R, Tetzlaff K, Watz H, Wouters EF, Disse B, Finnigan H, Magnussen H, Calverley PM. Daily home-based spirometry during withdrawal of inhaled corticosteroid in severe to very severe chronic obstructive pulmonary disease. Int J Chron Obstruct Pulmon Dis. 2016 Aug 22;11:1973-81. doi: 10.2147/COPD.S106142. eCollection 2016. PubMed PMID: 27578972; PubMed Central PMCID: PMC5001655.

Schwarzkopf L, Wacker M, Ertl J, Hapfelmeier J, Larisch K, Leidl R. Impact of chronic ischemic heart disease on the health care costs of COPD patients – An analysis of German claims data. Respir Med. 2016 Sep;118:112-8. doi: 10.1016/j.rmed.2016.08.001. Epub 2016 Aug 2. PubMed PMID: 27578479.

Selge C, Thomas S, Nowak D, Radon K, Wolfarth B. Asthma prevalence in German Olympic athletes: A comparison of winter and summer sport disciplines. Respir Med. 2016 Sep;118:15-21. doi: 10.1016/j.rmed.2016.07.008. Epub 2016 Jul 14. PubMed PMID: 27578466.

Campo I, Luisetti M, Griese M, Trapnell BC, Bonella F, Grutters J, Nakata K, Van Moorsel CH, Costabel U, Cottin V, Ichiwata T, Inoue Y, Braschi A, Bonizzoni G, Iotti GA, Tinelli C, Rodi G; WLL International Study Group. Whole lung lavage therapy for pulmonary alveolar proteinosis: a global survey of current practices and procedures. Orphanet J Rare Dis. 2016 Aug 31;11(1):115. doi: 10.1186/s13023-016-0497-9. PubMed PMID: 27577926; PubMed Central PMCID: PMC5006612.

Konstantinides SV, Barco S, Rosenkranz S, Lankeit M, Held M, Gerhardt F, Bruch L, Ewert R, Faehling M, Freise J, Ghofrani HA, Grünig E, Halank M, Heydenreich N, Hoeper MM, Leuchte HH, Mayer E, Meyer FJ, Neurohr C, Opitz C, Pinto A, Seyfarth HJ, Wachter R, Zäpf B, Wilkens H, Binder H, Wild PS. Late outcomes after acute pulmonary embolism: rationale and design of FOCUS, a prospective observational multicenter cohort study. J Thromb Thrombolysis. 2016 Aug 30. [Epub ahead of print] PubMed PMID: 27577542.

Firnkorn D, Merker S, Ganzinger M, Muley T, Knaup P. Unlocking Data for Statistical Analyses and Data Mining: Generic Case Extraction of Clinical Items from i2b2 and tranSMART. Stud Health Technol Inform. 2016;228:567-71. PubMed PMID: 27577447.

Hilgendorff A, Windhorst A, Klein M, Tchatalbachev S, Windemuth-Kieselbach C, Kreuder J, Heckmann M, Gkatzoflia A, Ehrhardt H, Mysliwietz J, Maier M, Izar B, Billion A, Gortner L, Chakraborty T, Hossain H. Gene expression profiling at birth characterizing the preterm infant with early onset infection. J Mol Med (Berl). 2016 Aug 30. [Epub ahead of print] PubMed PMID: 27576916.

Depner M, Ege MJ, Cox MJ, Dwyer S, Walker AW, Birzele LT, Genuneit J, Horak E, Braun-Fahrländer C, Danielewicz H, Maier RM, Moffatt MF, Cookson WO, Heederik D, von Mutius E, Legatzki A. Bacterial microbiota of the upper respiratory tract and childhood asthma. J Allergy Clin Immunol. 2016 Jul 27. pii: S0091-6749(16)30710-2. doi: 10.1016/j.jaci.2016.05.050. [Epub ahead of print] PubMed PMID: 27576124.

Stahl M, Wielpütz MO, Graeber SY, Joachim C, Sommerburg O, Kauczor HU, Puderbach M, Eichinger M, Mall MA. Comparison of Lung Clearance Index and Magnetic Resonance Imaging for Assessment of Lung Disease in Children With Cystic Fibrosis. Am J Respir Crit Care Med. 2016 Aug 30. [Epub ahead of print] PubMed PMID: 27575911.

Tiede SL, Wassenberg M, Christ K, Schermuly RT, Seeger W, Grimminger F, Ghofrani HA, Gall H. Biomarkers of tissue remodeling predict survival in patients with pulmonary hypertension. Int J Cardiol. 2016 Aug 13;223:821-826. doi: 10.1016/j.ijcard.2016.08.240. [Epub ahead of print] PubMed PMID: 27575785.

Martinez FJ, Rabe KF, Sethi S, Pizzichini E, McIvor A, Anzueto A, Alagappan VK, Siddiqui S, Rekeda L, Miller CJ, Zetterstrand S, Reisner C, Rennard SI. Effect of Roflumilast and Inhaled Corticosteroid/Long-Acting β2-Agonist on Chronic Obstructive Pulmonary Disease Exacerbations (RE(2)SPOND). A Randomized Clinical Trial. Am J Respir Crit Care Med. 2016 Sep 1;194(5):559-67. doi: 10.1164/rccm.201607-1349OC. PubMed PMID: 27585384.

Radon K, Nowak D, Vogelberg C, Ruëff F. Career Advice for Young Allergy Patients. Dtsch Arztebl Int. 2016 Aug 8;113(31-32):519-24. doi: 10.3238/arztebl.2016.0519. PubMed PMID: 27581504.

Belvisi MG, Morty RE, Rohde G, Miravitlles M, Forrest KA, Genton C, Ritter N, Luludi N, Jimenez A, Rigau D, Tonia T, Vaccaro V, Pannetier C, Brusselle GG, Holgate ST. The ever-expanding ERS fellowship programmes: achievements over the past 3 years. Eur Respir J. 2016 Sep;48(3):595-9. doi: 10.1183/13993003.01146-2016. PubMed PMID: 27581399.

Valipour A, Slebos DJ, Herth F, Darwiche K, Wagner M, Ficker JH, Petermann C, Hubner RH, Stanzel F, Eberhardt R; IMPACT-Study-Team. Endobronchial Valve Therapy in Patients with Homogeneous Emphysema: Results from the IMPACT Study. Am J Respir Crit Care Med. 2016 Aug 31. [Epub ahead of print] PubMed PMID: 27580428.

Kuo CS, Pavlidis S, Loza M, Baribaud F, Rowe A, Pandis I, Hoda U, Rossios C, Sousa A, Wilson SJ, Howarth P, Dahlen B, Dahlen SE, Chanez P, Shaw D, Krug N, Sandström T, De Meulder B, Lefaudeux D, Fowler S, Fleming L, Corfield J, Auffray C, Sterk PJ, Djukanovic R, Guo Y, Adcock IM, Chung KF; U-BIOPRED Project Team. A Transcriptome-driven Analysis of Epithelial Brushings and Bronchial Biopsies to Define Asthma Phenotypes in U-BIOPRED. Am J Respir Crit Care Med. 2016 Aug 31. [Epub ahead of print] PubMed PMID: 27580351.

Greer M, Riise GC, Hansson L, Perch M, Hämmäinen P, Roux A, Hirschi S, Lhuillier E, Reynaud-Gaubert M, Philit F, Claustre J, Stern M, Gottlieb J, Holm AM. Dichotomy in pulmonary graft-versus-host disease evident among allogeneic stem-cell transplant recipients undergoing lung transplantation. Eur Respir J. 2016 Sep 1. pii: ERJ-01121-2016. doi: 10.1183/13993003.01121-2016. [Epub ahead of print] PubMed PMID: 27587560.

Fernandez IE, Greiffo FR, Frankenberger M, Bandres J, Heinzelmann K, Neurohr C, Hatz R, Hartl D, Behr J, Eickelberg O. Peripheral blood myeloid-derived suppressor cells reflect disease status in idiopathic pulmonary fibrosis. Eur Respir J. 2016 Sep 1. pii: ERJ-01826-2015. doi: 10.1183/13993003.01826-2015. [Epub ahead of print] PubMed PMID: 27587556.

Cottin V, Bel E, Bottero P, Dalhoff K, Humbert M, Lazor R, Sinico RA, Sivasothy P, Wechsler ME, Groh M, Marchand-Adam S, Khouatra C, Wallaert B, Taillé C, Delaval P, Cadranel J, Bonniaud P, Prévot G, Hirschi S, Gondouin A, Dunogué B, Chatté G, Briault A, Jayne D, Guillevin L, Cordier JF;    the Groupe d'Etudes et de Recherche sur les Maladies Orphelines Pulmonaires (GERM“O”P). Respiratory manifestations of eosinophilic granulomatosis with polyangiitis (Churg-Strauss). Eur Respir J. 2016 Sep 1. pii: ERJ-00097-2016. doi: 10.1183/13993003.00097-2016. [Epub ahead of print] PubMed PMID: 27587545.

Heigener DF, Horn M, Reck M. [Targeted therapy and precision medicine : More than just words in the treatment of lung cancer]. Internist (Berl). 2016 Sep 1. [Epub ahead of print] German. PubMed PMID: 27587193.

Serpa Neto A, Schmidt M, Azevedo LC, Bein T, Brochard L, Beutel G, Combes A, Costa EL, Hodgson C, Lindskov C, Lubnow M, Lueck C, Michaels AJ, Paiva JA, Park M, Pesenti A, Pham T, Quintel M, Marco Ranieri V, Ried M, Roncon-Albuquerque R Jr, Slutsky AS, Takeda S, Terragni PP, Vejen M, Weber-Carstens S, Welte T, Gama de Abreu M, Pelosi P, Schultz MJ; ReVA Research Network and the PROVE Network Investigators. Associations between ventilator settings during extracorporeal membrane oxygenation for refractory hypoxemia and outcome in patients with acute respiratory distress syndrome: a pooled individual patient data analysis: Mechanical ventilation during ECMO. Intensive Care Med. 2016 Sep 1. [Epub ahead of print] PubMed PMID: 27586996.

Mascherbauer J, Grünig E, Halank M, Hohenforst-Schmidt W, Kammerlander AA, Pretsch I, Steringer-Mascherbauer R, Ulrich S, Lang IM, Wargenau M, Frey R, Bonderman D. Evaluation of the pharmacoDYNAMIC effects of riociguat in subjects with pulmonary hypertension and heart failure with preserved ejection fraction: Study protocol for a randomized controlled trial. Wien Klin Wochenschr. 2016 Sep 2. [Epub ahead of print] PubMed PMID: 27590259.

August 2016

New in PubMed from DZL Faculty/ Neu von der DZL-Fakultät in der Woche bis 29. August 2016:

Bonella F, Kreuter M, Hagmeyer L, Neurohr C, Keller C, Kohlhaeufl MJ, Müller-Quernheim J, Milger K, Prasse A; German Nintedanib Compassionate Use Consortium. Insights from the German Compassionate Use Program of Nintedanib for the Treatment of Idiopathic Pulmonary Fibrosis. Respiration. 2016 Aug 20. [Epub ahead of print] PubMed PMID: 27544537.

Stein K, Brand S, Jenckel A, Sigmund A, Chen ZJ, Kirschning CJ, Kauth M, Heine H. Endosomal recognition of Lactococcus lactis G121 and its RNA by dendritic cells is key to its allergy-protective effects. J Allergy Clin Immunol. 2016 Jul 15. pii: S0091-6749(16)30609-1. doi: 10.1016/j.jaci.2016.06.018. [Epub ahead of print] PubMed PMID: 27544739.

Bhat J, Sosna J, Fritsch J, Quabius ES, Schütze S, Zeissig S, Ammerpohl O, Adam D, Kabelitz D. Expression of non-secreted IL-4 is associated with HDAC inhibitor-induced cell death, histone acetylation and c-Jun regulation in human gamma/delta T-cells. Oncotarget. 2016 Aug 20. doi: 10.18632/oncotarget.11462. [Epub ahead of print] PubMed PMID: 27556516.

Pfeil U, Bharathala S, Murtaza G, Mermer P, Papadakis T, Boening A, Kummer W. Spatial expression of components of a calcitonin receptor-like receptor (CRL) signalling system (CRL, calcitonin gene-related peptide, adrenomedullin, adrenomedullin-2/intermedin) in mouse and human heart valves. Cell Tissue Res. 2016 Aug 23. [Epub ahead of print] PubMed PMID: 27553639.

Achelrod D, Welte T, Schreyögg J, Stargardt T. Costs and outcomes of the German disease management programme (DMP) for chronic obstructive pulmonary disease (COPD)-A large population-based cohort study. Health Policy. 2016 Aug 9. pii: S0168-8510(16)30205-6. doi: 10.1016/j.healthpol.2016.08.002. [Epub ahead of print] PubMed PMID: 27552849.

Zimmermann-Geller B, Köppert S, Fischer S, Cabrera-Fuentes HA, Lefèvre S, Rickert M, Steinmeyer J, Rehart S, Umscheid T, Schönburg M, Müller-Ladner U, Preissner KT, Frommer KW, Neumann E. Influence of Extracellular RNAs, Released by Rheumatoid Arthritis Synovial Fibroblasts, on Their Adhesive and Invasive Properties. J Immunol. 2016 Aug 22. pii: 1501580. [Epub ahead of print] PubMed PMID: 27549172.

Rosell R, Neninger E, Nicolson M, Huber RM, Thongprasert S, Parikh PM, D'Hondt E. Pathway Targeted Immunotherapy: Rationale and Evidence of Durable Clinical Responses with a Novel, EGF-directed Agent for Advanced Non-small Cell Lung Cancer. J Thorac Oncol. 2016 Aug 23. pii: S1556-0864(16)30898-X. doi: 10.1016/j.jtho.2016.08.132. [Epub ahead of print] Review. PubMed PMID: 27566188.

Smit EF, Wu YL, Gervais R, Zhou C, Felip E, Feng J, Guclu SZ, Hoiczyk M, Dorokhova E, Freudensprung U, Grange S, Perez-Moreno PD, Mitchell L, Reck M. A randomized, double-blind, phase III study comparing two doses of erlotinib for second-line treatment of current smokers with advanced non-small-cell lung cancer (CurrentS). Lung Cancer. 2016 Sep;99:94-101. doi: 10.1016/j.lungcan.2016.06.019. Epub 2016 Jun 27. PubMed PMID: 27565921.

Zuber V, Marconett CN, Shi J, Hua X, Wheeler W, Yang C, Song L, Dale AM, Laplana M, Risch A, Witoelar A, Thompson WK, Schork AJ, Bettella F, Wang Y, Djurovic S, Zhou B, Borok Z, van der Heijden HF, de Graaf J, Swinkels D, Aben KK, McKay J, Hung RJ, Bikeböller H, Stevens VL, Albanes D, Caporaso NE, Han Y, Wei Y, Panadero MA, Mayordomo JI, Christiani DC, Kiemeney L, Andreassen OA, Houlston R, Amos CI, Chatterjee N, Laird-Offringa IA, Mills IG, Landi MT. Pleiotropic Analysis of Lung Cancer and Blood Triglycerides. J Natl Cancer Inst. 2016 Aug26;108(12). pii: djw167. Print 2016 Dec. PubMed PMID: 27565901.

Griese M, Scheuch G. Delivery of Alpha-1 Antitrypsin to Airways. Ann Am Thorac Soc. 2016 Aug;13(Supplement_4): S346-S351. PubMed PMID: 27564672.

Janciauskiene S, Welte T. Well-Known and Less Well-Known Functions of Alpha-1Antitrypsin. Its Role in Chronic Obstructive Pulmonary Disease and Other Disease Developments. Ann Am Thorac Soc. 2016 Aug;13(Supplement_4): S280-S288. PubMed PMID: 27564662.

Li M, Riddle S, Zhang H, D'Alessandro A, Flockton A, Serkova NJ, Hansen KC, Moldvan R, McKeon BA, Frid M, Kumar S, Li H, Liu H, Cánovas A, Medrano JF, Thomas MG, Iloska D, Plecita-Hlavata L, Jezek P, Pullamsetti S, Fini MA, El Kasmi KC, Zhang Q, Stenmark KR. Metabolic Reprogramming Regulates the Proliferative and Inflammatory Phenotype of Adventitial Fibroblasts in Pulmonary Hypertension Through the Transcriptional Co-Repressor C-terminal Binding Protein-1. Circulation. 2016 Aug 25. pii: CIRCULATIONAHA.116.023171. [Epub ahead of print] PubMed PMID: 27562971.

Skowasch D, Fertl A, Schwick B, Schäfer H, Hellmann A, Herth FJ; LIVE Study Investigators. A Long-Term Follow-Up Investigation of Endobronchial Valves in Emphysema (the LIVE Study): Study Protocol and Six-Month Interim Analysis Results of a Prospective Five-Year Observational Study. Respiration. 2016 Aug 24;92(2). [Epub ahead of print] PubMed PMID: 27562904.

Mühlfeld C, Madsen J, Mackay RM, Schneider JP, Schipke J, Lutz D, Birkelbach B, Knudsen L, Botto M, Ochs M, Clark H. Effect of irradiation/bone marrow transplantation on alveolar epithelial type II cells is aggravated in surfactant protein D deficient mice. Histochem Cell Biol. 2016 Aug 26. [Epub ahead of print] PubMed PMID: 27565967.

Wälscher J, Gompelmann D. [Bronchoscopy]. Dtsch Med Wochenschr. 2016 Aug;141(17):1236-8. doi: 10.1055/s-0042-111420. Epub 2016 Aug 24. German. PubMed PMID: 27557070.

Dietz K, Jiménez ML, Gollwitzer ES, Chaker AM, Zissler UM, Rådmark OP, Baarsma HA, Königshoff M, Schmidt-Weber CB, Marsland BJ, Bieren JE. Age dictates a steroid resistant cascade of Wnt5a, transglutaminase-2 and leukotrienes in inflamed airways. J Allergy Clin Immunol. 2016 Aug 20. pii: S0091-6749(16)30796-5. doi: 10.1016/j.jaci.2016.07.014. [Epub ahead of print] PubMed PMID: 27554815.

Smith MP, Berdel D, Bauer CP, Koletzko S, Nowak D, Heinrich J, Schulz H. Asthma and Rhinitis Are Associated with Less Objectively-Measured Moderate and Vigorous Physical Activity, but Similar Sport Participation, in Adolescent German Boys: GINIplus and LISAplus Cohorts. PLoS One. 2016 Aug 25;11(8):e0161461. doi: 10.1371/journal.pone.0161461. eCollection 2016. PubMed PMID: 27560942.

New in PubMed from DZL Faculty/ Neu von der DZL-Fakultät in der Woche bis 22. August 2016:

Abere B, Schulz TF. KSHV non-structural membrane proteins involved in the activation of intracellular signaling pathways and the pathogenesis of Kaposi's sarcoma. Curr Opin Virol. 2016 Aug 9;20:11-19. doi: 10.1016/j.coviro.2016.07.008. [Epub ahead of print] Review. PubMed PMID: 27518127.

Kröner C, Wittmann T, Reu S, Teusch V, Klemme M, Rauch D, Hengst M, Kappler M, Cobanoglu N, Sismanlar T, Aslan AT, Campo I, Proesmans M, Schaible T, Terheggen-Lagro S, Regamey N, Eber E, Seidenberg J, Schwerk N, Aslanidis C, Lohse P, Brasch F, Zarbock R, Griese M. Lung disease caused by ABCA3 mutations. Thorax. 2016 Aug 11. pii: thoraxjnl-2016-208649. doi: 10.1136/thoraxjnl-2016-208649. [Epub ahead of print] PubMed PMID: 27516224.

Liu R, Fan W, Krüger K, Xiao Y, Pilat C, Seimetz M, Ringseis R, Baumgart-Vogt E, Eder K, Weissmann N, Mooren FC. Exercise Affects T Cell Function via Modifying Intracellular Calcium Homeostasis. Med Sci Sports Exerc. 2016 Aug 12. [Epub ahead of print] PubMed PMID: 27525377.

Husain-Syed F, Birk HW, Seeger W, Ronco C. A Protective Kidney-Lung Approach to Improve Outcomes in Mechanically Ventilated Patients. Blood Purif. 2016 Aug 13;42(3):214-218. [Epub ahead of print] PubMed PMID: 27522219.

Kerrin A, Fitch P, Errington C, Kerr D, Waxman L, Riding K, McCormack J, Mehendele F, McSorley H, MacKenzie K, Wronski S, Braun A, Levin R, Theilen U, Schwarze J. Differential lower airway dendritic cell patterns may reveal distinct endotypes of RSV bronchiolitis. Thorax. 2016 Aug 16. pii: thoraxjnl-2015-207358. doi: 10.1136/thoraxjnl-2015-207358. [Epub ahead of print] PubMed PMID: 27531529.

Dietz S, Schirmer U, Mercé C, von Bubnoff N, Dahl E, Meister M, Muley T, Thomas M, Sültmann H. Low Input Whole-Exome Sequencing to Determine the Representation of the Tumor Exome in Circulating DNA of Non-Small Cell Lung Cancer Patients. PLoS One. 2016 Aug 16;11(8):e0161012. doi: 10.1371/journal.pone.0161012. eCollection 2016. PubMed PMID: 27529345.

Flechsig P, Frank P, Kratochwil C, Antoch G, Rath D, Moltz J, Rieser M, Warth A, Kauczor HU, Schwartz LH, Haberkorn U, Giesel FL. Radiomic Analysis using Density Threshold for FDG-PET/CT-Based N-Staging in Lung Cancer Patients. Mol Imaging Biol. 2016 Aug 18. [Epub ahead of print] PubMed PMID: 27539308.

Beermann J, Piccoli MT, Viereck J, Thum T. Non-coding RNAs in Development and Disease: Background, Mechanisms, and Therapeutic Approaches. Physiol Rev. 2016 Oct;96(4):1297-325. doi: 10.1152/physrev.00041.2015. Review. PubMed PMID: 27535639.

Ahnert P, Creutz P, Scholz M, Schütte H, Engel C, Hossain H, Chakraborty T, Bauer M, Kiehntopf M, Völker U, Hammerschmidt S, Loeffler M, Suttorp N; PROGRESS study group. PROGRESS - prospective observational study on hospitalized community acquired pneumonia. BMC Pulm Med. 2016 Jul 28;16(1):108. doi: 10.1186/s12890-016-0255-8. PubMed PMID: 27535544; PubMed Central PMCID: PMC4987996.

Gompelmann D, Lim HJ, Eberhardt R, Gerovasili V, Herth FJ, Heussel CP, Eichinger M. Predictors of pneumothorax following endoscopic valve therapy in patients with severe emphysema. Int J Chron Obstruct Pulmon Dis. 2016 Aug 1;11:1767-73. doi: 10.2147/COPD.S106439. eCollection 2016. PubMed PMID: 27536088;PubMed Central PMCID: PMC4976918.

Houben-Wilke S, Jörres RA, Bals R, Franssen FM, Gläser S, Holle R, Karch A, Koch A, Magnussen H, Obst A, Schulz H, Spruit MA, Wacker ME, Welte T, Wouters EF, Vogelmeier C, Watz H. Peripheral Artery Disease and its Clinical Relevance in Patients with COPD in the COSYCONET Study. Am J Respir Crit Care Med. 2016 Aug 17. [Epub ahead of print] PubMed PMID: 27532739.

New in PubMed from DZL Faculty/ Neu von der DZL-Fakultät in der Woche bis 15. August 2016:

Birzele LT, Depner M, Ege MJ, Engel M, Kublik S, Bernau C, Loss GJ, Genuneit J, Horak E, Schloter M, Braun-Fahrländer C, Danielewicz H, Heederik D, von Mutius E, Legatzki A. Environmental and mucosal microbiota and their role in childhood asthma. Allergy. 2016 Aug 9. doi: 10.1111/all.13002. [Epub ahead of print] PubMed PMID: 27503830.

Dietrich CF, Jenssen C, Herth FJ. Endobronchial ultrasound elastography. Endosc Ultrasound. 2016 Jul-Aug;5(4):233-8. doi: 10.4103/2303-9027.187866. Review. PubMed PMID: 27503154.

Joerger M, von Pawel J, Kraff S, Fischer JR, Eberhardt W, Gauler TC, Mueller L, Reinmuth N, Reck M, Kimmich M, Mayer F, Kopp HG, Behringer DM, Ko YD, Hilger RA, Roessler M, Kloft C, Henrich A, Moritz B, Miller MC, Salamone SJ, Jaehde U. Open-label, randomised study of individualized, pharmacokinetically (PK)-guided dosing of paclitaxel combined with carboplatin or cisplatin in patients with advanced non-small cell lung cancer (NSCLC). Ann Oncol. 2016 Aug 8. pii: mdw290. [Epub ahead of print] PubMed PMID: 27502710.

Mahavadi P, Knudsen L, Venkatesan S, Henneke I, Hegermann J, Wrede C, Ochs M, Ahuja S, Chillappagari S, Ruppert C, Seeger W, Korfei M, Guenther A. Regulation of macroautophagy in amiodarone-induced pulmonary fibrosis. J Pathol Clin Res. 2015 Jun 3;1(4):252-63. doi: 10.1002/cjp2.20. eCollection 2015 Oct. PubMed PMID: 27499909; PubMed Central PMCID: PMC4939895.

Buhl R, Criée CP, Kardos P, Vogelmeier C, Lossi N, Mailänder C, Worth H. A year in the life of German patients with COPD: the DACCORD observational study. Int J Chron Obstruct Pulmon Dis. 2016 Jul 20;11:1639-46. doi: 10.2147/COPD.S112110. eCollection 2016. PubMed PMID: 27499620; PubMed Central PMCID: PMC4959587.

Schuette W, Dietel M, Thomas M, Eberhardt W, Griesinger F, Zirrgiebel U, Radke S, Schirmacher P. [Exon-dependent Subgroup-analysis of the Non-interventional REASON-Study: PFS and OS in EGFR-mutated NSCLC Patients Treated with Gefitinib or Chemotherapy]. Pneumologie. 2016 Aug;70(8):514-21. doi: 10.1055/s-0042-109749. Epub 2016 Aug 11. German. PubMed PMID: 27512931.

Avsar K, Behr J, Lindner M, Morresi-Hauf A. [Endobronchial Ultrasound Guided Needle Aspiration of a Lung Cyst and Eosinophilic Pneumonia]. Pneumologie. 2016 Aug;70(8):505-9. doi: 10.1055/s-0042-109483. Epub 2016 Aug 11. German. PubMed PMID: 27512929.

Shima K, Coopmeiners J, Graspeuntner S, Dalhoff K, Rupp J. Impact of micro-environmental changes on respiratory tract infections caused by intracellular bacteria. FEBS Lett. 2016 Aug 10. doi: 10.1002/1873-3468.12353. [Epub ahead of print] Review. PubMed PMID: 27509029.

Scheel AH, Dietel M, Heukamp LC, Jöhrens K, Kirchner T, Reu S, Rüschoff J, Schildhaus HU, Schirmacher P, Tiemann M, Warth A, Weichert W, Fischer RN, Wolf J, Büttner R. [Predictive PD-L1 immunohistochemistry for non-small cell lung cancer: Current state of the art and experiences of the first German harmonization study]. Pathologe. 2016 Aug 10. [Epub ahead of print] German. PubMed PMID: 27510417.

Born F, Khaladj N, Pichlmaier M, Schramm R, Hagl C, Guenther SP. Potential impact of oxygenators with venous air trap on air embolism in veno-arterial extracorporeal life support. Technol Health Care. 2016 Jul 29. [Epub ahead of print] PubMed PMID: 27497463.

New in PubMed from DZL Faculty/ Neu von der DZL-Fakultät in der Woche bis 08. August 2016:

Jia J, Conlon TM, Ballester-Lopez C, Seimetz M, Bednorz M, Zhou-Suckow Z, Weissmann N, Eickelberg O, Mall MA, Yildirim AÖ. Cigarette smoke causes acute airways disease and exacerbates chronic obstructive lung disease in neonatal mice. Am J Physiol Lung Cell Mol Physiol. 2016 Jul 22:ajplung.00124.2016. doi: 10.1152/ajplung.00124.2016. [Epub ahead of print] PubMed PMID: 27448665.

Shah PL, Gompelmann D, Valipour A, McNulty WH, Eberhardt R, Grah C, Egan J, Ficker JH, Wagner M, Witt C, Liebers U, Hopkins P, Gesierich W, Phillips M, Stanzel F, Petermann C, Strange C, Snell G, Herth FJ. Thermal vapour ablation reduce segmental volume in patients with severe emphysema: STEP-UP 12 month results. Lancet Respir Med. 2016 Jul 20. pii: S2213-2600(16)30199-0. doi: 10.1016/S2213-2600(16)30199-0. [Epub ahead of print] PubMed PMID: 27451345.

Buzan MT, Pop CM, Raduta M, Eichinger M, Heussel CP. Respiratory tuberculosis in children and adolescents: Assessment of radiological severity pattern and age-related changes within two decades. Pneumologia. 2015 Oct-Dec;64(4):8-12. PubMed PMID: 27451588.

Aggarwal N, Korenbaum E, Mahadeva R, Immenschuh S, Grau V, Dinarello CA, Welte T, Janciauskiene S. α-Linoleic acid enhances the capacity of α-1 antitrypsin to inhibit lipopolysaccharide-induced IL-1β in human blood neutrophils. Mol Med. 2016 Jul 13;22. doi: 10.2119/molmed.2016.00119. [Epub ahead of print] PubMed PMID: 27452044.

Karami S, Han Y, Pande M, Cheng I, Rudd J, Pierce BL, Nutter EL, SchumacherFR, Kote-Jarai Z, Lindstrom S, Witte JS, Fang S, Han J, Kraft P, Hunter D, Song F, Hung RJ, McKay J, Gruber SB, Chanock SJ, Risch A, Shen H, Haiman CA, Boardman L, Ulrich CM, Casey G, Peters U, Amin Al Olama A, Berchuck A, Berndt SI, Bezieau S, Brennan P, Brenner H, Brinton L, Caporaso N, Chan AT, Chang-Claude J, Christiani DC, Cunningham JM, Easton D, Eeles RA, Eisen T, Gala M, Gallinger SJ, Gayther SA, Goode EL, Grönberg H, Henderson BE, Houlston R, Joshi AD, Küry S, Landi MT, Le Marchand L, Muir K, Newcomb PA, Permuth-Wey J, Pharoah P, Phelan C, Potter JD, Ramus SJ, Risch H, Schildkraut J, Slattery ML, Song H, Wentzensen N, White E, Wiklund F, Zanke BW, Sellers TA, Zheng W, Chatterjee N, Amos CI, Doherty JA; GECCO and the GAME-ON Network: CORECT, DRIVE, ELLIPSE, FOCI, and TRICL. Telomere structure and maintenance gene variants and risk of five cancer types. Int J Cancer. 2016 Jul 26. doi: 10.1002/ijc.30288. [Epub ahead of print] PubMed PMID: 27459707.

Reck M, Luft A, Szczesna A, Havel L, Kim SW, Akerley W, Pietanza MC, Wu YL, Zielinski C, Thomas M, Felip E, Gold K, Horn L, Aerts J, Nakagawa K, Lorigan P, Pieters A, Kong Sanchez T, Fairchild J, Spigel D. Phase III Randomized Trial of Ipilimumab Plus Etoposide and Platinum Versus Placebo Plus Etoposide and Platinum in Extensive-Stage Small-Cell Lung Cancer. J Clin Oncol. 2016 Jul 25. pii: JCO676601. [Epub ahead of print] PubMed PMID: 27458307.

Humbert M, Coghlan JG, Ghofrani HA, Grimminger F, He JG, Riemekasten G, Vizza CD, Boeckenhoff A, Meier C, de Oliveira Pena J, Denton CP. Riociguat for thetreatment of pulmonary arterial hypertension associated with connective tissue disease: results from PATENT-1 and PATENT-2. Ann Rheum Dis. 2016 Jul 25. pii: annrheumdis-2015-209087. doi: 10.1136/annrheumdis-2015-209087. [Epub ahead of print] PubMed PMID: 27457511.

Wagner CJ, Schultz C, Mall MA. Neutrophil elastase and matrix metalloproteinase 12 in cystic fibrosis lung disease. Mol Cell Pediatr. 2016 Dec;3(1):25. doi: 10.1186/s40348-016-0053-7. Epub 2016 Jul 25. Review. PubMed PMID: 27456476.

Hochwallner H, Schulmeister U, Swoboda I, Focke-Tejkl M, Reininger R, Civaj V, Campana R, Thalhamer J, Scheiblhofer S, Balic N, Horak F, Ollert M, Papadopoulos NG, Quirce S, Szepfalusi Z, Herz U, van Tol EA, Spitzauer S, Valenta R. Infant milk formulas differ regarding their allergenic activity and induction of T cell and cytokine responses. Allergy. 2016 Jul 25. doi: 10.1111/all.12992. [Epub ahead of print] PubMed PMID: 27455132.

Mucci A, Kunkiel J, Suzuki T, Brennig S, Glage S, Kühnel MP, Ackermann M, Happle C, Kuhn A, Schambach A, Trapnell BC, Hansen G, Moritz T, Lachmann N. Murine iPSC-Derived Macrophages as a Tool for Disease Modeling of Hereditary Pulmonary Alveolar Proteinosis due to Csf2rb Deficiency. Stem Cell Reports. 2016 Jul 20. pii: S2213-6711(16)30103-5. doi: 10.1016/j.stemcr.2016.06.011. [Epub ahead of print] PubMed PMID: 27453007.

Ehrhardt H, Zimmer KP. The need for coordination of research activities inpediatric lung diseases. Mol Cell Pediatr. 2016 Dec;3(1):26. doi: 10.1186/s40348-016-0060-8. Epub 2016 Jul 27. PubMed PMID: 27465412.

Novello S, Scagliotti G, de Castro G Jr, Kiyik M, Kowalyszyn R, Deppermann KM, Arriola E, Bosquee L, Novosiadly RD, Nguyen TS, Forest A, Tang S, Kambhampati SR, Cosaert J, Reck M. Brief Report: An Open-Label, Multicenter, Randomized, Phase II Study of Cisplatin and Pemetrexed With or Without Cixutumumab (IMC-A12) as a First-Line Therapy in Patients With Advanced Nonsquamous Non-Small Cell Lung Cancer. J Thorac Oncol. 2016 Jul 24. pii: S1556-0864(16)30631-1. doi: 10.1016/j.jtho.2016.07.013. [Epub ahead of print] PubMed PMID: 27464970.

Blanco I, Lipsker D, Lara B, Janciauskiene S. Neutrophilic panniculitis and autoinflammation: what's the link?: reply from authors. Br J Dermatol. 2016 Jul 27. doi: 10.1111/bjd.14614. [Epub ahead of print] PubMed PMID: 27463611.

Stahr CS, Samarage CR, Donnelley M, Farrow N, Morgan KS, Zosky G, Boucher RC, Siu KK, Mall MA, Parsons DW, Dubsky S, Fouras A. Quantification of heterogeneity in lung disease with image-based pulmonary function testing. Sci Rep. 2016 Jul 27;6:29438. doi: 10.1038/srep29438. PubMed PMID: 27461961.

Weidler S, Stopsack KH, Hammermann J, Sommerburg O, Mall MA, Hoffmann GF, Kohlmüller D, Okun JG, Macek M Jr, Votava F, Krulišová V, Balaščaková M, Skalická V, Lee-Kirsch MA, Stopsack M. A product of immunoreactive trypsinogen and pancreatitis-associated protein as second-tier strategy in cystic fibrosis newborn screening. J Cyst Fibros. 2016 Jul 22. pii: S1569-1993(16)30559-8. doi: 10.1016/j.jcf.2016.07.002. [Epub ahead of print] PubMed PMID: 27461140.

Damm-Welk C, Siddiqi F, Fischer M, Hero B, Narayanan V, Camidge DR, Harris M, Burke A, Lehrnbecher T, Pulford K, Oschlies I, Siebert R, Turner S, Woessmann W. Anti-ALK Antibodies in Patients with ALK-Positive Malignancies Not Expressing NPM-ALK. J Cancer. 2016 Jun 30;7(11):1383-7. doi: 10.7150/jca.15238. eCollection 2016. PubMed PMID: 27471553; PubMed Central PMCID: PMC4964121.

Dabral S, Tian X, Kojonazarov B, Savai R, Ghofrani HA, Weissmann N, Florio M, Sun J, Jonigk D, Maegel L, Grimminger F, Seeger W, Savai Pullamsetti S, Schermuly RT. Notch1 signalling regulates endothelial proliferation and apoptosis in pulmonary arterial hypertension. Eur Respir J. 2016 Jul 28. pii: ERJ-00773-2015. doi: 10.1183/13993003.00773-2015. [Epub ahead of print] PubMed PMID: 27471204.

Caobelli F, Wollenweber T, Bavendiek U, Kühn C, Schütze C, Geworski L, Thackeray JT, Bauersachs J, Haverich A, Bengel FM. Simultaneous dual-isotope solid-state detector SPECT for improved tracking of white blood cells in suspected endocarditis. Eur Heart J. 2016 Jul 28. pii: ehw231. [Epub ahead ofprint] PubMed PMID: 27469371.

Reck M, Hagiwara K, Han B, Tjulandin S, Grohé C, Yokoi T, Morabito A, NovelloS, Arriola E, Molinier O, McCormack R, Ratcliffe M, Normanno N. Circulating Free Tumor-derived DNA (ctDNA) Determination of EGFR Mutation Status in European and Japanese Patients with Advanced NSCLC: the ASSESS Study. J Thorac Oncol. 2016 Jun 30. pii: S1556-0864(16)30588-3. doi: 10.1016/j.jtho.2016.05.036. [Epub ahead of print] PubMed PMID: 27468938.

Richter MJ, Gall H, Grimminger J, Grimminger F, Ghofrani HA. Selexipag for the treatment of pulmonary arterial hypertension. Expert Opin Pharmacother. 2016 Jul 28. [Epub ahead of print] PubMed PMID: 27467883.

Kriegsmann M, Casadonte R, Kriegsmann J, Dienemann H, Schirmacher P, KobargJH, Schwamborn K, Stenzinger A, Warth A, Weichert W. Reliable entity subtyping in Non-small cell Lung Cancer by MALDI Imaging Mass Spectrometry on Formalin-fixed Paraffin-embedded Tissue Specimens. Mol Cell Proteomics. 2016 Jul 29. pii: mcp.M115.057513. [Epub ahead of print] PubMed PMID: 27473201.

Landgraf-Rauf K, Anselm B, Schaub B. The puzzle of immune phenotypes of childhood asthma. Mol Cell Pediatr. 2016 Dec;3(1):27. doi: 10.1186/s40348-016-0057-3. Epub 2016 Jul 28. Review. PubMed PMID: 27468754.

Tenekeci U, Poppe M, Beuerlein K, Buro C, Müller H, Weiser H, Kettner-Buhrow D, Porada K, Newel D, Xu M, Chen ZJ, Busch J, Schmitz ML, Kracht M. K63-Ubiquitylation and TRAF6 Pathways Regulate Mammalian P-Body Formation and mRNA Decapping. Mol Cell. 2016 Aug 4;63(3):540. doi: 10.1016/j.molcel.2016.07.009. PubMed PMID: 27494559.

Merkle R, Steiert B, Salopiata F, Depner S, Raue A, Iwamoto N, Schelker M, Hass H, Wäsch M, Böhm ME, Mücke O, Lipka DB, Plass C, Lehmann WD, Kreutz C, Timmer J, Schilling M, Klingmüller U. Identification of Cell Type-Specific Differences in Erythropoietin Receptor Signaling in Primary Erythroid and Lung Cancer Cells. PLoS Comput Biol. 2016 Aug 5;12(8):e1005049. doi: 10.1371/journal.pcbi.1005049. eCollection 2016 Aug. PubMed PMID: 27494133; PubMed Central PMCID: PMC4975441.

Gamen E, Seeger W, Pullamsetti SS. The emerging role of epigenetics in pulmonary hypertension. Eur Respir J. 2016 Sep;48(3):903-17. doi: 10.1183/13993003.01714-2015. Epub 2016 Aug 4. PubMed PMID: 27492834.

Vogelmeier C, Paggiaro PL, Dorca J, Sliwinski P, Mallet M, Kirsten AM, Beier J, Seoane B, Segarra RM, Leselbaum A. Efficacy and safety of aclidinium/formoterol versus salmeterol/fluticasone: a phase 3 COPD study. Eur Respir J. 2016 Aug 4. pii: ERJ-00216-2016. doi: 10.1183/13993003.00216-2016. [Epub ahead of print] PubMed PMID: 27492833.

Ringkowski S, Loke J, Huang S, Ahmadzai H, Herth FJ, Thomas PS, Herbert C. Enhanced LPS-induced activation of IL-27 signalling in sarcoidosis. Respir Med. 2016 Aug;117:243-53. doi: 10.1016/j.rmed.2016.06.021. Epub 2016 Jul 1. PubMed PMID: 27492538.

Sommer N, Hecker M, Tello K, Richter M, Liebetrau C, Weigand MA, Seeger W, Ghofrani A, Gall H. [Pulmonary hypertension: What is new in therapy?].Anaesthesist. 2016 Aug;65(8):635-52. doi: 10.1007/s00101-016-0207-y. German. PubMed PMID: 27492004.

Strilic B, Yang L, Albarrán-Juárez J, Wachsmuth L, Han K, Müller UC, Pasparakis M, Offermanns S. Tumour-cell-induced endothelial cell necroptosis via death receptor 6 promotes metastasis. Nature. 2016 Aug 11;536(7615):215-8. PubMed PMID: 27487218.

Wallmeier J, Shiratori H, Dougherty GW, Edelbusch C, Hjeij R, Loges NT, Menchen T, Olbrich H, Pennekamp P, Raidt J, Werner C, Minegishi K, Shinohara K, Asai Y, Takaoka K, Lee C, Griese M, Memari Y, Durbin R, Kolb-Kokocinski A, Sauer S, Wallingford JB, Hamada H, Omran H. TTC25 Deficiency Results in Defects of the Outer Dynein Arm Docking Machinery and Primary Ciliary Dyskinesia with Left-Right Body Asymmetry Randomization. Am J Hum Genet. 2016 Aug 4;99(2):460-9. doi:10.1016/j.ajhg.2016.06.014. PubMed PMID: 27486780; PubMed Central PMCID: PMC4974089.

Peteranderl C, Herold S, Schmoldt C. Human Influenza Virus Infections. Semin Respir Crit Care Med. 2016 Aug;37(4):487-500. doi: 10.1055/s-0036-1584801. Epub 2016 Aug 3. PubMed PMID: 27486731.

Rösler B, Herold S. Lung epithelial GM-CSF improves host defense function and epithelial repair in influenza virus pneumonia-a new therapeutic strategy? MolCell Pediatr. 2016 Dec;3(1):29. doi: 10.1186/s40348-016-0055-5. Epub 2016 Aug 1. Review. PubMed PMID: 27480877; PubMed Central PMCID: PMC4969252.

Rabe KF. Update in Asthma 2015. Am J Respir Crit Care Med. 2016 Aug 1;194(3):259-64. doi: 10.1164/rccm.201602-0222UP. PubMed PMID: 27479060.

Bousquet J, Farrell J, Crooks G, Hellings P, Bel EH, Bewick M, Chavannes NH, de Sousa JC, Cruz AA, Haahtela T, Joos G, Khaltaev N, Malva J, Muraro A, Nogues M, Palkonen S, Pedersen S, Robalo-Cordeiro C, Samolinski B, Strandberg T, Valiulis A, Yorgancioglu A, Zuberbier T, Bedbrook A, Aberer W, Adachi M, Agusti A, Akdis CA, Akdis M, Ankri J, Alonso A, Annesi-Maesano I, Ansotegui IJ, Anto JM, Arnavielhe S, Arshad H, Bai C, Baiardini I, Bachert C, Baigenzhin AK, Barbara C, Bateman ED, Beghé B, Kheder AB, Bennoor KS, Benson M, Bergmann KC, Bieber T, Bindslev-Jensen C, Bjermer L, Blain H, Blasi F, Boner AL, Bonini M, Bonini S, Bosnic-Anticevitch S, Boulet LP, Bourret R, Bousquet PJ, Braido F, Briggs AH, Brightling CE, Brozek J, Buhl R, Burney PG, Bush A, Caballero-Fonseca F, Caimmi D, Calderon MA, Calverley PM, Camargos PA, Canonica GW, Camuzat T, Carlsen KH, Carr W, Carriazo A, Casale T, Cepeda Sarabia AM, Chatzi L, Chen YZ, Chiron R, Chkhartishvili E, Chuchalin AG, Chung KF, Ciprandi G, Cirule I, Cox L, Costa DJ, Custovic A, Dahl R, Dahlen SE, Darsow U, De Carlo G, De Blay F, Dedeu T, Deleanu D, De Manuel Keenoy E, Demoly P, Denburg JA, Devillier P, Didier A, Dinh-Xuan AT, Djukanovic R, Dokic D, Douagui H, Dray G, Dubakiene R, Durham SR, Dykewicz MS, El-Gamal Y, Emuzyte R, Fabbri LM, Fletcher M, Fiocchi A, Fink Wagner A, Fonseca J, Fokkens WJ, Forastiere F, Frith P, Gaga M, Gamkrelidze A, Garces J, Garcia-Aymerich J, Gemicioğlu B, Gereda JE, González Diaz S, Gotua M, Grisle I, Grouse L, Gutter Z, Guzmán MA, Heaney LG, Hellquist-Dahl B, Henderson D, Hendry A, Heinrich J, Heve D, Horak F, Hourihane JO, Howarth P, Humbert M, Hyland ME, Illario M, Ivancevich JC, Jardim JR, Jares EJ, Jeandel C, Jenkins C, Johnston SL, Jonquet O, Julge K, Jung KS, Just J, Kaidashev I, Kaitov MR, Kalayci O, Kalyoncu AF, Keil T, Keith PK, Klimek L, Koffi N'Goran B, Kolek V, Koppelman GH, Kowalski ML, Kull I, Kuna P, Kvedariene V, Lambrecht B, Lau S, Larenas-Linnemann D, Laune D, Le LT, Lieberman P, Lipworth B, Li J, Lodrup Carlsen K, Louis R, MacNee W, Magard Y, Magnan A, Mahboub B, Mair A, Majer I, Makela MJ, Manning P, Mara S, Marshall GD, Masjedi MR, Matignon P, Maurer M, Mavale-Manuel S, Melén E, Melo-Gomes E, Meltzer EO, Menzies-Gow A, Merk H, Michel JP, Miculinic N, Mihaltan F, Milenkovic B, Mohammad GM, Molimard M, Momas I, Montilla-Santana A, Morais-Almeida M, Morgan M, Mösges R, Mullol J, Nafti S, Namazova-Baranova L, Naclerio R, Neou A, Neffen H, Nekam K, Niggemann B, Ninot G, Nyembue TD, O'Hehir RE, Ohta K, Okamoto Y, Okubo K, Ouedraogo S, Paggiaro P, Pali-Schöll I, Panzner P, Papadopoulos N, Papi A, Park HS, Passalacqua G, Pavord I, Pawankar R, Pengelly R, Pfaar O, Picard R, Pigearias B, Pin I, Plavec D, Poethig D, Pohl W, Popov TA, Portejoie F, Potter P, Postma D, Price D, Rabe KF, Raciborski F, Radier Pontal F, Repka-Ramirez S, Reitamo S, Rennard S, Rodenas F, Roberts J, Roca J, Rodriguez Mañas L, Rolland C, Roman Rodriguez M, Romano A, Rosado-Pinto J, Rosario N, Rosenwasser L, Rottem M, Ryan D, Sanchez-Borges M, Scadding GK, Schunemann HJ, Serrano E, Schmid-Grendelmeier P, Schulz H, Sheikh A, Shields M, Siafakas N, Sibille Y, Similowski T, Simons FE, Sisul JC, Skrindo I, Smit HA, Solé D, Sooronbaev T, Spranger O, Stelmach R, Sterk PJ, Sunyer J, Thijs C, To T, Todo-Bom A, Triggiani M, Valenta R, Valero AL, Valia E, Valovirta E, Van Ganse E, van Hage M, Vandenplas O, Vasankari T, Vellas B, Vestbo J, Vezzani G, Vichyanond P, Viegi G, Vogelmeier C, Vontetsianos T, Wagenmann M, Wallaert B, Walker S, Wang DY, Wahn U, Wickman M, Williams DM, Williams S, Wright J, Yawn BP, Yiallouros PK, Yusuf OM, Zaidi A, Zar HJ, Zernotti ME, Zhang L, Zhong N, Zidarn M, Mercier J. Scaling up strategies of the chronic respiratory disease programme of the European Innovation Partnership on Active and Healthy Ageing (Action Plan B3: Area 5). Clin Transl Allergy. 2016 Jul 29; 6:29. doi: 10.1186/s13601-016-0116-9. eCollection 2016. Review. PubMed PMID: 27478588; PubMed Central PMCID: PMC4966705

Juli 2016

New in PubMed from DZL Faculty/ Neu von der DZL-Fakultät in der Woche bis 31. Juli 2016:

Aggarwal N, Korenbaum E, Mahadeva R, Immenschuh S, Grau V, Dinarello CA, Welte T, Janciauskiene S. α-Linoleic acid enhances the capacity of α-1 antitrypsin to inhibit lipopolysaccharide-induced IL-1β in human blood neutrophils. Mol Med. 2016 Jul 13;22. doi: 10.2119/molmed.2016.00119. [Epub ahead of print] PubMed PMID: 27452044.

Blanco I, Lipsker D, Lara B, Janciauskiene S. Neutrophilic panniculitis and autoinflammation: what's the link?: reply from authors. Br J Dermatol. 2016 Jul 27. doi: 10.1111/bjd.14614. [Epub ahead of print] PubMed PMID: 27463611.

Buzan MT, Pop CM, Raduta M, Eichinger M, Heussel CP. Respiratory tuberculosis in children and adolescents: Assessment of radiological severity pattern and age-related changes within two decades. Pneumologia. 2015 Oct-Dec;64(4):8-12. PubMed PMID: 27451588.

Chauveau A, Dalphin ML, Kaulek V, Roduit C, Pugin A, von Mutius E, Vuitton DA, Dalphin JC. Disagreement between Skin Prick Tests and Specific IgE in Early Childhood. Int Arch Allergy Immunol. 2016 Jul 26;170(2):69-74. [Epub ahead of print] PubMed PMID: 27454436.

Dabral S, Tian X, Kojonazarov B, Savai R, Ghofrani HA, Weissmann N, Florio M, Sun J, Jonigk D, Maegel L, Grimminger F, Seeger W, Savai Pullamsetti S, Schermuly RT. Notch1 signalling regulates endothelial proliferation and apoptosis in pulmonary arterial hypertension. Eur Respir J. 2016 Jul 28. pii: ERJ-00773-2015. doi: 10.1183/13993003.00773-2015. [Epub ahead of print] PubMed PMID: 27471204.

Damm-Welk C, Siddiqi F, Fischer M, Hero B, Narayanan V, Camidge DR, Harris M, Burke A, Lehrnbecher T, Pulford K, Oschlies I, Siebert R, Turner S, Woessmann W. Anti-ALK Antibodies in Patients with ALK-Positive Malignancies Not Expressing NPM-ALK. J Cancer. 2016 Jun 30;7(11):1383-7. doi: 10.7150/jca.15238. eCollection 2016. PubMed PMID: 27471553; PubMed Central PMCID: PMC4964121.

Ehrhardt H, Zimmer KP. The need for coordination of research activities in pediatric lung diseases. Mol Cell Pediatr. 2016 Dec;3(1):26. doi: 10.1186/s40348-016-0060-8. Epub 2016 Jul 27. PubMed PMID: 27465412.

Hochwallner H, Schulmeister U, Swoboda I, Focke-Tejkl M, Reininger R, Civaj V, Campana R, Thalhamer J, Scheiblhofer S, Balic N, Horak F, Ollert M, Papadopoulos  NG, Quirce S, Szepfalusi Z, Herz U, van Tol EA, Spitzauer S, Valenta R. Infant milk formulas differ regarding their allergenic activity and induction of T cell and cytokine responses. Allergy. 2016 Jul 25. doi: 10.1111/all.12992. [Epub ahead of print] PubMed PMID: 27455132.

Humbert M, Coghlan JG, Ghofrani HA, Grimminger F, He JG, Riemekasten G, Vizza CD, Boeckenhoff A, Meier C, de Oliveira Pena J, Denton CP. Riociguat for the treatment of pulmonary arterial hypertension associated with connective tissue disease: results from PATENT-1 and PATENT-2. Ann Rheum Dis. 2016 Jul 25. pii: annrheumdis-2015-209087. doi: 10.1136/annrheumdis-2015-209087. [Epub ahead of print] PubMed PMID: 27457511.

Jia J, Conlon TM, Ballester-Lopez C, Seimetz M, Bednorz M, Zhou-Suckow Z, Weissmann N, Eickelberg O, Mall MA, Yildirim AÖ. Cigarette smoke causes acute airways disease and exacerbates chronic obstructive lung disease in neonatal mice. Am J Physiol Lung Cell Mol Physiol. 2016 Jul 22: ajplung.00124.2016. doi:10.1152/ajplung.00124.2016. [Epub ahead of print] PubMed PMID: 27448665.

Karami S, Han Y, Pande M, Cheng I, Rudd J, Pierce BL, Nutter EL, Schumacher FR, Kote-Jarai Z, Lindstrom S, Witte JS, Fang S, Han J, Kraft P, Hunter D, Song F, Hung RJ, McKay J, Gruber SB, Chanock SJ, Risch A, Shen H, Haiman CA, Boardman L, Ulrich CM, Casey G, Peters U, Amin Al Olama A, Berchuck A, Berndt SI, Bezieau S, Brennan P, Brenner H, Brinton L, Caporaso N, Chan AT, Chang Claude J, Christiani DC, Cunningham JM, Easton D, Eeles RA, Eisen T, Gala M, Gallinger SJ,  Gayther SA, Goode EL, Grönberg H, Henderson BE, Houlston R, Joshi AD, Küry S, Landi MT, Le Marchand L, Muir K, Newcomb PA, Permuth-Wey J, Pharoah P, Phelan C, Potter JD, Ramus SJ, Risch H, Schildkraut J, Slattery ML, Song H, Wentzensen N, White E, Wiklund F, Zanke BW, Sellers TA, Zheng W, Chatterjee N, Amos CI, Doherty JA; GECCO and the GAME-ON Network: CORECT, DRIVE, ELLIPSE, FOCI, and TRICL. Telomere structure and maintenance gene variants and risk of five cancer types. Int J Cancer. 2016 Jul 26. doi: 10.1002/ijc.30288. [Epub ahead of print] PubMed PMID: 27459707.

Kriegsmann M, Casadonte R, Kriegsmann J, Dienemann H, Schirmacher P, Kobarg JH, Schwamborn K, Stenzinger A, Warth A, Weichert W. Reliable entity subtyping in Non-small cell Lung Cancer by MALDI Imaging Mass Spectrometry on Formalin-fixed Paraffin-embedded Tissue Specimens. Mol Cell Proteomics. 2016 Jul 29. pii: mcp.M115.057513. [Epub ahead of print] PubMed PMID: 27473201.

Landgraf-Rauf K, Anselm B, Schaub B. The puzzle of immune phenotypes of childhood asthma. Mol Cell Pediatr. 2016 Dec;3(1):27. doi: 10.1186/s40348-016-0057-3. Epub 2016 Jul 28. Review. PubMed PMID: 27468754.

Mucci A, Kunkiel J, Suzuki T, Brennig S, Glage S, Kühnel MP, Ackermann M, Happle C, Kuhn A, Schambach A, Trapnell BC, Hansen G, Moritz T, Lachmann N. Murine iPSC-Derived Macrophages as a Tool for Disease Modeling of Hereditary Pulmonary Alveolar Proteinosis due to Csf2rb Deficiency. Stem Cell Reports. 2016 Jul 20. pii: S2213-6711(16)30103-5. doi: 10.1016/j.stemcr.2016.06.011. [Epub ahead of print] PubMed PMID: 27453007.

Novello S, Scagliotti G, de Castro G Jr, Kiyik M, Kowalyszyn R, Deppermann KM, Arriola E, Bosquee L, Novosiadly RD, Nguyen TS, Forest A, Tang S, Kambhampati SR, Cosaert J, Reck M. Brief Report: An Open-Label, Multicenter, Randomized, Phase II Study of Cisplatin and Pemetrexed With or Without Cixutumumab (IMC-A12) as a First-Line Therapy in Patients With Advanced Nonsquamous Non-Small Cell Lung Cancer. J Thorac Oncol. 2016 Jul 24. pii: S1556-0864(16)30631-1. doi: 10.1016/j.jtho.2016.07.013. [Epub ahead of print] PubMed PMID: 27464970.

Reck M, Hagiwara K, Han B, Tjulandin S, Grohé C, Yokoi T, Morabito A, Novello S, Arriola E, Molinier O, McCormack R, Ratcliffe M, Normanno N. Circulating Free Tumor-derived DNA (ctDNA) Determination of EGFR Mutation Status in European and Japanese Patients with Advanced NSCLC: the ASSESS Study. J Thorac Oncol. 2016 Jun 30. pii: S1556-0864(16)30588-3. doi: 10.1016/j.jtho.2016.05.036. [Epub ahead of print] PubMed PMID: 27468938.

Reck M, Luft A, Szczesna A, Havel L, Kim SW, Akerley W, Pietanza MC, Wu YL, Zielinski C, Thomas M, Felip E, Gold K, Horn L, Aerts J, Nakagawa K, Lorigan P, Pieters A, Kong Sanchez T, Fairchild J, Spigel D. Phase III Randomized Trial of Ipilimumab Plus Etoposide and Platinum Versus Placebo Plus Etoposide and Platinum in Extensive-Stage Small-Cell Lung Cancer. J Clin Oncol. 2016 Jul 25. pii: JCO676601. [Epub ahead of print] PubMed PMID: 27458307.

Richter MJ, Gall H, Grimminger J, Grimminger F, Ghofrani HA. Selexipag for the treatment of pulmonary arterial hypertension. Expert Opin Pharmacother. 2016 Jul 28. [Epub ahead of print] PubMed PMID: 27467883.

Shah PL, Gompelmann D, Valipour A, McNulty WH, Eberhardt R, Grah C, Egan J, Ficker JH, Wagner M, Witt C, Liebers U, Hopkins P, Gesierich W, Phillips M, Stanzel F, Petermann C, Strange C, Snell G, Herth FJ. Thermal vapour ablation to reduce segmental volume in patients with severe emphysema: STEP-UP 12 month results. Lancet Respir Med. 2016 Jul 20. pii: S2213-2600(16)30199-0. doi: 10.1016/S2213-2600(16)30199-0. [Epub ahead of print] PubMed PMID: 27451345.

Stahr CS, Samarage CR, Donnelley M, Farrow N, Morgan KS, Zosky G, Boucher RC, Siu KK, Mall MA, Parsons DW, Dubsky S, Fouras A. Quantification of heterogeneity in lung disease with image-based pulmonary function testing. Sci Rep. 2016 Jul 27;6:29438. doi: 10.1038/srep29438. PubMed PMID: 27461961.

Wagner CJ, Schultz C, Mall MA. Neutrophil elastase and matrix metalloproteinase 12 in cystic fibrosis lung disease. Mol Cell Pediatr. 2016 Dec;3(1):25. doi: 10.1186/s40348-016-0053-7. Epub 2016 Jul 25. Review. PubMed PMID: 27456476.

 Weidler S, Stopsack KH, Hammermann J, Sommerburg O, Mall MA, Hoffmann GF, Kohlmüller D, Okun JG, Macek M Jr, Votava F, Krulišová V, Balaščaková M, Skalická V, Lee-Kirsch MA, Stopsack M. A product of immunoreactive trypsinogen and pancreatitis-associated protein as second-tier strategy in cystic fibrosis newborn screening. J Cyst Fibros. 2016 Jul 22. pii: S1569-1993(16)30559-8. doi: 10.1016/j.jcf.2016.07.002. [Epub ahead of print] PubMed PMID: 27461140.

New in PubMed from DZL Faculty/ Neu von der DZL-Fakultät in der Woche bis 24. Juli 2016:

Franssen FM, Soriano JB, Roche N, Bloomfield PH, Brusselle G, Fabbri LM, García-Rio F, Kearney MT, Kwon N, Lundbäck B, Rabe KF, Raillard A, Muellerova H,  Cockcroft JR. Lung Function Abnormalities in Smokers With Ischemic Heart Disease. Am J Respir Crit Care Med. 2016 Jul 21. [Epub ahead of print] PubMed PMID: 27442601.

Fritsch K, Mernberger M, Nist A, Stiewe T, Brehm A, Jacob R. Galectin-3 interacts with components of the nuclear ribonucleoprotein complex. BMC Cancer. 2016 Jul 19;16(1):502. doi: 10.1186/s12885 016-2546-0. PubMed PMID: 27435226; PubMed Central PMCID: PMC4952364.

Fritzenwanker M, Hain T, Kesper DA, Harb H, Renz H, Domann E. Draft Genome Sequence and Complete Plasmid Sequence of Acinetobacter lwoffii F78, an Isolate with Strong Allergy-Protective Properties. Genome Announc. 2016 Jul 21;4(4). pii: e00685-16. doi: 10.1128/genomeA.00685-16. PubMed PMID: 27445377; PubMed Central PMCID: PMC4956450.

Hüls A, Krämer U, Gappa M, Müller-Brandes C, Schikowski T, von Berg A, Hoffmann B, Schuster A, Wisbauer M, Flexeder C, Heinrich J, Schulz H, Berdel D. Age Dependency of GLI Reference Values Compared with Paediatric Lung Function Data in Two German Studies (GINIplus and LUNOKID). PLoS One. 2016 Jul 20;11(7):e0159678. doi: 10.1371/journal.pone.0159678. eCollection 2016. PubMed PMID: 27438002.

Karpf S, Eibl M, Sauer B, Reinholz F, Hüttmann G, Huber R. Two-photon microscopy using fiber based nanosecond excitation. Biomed Opt Express. 2016 Jun 1;7(7):2432-40. doi: 10.1364/BOE.7.002432. eCollection 2016 Jul 1. PubMed PMID: 27446680; PubMed Central PMCID: PMC4948604.

Martire A, Bedada FB, Uchida S, Pöling J, Krüger M, Warnecke H, Richter M, Kubin T, Herold S, Braun T. Mesenchymal stem cells attenuate inflammatory processes in the heart and lung via inhibition of TNF signaling. Basic Res Cardiol. 2016 Sep;111(5):54. doi: 10.1007/s00395-016-0573-2. Epub 2016 Jul 19. PubMed PMID: 27435289; PubMed Central PMCID: PMC4951509.

Mijošek V, Lasitschka F, Warth A, Zabeck H, Dalpke AH, Weitnauer M. Endoplasmic Reticulum Stress Is a Danger Signal Promoting Innate Inflammatory Responses in Bronchial Epithelial Cells. J Innate Immun. 2016 Jul 16. [Epub ahead of print] PubMed PMID: 27423489.

Opitz CF, Hoeper MM, Gibbs JS, Kaemmerer H, Pepke-Zaba J, Coghlan JG, Scelsi L, D'Alto M, Olsson KM, Ulrich S, Scholtz W, Schulz U, Grünig E, Vizza CD, Staehler G, Bruch L, Huscher D, Pittrow D, Rosenkranz S. Pre-Capillary, Combined, and Post-Capillary Pulmonary Hypertension: A Pathophysiological Continuum. J Am Coll Cardiol. 2016 Jul 26;68(4):368-78. doi: 10.1016/j.jacc.2016.05.047. PubMed PMID: 27443433.

Radon K, Llanqui U, Arce A, Herrera R, Herbig B, Nowak D, Parra M. Job strain, bullying and violence at work and asthma in Peruvian cleaners – a cross-sectional analysis. J Asthma. 2016 Jul 20:0. [Epub ahead of print] PubMed PMID: 27437609.

Schamberger AC, Schiller HB, Fernandez IE, Sterclova M, Heinzelmann K, Hennen E, Hatz R, Behr J,  Vašáková M, Mann M, Eickelberg O, Staab-Weijnitz CA. Glutathione peroxidase 3 localizes to the  epithelial lining fluid and the extracellular matrix in interstitial lung disease. Sci Rep. 2016 Jul 20;6:29952. doi: 10.1038/srep29952. PubMed PMID: 27435875; PubMed Central PMCID: PMC4951690.

Smirnova NF, Schamberger AC, Nayakanti S, Hatz R, Behr J, Eickelberg O. Detection and quantification of epithelial progenitor cell populations in human healthy and IPF lungs. Respir Res. 2016 Jul 16;17(1):83. doi:10.1186/s12931-016-0404-x. PubMed PMID: 27423691; PubMed Central PMCID: PMC4947297.

Trudzinski FC, Minko P, Rapp D, Fähndrich S, Haake H, Haab M, Bohle RM, Flaig M, Kaestner F, Bals R, Wilkens H, Muellenbach RM, Link A, Groesdonk HV, Lensch C, Langer F, Lepper PM. Runtime and aPTT predict venous thrombosis and thromboembolism in patients on extracorporeal membrane oxygenation: a retrospective analysis. Ann Intensive Care. 2016 Dec;6(1):66. doi: 10.1186/s13613-016-0172-2. Epub 2016 Jul 19. PubMed PMID: 27432243; PubMed Central PMCID: PMC4949188.

Wiskemann J, Hummler S, Diepold C, Keil M, Abel U, Steindorf K, Beckhove P, Ulrich CM, Steins M, Thomas M. POSITIVE study: physical exercise program in non-operable lung cancer patients undergoing palliative treatment. BMC Cancer. 2016 Jul 19;16(1):499. doi: 10.1186/s12885-016 2561 1. PubMed PMID: 27430336; PubMed Central PMCID: PMC4949758.

Doellinger F, Weinheimer O, Zwiener I, Mayer E, Buhl R, Fahlenkamp UL, Dueber C, Achenbach T. Differences of airway dimensions between patients with and without bronchiolitis obliterans syndrome after lung transplantation-Computer-assisted quantification of computed tomography. Eur J Radiol. 2016 Aug;85(8):1414-20. doi: 10.1016/j.ejrad.2016.05.018. Epub 2016 May 26. PubMed PMID: 27423681.

Wang S, Hüttmann G, Rudnitzki F, Diddens-Tschoeke H, Zhang Z, Rahmanzadeh R. Indocyanine green as effective antibody conjugate for intracellular molecular targeted photodynamic therapy. J Biomed Opt. 2016 Jul 1;21(7):78001. doi:10.1117/1.JBO.21.7.078001. PubMed PMID: 27424607.

New in PubMed from DZL Faculty/ Neu von der DZL-Fakultät in der Woche bis 17. Juli 2016:

Meder D, Morales M, Pepperkok R, Schlapbach R, Tiran A, Van Minnebruggen G. Institutional core facilities: prerequisite for breakthroughs in the life sciences: Core facilities play an increasingly important role in biomedical research by providing scientists access to sophisticated technology and expertise. EMBO Rep. 2016 Jul 13. pii: e201642857. [Epub ahead of print] PubMed PMID: 27412771.

von Stackelberg O, Kauczor HU. [Lung cancer screening with thoracic X‑ray and CT : Current situation]. Radiologe. 2016 Jul 13. [Epub ahead of print] German. PubMed PMID: 27411917.

David S, Napp LC, Kühn C, Hoeper MM. [Extracorporeal membrane oxygenation: Principles and medical indications]. Internist (Berl). 2016 Jul 13. [Epub ahead of print] German. PubMed PMID: 27411792.

Kloth C, Berg C, Miller S, Nikolaou K, Schraml C. Abdominelle Tuberkulose mit parenchymatösem und intestinalem Befall. Rofo. 2016 Jul 13. [Epub ahead of print] German. PubMed PMID: 27409060.

Tufman A, Winter H, Kahnert K, Reu S, Müller-Lisse U, Huber RM. A persistent pneumothorax? 5-year follow-up after diagnosis of Swyer-James-MacLeod syndrome. Breathe (Sheff). 2016 Jun;12(2):e55-E58. doi: 10.1183/20734735.000316. PubMed PMID: 27408647; PubMed Central PMCID: PMC4933609.

Meiners S, Hilgendorff A. Early injury of the neonatal lung contributes to premature lung aging: a hypothesis. Mol Cell Pediatr. 2016 Dec;3(1):24. doi: 10.1186/s40348-016-0052-8. Epub 2016 Jul 12. Review. PubMed PMID: 27406259.

Wacker ME, Jörres RA, Karch A, Koch A, Heinrich J, Karrasch S, Schulz H, Peters A, Gläser S, Ewert R, Baumeister SE, Vogelmeier C, Leidl R, Holle R; COSYCONET study group. Relative impact of COPD and comorbidities on generic health-related quality of life: a pooled analysis of the COSYCONET patient cohort and control subjects from the KORA and SHIP studies. Respir Res. 2016 Jul 12;17(1):81. doi: 10.1186/s12931-016-0401-0. PubMed PMID: 27405652; PubMed Central PMCID: PMC4943009.

Kanrai P, Mostafa A, Madhugiri R, Lechner M, Wilk E, Schughart K, Ylösmäki L, Saksela K, Ziebuhr J, Pleschka S. Identification of specific residues in avian influenza A virus NS1 that enhance viral replication and pathogenicity in mammalian systems. J Gen Virol. 2016 Jul 12. doi: 10.1099/jgv.0.000542. [Epub ahead of print] PubMed PMID: 27405649.

Landecy M, Paquette B, Revel L, Behr J, Badet N, Delabrousse E. Does IV contrast extravasation on CT in anticoagulant-related rectus sheath and iliopsoas hematoma predict hematoma expansion and patient outcomes? Abdom Radiol (NY). 2016 Jul 12. [Epub ahead of print] PubMed PMID: 27405643.

Watz H. [Every second smoker shows symptoms despite good pulmonary function]. Dtsch Med Wochenschr. 2016 Jul;141(14):1002. doi: 10.1055/s-0042-108516. Epub 2016 Jul 12. German. PubMed PMID: 27404926.

Donner J, Reck M, Bergmann S, Kirschning A, Müller R, Wagner-Döbler I. The biofilm inhibitor Carolacton inhibits planktonic growth of virulent pneumococci via a conserved target. Sci Rep. 2016 Jul 11;6:29677. doi: 10.1038/srep29677. PubMed PMID: 27404808; PubMed Central PMCID: PMC4939601.

Kretschmer S, Pieper M, Hüttmann G, Bölke T, Wollenberg B, Marsh LM, Garn H, König P. Autofluorescence multiphoton microscopy for visualization of tissue morphology and cellular dynamics in murine and human airways. Lab Invest. 2016 Jul 11. doi: 10.1038/labinvest.2016.69. [Epub ahead of print] PubMed PMID: 27400364.

Kahnert K, Kauffmann-Guerrero D, Huber RM. SCLC-State of the Art and What Does the Future Have in Store? Clin Lung Cancer. 2016 Jun 8. pii: S1525-7304(16)30130-9. doi: 10.1016/j.cllc.2016.05.014. [Epub ahead of print] Review. PubMed PMID: 27397481.

Campo I, Luisetti M, Griese M, Trapnell BC, Bonella F, Grutters JC, Nakata K, Van Moorsel CH, Costabel U, Cottin V, Ichiwata T, Inoue Y, Braschi A, Bonizzoni G, Iotti GA, Tinelli C, Rodi G; WLL International Study Group. A Global Survey on Whole Lung Lavage in Pulmonary Alveolar Proteinosis. Chest. 2016 Jul;150(1):251-3. doi: 10.1016/j.chest.2016.04.030. PubMed PMID: 27396783.

Reinlein C, Damm C, Lange N, Kamm A, Mohaupt M, Brady A, Goy M, Leonhard N, Eberhardt R, Zeitner U, Tünnermann A. Temporally-stable active precision mount for large optics. Opt Express. 2016 Jun 13;24(12):13527-41. doi: 10.1364/OE.24.013527. PubMed PMID: 27410369.

New in PubMed from DZL Faculty/ Neu von der DZL-Fakultät in der Woche bis 10. Juli 2016:

Garn H, Bahn S, Baune BT, Binder EB, Bisgaard H, Chatila TA, Chavakis T, Culmsee C, Dannlowski U, Gay S, Gern J, Haahtela T, Kircher T, Müller-Ladner U, Neurath MF, Preissner KT, Reinhardt C, Rook G, Russell S, Schmeck B, Stappenbeck T, Steinhoff U, van Os J, Weiss S, Zemlin M, Renz H. Current concepts in chronic inflammatory diseases: Interactions between microbes, cellular metabolism, and inflammation. J Allergy Clin Immunol. 2016 Jul;138(1):47-56. doi: 10.1016/j.jaci.2016.02.046. PubMed PMID: 27373325.

Richter MJ, Sommer N, Schermuly R, Grimminger B, Seeger W, Tello K, Ghofrani HA, Gall H. The prognostic impact of thyroid function in pulmonary hypertension. J Heart Lung Transplant. 2016 Jun 3. pii: S1053-2498(16)30162-0. doi: 10.1016/j.healun.2016.05.022. [Epub ahead of print] PubMed PMID: 27373820.

Vogl M, Warnecke G, Haverich A, Gottlieb J, Welte T, Hatz R, Hunger M, Leidl R, Lingner H, Behr J, Winter H, Schramm R, Zwissler B, Hagl C, Strobl N, Jaeger C, Preissler G. Lung transplantation in the spotlight: Reasons for high-cost procedures. J Heart Lung Transplant. 2016 Jun 7. pii: S1053-2498(16)30165-6. doi: 10.1016/j.healun.2016.05.024. [Epub ahead of print] PubMed PMID: 27377220.

Stanke F, Tümmler B. Classification of CFTR mutation classes. Lancet Respir Med. 2016 Jul 1. pii: S2213-2600(16)30147-3. doi: 10.1016/S2213-2600(16)30147-3. [Epub ahead of print] PubMed PMID: 27377412.

Richter MJ, Milger K, Tello K, Stille P, Seeger W, Mayer E, Ghofrani HA, Gall H. Heart rate response during 6-minute walking testing predicts outcome in operable chronic thromboembolic pulmonary hypertension. BMC Pulm Med. 2016 Jul 4;16(1):96. doi: 10.1186/s12890-016-0260-y. PubMed PMID: 27377832; PubMed Central PMCID: PMC4932688.

Kappler M, Nagel F, Feilcke M, Kröner C, Pawlita I, Naehrig S, Ripper J, Hengst M, von Both U, Forstner M, Hector A, Griese M. Eradication of methicillin resistant Staphylococcus aureus detected for the first time in cystic fibrosis: A single center observational study. Pediatr Pulmonol. 2016 Jul 5. doi: 10.1002/ppul.23519. [Epub ahead of print] PubMed PMID: 27378061.

Schaefer MB, Schaefer CA, Schifferings S, Kuhlmann CR, Urban A, Benscheid U, Fischer T, Hecker M, Morty RE, Vadasz I, Herold S, Witzenrath M, Seeger W, Erdogan A, Mayer K. N-3 vs. n-6 fatty acids differentially influence calcium signalling and adhesion of inflammatory activated monocytes: impact of lipid rafts. Inflamm Res. 2016 Jul 6. [Epub ahead of print] PubMed PMID: 27384606.

Rehnitz C, Klaan B, Burkholder I, von Stillfried F, Kauczor HU, Weber MA. Delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) and T(2) mapping at 3T MRI of the wrist: Feasibility and clinical application. J Magn Reson Imaging. 2016 Jul 5. doi: 10.1002/jmri.25371. [Epub ahead of print] PubMed PMID: 27381489.

Marquardt K, Eicher AC, Dobler D, Höfer F, Schmidts T, Schäfer J, Renz H, Runkel F. Degradation and protection of DNAzymes on human skin. Eur J Pharm Biopharm. 2016 Jul 1. pii: S0939-6411(16)30260-0. doi: 10.1016/j.ejpb.2016.07.001. [Epub ahead of print] PubMed PMID: 27378285.

Schnerch J, Prasse A, Vlachakis D, Schuchardt KL, Pechkovsky DV, Goldmann T, Gaede KI, Müller-Quernheim J, Zissel G. Functional TLR9 Expression and CXCR3 Ligand Release in Pulmonary Sarcoidosis. Am J Respir Cell Mol Biol. 2016 Jul 8. [Epub ahead of print] PubMed PMID: 27390897.

Umminger J, Reitz M, Rojas SV, Stiefel P, Shrestha M, Haverich A, Ismail I, Martens A. Does the surgeon's experience have an impact on outcome after total arterial revascularization with composite T-grafts? A risk factor analysis. Interact Cardiovasc Thorac Surg. 2016 Jul 7. pii: ivw207. [Epub ahead of print] PubMed PMID: 27390370.

Hezaveh K, Kloetgen A, Bernhart SH, Mahapatra KD, Lenze D, Richter J, Haake A, Bergmann AK, Brors B, Burkhardt B, Claviez A, Drexler HG, Eils R, Haas S, Hoffmann S, Karsch D, Klapper W, Kleinheinz K, Korbel J, Kretzmer H, Kreuz M, Küppers R, Lawerenz C, Leich E, Loeffler M, Mantovani-Loeffler L, López C, McHardy AC, Möller P, Rohde M, Rosenstiel P, Rosenwald A, Schilhabel M, Schlesner M, Scholz I, Stadler PF, Stilgenbauer S, Sungalee S, Szczepanowski M, Trümper L, Weniger MA, Siebert R, Borkhardt A, Hummel M, Hoell JI. Alterations of miRNAs and miRNA-regulated mRNA expression in GC B cell lymphomas determined by integrative sequencing analysis. Haematologica. 2016 Jul 6. pii: haematol.2016.143891. [Epub ahead of print] PubMed PMID: 27390358.

Tufman A, Huber RM, Völk S, Aigner F, Edelmann M, Gamarra F, Kiefl R, Kahnert K, Tian F, Boulesteix AL, Endres S, Kobold S. Interleukin-22 is elevated in lavage from patients with lung cancer and other pulmonary diseases. BMC Cancer. 2016 Jul 7;16(1):409. PubMed PMID: 27388918; PubMed Central PMCID: PMC4936283.

Biancosino C, Krüger M, Vollmer E, Welker L. Intraoperative fine needle aspirations - diagnosis and typing of lung cancer in small biopsies: challenges and limitations. Diagn Pathol. 2016 Jul 7;11(1):59. PubMed PMID: 27388913; PubMed Central PMCID: PMC4937589.

Karrasch S, Linde K, Rücker G, Sommer H, Karsch-Völk M, Kleijnen J, Jörres RA, Schneider A. Accuracy of FENO for diagnosing asthma: a systematic review. Thorax. 2016 Jul 7. pii: thoraxjnl-2016-208704. doi: 10.1136/thoraxjnl-2016-208704. [Epub ahead of print] PubMed PMID: 27388487.

Dalpke A, Zimmermann S, Schnitzler P. Underdiagnosing of Mycoplasma pneumoniae infections as revealed by use of a respiratory multiplex PCR panel. Diagn Microbiol Infect Dis. 2016 Jun 17. pii: S0732-8893(16)30173-0. doi: 10.1016/j.diagmicrobio.2016.06.013. [Epub ahead of print] PubMed PMID: 27377674.

Usemann J, Fuchs O, Anagnostopoulou P, Korten I, Gorlanova O, Röösli M, Latzin P, Frey U. Predictive value of exhaled nitric oxide in healthy infants for asthma at school age. Eur Respir J. 2016 Jul 7. pii: ERJ-00439-2016. doi: 10.1183/13993003.00439-2016. [Epub ahead of print] PubMed PMID: 27390276.

Scheel AH, Dietel M, Heukamp LC, Jöhrens K, Kirchner T, Reu S, Rüschoff J, Schildhaus HU, Schirmacher P, Tiemann M, Warth A, Weichert W, Fischer RN, Wolf J, Buettner R. Harmonized PD-L1 immunohistochemistry for pulmonary squamous-cell and adenocarcinomas. Mod Pathol. 2016 Jul 8. doi: 10.1038/modpathol.2016.117. [Epub ahead of print] PubMed PMID: 27389313.

Hien TT, Turczyńska KM, Dahan D, Ekman M, Grossi M, Sjögren J, Nilsson J, Braun T, Boettger T, Garcia-Vaz E, Stenkula K, Swärd K, Gomez MF, Albinsson. Elevated Glucose Levels Promote Contractile and Cytoskeletal Gene Expression in Vascular Smooth Muscle via Rho/Protein Kinase C and Actin Polymerization. J Biol Chem. 2016 Feb 12;291(7):3552-68. doi: 10.1074/jbc.M115.654384. Epub 2015 Dec 18

New in PubMed from DZL Faculty/ Neu von der DZL-Fakultät in der Woche bis 03. Juli 2016:

Dalla-Bona AC, Schmehl T, Gessler T, Seeger W, Beck-Broichsitter M. Systematic aging of degradable nanosuspension ameliorates vibrating-mesh nebulizer performance. Drug Dev Ind Pharm. 2015;41(10):1704-9. doi: 10.3109/03639045.2014.993399. Epub 2014 Dec 18. PubMed PMID: 25519975.

Trump S, Bieg M, Gu Z, Thürmann L, Bauer T, Bauer M, Ishaque N, Röder S, Gu L, Herberth G, Lawerenz C, Borte M, Schlesner M, Plass C, Diessl N, Eszlinger M, Mücke O, Elvers HD, Wissenbach DK, von Bergen M, Herrmann C, Weichenhan D, Wright RJ, Lehmann I, Eils R. Prenatal maternal stress and wheeze in children: novel insights into epigenetic regulation. Sci Rep. 2016 Jun 28;6:28616. doi: 10.1038/srep28616. PubMed PMID: 27349968; PubMed Central PMCID: PMC4923849.

Krombach GA. [Imaging signs in chest diagnostics]. Radiologe. 2016 Jul 1. [Epub ahead of print] German. PubMed PMID: 27369549.

Gompelmann D, Herth FJ. [Endoscopic interventions in pulmonology]. Internist (Berl). 2016 Jun 28. [Epub ahead of print] German. PubMed PMID: 27351790.

Colombi D, Ehlers-Tenenbaum S, Palmowski K, Heussel CP, Sverzellati N, Silva M, Eichinger M, Kreuter M. Spontaneous Pneumomediastinum as a Potential Predictor of Mortality in Patients with Idiopathic Pulmonary Fibrosis. Respiration. 2016 Jun 28. [Epub ahead of print] PubMed PMID: 27348534.

Dewi NU, Boshuizen HC, Johansson M, Vineis P, Kampman E, Steffen A, Tjønneland A, Halkjær J, Overvad K, Severi G, Fagherazzi G, Boutron-Ruault MC, Kaaks R, Li K, Boeing H, Trichopoulou A, Bamia C, Klinaki E, Tumino R, Palli D, Mattiello A, Tagliabue G, Peeters PH, Vermeulen R, Weiderpass E, Torhild Gram I, Huerta JM, Agudo A, Sánchez MJ, Ardanaz E, Dorronsoro M, Quirós JR, Sonestedt E, Johansson M, Grankvist K, Key T, Khaw KT, Wareham N, Cross AJ, Norat T, Riboli E, Fanidi A, Muller D, Bueno-de-Mesquita HB. Anthropometry and the Risk of Lung Cancer in EPIC. Am J Epidemiol. 2016 Jul 1. pii: kwv298. [Epub ahead of print] PubMed PMID: 27370791.

Kropp C, Kempf H, Halloin C, Robles-Diaz D, Franke A, Scheper T, Kinast K, Knorpp T, Joos TO, Haverich A, Martin U, Zweigerdt R, Olmer R. Impact of Feeding Strategies on the Scalable Expansion of Human Pluripotent Stem Cells in Single-Use Stirred Tank Bioreactors. Stem Cells Transl Med. 2016 Jul 1. pii: sctm.2015-0253. [Epub ahead of print] PubMed PMID: 27369897.

Bandorski D, Bogossian H, Ecke A, Wiedenroth C, Gruenig E, Benjamin N, Arlt M, Seeger W, Mayer E, Ghofrani A, Hoeltgen R, Gall H. Evaluation of the prognostic value of electrocardiography parameters and heart rhythm in patients with pulmonary hypertension. Cardiol J. 2016 Jul 1. doi: 10.5603/CJ.a2016.0044. [Epub ahead of print] PubMed PMID: 27367480.

Bush A, Barbato A, Clement A, Cunningham S, Blic Jd, Gilbert C, Goldbeck L, Kiper N, Schwerk N, Griese M. European idiopathic pulmonary fibrosis Patient Charter: a missed opportunity. Eur Respir J. 2016 Jul;48(1):282-3. doi: 10.1183/13993003.00505-2016. PubMed PMID: 27365515.

Ziesing S, Suerbaum S, Sedlacek L. Fungal epidemiology and diversity in cystic fibrosis patients over a 5-year period in a national reference center. Med Mycol. 2016 Jun 30. pii: myw035. [Epub ahead of print] PubMed PMID: 27364649.

Schmauck-Gómez JS, Menrath I, Kaiser MM, Herz A, Kopp MV. [Children and Adolescents with Asthma Differ in Lung Function Parameters and Exhaled NO from Children and Adolescents with Obesity]. Klin Padiatr. 2016 Jul;228(4):189-94. doi: 10.1055/s-0042-102254. Epub 2016 Jun 30. German. PubMed PMID: 27362410.

Shahzad T, Radajewski S, Chao CM, Bellusci S, Ehrhardt H. Pathogenesis of bronchopulmonary dysplasia: when inflammation meets organ development. Mol Cell Pediatr. 2016 Dec;3(1):23. doi: 10.1186/s40348-016-0051-9. Epub 2016 Jun 29. Review. PubMed PMID: 27357257.

Dam S, Kracht M, Pleschka S, Schmitz ML. The influenza A virus genotype determines the anti-viral function of NF-κB. J Virol. 2016 Jun 29. pii: JVI.00946-16. [Epub ahead of print] PubMed PMID: 27356900.

Horn L, Reck M, Spigel DR. The Future of Immunotherapy in the Treatment of Small Cell Lung Cancer. Oncologist. 2016 Jun 27. pii: theoncologist.2015-0523. [Epub ahead of print] PubMed PMID: 27354668.

Brinker TJ, Seeger W, Buslaff F. Photoaging Mobile Apps in School-Based Tobacco Prevention: The Mirroring Approach. J Med Internet Res. 2016 Jun 28;18(6):e183. doi: 10.2196/jmir.6016. PubMed PMID: 27352819.

Frixel S, Lotz-Havla AS, Kern S, Kaltenborn E, Wittmann T, Gersting SW, Muntau AC, Zarbock R, Griese M. Homooligomerization of ABCA3 and its functional significance. Int J Mol Med. 2016 Jun 21. doi: 10.3892/ijmm.2016.2650. [Epub ahead of print] PubMed PMID: 27352740.

Gompelmann D, Herth FJ. [Endoscopic interventions in pulmonology]. Internist (Berl). 2016 Jun 28. [Epub ahead of print] German. PubMed PMID: 27351790.

Welte T, Kim IS, Tian L, Gao X, Wang H, Li J, Holdman XB, Herschkowitz JI, Pond A, Xie G, Kurley S, Nguyen T, Liao L, Dobrolecki LE, Pang L, Mo Q, Edwards DP, Huang S, Xin L, Xu J, Li Y, Lewis MT, Wang T, Westbrook TF, Rosen JM, Zhang XH. Erratum: Oncogenic mTOR signalling recruits myeloid-derived suppressor cells to promote tumour initiation. Nat Cell Biol. 2016 Jun 28;18(7):822. doi: 10.1038/ncb3379. PubMed PMID: 27350446.

Richter K, Mathes V, Fronius M, Althaus M, Hecker A, Krasteva-Christ G, Padberg W, Hone AJ, McIntosh JM, Zakrzewicz A, Grau V. Phosphocholine - an agonist of metabotropic but not of ionotropic functions of α9-containing nicotinic acetylcholine receptors. Sci Rep. 2016 Jun 28;6:28660. doi: 10.1038/srep28660. PubMed PMID: 27349288; PubMed Central PMCID: PMC4923896.

Colombi D, Ehlers-Tenenbaum S, Palmowski K, Heussel CP, Sverzellati N, Silva M, Eichinger M, Kreuter M. Spontaneous Pneumomediastinum as a Potential Predictor of Mortality in Patients with Idiopathic Pulmonary Fibrosis. Respiration. 2016 Jun 28. [Epub ahead of print] PubMed PMID: 27348534.

Merkert S, Martin U. Site-Specific Genome Engineering in Human Pluripotent Stem Cells. Int J Mol Sci. 2016 Jun 24;17(7). pii: E1000. doi: 10.3390/ijms17071000. Review. PubMed PMID: 27347935.

Mederos Y Schnitzler M, Storch U, Gudermann T. Mechanosensitive G(q/11)-protein coupled receptors mediate myogenic vasoconstriction. Microcirculation. 2016 Jun 25. doi: 10.1111/micc.12293. [Epub ahead of print] PubMed PMID: 27344060.

Kammerl IE, Meiners S. Proteasome function shapes innate and adaptive immune responses. Am J Physiol Lung Cell Mol Physiol. 2016 Jun 24:ajplung.00156.2016. doi: 10.1152/ajplung.00156.2016. [Epub ahead of print] PubMed PMID: 27343191.

Aho JM, Dietz AB, Radel DJ, Butler GW, Thomas M, Nelson TJ, Carlsen BT, Cassivi SD, Resch ZT, Faubion WA, Wigle DA. Closure of a Recurrent Bronchopleural Fistula Using a Matrix Seeded With Patient-Derived Mesenchymal Stem Cells. Stem Cells Transl Med. 2016 Jun 24. pii: sctm.2016-0078. [Epub ahead of print] PubMed PMID: 27343169.

Bobylev D, Warnecke G, Dennhardt N, Horke A. Giant pleuropulmonary blastoma. Eur J Cardiothorac Surg. 2016 Jun 23. pii: ezw217. [Epub ahead of print] PubMed PMID: 27341849.

Juni 2016

New in PubMed from DZL Faculty/ Neu von der DZL-Fakultät in der Woche bis 26. Juni 2016:

Albarrán-Juárez J, Kaur H, Grimm M, Offermanns S, Wettschureck N. Lineage tracing of cells involved in atherosclerosis. Atherosclerosis. 2016 Jun 11. pii: S0021-9150(16)30257-X. doi: 10.1016/j.atherosclerosis.2016.06.012. [Epub ahead of print] PubMed PMID: 27320174.

Klietz M, Keber U, Carlsson T, Chiu WH, Höglinger GU, Weihe E, Schäfer MK, Depboylu C. l-DOPA-induced dyskinesia is associated with a deficient numerical downregulation of striatal tyrosine hydroxylase mRNA-expressing neurons. Neuroscience. 2016 Jun 16. pii: S0306-4522(16)30247-0. doi: 10.1016/j.neuroscience.2016.06.017. [Epub ahead of print] PubMed PMID: 27320210.

Booth JL, Duggan ES, Patel VI, Langer M, Wu W, Braun A, Coggeshall KM, Metcalf JP. Bacillus anthracis spore movement does not require a carrier cell and is not affected by lethal toxin in human lung models. Microbes Infect. 2016 Jun 16. pii: S1286-4579(16)30073-9. doi: 10.1016/j.micinf.2016.06.004. [Epub ahead of print] PubMed PMID: 27320392.

Baranyi U, Farkas AM, Hock K, Mahr B, Linhart B, Gattringer M, Focke-Tejkl M, Petersen A, Wrba F, Rülicke T, Valenta R, Wekerle T. Cell Therapy for Prophylactic Tolerance in Immunoglobulin E-mediated Allergy. EBioMedicine. 2016 May;7:230-9. doi: 10.1016/j.ebiom.2016.03.028. Epub 2016 Mar 20. PubMed PMID: 27322476; PubMed Central PMCID: PMC4909362.

Quantius J, Schmoldt C, Vazquez-Armendariz AI, Becker C, El Agha E, Wilhelm J, Morty RE, Vadász I, Mayer K, Gattenloehner S, Fink L, Matrosovich M, Li X, Seeger W, Lohmeyer J, Bellusci S, Herold S. Influenza Virus Infects Epithelial Stem/Progenitor Cells of the Distal Lung: Impact on Fgfr2b-Driven Epithelial Repair. PLoS Pathog. 2016 Jun 20;12(6):e1005544. doi: 10.1371/journal.ppat.1005544. eCollection 2016 Jun. PubMed PMID: 27322618.

Bens S, Kolarova J, Beygo J, Buiting K, Caliebe A, Eggermann T, Gillessen-Kaesbach G, Prawitt D, Thiele-Schmitz S, Begemann M, Enklaar T, Gutwein J, Haake A, Paul U, Richter J, Soellner L, Vater I, Monk D, Horsthemke B, Ammerpohl O, Siebert R. Phenotypic spectrum and extent of DNA methylation defects associated with multilocus imprinting disturbances. Epigenomics. 2016 Jun 20. [Epub ahead of print] PubMed PMID: 27323310.

Weckmann M, Schultheiss C, Hollaender A, Bobis I, Rupp J, Kopp MV. Treatment with rhDNase in patients with cystic fibrosis alters in-vitro CHIT-1 activity of isolated leucocytes. Clin Exp Immunol. 2016 Jun 20. doi: 10.1111/cei.12827. [Epub ahead of print] PubMed PMID: 27324468.

Li Y, Siemeni T, Optenhoefel J, Martens A, Boethig D, Haverich A, Shrestha M. Pressure level required during prolonged cerebral perfusion time has no impact on neurological outcome: a propensity score analysis of 800 patients undergoing selective antegrade cerebral perfusion. Interact Cardiovasc Thorac Surg. 2016 Jun 19. pii: ivw199. [Epub ahead of print] PubMed PMID: 27324731.

Stahl M, Holfelder C, Kneppo C, Kieser M, Kasperk C, Schoenau E, Sommerburg O, Tönshoff B. Multiple prevalent fractures in relation to macroscopic bone architecture in patients with cystic fibrosis. J Cyst Fibros. 2016 Jun 17. pii: S1569-1993(16)30547-1. doi: 10.1016/j.jcf.2016.06.004. [Epub ahead of print] PubMed PMID: 27324551.

Cherian AV, Fukuda R, Augustine SM, Maischein HM, Stainier DY. N-cadherin relocalization during cardiac trabeculation. Proc Natl Acad Sci U S A. 2016 Jun 23. pii: 201606385. [Epub ahead of print] PubMed PMID: 27339140.

Papaioannou AI, Kostikas K, Manali ED, Papadaki G, Roussou A, Spathis A, Mazioti A, Tomos I, Papanikolaou I, Loukides S, Chainis K, Karakitsos P, Griese M, Papiris S. Serum Levels of Surfactant Proteins in Patients with Combined Pulmonary Fibrosis and Emphysema (CPFE). PLoS One. 2016 Jun 23;11(6):e0157789. doi: 10.1371/journal.pone.0157789. eCollection 2016. PubMed PMID: 27337142.

Warnecke G. Ex Vivo Treatment. Transplantation. 2016 Jul;100(7):1400-1. doi: 10.1097/TP.0000000000001182. PubMed PMID: 27331360.

Chen S, Yin R, Mutze K, Yu Y, Takenaka S, Königshoff M, Stoeger T. No involvement of alveolar macrophages in the initiation of carbon nanoparticle induced acute lung inflammation in mice. Part Fibre Toxicol. 2016 Jun 21;13(1):33. doi: 10.1186/s12989-016-0144-6. PubMed PMID: 27328634; PubMed Central PMCID: PMC4915176.

Kolb C, Wetscherek A, Buzan MT, Werner R, Rank CM, Kachelrie M, Kreuter M, Dinkel J, Heuel CP, Maier-Hein K. Regional Lung Ventilation Analysis Using Temporally Resolved Magnetic Resonance Imaging. J Comput Assist Tomogr. 2016 Jun 22. [Epub ahead of print] PubMed PMID: 27331925.

Shostak A, Ruppert B, Ha N, Bruns P, Toprak UH; ICGC MMML-Seq Project, Eils R, Schlesner M, Diernfellner A, Brunner M. MYC/MIZ1-dependent gene repression inversely coordinates the circadian clock with cell cycle and proliferation. Nat Commun. 2016 Jun 24;7:11807. doi: 10.1038/ncomms11807. PubMed PMID: 27339797.

Mendler L, Braun T, Müller S. The Ubiquitin-Like SUMO System and Heart Function: From Development to Disease. Circ Res. 2016 Jan 8;118(1):132-44. doi: 10.1161/CIRCRESAHA.115.307730. Review. PubMed PMID: 26837744.

Bergmann O, Braun T. Caught Red-Handed: Cycling Cardiomyocytes. Circ Res. 2016 Jan 8;118(1):3-5. doi: 10.1161/CIRCRESAHA.115.307936. PubMed PMID: 26837736.

New in PubMed from DZL Faculty/ Neu von der DZL-Fakultät in der Woche bis 19. Juni 2016:

Fleischmann C, Hartmann M, Hartog CS, Welte T, Heublein S, Thomas-Rueddel D, Dennler U, Reinhart K. Epidemiology of Sepsis in Germany: Incidence, Mortality And Associated Costs of Care 2007-2013. Intensive Care Med Exp. 2015 Dec;3(Suppl 1):A50. doi: 10.1186/2197-425X-3-S1-A50. PubMed PMID: 27290058.

Housley MP, Njaine B, Ricciardi F, Stone OA, Hölper S, Krüger M, Kostin S, Stainier DY. Cavin4b/Murcb Is Required for Skeletal Muscle Development and Function in Zebrafish. PLoS Genet. 2016 Jun 13;12(6):e1006099. doi: 10.1371/journal.pgen.1006099. eCollection 2016 Jun. PubMed PMID: 27294373.

Socinski MA, Obasaju C, Gandara D, Hirsch FR, Bonomi P, Bunn P, Kim ES, Langer CJ, Natale RB, Novello S, Paz-Ares L, Pérol M, Reck M, Ramalingam SS, Reynolds CH, Spigel DR, Stinchcombe TE, Wakelee H, Mayo C, Thatcher N. Clinicopathologic features of advanced squamous non-small cell lung cancer. J Thorac Oncol. 2016 Jun 10. pii: S1556-0864(16)30499-3. doi: 10.1016/j.jtho.2016.05.024. [Epub ahead of print] Review. PubMed PMID: 27296106.

Fuchs SI, Schwerk N, Pittschieler K, Ahrens F, Baden W, Bals R, Fähndrich S, Gleiber W, Griese M, Hülskamp G, Köhnlein T, Reckling L, Rietschel E, Staab D, Gappa M. Lung clearance index for monitoring early lung disease in alpha-1-antitrypsin deficiency. Respir Med. 2016 Jul;116:93-9. doi: 10.1016/j.rmed.2016.04.015. Epub 2016 Apr 27. PubMed PMID: 27296827.

Robles EF, Mena-Varas M, Barrio L, Merino-Cortes SV, Balogh P, Du MQ, Akasaka T, Parker A, Roa S, Panizo C, Martin-Guerrero I, Siebert R, Segura V, Agirre X, Macri-Pellizeri L, Aldaz B, Vilas-Zornoza A, Zhang S, Moody S, Calasanz MJ, Tousseyn T, Broccardo C, Brousset P, Campos-Sanchez E, Cobaleda C, Sanchez-Garcia I, Fernandez-Luna JL, Garcia-Muñoz R, Pena E, Bellosillo B, Salar A, Baptista MJ, Hernandez-Rivas JM, Gonzalez M, Terol MJ, Climent J, Ferrandez A, Sagaert X, Melnick AM, Prosper F, Oscier DG, Carrasco YR, Dyer MJ, Martinez-Climent JA. Homeobox NKX2-3 promotes marginal-zone lymphomagenesis by activating B-cell receptor signalling and shaping lymphocyte dynamics. Nat Commun. 2016 Jun 14;7:11889. doi: 10.1038/ncomms11889. PubMed PMID: 27297662.

Collard HR, Ryerson CJ, Corte TJ, Jenkins G, Kondoh Y, Lederer DJ, Lee JS, Maher TM, Wells AU, Antoniou KM, Behr J, Brown KK, Cottin V, Flaherty KR, Fukuoka J, Hansell DM, Johkoh T, Kaminski N, Kim DS, Kolb M, Lynch DA, Myers JL, Raghu G, Richeldi L, Taniguchi H, Martinez FJ. Acute Exacerbation of Idiopathic Pulmonary Fibrosis: An International Working Group Report. Am J Respir Crit Care Med. 2016 Jun 14. [Epub ahead of print] PubMed PMID: 27299520.

Jiang D, Muschhammer J, Qi Y, Kügler A, de Vries JC, Saffarzadeh M, Sindrilaru A, Vander Beken S, Wlaschek M, Kluth MA, Ganss C, Frank NY, Frank MH, Preissner KT, Scharffetter-Kochanek K. Suppression of Neutrophil-Mediated Tissue Damage - A Novel Skill of Mesenchymal Stem Cells. Stem Cells. 2016 Jun 14. doi: 10.1002/stem.2417. [Epub ahead of print] PubMed PMID: 27299700.

Staab-Weijnitz CA, Eickelberg O. Repositioning compounds from cancer drug discovery to IPF: PI3K inhibition. Thorax. 2016 Jun 15. pii: thoraxjnl-2016-208680. doi: 10.1136/thoraxjnl-2016-208680. [Epub ahead of print] PubMed PMID: 27307018.

de Jong SE, Selman MH, Adegnika AA, Amoah AS, van Riet E, Kruize YC, Raynes JG, Rodriguez A, Boakye D, von Mutius E, Knulst AC, Genuneit J, Cooper PJ, Hokke CH, Wuhrer M, Yazdanbakhsh M. IgG1 Fc N-glycan galactosylation as a biomarker for immune activation. Sci Rep. 2016 Jun 16;6:28207. doi: 10.1038/srep28207. PubMed PMID: 27306703; PubMed Central PMCID: PMC4910062.

Boeselt T, Spielmanns M, Nell C, Storre JH, Windisch W, Magerhans L, Beutel B, Kenn K, Greulich T, Alter P, Vogelmeier C, Koczulla AR. Validity and Usability of Physical Activity Monitoring in Patients with Chronic Obstructive Pulmonary Disease (COPD). PLoS One. 2016 Jun 15;11(6):e0157229. doi: 10.1371/journal.pone.0157229. eCollection 2016. PubMed PMID: 27305105.

Högner K, Wolff T, Pleschka S, Plog S, Gruber AD, Kalinke U, Walmrath HD, Bodner J, Gattenlöhner S, Lewe-Schlosser P, Matrosovich M, Seeger W, Lohmeyer J, Herold S. Correction: Macrophage-expressed IFN-β Contributes to Apoptotic Alveolar Epithelial Cell Injury in Severe Influenza Virus Pneumonia. PLoS Pathog. 2016 Jun 15;12(6):e1005716. doi: 10.1371/journal.ppat.1005716. eCollection 2016 Jun. PubMed PMID: 27304804.

Watz H, Mailänder C, Baier M, Kirsten A. Effects of indacaterol/glycopyrronium (QVA149) on lung hyperinflation and physical activity in patients with moderate to severe COPD: a randomised, placebo-controlled, crossover study (The MOVE Study). BMC Pulm Med. 2016 Jun 14;16(1):95. doi: 10.1186/s12890-016-0256-7. PubMed PMID: 27301417; PubMed Central PMCID: PMC4908762.

Krause L, Mourantchanian V, Brockow K, Theis FJ, Schmidt-Weber CB, Knapp B, Mueller NS, Eyerich S. A computational model to predict severity of atopic eczema from 30 serum proteins. J Allergy Clin Immunol. 2016 May 13. pii: S0091-6749(16)30279-2. doi: 10.1016/j.jaci.2016.04.018. [Epub ahead of print] PubMed PMID: 27315765.

Tenekeci U, Poppe M, Beuerlein K, Buro C, Müller H, Weiser H, Kettner-Buhrow D, Porada K, Newel D, Xu M, Chen ZJ, Busch J, Schmitz ML, Kracht M. K63-Ubiquitylation and TRAF6 Pathways Regulate Mammalian P-Body Formation and mRNA Decapping. Mol Cell. 2016 Jun 16;62(6):943-57. doi: 10.1016/j.molcel.2016.05.017. PubMed PMID: 27315556.

Csernus R, Grigaliunas G, Zabeck H, Sumkauskaite M, Gődény M, Radeleff B, Kauczor HU, Heußel CP. [Solitary pulmonary nodule in a patient with osteosarcoma of the right humerus]. Med Klin Intensivmed Notfmed. 2016 Jun 17. [Epub ahead of print] German. PubMed PMID: 27315069.

Arbore G, West EE, Spolski R, Robertson AA, Klos A, Rheinheimer C, Dutow P, Woodruff TM, Yu ZX, O'Neill LA, Coll RC, Sher A, Leonard WJ, Köhl J, Monk P, Cooper MA, Arno M, Afzali B, Lachmann HJ, Cope AP, Mayer-Barber KD, Kemper C. T helper 1 immunity requires complement-driven NLRP3 inflammasome activity in CD4⁺ T cells. Science. 2016 Jun 17;352(6292):aad1210. doi: 10.1126/science.aad1210. PubMed PMID: 27313051.

Bilgin M, Born P, Fezza F, Heimes M, Mastrangelo N, Wagner N, Schultz C, Maccarrone M, Eaton S, Nadler A, Wilm M, Shevchenko A. Lipid Discovery by Combinatorial Screening and Untargeted LC-MS/MS. Sci Rep. 2016 Jun 17;6:27920. doi: 10.1038/srep27920. PubMed PMID: 27312775.

Hoefflin R, Lahrmann B, Warsow G, Hübschmann D, Spath C, Walter B, Chen X, Hofer L, Macher-Goeppinger S, Tolstov Y, Korzeniewski N, Duensing A, Grüllich C, Jäger D, Perner S, Schönberg G, Nyarangi-Dix J, Isaac S, Hatiboglu G, Teber D, Hadaschik B, Pahernik S, Roth W, Eils R, Schlesner M, Sültmann H, Hohenfellner M, Grabe N, Duensing S. Spatial niche formation but not malignant progression is a driving force for intratumoural heterogeneity. Nat Commun. 2016 Jun 13;7:ncomms11845. doi: 10.1038/ncomms11845. PubMed PMID: 27291893.

Kraut B, Maier HJ, Kókai E, Fiedler K, Boettger T, Illing A, Kostin S, Walther P, Braun T, Wirth T. Cardiac-Specific Activation of IKK2 Leads to Defects in Heart Development and Embryonic Lethality. PLoS One. 2015 Nov 5;10(11):e0141591. doi: 10.1371/journal.pone.0141591. eCollection 2015.

New in PubMed from DZL Faculty/ Neu von der DZL-Fakultät in der Woche bis 12. Juni 2016:

Ghofrani HA, Humbert M, Langleben D, Schermuly R, Stasch JP, Wilkins MR, Klinger JR. Riociguat: Mode of action and clinical development in pulmonary hypertension. Chest. 2016 Jun 2. pii: S0012-3692(16)49111-7. doi: 10.1016/j.chest.2016.05.024. [Epub ahead of print] Review. PubMed PMID: 27263466.

Frenz T, Grabski E, Buschjäger D, Vaas LA, Burgdorf N, Schmidt RE, Witte T, Kalinke U. CD4(+) T cells in patients with chronic inflammatory rheumatic disorders show distinct levels of exhaustion. J Allergy Clin Immunol. 2016 Jun 2. pii: S0091-6749(16)30250-0. doi: 10.1016/j.jaci.2016.04.013. [Epub ahead of print] PubMed PMID: 27264455.

Brenner DR, Brennan P, Boffetta P, Amos CI, Spitz MR, Chen C, Goodman G, Heinrich J, Bickeböller H, Rosenberger A, Risch A, Muley T, McLaughlin JR, Benhamou S, Bouchardy C, Lewinger JP, Witte JS, Chen G, Bull S, Hung RJ. Erratum to: Hierarchical modeling identifies novel lung cancer susceptibility variants in inflammation pathways among 10,140 cases and 11,012 controls. Hum Genet. 2016 Jun 6. [Epub ahead of print] PubMed PMID: 27264937.

Mainz JG, Schumacher U, Schädlich K, Hentschel J, Koitschev C, Koitschev A, Riethmüller J, Prenzel F, Sommerburg O, Wiedemann B, Staab D, Gleiber W, Fischer R, Beck JF, Arnold C; Cooperators. Sino nasal inhalation of isotonic versus hypertonic saline (6.0%) in CF patients with chronic rhinosinusitis - Results of a multicenter, prospective, randomized, double-blind, controlled trial. J Cyst Fibros. 2016 Jun 4. pii: S1569-1993(16)30052-2. doi: 10.1016/j.jcf.2016.05.003. [Epub ahead of print] PubMed PMID: 27267518.

Siemeni T, Knöfel AK, Madrahimov N, Sommer W, Avsar M, Salman J, Ius F, Frank N, Büchler G, Jonigk D, Jansson K, Maus U, Tudorache I, Falk CS, Haverich A, Warnecke G. In vivo development of transplant arteriosclerosis in humanized mice reflects alloantigen recognition and peripheral Treg phenotype of lung transplant recipients. Am J Transplant. 2016 Jun 7. doi: 10.1111/ajt.13905. [Epub ahead of print] PubMed PMID: 27273729.

Pinkenburg O, Meyer T, Bannert N, Norley S, Bolte K, Czudai-Matwich V, Herold S, Gessner A, Schnare M. The Human Antimicrobial Protein Bactericidal/Permeability-Increasing Protein (BPI) Inhibits the Infectivity of Influenza A Virus. PLoS One. 2016 Jun 6;11(6):e0156929. doi: 10.1371/journal.pone.0156929. eCollection 2016. PubMed PMID: 27273104.

Schmidt JJ, Bode-Böger SM, Wilhelmi M, Omar M, Martens-Lobenhoffer J, Welte T, Kielstein JT. Pharmacokinetics and total removal of fosfomycin in two patients undergoing intermittent haemodialysis and extended dialysis: prescription needs to avoid under-dosing. J Antimicrob Chemother. 2016 Jun 5. pii: dkw187. [Epub ahead of print] PubMed PMID: 27272722.

Vachiéry JL, Hoeper MM, Peacock AJ, Sitbon O, Cheli M, Church C, Olsson KM, Palazzini M, Waterhouse B, Langley J, Galié N. Ambrisentan use for pulmonary arterial hypertension in a post-authorization drug registry: The VOLibris Tracking Study. J Heart Lung Transplant. 2016 May 6. pii: S1053-2498(16)30117-6. doi: 10.1016/j.healun.2016.04.013. [Epub ahead of print] PubMed PMID: 27282418.

Greulich T, Nell C, Herr C, Vogelmeier C, Kotke V, Wiedmann S, Wencker M, Bals R, Koczulla AR. Results from a large targeted screening program for alpha-1-antitrypsin deficiency: 2003 - 2015. Orphanet J Rare Dis. 2016 Jun 10;11(1):75. doi: 10.1186/s13023-016-0453-8. PubMed PMID: 27282198; PubMed Central PMCID: PMC4901499.

Praveen P, Hülsmann H, Sültmann H, Kuner R, Fröhlich H. Cross-talk between AMPK and EGFR dependent Signaling in Non-Small Cell Lung Cancer. Sci Rep. 2016 Jun 9;6:27514. doi: 10.1038/srep27514. PubMed PMID: 27279498.

Grigaliūnas G, Csernus R, Op den Winkel J, Herth F, Dienemann H, Kauczor HU, Heußel CP. [A man who was sick of being sick]. Med Klin Intensivmed Notfmed. 2016 Jun 9. [Epub ahead of print] German. PubMed PMID: 27279377.

Cillóniz C, Torres A, Niederman M, van der Eerden M, Chalmers J, Welte T, Blasi F. Community-acquired pneumonia related to intracellular pathogens. Intensive Care Med. 2016 Jun 8. [Epub ahead of print] Review. PubMed PMID: 27276986.

Matricardi PM, Kleine-Tebbe J, Hoffmann HJ, Valenta R, Hilger C, Hofmaier S, Aalberse RC, Agache I, Asero R, Ballmer-Weber B, Barber D, Beyer K, Biedermann T, Bilò MB, Blank S, Bohle B, Bosshard PP, Breiteneder H, Brough HA, Caraballo L, Caubet JC, Crameri R, Davies JM, Douladiris N, Ebisawa M, EIgenmann PA, Fernandez-Rivas M, Ferreira F, Gadermaier G, Glatz M, Hamilton RG, Hawranek T, Hellings P, Hoffmann-Sommergruber K, Jakob T, Jappe U, Jutel M, Kamath SD, Knol EF, Korosec P, Kuehn A, Lack G, Lopata AL, Mäkelä M, Morisset M, Niederberger V, Nowak-Węgrzyn AH, Papadopoulos NG, Pastorello EA, Pauli G, Platts-Mills T, Posa D, Poulsen LK, Raulf M, Sastre J, Scala E, Schmid JM, Schmid-Grendelmeier P, van Hage M, van Ree R, Vieths S, Weber R, Wickman M, Muraro A, Ollert M. EAACI Molecular Allergology User's Guide. Pediatr Allergy Immunol. 2016 May;27 Suppl 23:1-250. doi: 10.1111/pai.12563. PubMed PMID: 27288833.

Hagner S, Rask C, Brimnes J, Andersen PS, Raifer H, Renz H, Garn H. House Dust Mite-Specific Sublingual Immunotherapy Prevents the Development of Allergic Inflammation in a Mouse Model of Experimental Asthma. Int Arch Allergy Immunol. 2016 Jun 9;170(1):22-34. [Epub ahead of print] PubMed PMID: 27287860.

Brandes RP, Harenkamp S, Schürmann C, Josipovic I, Rashid B, Rezende F, Löwe O, Moll F, Epah J, Eresch J, Nayak A, Kopaliani I, Penski C, Mittelbronn M, Weissmann N, Schröder K. The Cytosolic NADPH Oxidase Subunit NoxO1 Promotes an Endothelial Stalk Cell Phenotype. Arterioscler Thromb Vasc Biol. 2016 Jun 9. pii: ATVBAHA.116.307132. [Epub ahead of print] PubMed PMID: 27283741.

Santoso S, Wihadmadyatami H, Bakchoul T, Werth S, Al-Fakhri N, Bein G, Kiefel V, Zhu J, Newman PJ, Bayat B, Sachs UJ. Antiendothelial αvβ3 Antibodies Are a Major Cause of Intracranial Bleeding in Fetal/Neonatal Alloimmune Thrombocytopenia. Arterioscler Thromb Vasc Biol. 2016 Jun 9. pii: ATVBAHA.116.307281. [Epub ahead of print] PubMed PMID: 27283740.

Izykowski N, Kuehnel M, Hussein K, Mitschke K, Gunn M, Janciauskiene S, Haverich A, Warnecke G, Laenger F, Maus U, Jonigk D. Organizing pneumonia in mice and men. J Transl Med. 2016 Jun 10;14(1):169. doi: 10.1186/s12967-016-0933-6. PubMed PMID: 27282780; PubMed Central PMCID: PMC4901413.

Aliberti S, Masefield S, Polverino E, De Soyza A, Loebinger MR, Menendez R, Ringshausen FC, Vendrell M, Powell P, Chalmers JD; on behalf of the EMBARC Study Group. Research priorities in bronchiectasis: a consensus statement from the EMBARC Clinical Research Collaboration. Eur Respir J. 2016 Jun 10. pii: ERJ-01888-2015. doi: 10.1183/13993003.01888-2015. [Epub ahead of print] PubMed PMID: 27288031.

New in PubMed from DZL Faculty/ Neu von der DZL-Fakultät in der Woche bis 05. Juni 2016:

Barckhausen C, Rice B, Baila S, Sensebé L, Schrezenmeier H, Nold P, Hackstein H, Rojewski MT. GMP-Compliant Expansion of Clinical-Grade Human Mesenchymal Stromal/Stem Cells Using a Closed Hollow Fiber Bioreactor. Methods Mol Biol. 2016;1416:389-412. doi: 10.1007/978-1-4939-3584-0_23. PubMed PMID: 27236685.

Baum C, Ojeda FM, Wild PS, Rzayeva N, Zeller T, Sinning CR, Pfeiffer N, Beutel M, Blettner M, Lackner KJ, Blankenberg S, Münzel T, Rabe KF, Schnabel RB; Gutenberg Health Study investigators. Subclinical impairment of lung function is related to mild cardiac dysfunction and manifest heart failure in the general population. Int J Cardiol. 2016 May 14;218:298-304. doi: 10.1016/j.ijcard.2016.05.034. [Epub ahead of print] PubMed PMID: 27240155.

Bahmer T, Kirsten AM, Waschki B, Rabe KF, Magnussen H, Kirsten D, Gramm M, Hummler S, Brunnemer E, Kreuter M, Watz H. Clinical Correlates of Reduced Physical Activity in Idiopathic Pulmonary Fibrosis. Respiration. 2016 Jun 1. [Epub ahead of print] PubMed PMID: 27240427.

Henkenberens C, Zinne N, Biancosino C, Höffler K, Schmitto JD, Bremer M, Haverich A, Krüger M. A new era of thoracic oncology? Ex-vivo stereotactic ablative radiosurgery within Ex-vivo Lung Treatment System as a hybrid therapy for unresectable locally advanced pulmonary malignancies. Med Hypotheses. 2016 Jul;92:31-4. doi: 10.1016/j.mehy.2016.04.029. Epub 2016 Apr 16. PubMed PMID: 27241251.

Kramm T, Guth S, Wiedenroth CB, Ghofrani HA, Mayer E. [Treatment of acute and chronic right ventricular failure]. Med Klin Intensivmed Notfmed. 2016 May 30. [Epub ahead of print] German. PubMed PMID: 27241776.

Risch M, Risch L, Purde MT, Renz H, Ambühl P, Szucs T, Tomonaga Y. Association of the cystatin C/creatinine ratio with the renally cleared hormones parathyroid hormone (PTH) and brain natriuretic peptide (BNP) in primary care patients: a cross-sectional study. Scand J Clin Lab Invest. 2016 May 31:1-7. [Epub ahead of print] PubMed PMID: 27242017.

Gompelmann D, Hofbauer T, Gerovasili V, Eberhardt R, Lim HJ, Herth F, Heussel CP. Predictors of clinical outcome in emphysema patients with atelectasis following endoscopic valve therapy: A retrospective study. Respirology. 2016 Jun 1. doi: 10.1111/resp.12819. [Epub ahead of print] PubMed PMID: 27250924.

Glanville AR, Hoeper MM. Don't Let (Dl)CO Be Misunderstood. Am J Respir Crit Care Med. 2016 Jun 1;193(11):1200-1. doi: 10.1164/rccm.201601-0079ED. PubMed PMID: 27248589.

Kwon HB, Wang S, Helker CS, Rasouli SJ, Maischein HM, Offermanns S, Herzog W, Stainier DY. In vivo modulation of endothelial polarization by Apelin receptor signalling. Nat Commun. 2016 Jun 1;7:11805. doi: 10.1038/ncomms11805. PubMed PMID: 27248505.

Chelladurai P, Seeger W, Pullamsetti SS. Epigenetic mechanisms in pulmonary arterial hypertension: the need for global perspectives. Eur Respir Rev. 2016 Jun;25(140):135-40. doi: 10.1183/16000617.0036-2016. PubMed PMID: 27246590.

Wang S, Hüttmann G, Scholzen T, Zhang Z, Vogel A, Hasan T, Rahmanzadeh R. A light-controlled switch after dual targeting of proliferating tumor cells via the membrane receptor EGFR and the nuclear protein Ki-67. Sci Rep. 2016 Jun 1;6:27032. doi: 10.1038/srep27032. PubMed PMID: 27246531.

Börger AK, Eicke D, Wolf C, Gras C, Aufderbeck S, Schulze K, Engels L, Eiz-Vesper B, Schambach A, Guzman CA, Lachmann N, Moritz T, Martin U, Blasczyk R, Figueiredo C. Generation of HLA-universal iPSCs-derived megakaryocytes and platelets for survival under refractoriness conditions. Mol Med. 2016 May 6;22. doi: 10.2119/molmed.2015.00235. [Epub ahead of print] PubMed PMID: 27262025.

Afshar-Oromieh A, Hetzheim H, Kübler W, Kratochwil C, Giesel FL, Hope TA, Eder M, Eisenhut M, Kopka K, Haberkorn U. Radiation dosimetry of (68)Ga-PSMA-11 (HBED-CC) and preliminary evaluation of optimal imaging timing. Eur J Nucl Med Mol Imaging. 2016 Jun 3. [Epub ahead of print] PubMed PMID: 27260521.

Reinmuth N, Reck M. Immunotherapy for Lung Cancer. Oncol Res Treat. 2016;39(6):360-8. doi: 10.1159/000446726. Epub 2016 May 25. PubMed PMID: 27259861.

Behrsing H, Raabe H, Manuppello J, Bombick B, Curren R, Sullivan K, Sethi S, Phipps R, Tesfaigzi Y, Yan S, D'Ruiz C, Tarran R, Constant S, Phillips G, Gaça M, Hayden P, Cao X, Mathis C, Hoeng J, Braun A, Hill E. Assessment of in vitro COPD models for tobacco regulatory science: Workshop proceedings, conclusions and paths forward for in vitro model use. Altern Lab Anim. 2016 May;44(2):129-66. PubMed PMID: 27256455.

Lueer K, Biller H, Casper A, Windt H, Mueller M, Badorrek P, Haefner D, Framke T, Koch A, Ziehr H, Krug N, Koch W, Hohlfeld JM. Safety, efficacy and repeatability of a novel house dust mite allergen challenge technique in the Fraunhofer Allergen Challenge Chamber. Allergy. 2016 Jun 3. doi: 10.1111/all.12947. [Epub ahead of print] PubMed PMID: 27255590.

Smits HH, van der Vlugt LE, von Mutius E, Hiemstra PS. Childhood allergies and asthma: New insights on environmental exposures and local immunity at the lung barrier. Curr Opin Immunol. 2016 May 30;42:41-47. doi: 10.1016/j.coi.2016.05.009. [Epub ahead of print] Review. PubMed PMID: 27254380.

Paprottka KJ, Lehner S, Fendler WP, Ilhan H, Rominger A, Sommer W, Clevert DA, Op den Winkel M, Heinemann V, Paprottka PM. Reduced peri-procedural analgesia following replacement of water for injection (WFI) with glucose 5% (G5) solution as the infusion medium for 90 yttrium resin microspheres. J Nucl Med. 2016 Jun 3. pii: jnumed.115.170779. [Epub ahead of print] PubMed PMID: 27261516.

Wehler P, Niopek D, Eils R, Di Ventura B. Optogenetic Control of Nuclear Protein Import in Living Cells Using Light-Inducible Nuclear Localization Signals (LINuS). Curr Protoc Chem Biol. 2016 Jun 2;8(2):131-45. doi: 10.1002/cpch.4. PubMed PMID: 27258691.

Singh I, Ozturk N, Cordero J, Mehta A, Hasan D, Cosentino C, Sebastian C, Krüger M, Looso M, Carraro G, Bellusci S, Seeger W, Braun T, Mostoslavsky R, Barreto G. High mobility group protein-mediated transcription requires DNA damage marker γ-H2AX. Cell Res. 2015 Jul;25(7):837-50. doi: 10.1038/cr.2015.67. Epub 2015 Jun 5.

Mai 2016

New in PubMed from DZL Faculty/ Neu von der DZL-Fakultät in der Woche bis 29. Mai 2016:

Grimminger J, Ghofrani HA, Weissmann N, Klose H, Grimminger F. COPD-associated pulmonary hypertension: clinical implications and current methods for treatment. Expert Rev Respir Med. 2016 May 21. [Epub ahead of print] PubMed PMID: 27212458.

Rademacher J, Ringshausen FC, Suhling H, Fuge J, Marsch G, Warnecke G, Haverich A, Welte T, Gottlieb J. Lung transplantation for non-cystic fibrosis bronchiectasis. Respir Med. 2016 Jun;115:60-5. doi: 10.1016/j.rmed.2016.04.007. Epub 2016 Apr 20. PubMed PMID: 27215505.

Hicks KA, Yuen ME, Zhen WF, Gerwig TJ, Story RW, Kopp M, Snider MJ. Structural and Biochemical Characterization of 6-Hydroxynicotinic Acid 3-Monooxygenase, a Novel Decarboxylative Hydroxylase Involved in Aerobic Nicotinate Degradation. Biochemistry. 2016 May 24. [Epub ahead of print] PubMed PMID: 27218267.

Nardiello C, Morty RE. MicroRNA in late lung development and bronchopulmonary dysplasia: the need to demonstrate causality. Mol Cell Pediatr. 2016 Dec;3(1):19. doi: 10.1186/s40348-016-0047-5. Epub 2016 May 23. Review. PubMed PMID: 27216745.

Hackstein H, Tschipakow I, Bein G, Nold P, Brendel C, Baal N. Contact-dependent abrogation of bone marrow-derived plasmacytoid dendritic cell differentiation by murine mesenchymal stem cells. Biochem Biophys Res Commun. 2016 May 24. pii: S0006-291X(16)30816-6. doi: 10.1016/j.bbrc.2016.05.108. [Epub ahead of print] PubMed PMID: 27233615.

Le Reste JY, Nabbe P, Lazic D, Assenova R, Lingner H, Czachowski S, Argyriadou S, Sowinska A, Lygidakis C, Doerr C, Claveria A, Le Floch B, Derriennic J, Van Marwijk H, Van Royen P. How do general practitioners recognize the definition of multimorbidity? A European qualitative study. Eur J Gen Pract. 2016 May 27:1-10. [Epub ahead of print] PubMed PMID: 27232846.

Liu XQ, Kiefl R, Roskopf C, Tian F, Huber RM. Interactions among Lung Cancer Cells, Fibroblasts, and Macrophages in 3D Co-Cultures and the Impact on MMP-1 and VEGF Expression. PLoS One. 2016 May 27;11(5):e0156268. doi: 10.1371/journal.pone.0156268. eCollection 2016. PubMed PMID: 27232698.

Tischer C, Weikl F, Probst AJ, Standl M, Heinrich J, Pritsch K. Urban Dust Microbiome: Impact on Later Atopy and Wheezing. Environ Health Perspect. 2016 May 27. [Epub ahead of print] PubMed PMID: 27232328.

Krüger M, Zinne N, Biancosino C, Höffler K, Rajab TK, Waldmann KH, Jonigk D, Avsar M, Haverich A, Hoeltig D. Porcine pulmonary auto-transplantation for ex vivo therapy as a model for new treatment strategies. Interact Cardiovasc Thorac Surg. 2016 May 26. pii: ivw160. [Epub ahead of print] PubMed PMID: 27230537.

Subramanian DR, Gupta S, Burggraf D, Vom Silberberg SJ, Heimbeck I, Heiss-Neumann MS, Haeussinger K, Newby C, Hargadon B, Raj V, Singh D, Kolsum U, Hofer TP, Al-Shair K, Luetzen N, Prasse A, Müller-Quernheim J, Benea G, Leprotti S, Boschetto P, Gorecka D, Nowinski A, Oniszh K, Castell WZ, Hagen M, Barta I, Döme B, Strausz J, Greulich T, Vogelmeier C, Koczulla AR, Gut I, Hohlfeld J, Welte T, Lavae-Mokhtari M, Ziegler-Heitbrock L, Brightling C, Parr DG. Emphysema- and airway-dominant COPD phenotypes defined by standardised quantitative computed tomography. Eur Respir J. 2016 May 26. pii: ERJ-01878-2015. doi: 10.1183/13993003.01878-2015. [Epub ahead of print] PubMed PMID: 27230444.

Sharma AK, Eils R, König R. Copy number alterations in enzyme-coding and cancer-causing genes reprogram tumor metabolism. Cancer Res. 2016 May 23. pii: canres.2350.2015. [Epub ahead of print] PubMed PMID: 27216182.

Richter M, Lautze HJ, Walther T, Braun T, Kostin S, Kubin T. The failing heart is a major source of circulating FGF23 via oncostatin M receptor activation. J Heart Lung Transplant. 2015 Sep;34(9):1211-4. doi: 10.1016/j.healun.2015.06.007. Epub 2015 Jun 17.

New in PubMed from DZL Faculty/ Neu von der DZL-Fakultät in der Woche bis 22. Mai 2016: 

Fehringer G, Kraft P, Pharoah PD, Eeles RA, Chatterjee N, Schumacher FR, Schildkraut JM, Lindstrom S, Brennan P, Bickeböller H, Houlston RS, Landi MT, Caporaso NE, Risch A, Amin Al Olama A, Berndt SI, Giovannucci E, Gronberg H, Kote-Jarai Z, Ma J, Muir K, Stampfer MJ, Stevens VL, Wiklund F, Willett WC, Goode EL, Permuth JB, Risch HA, Reid BM, Bezieau S, Brenner H, Chan AT, Chang-Claude J, Hudson TJ, Kocarnik J, Newcomb PA, Schoen RE, Slattery ML, White E, Adank MA, Ahsan H, Aittomaki K, Baglietto L, Blomquist C, Canzian F, Czene K, Dos Santos Silva I, Eliassen AH, Figueroa JD, Flesch-Janys D, Fletcher O, Garcia-Closas M, Gaudet MM, Johnson N, Hall P, Hazra A, Hein R, Hofman A, Hopper JL, Irwanto A, Johansson M, Kaaks R, Kibriya MG, Lichtner P, Liu JJ, Lund E, Makalic E, Meindl A, Müller-Myhsok B, Muranen TA, Nevanlinna H, Peeters PH, Peto J, Prentice RL, Rahman N, Sanchez MJ, Schmidt DF, Schmutzler RK, Southey MC, Tamimi RM, Travis RC, Turnbull C, Uitterlinden AG, Wang Z, Whittemore AS, Yang XR, Zheng W, Rafnar T, Gudmundsson J, Stacey SN, Stefansson K, Sulem P, Chen YA, Tyrer JP, Christiani DC, Wei Y, Shen H, Hu Z, Shu XO, Shiraishi K, Takahashi A, Bossé Y, Obeidat M, Nickle D, Timens W, Freedman ML, Li Q, Seminara D, Chanock SJ, Gong J, Peters U, Gruber SB, Amos CI, Sellers TA, Easton DF, Hunter DJ, Haiman CA, Henderson BE, Hung RJ. Cross-cancer genome-wide analysis of lung, ovary, breast, prostate and colorectal cancer reveals novel pleiotropic associations. Cancer Res. 2016 Apr 20. pii: canres.2980.2015. [Epub ahead of print] PubMed PMID: 27197191.

Roengvoraphoi O, Wijaya C, Eze C, Fendler W, Gerum S, Belka C, Manapov F. 123P: Impact of the primary tumor metabolic volume (PT-MV) changes in the course of multimodality treatment on overall survival in patients with locally-advanced non-small cell lung cancer. J Thorac Oncol. 2016 Apr;11(4 Suppl):S109. doi: 10.1016/S1556-0864(16)30236-2. Epub 2016 Apr 15. PubMed PMID: 27198263.

Eze C, Roengvoraphoj O, Gerum S, Belka C, Manapov F. 127P: Maximum treatment response and prophylactic cranial irradiation are important prognostic factors in limited disease small-cell lung cancer patients comprehensively staged with cranial magnetic resonance imaging. J Thorac Oncol. 2016 Apr;11(4 Suppl):S111. doi: 10.1016/S1556-0864(16)30240-4. Epub 2016 Apr 15. PubMed PMID: 27198269.

Arriola E, Paredes A, Gomez RG, Diz P, Constenla M, Girón CG, Amador M, Reck M, Vivanco GL. 147P: Level of concordance between EGFR mutation status obtained from tissue/cytology and blood (plasma) for advanced non-small-cell lung cancer in Spain: ASSESS study. J Thorac Oncol. 2016 Apr;11(4 Suppl):S122. doi: 10.1016/S1556-0864(16)30257-X. Epub 2016 Apr 15. PubMed PMID: 27198285.

Tan D, Liu G, Kim DW, Thomas M, Felip E, Signorovitch J, Zhang J, Szczudlo T, Shaw AT. 178P: Continuation of ceritinib beyond disease progression is associated with prolonged post-progression survival (PPS) in ALK+ NSCLC. J Thorac Oncol. 2016 Apr;11(4 Suppl):S134-5. doi: 10.1016/S1556-0864(16)30288-X. Epub 2016 Apr 15. PubMed PMID: 27198316.

Normanno N, Brown H, Haddad V, Ratcliffe M, McCormack R, Tjulandin S, Hagiwara K, Han B, Reck M. 580_PR: Clinical and demographic features that influence EGFR mutation detection in plasma from patients (pts) with aNSCLC: The ASSESS experience. J Thorac Oncol. 2016 Apr;11(4 Suppl):S151. doi: 10.1016/S1556-0864(16)30323-9. Epub 2016 Apr 15. PubMed PMID: 27198351.

Han B, Ratcliffe M, Haddad V, Brown H, Tjulandin S, Hagiwara K, Reck M, Normanno N. 59PD Association of EGFR mutation subtypes with clinical and demographic characteristics of patients (pts) with aNSCLC: IGNITE and ASSESS pooled analysis. J Thorac Oncol. 2016 Apr;11(4 Suppl):S79-80. doi: 10.1016/S1556-0864(16)30172-1. Epub 2016 Apr 15. PubMed PMID: 27198415.

Frerichs I, Zhao Z, Becher T, Zabel P, Weiler N, Vogt B. Regional lung function determined by electrical impedance tomography during bronchodilator reversibility testing in patients with asthma. Physiol Meas. 2016 May 20;37(6):698-712. [Epub ahead of print] PubMed PMID: 27203725.

Suhling H, Dettmer S, Greer M, Fuehner T, Avsar M, Haverich A, Welte T, Gottlieb J. Phenotyping chronic lung allograft dysfunction using bodyplethysmography and computer tomography. Am J Transplant. 2016 May 20. doi: 10.1111/ajt.13876. [Epub ahead of print] PubMed PMID: 27203799.

Sauvé M, Hui SK, Dinh DD, Foltz WD, Momen A, Nedospasov SA, Offermanns S, Husain M, Kroetsch JT, Lidington D, Bolz SS. Tumor necrosis factor / sphingosine-1-phosphate signaling augments resistance artery myogenic tone in diabetes. Diabetes. 2016 Apr 5. pii: db151450. [Epub ahead of print] PubMed PMID: 27207546.

Marwitz S, Depner S, Dvornikov D, Merkle R, Szczygiel M, Müller-Decker K, Lucarelli P, Wäsch M, Mairbäurl H, Rabe KF, Kugler C, Vollmer E, Reck M, Scheufele S, Kröger M, Ammerpohl O, Siebert R, Goldmann T, Klingmüller U. Downregulation of the TGF-β pseudoreceptor BAMBI in non-small cell lung cancer enhances TGF-β signaling and invasion. Cancer Res. 2016 May 17. pii: canres.1326.2015. [Epub ahead of print] PubMed PMID: 27197161.

Herth FJ, Eberhardt R, Schuhmann M. Bronchoscopy in lung cancer: navigational modalities and their clinical use. Expert Rev Respir Med. 2016 May 19. [Epub ahead of print] PubMed PMID: 27196405.

Duda KA, Petersen S, Holst O. Structural characterization of the lipoteichoic acid isolated from Staphylococcus sciuri W620. Carbohydr Res. 2016 May 4;430:44-47. doi: 10.1016/j.carres.2016.04.026. [Epub ahead of print] PubMed PMID: 27196311.

Rapp M, Grassmann S, Chaloupka M, Layritz P, Kruger S, Ormanns S, Rataj F, Janssen KP, Endres S, Anz D, Kobold S. C-C chemokine receptor type-4 transduction of T cells enhances interaction with dendritic cells, tumor infiltration and therapeutic efficacy of adoptive T cell transfer. Oncoimmunology. 2015 Oct 29;5(3):e1105428. eCollection 2016 Mar. PubMed PMID: 27195186; PubMed Central PMCID: PMC4859768.

Ringshausen FC, Wagner D, de Roux A, Diel R, Hohmann D, Hickstein L, Welte T, Rademacher J. Prevalence of Nontuberculous Mycobacterial Pulmonary Disease, Germany, 2009-2014. Emerg Infect Dis. 2016 Jun;22(6):1102-5. doi: 10.3201/eid2206.151642. PubMed PMID: 27191473.

Gren ST, Janciauskiene S, Sandeep S, Jonigk D, Kvist PH, Gerwien JG, Håkansson K, Grip O. The protease inhibitor cystatin C down-regulates the release of IL-β and TNF-α in lipopolysaccharide activated monocytes. J Leukoc Biol. 2016 May 17. pii: jlb.5A0415-174R. [Epub ahead of print] PubMed PMID: 27190304.

Vogt B, Zhao Z, Zabel P, Weiler N, Frerichs I. Regional lung response to bronchodilator reversibility testing determined by electrical impedance tomography in chronic obstructive pulmonary disease. Am J Physiol Lung Cell Mol Physiol. 2016 May 17:ajplung.00463.2015. doi: 10.1152/ajplung.00463.2015. [Epub ahead of print] PubMed PMID: 27190067.

Maenner D, Werth S, Bein G, Santoso S. Rapid characterization of hybridomas producing monoclonal antibodies against platelet β3 integrin using ELIspot. Platelets. 2016 May 16:1-6. [Epub ahead of print] PubMed PMID: 27185103.

Tomar D, Dong Z, Shanmughapriya S, Koch DA, Thomas T, Hoffman NE, Timbalia SA, Goldman SJ, Breves SL, Corbally DP, Nemani N, Fairweather JP, Cutri AR, Zhang X, Song J, Jaña F, Huang J, Barrero C, Rabinowitz JE, Luongo TS, Schumacher SM, Rockman ME, Dietrich A, Merali S, Caplan J, Stathopulos P, Ahima RS, Cheung JY, Houser SR, Koch WJ, Patel V, Gohil VM, Elrod JW, Rajan S, Madesh M. MCUR1 Is a Scaffold Factor for the MCU Complex Function and Promotes Mitochondrial Bioenergetics. Cell Rep. 2016 May 11. pii: S2211-1247(16)30477-6. doi: 10.1016/j.celrep.2016.04.050. [Epub ahead of print] PubMed PMID: 27184846.

Vincent JL, Bassetti M, François B, Karam G, Chastre J, Torres A, Roberts JA, Taccone FS, Rello J, Calandra T, De Backer D, Welte T, Antonelli M. Advances in antibiotic therapy in the critically ill. Crit Care. 2016 May 17;20(1):133. doi: 10.1186/s13054-016-1285-6. Review. PubMed PMID: 27184564; PubMed Central PMCID: PMC4869332.

Henke C, Budweiser S, Jörres RA. Lung function and associations with multiple dimensions of dental health: a prospective observational cross-sectional study. BMC Res Notes. 2016 May 17;9(1):274. doi: 10.1186/s13104-016-2079-2. PubMed PMID: 27184138; PubMed Central PMCID: PMC4869198.

Kerzel S, Rogosch T, Struecker B, Maier RF, Kabesch M, Zemlin M. Unlike in Children with Allergic Asthma, IgE Transcripts from Preschool Children with Atopic Dermatitis Display Signs of Superantigen-Driven Activation. J Immunol. 2016 May 9. pii: 1402889. [Epub ahead of print] PubMed PMID: 27183570.

Welte T, Kim IS, Tian L, Gao X, Wang H, Li J, Holdman XB, Herschkowitz JI, Pond A, Xie G, Kurley S, Nguyen T, Liao L, Dobrolecki LE, Pang L, Mo Q, Edwards DP, Huang S, Xin L, Xu J, Li Y, Lewis MT, Wang T, Westbrook TF, Rosen JM, Zhang XH. Oncogenic mTOR signalling recruits myeloid-derived suppressor cells to promote tumour initiation. Nat Cell Biol. 2016 May 16. doi: 10.1038/ncb3355. [Epub ahead of print] PubMed PMID: 27183469.

Nicolau DP, Dimopoulos G, Welte T, Luyt CE. Can we improve clinical outcomes in patients with pneumonia treated with antibiotics in the intensive care unit? Expert Rev Respir Med. 2016 May 14. [Epub ahead of print] PubMed PMID: 27181707.

Wedzicha JA, Banerji D, Chapman KR, Vestbo J, Roche N, Ayers RT, Thach C, Fogel R, Patalano F, Vogelmeier CF; FLAME Investigators. Indacaterol-Glycopyrronium versus Salmeterol-Fluticasone for COPD. N Engl J Med. 2016 May 15. [Epub ahead of print] PubMed PMID: 27181606.

Sciurba FC, Criner GJ, Strange C, Shah PL, Michaud G, Connolly TA, Deslée G, Tillis WP, Delage A, Marquette CH, Krishna G, Kalhan R, Ferguson JS, Jantz M, Maldonado F, McKenna R, Majid A, Rai N, Gay S, Dransfield MT, Angel L, Maxfield R, Herth FJ, Wahidi MM, Mehta A, Slebos DJ; RENEW Study Research Group. Effect of Endobronchial Coils vs Usual Care on Exercise Tolerance in Patients With Severe Emphysema: The RENEW Randomized Clinical Trial. JAMA. 2016 May 15. doi: 10.1001/jama.2016.6261. [Epub ahead of print] PubMed PMID: 27179849.

Bauer CM, Schmähl A, Kreuter M. [Imaging and Laboratory Diagnostics for Tuberculosis]. Klin Monbl Augenheilkd. 2016 May;233(5):587-93. doi: 10.1055/s-0042-104062. Epub 2016 May 17. German. PubMed PMID: 27187878.

Göbel K, Pankratz S, Asaridou CM, Herrmann AM, Bittner S, Merker M, Ruck T, Glumm S, Langhauser F, Kraft P, Krug TF, Breuer J, Herold M, Gross CC, Beckmann D, Korb-Pap A, Schuhmann MK, Kuerten S, Mitroulis I, Ruppert C, Nolte MW, Panousis C, Klotz L, Kehrel B, Korn T, Langer HF, Pap T, Nieswandt B, Wiendl H, Chavakis T, Kleinschnitz C, Meuth SG. Blood coagulation factor XII drives adaptive immunity during neuroinflammation via CD87-mediated modulation of dendritic cells. Nat Commun. 2016 May 18;7:11626. doi: 10.1038/ncomms11626.
PubMed PMID: 27188843.

Herth FJ, Eberhardt R, Schuhmann M. Bronchoscopy in lung cancer: navigational modalities and their clinical use. Expert Rev Respir Med. 2016 May 19. [Epub ahead of print] PubMed PMID: 27196405.

Gu Z, Eils R, Schlesner M. Complex heatmaps reveal patterns and correlations in multidimensional genomic data. Bioinformatics. 2016 May 20. pii: btw313. [Epub ahead of print] PubMed PMID: 27207943.

 

New in PubMed from DZL Faculty/ Neu von der DZL-Fakultät in der Woche bis 15. Mai 2016: 

Skevaki C, Van den Berg J, Jones N, Garssen J, Vuillermin P, Levin M, Landay A, Renz H, Calder PC, Thornton CA. Immune biomarkers in the spectrum of childhood noncommunicable diseases. J Allergy Clin Immunol. 2016 May;137(5):1302-16. doi: 10.1016/j.jaci.2016.03.012. Review. PubMed PMID: 27155027.

Potaczek DP, Garn H, Unger SD, Renz H. Antisense molecules: A new class of drugs. J Allergy Clin Immunol. 2016 May;137(5):1334-46. doi: 10.1016/j.jaci.2015.12.1344. Review. PubMed PMID: 27155029.

Brand P, Bertram J, Chaker A, Jörres RA, Kronseder A, Kraus T, Gube M. Biological effects of inhaled nitrogen dioxide in healthy human subjects. Int Arch Occup Environ Health. 2016 May 7. [Epub ahead of print] PubMed PMID: 27155612.

Welte T. [Severe pneumonia in the intensive care unit]. Med Klin Intensivmed Notfmed. 2016 May 9. [Epub ahead of print] German. PubMed PMID: 27160261.

Wacker ME, Jörres RA, Karch A, Wilke S, Heinrich J, Karrasch S, Koch A, Schulz H, Watz H, Leidl R, Vogelmeier C, Holle R; COSYCONET-Consortium. Assessing health-related quality of life in COPD: comparing generic and disease-specific instruments with focus on comorbidities. BMC Pulm Med. 2016 May 10;16(1):70. doi: 10.1186/s12890-016-0238-9. PubMed PMID: 27160582; PubMed Central PMCID: PMC4862227.

Behr J, Bendstrup E, Crestani B, Günther A, Olschewski H, Sköld CM, Wells A, Wuyts W, Koschel D, Kreuter M, Wallaert B, Lin CY, Beck J, Albera C. Safety and tolerability of acetylcysteine and pirfenidone combination therapy in idiopathic pulmonary fibrosis: a randomised, double-blind, placebo-controlled, phase 2 trial. Lancet Respir Med. 2016 May 5. pii: S2213-2600(16)30044-3. doi: 10.1016/S2213-2600(16)30044-3. [Epub ahead of print] PubMed PMID: 27161257.

Hövelmann F, Kedziora KM, Nadler A, Müller R, Jalink K, Schultz C. Optotaxis: Caged Lysophosphatidic Acid Enables Optical Control of a Chemotactic Gradient. Cell Chem Biol. 2016 May 5. pii: S2451-9456(16)30101-5. doi: 10.1016/j.chembiol.2015.11.019. [Epub ahead of print] PubMed PMID: 27161483.

Schneider SA, Scharffetter C, Wagner AE, Boesch C, Bruchhaus I, Rimbach G, Roeder T. Social stress increases the susceptibility to infection in the ant Harpegnathos saltator. Sci Rep. 2016 May 10;6:25800. doi: 10.1038/srep25800.
PubMed PMID: 27161621.

Prieto A, Urcola I, Blanco J, Dahbi G, Muniesa M, Quirós P, Falgenhauer L, Chakraborty T, Hüttener M, Juárez A. Tracking bacterial virulence: global modulators as indicators. Sci Rep. 2016 May 12;6:25973. doi: 10.1038/srep25973. PubMed PMID: 27169404.

Bleyer M, Curths C, Dahlmann F, Wichmann J, Bauer N, Moritz A, Braun A, Knauf S, Kaup FJ, Gruber-Dujardin E. Morphology and staining behavior of neutrophilic and eosinophilic granulocytes of the common marmoset (Callithrix jacchus). Exp Toxicol Pathol. 2016 May 7. pii: S0940-2993(16)30052-5. doi: 10.1016/j.etp.2016.05.002. [Epub ahead of print] PubMed PMID: 27165445.

Wittmann T, Schindlbeck U, Höppner S, Kinting S, Frixel S, Kröner C, Liebisch G, Hegermann J, Aslanidis C, Brasch F, Reu S, Lasch P, Zarbock R, Griese M. Tools to explore ABCA3 mutations causing interstitial lung disease. Pediatr Pulmonol. 2016 May 13. doi: 10.1002/ppul.23471. [Epub ahead of print] PubMed PMID: 27177387.

Watz H. [Asthma-COPD-Overlap-Syndrome - when a diagnostic dilemma results in a new syndrome]. Dtsch Med Wochenschr. 2016 May;141(10):700-3. doi: 10.1055/s-0042-105173. Epub 2016 May 13. German. PubMed PMID: 27176063.

Bose-O'Reilly S, Schierl R, Nowak D, Siebert U, William JF, Owi FT, Ir YI. A preliminary study on health effects in villagers exposed to mercury in a small-scale artisanal gold mining area in Indonesia. Environ Res. 2016 May 9. pii: S0013-9351(16)30130-X. doi: 10.1016/j.envres.2016.04.007. [Epub ahead of print] PubMed PMID: 27174690.

Herth FJ, Nitschmann S. [Bronchoscopic lung volume reduction in emphysema without collateral ventilation : STELVIO trial]. Internist (Berl). 2016 May 12. [Epub ahead of print] German. PubMed PMID: 27174008.

Farrell PM, Sommerburg O. Toward quality improvement in cystic fibrosis newborn screening: Progress and continuing challenges. J Cyst Fibros. 2016 May 9. pii: S1569-1993(16)30025-X. doi: 10.1016/j.jcf.2016.04.008. [Epub ahead of print] PubMed PMID: 27172835.

Schröder PC, Casaca VI, Illi S, Schieck M, Michel S, Böck A, Roduit C, Frei R, Lluis A, Genuneit J, Pfefferle P, Roponen M, Weber J, Braun-Fahrländer C, Riedler J, Lauener R, Vuitton DA, Dalphin JC, Pekkanen J, von Mutius E, Kabesch M, Schaub B; PASTURE study group.. IL-33 polymorphisms are associated with increased risk of hay fever and reduced Regulatory T cells in a birth cohort. Pediatr Allergy Immunol. 2016 May 12. doi: 10.1111/pai.12597. [Epub ahead of print] PubMed PMID: 27171815.

Bhattacharya J, Westphalen K. Macrophage-epithelial interactions in pulmonary alveoli. Semin Immunopathol. 2016 May 12. [Epub ahead of print] Review. PubMed PMID: 27170185.

New in PubMed from DZL Faculty/ Neu von der DZL-Fakultät in der Woche bis 08. Mai 2016: 

Ulrich V, Rotllan N, Araldi E, Luciano A, Skroblin P, Abonnenc M, Perrotta P, Yin X, Bauer A, Leslie KL, Zhang P, Aryal B, Montgomery RL, Thum T, Martin K, Suarez Y, Mayr M, Fernandez-Hernando C, Sessa WC. Chronic miR-29 antagonism promotes favorable plaque remodeling in atherosclerotic mice. EMBO Mol Med. 2016 May 2. pii: e201506031. doi: 10.15252/emmm 201506031. [Epub ahead of print] PubMed PMID: 27137489.

Simon B, Huart AS, Temmerman K, Vahokoski J, Mertens HD, Komadina D, Hoffmann JE, Yumerefendi H, Svergun DI, Kursula P, Schultz C, McCarthy AA, Hart DJ, Wilmanns M. Death-Associated Protein Kinase Activity Is Regulated by Coupled Calcium/Calmodulin Binding to Two Distinct Sites. Structure. 2016 Apr 20. pii: S0969-2126(16)30030-2. doi: 10.1016/j.str.2016.03.020. [Epub ahead of print] PubMed PMID: 27133022.

Fuertes E, Heinrich J, Schultz H. Re: The effect of air pollution on lung function in children. Int J Hyg Environ Health. 2016 Apr 16. pii: S1438-4639(16)30028-1. doi: 10.1016/j.ijheh.2016.04.005. [Epub ahead of print] PubMed PMID: 27134217.

Lorenzen JM, Thum T. Long noncoding RNAs in kidney and cardiovascular diseases. Nat Rev Nephrol. 2016 May 3. doi: 10.1038/nrneph.2016.51. [Epub ahead of print] Review. PubMed PMID: 27140855.

Pradhan K, Sydykov A, Tian X, Mamazhakypov A, Neupane B, Luitel H, Weissmann N, Seeger W, Grimminger F, Kretschmer A, Stasch JP, Ghofrani HA, Schermuly RT. Soluble guanylate cyclase stimulator riociguat and phosphodiesterase 5 inhibitor sildenafil ameliorate pulmonary hypertension due to left heart disease in mice. Int J Cardiol. 2016 Apr 16;216:85-91. doi: 10.1016/j.ijcard.2016.04.098. [Epub ahead of print] PubMed PMID: 27140341.

Schlett CL, Hendel T, Weckbach S, Reiser M, Kauczor HU, Nikolaou K, Günther M, Forsting M, Hosten N, Völzke H, Bamberg F. Population-Based Imaging and Radiomics: Rationale and Perspective of the German National Cohort MRI Study. Rofo. 2016 May 3. [Epub ahead of print] PubMed PMID: 27139177.

Weber S, Haverich A. [Pioneering surgical innovations in Germany : Part 2: public funding and origins of surgical innovations]. Chirurg. 2016 May 2. [Epub ahead of print] German. PubMed PMID: 27138267.

Lacour A, Ellinghaus D, Schreiber S, Franke A, Becker T. Haplotype synthesis analysis reveals functional variants underlying known genome-wide associated susceptibility loci. Bioinformatics. 2016 Mar 21. pii: btw125. [Epub ahead of print] PubMed PMID: 27153721.

Kolahian S, Fernandez IE, Eickelberg O, Hartl D. Immune Mechanisms in Pulmonary Fibrosis. Am J Respir Cell Mol Biol. 2016 May 5. [Epub ahead of print] PubMed PMID: 27149613.

Breit A, Wicht K, Boekhoff I, Glas E, Lauffer L, Mückter H, Gudermann T. Glucose enhances basal or melanocortin-induced cAMP response element activity in hypothalamic cells. Mol Endocrinol. 2016 May 4:me20161001. [Epub ahead of print] PubMed PMID: 27144291.

Gu Z, Eils R, Schlesner M. HilbertCurve: an R/Bioconductor package for high-resolution visualization of genomic data. Bioinformatics. 2016 Mar 24. pii: btw161. [Epub ahead of print] PubMed PMID: 27153599.

Degenhardt F, Niklowitz P, Szymczak S, Jacobs G, Lieb W, Menke T, Laudes M, Esko T, Weidinger S, Franke A, Döring F, Onur S. Genome-wide association study of serum coenzyme Q10 levels identifies susceptibility loci linked to neuronal diseases. Hum Mol Genet. 2016 May 5. pii: ddw134. [Epub ahead of print] PubMed PMID: 27149984.

New in PubMed from DZL Faculty/ Neu von der DZL-Fakultät in der Woche bis 01. Mai 2016: 

Bonella F, Long X, Ohshimo S, Horimasu Y, Griese M, Guzman J, Kohno N, Costabel U. MUC1 gene polymorphisms are associated with serum KL-6 levels and pulmonary dysfunction in pulmonary alveolar proteinosis. Orphanet J Rare Dis. 2016 Apr 23;11:48. doi: 10.1186/s13023-016-0430-2. PubMed PMID: 27108412; PubMed Central PMCID: PMC4841967.

Halpin DM, Vogelmeier C, Pieper MP, Metzdorf N, Richard F, Anzueto A. Effect of tiotropium on COPD exacerbations: A systematic review. Respir Med. 2016 May;114:1-8. doi: 10.1016/j.rmed.2016.02.012. Epub 2016 Mar 2. Review. PubMed PMID: 27109805.

Karch A, Vogelmeier C, Welte T, Bals R, Kauczor HU, Biederer J, Heinrich J, Schulz H, Gläser S, Holle R, Watz H, Korn S, Adaskina N, Biertz F, Vogel C, Vestbo J, Wouters EF, Rabe KF, Söhler S, Koch A, Jörres RA; COSYCONET Study Group. The German COPD cohort COSYCONET: Aims, methods and descriptive analysis of the study population at baseline. Respir Med. 2016 May;114:27-37. doi: 10.1016/j.rmed.2016.03.008. Epub 2016 Mar 11. PubMed PMID: 27109808.

Gompelmann D, Herth FJ. Novel Technologies in Endoscopic Lung Volume Reduction. Thorac Surg Clin. 2016 May;26(2):177-86. doi: 10.1016/j.thorsurg.2015.12.006. Review. PubMed PMID: 27112257.

Mall MA. Unplugging Mucus in Cystic Fibrosis and Chronic Obstructive Pulmonary Disease. Ann Am Thorac Soc. 2016 Apr;13 Suppl 2:S177-85. doi: 10.1513/AnnalsATS.201509-641KV. PubMed PMID: 27115954.

Josipovic I, Fork C, Preussner J, Prior KK, Iloska D, Vasconez AE, Labocha S, Angioni C, Thomas D, Ferreirós N, Looso M, Pullamsetti SS, Geisslinger G, Steinhilber D, Brandes RP, Leisegang MS. PAFAH1B1 and the lncRNA NONHSAT073641 maintain an angiogenic phenotype in human endothelial cells. Acta Physiol (Oxf). 2016 Apr 28. doi: 10.1111/apha.12700. [Epub ahead of print] PubMed PMID: 27124368.

Rodriguez-Gil A, Ritter O, Hornung J, Stekman H, Krüger M, Braun T, Kremmer E, Kracht M, Schmitz ML. HIPK family kinases bind and regulate the function of the CCR4-NOT complex. Mol Biol Cell. 2016 Apr 27. pii: mbc.E15-09-0629. [Epub ahead of print] PubMed PMID: 27122605.

Kleinert E, Langenmayer MC, Reichart B, Kindermann J, Griemert B, Blutke A, Troidl K, Mayr T, Grantzow T, Noyan F, Abicht JM, Fischer S, Preissner KT, Wanke R, Deindl E, Guethoff S. Ribonuclease (RNase) Prolongs Survival of Grafts in Experimental Heart Transplantation. J Am Heart Assoc. 2016 Apr 27;5(5). pii: e003429. doi: 10.1161/JAHA.116.003429. PubMed PMID: 27121849.

Bougioukas I, Didilis V, Emigholz J, Waldmann-Beushausen R, Stojanovic T, Mühlfeld C, Schoendube FA, Danner BC. The effect of amifostine on lung ischaemia-reperfusion injury in rats. Interact Cardiovasc Thorac Surg. 2016 Apr 27. pii: ivw105. [Epub ahead of print] PubMed PMID: 27121071.

Altmaier E, Menni C, Heier M, Meisinger C, Thorand B, Quell J, Kobl M, Römisch-Margl W, Valdes AM, Mangino M, Waldenberger M, Strauch K, Illig T, Adamski J, Spector T, Gieger C, Suhre K, Kastenmüller G. The Pharmacogenetic Footprint of ACE Inhibition: A Population-Based Metabolomics Study. PLoS One. 2016 Apr 27;11(4):e0153163. doi: 10.1371/journal.pone.0153163. eCollection 2016. PubMed PMID: 27120469.

Sarnowski C, Sugier PE, Granell R, Jarvis D, Dizier MH, Ege M, Imboden M, Laprise C, Khusnutdinova EK, Freidin MB, Cookson WO, Moffatt M, Lathrop M, Siroux V, Ogorodova LM, Karunas AS, James A, Probst-Hensch NM, von Mutius E, Pin I, Kogevinas M, Henderson AJ, Demenais F, Bouzigon E. Identification of a new locus at 16q12 associated with time to asthma onset. J Allergy Clin Immunol. 2016 Apr 6. pii: S0091-6749(16)30016-1. doi: 10.1016/j.jaci.2016.03.018. [Epub ahead of print] PubMed PMID: 27130862.

Du Bois I, Marsico A, Bertrams W, Schweiger MR, Caffrey BE, Sittka-Stark A, Eberhardt M, Vera J, Vingron M, Schmeck B. Genome-wide chromatin profiling of Legionella pneumophila-infected human macrophages reveals activation of the pro-bacterial host factor TNFAIP2. J Infect Dis. 2016 Apr 29. pii: jiw171. [Epub ahead of print] PubMed PMID: 27130431.

Skuljec J, Cabanski M, Surdziel E, Lachmann N, Brennig S, Pul R, Jirmo AC, Habener A, Visic J, Dalüge K, Hennig C, Moritz T, Happle C, Hansen G. Monocyte/macrophage lineage commitment and distribution are affected by the lack of regulatory T cells in scurfy mice. Eur J Immunol. 2016 Apr 30. doi: 10.1002/eji.201546200. [Epub ahead of print] PubMed PMID: 27130185.

Welk V, Coux O, Kleene V, Abeza C, Truembach D, Eickelberg O, Meiners S. Inhibition of Proteasome Activity Induces Formation of Alternative Proteasome Complexes. J Biol Chem. 2016 Apr 18. pii: jbc.M116.717652. [Epub ahead of print] PubMed PMID: 27129254.

Aggarwal N, Koepke J, Matamala N, Martinez-Delgado B, Martinez MT, Golpon H, Stolk J, Janciauskiene S, Koczulla R. Alpha-1 Antitrypsin Regulates Transcriptional Levels of Serine Proteases in Blood Mononuclear Cells. Am J Respir Crit Care Med. 2016 May 1;193(9):1065-7. doi: 10.1164/rccm.201510-2062LE. PubMed PMID: 27128707.

D'Andrea A, D'Alto M, Di Maio M, Vettori S, Benjamin N, Cocchia R, Argiento P, Romeo E, Di Marco G, Russo MG, Valentini G, Calabrò R, Bossone E, Grünig E. Right atrial morphology and function in patients with systemic sclerosis compared to healthy controls: a two-dimensional strain study. Clin Rheumatol. 2016 Apr 27. [Epub ahead of print] PubMed PMID: 27118201.

Simonneau G, D'Armini AM, Ghofrani HA, Grimminger F, Hoeper MM, Jansa P, Kim NH, Wang C, Wilkins MR, Fritsch A, Davie N, Colorado P, Mayer E. Riociguat for the treatment of chronic thromboembolic pulmonary hypertension: a long-term extension study (CHEST-2). Eur Respir J. 2015 May;45(5):1293-302. doi: 10.1183/09031936.00087114. Epub 2014 Nov 13.

April 2016

New in PubMed from DZL Faculty/ Neu von der DZL-Fakultät in der Woche bis 24. April 2016: 

Tufa DM, Ahmad F, Chatterjee D, Ahrenstorf G, Schmidt RE, Jacobs R. IL-1β limits the extent of human 6-sulfo LacNAc dendritic cell (slanDC)-mediated NK cell activation and regulates CD95-induced apoptosis. Cell Mol Immunol. 2016 Apr 18. doi: 10.1038/cmi.2016.17. [Epub ahead of print] PubMed PMID: 27086951.

Fuertes E, Markevych I, Bowatte G, Gruzieva O, Gehring U, Becker A, Berdel D, von Berg A, Bergström A, Brauer M, Brunekreef B, Brüske I, Carlsten C, Chan-Yeung M, Dharmage SC, Hoffmann B, Klümper C, Koppelman GH, Kozyrskyj A, Korek M, Kull I, Lodge C, Lowe A, MacIntyre E, Pershagen G, Standl M, Sugiri D, Wijga A, Heinrich J. Residential greenness is differentially associated with childhood allergic rhinitis and aeroallergen sensitization in seven birth cohorts. Allergy. 2016 Apr 18. doi: 10.1111/all.12915. [Epub ahead of print] PubMed PMID: 27087129.

Hoffmann H, Junker K, Kugler C, Schnabel PA, Warth A. [Application and interpretation of the R classification for lung cancer : Results of a survey of certified lung cancer centers]. Pathologe. 2016 Apr 18. [Epub ahead of print] German. PubMed PMID: 27091658.

Reinartz MT, Wetzke M, Happle C, Kälble S, Scherer R, Kabesch M, Seifert R. Neutrophilic superoxide production can assess pharmacological and pharmacogenetic β-adrenoreceptor effects. Allergy. 2016 Apr 19. doi: 10.1111/all.12918. [Epub ahead of print] PubMed PMID: 27091647.

Weber S, Haverich A. [Pioneering surgical innovations in Germany : Part 1: generation of medical evidence]. Chirurg. 2016 Apr 18. [Epub ahead of print] German. PubMed PMID: 27090414.

Gerl MJ, Bittl V, Kirchner S, Sachsenheimer T, Brunner HL, Lüchtenborg C, Özbalci C, Wiedemann H, Wegehingel S, Nickel W, Haberkant P, Schultz C, Krüger M, Brügger B. Sphingosine-1-Phosphate Lyase Deficient Cells as a Tool to Study Protein Lipid Interactions. PLoS One. 2016 Apr 21;11(4):e0153009. doi: 10.1371/journal.pone.0153009. eCollection 2016. PubMed PMID: 27100999.

Chao CM, Moiseenko A, Zimmer KP, Bellusci S. Alveologenesis: key cellular players and fibroblast growth factor 10 signaling. Mol Cell Pediatr. 2016 Dec;3(1):17. doi: 10.1186/s40348-016-0045-7. Epub 2016 Apr 21. Review. PubMed
PMID: 27098664.

Yushchenko DA, Nadler A, Schultz C. Manipulating cell signaling with subcellular spatial resolution. Cell Cycle. 2016 Apr 17;15(8):1023-4. doi: 10.1080/15384101.2016.1157974. PubMed PMID: 27097368.

Crnkovic S, Schmidt A, Egemnazarov B, Wilhelm J, Marsh LM, Ghanim B, Klepetko W, Olschewski A, Olschewski H, Kwapiszewska G. Functional and molecular factors associated with TAPSE in hypoxic pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol. 2016 Apr 22:ajplung.00381.2015. doi: 10.1152/ajplung.00381.2015. [Epub ahead of print] PubMed PMID: 27106290.

Lopez-Rodriguez E, Boden C, Echaide M, Perez-Gil J, Kolb MR, Gauldie J, Maus UA, Ochs M, Knudsen L. Surfactant dysfunction during over-expression of TGF-β1 precedes profibrotic lung remodeling in vivo. Am J Physiol Lung Cell Mol Physiol. 2016 Apr 22:ajplung.00065.2016. doi: 10.1152/ajplung.00065.2016. [Epub ahead of print] PubMed PMID: 27106287.

Warth A, Endris V, Stenzinger A, Penzel R, Harms A, Duell T, Abdollahi A, Lindner M, Schirmacher P, Muley T, Dienemann H, Fink L, Morresi-Hauf A, Pfarr N, Weichert W. Genetic changes of non-small cell lung cancer under neoadjuvant therapy. Oncotarget. 2016 Apr 20. doi: 10.18632/oncotarget.8858. [Epub ahead of print] PubMed PMID: 27105513.

Jung AL, Stoiber C, Herkt CE, Schulz C, Bertrams W, Schmeck B. Legionella pneumophila-Derived Outer Membrane Vesicles Promote Bacterial Replication in Macrophages. PLoS Pathog. 2016 Apr 22;12(4):e1005592. doi: 10.1371/journal.ppat.1005592. eCollection 2016 Apr. PubMed PMID: 27105429.

Strueber M, Warnecke G, Fuge J, Simon AR, Zhang R, Welte T, Haverich A, Gottlieb J. Everolimus versus mycophenolate mofetil de novo after lung transplantation - a prospective, randomized, open-label trial. Am J Transplant. 2016 Apr 22. doi: 10.1111/ajt.13835. [Epub ahead of print] PubMed PMID: 27104933.

Muehlich S, Hermanns C, Meier MA, Kircher P, Gudermann T. Unravelling a new mechanism linking actin polymerization and gene transcription. Nucleus. 2016 Apr 22:1-5. [Epub ahead of print] PubMed PMID: 27104924.

Boeck L, Soriano JB, Brusse-Keizer M, Blasi F, Kostikas K, Boersma W, Milenkovic B, Louis R, Lacoma A, Djamin R, Aerts J, Torres A, Rohde G, Welte T, Martinez-Camblor P, Rakic J, Scherr A, Koller M, van der Palen J, Marin JM, Alfageme I, Almagro P, Casanova C, Esteban C, Soler-Cataluña JJ, de Torres JP, Miravitlles M, Celli BR, Tamm M, Stolz D. Prognostic assessment in COPD without lung function: the B-AE-D indices. Eur Respir J. 2016 Apr 21. pii: ERJ-01485-2015. doi: 10.1183/13993003.01485-2015. [Epub ahead of print] PubMed PMID: 27103389.

Bradley P, Gordon NC, Walker TM, Dunn L, Heys S, Huang B, Earle S, Pankhurst LJ, Anson L, de Cesare M, Piazza P, Votintseva AA, Golubchik T, Wilson DJ, Wyllie DH, Diel R, Niemann S, Feuerriegel S, Kohl TA, Ismail N, Omar SV, Smith EG, Buck D, McVean G, Walker AS, Peto TE, Crook DW, Iqbal Z. Corrigendum: Rapid antibiotic-resistance predictions from genome sequence data for Staphylococcus aureus and Mycobacterium tuberculosis. Nat Commun. 2016 Apr 20;7:11465. doi: 10.1038/ncomms11465. PubMed PMID: 27095245.

Gu Z, Eils R, Schlesner M. gtrellis: an R/Bioconductor package for making genome-level Trellis graphics. BMC Bioinformatics. 2016 Apr 18;17:169. doi: 10.1186/s12859-016-1051-4. PubMed PMID: 27089965; PubMed Central PMCID: PMC4835841.

Kreuter M, Wijsenbeek MS, Vasakova M, Spagnolo P, Kolb M, Costabel U, Weycker D, Kirchgaessler KU, Maher TM. Unfavourable effects of medically indicated oral anticoagulants on survival in idiopathic pulmonary fibrosis. Eur Respir J. 2016 Apr 21. pii: ERJ-02087-2015. doi: 10.1183/13993003.02087-2015. [Epub ahead of print] PubMed PMID: 27103382.

Gisch N, Schwudke D, Thomsen S, Heß N, Hakenbeck R, Denapaite D. Corrigendum: Lipoteichoic acid of Streptococcus oralis Uo5: a novel biochemical structure comprising an unusual phosphorylcholine substitution pattern compared to Streptococcus pneumoniae. Sci Rep. 2016 Apr 22;6:24424. doi: 10.1038/srep24424. PubMed PMID: 27103585.

New in PubMed from DZL Faculty/ Neu von der DZL-Fakultät in der Woche bis 17. April 2016: 

Gilles-Stein S, Beck I, Chaker A, Bas M, McIntyre M, Cifuentes L, Petersen A, Gutermuth J, Schmidt-Weber C, Behrendt H, Traidl-Hoffmann C. Pollen derived low molecular compounds enhance the human allergen specific immune response in vivo. Clin Exp Allergy. 2016 Apr 7. doi: 10.1111/cea.12739. [Epub ahead of print] PubMed PMID: 27061126.

Leuschner G, Wenter V, Milger K, Zimmermann GS, Matthes S, Meinel FG, Lehner S, Neurohr C, Behr J, Kneidinger N. Suspected pulmonary embolism in patients with pulmonary fibrosis: Discordance between ventilation/perfusion SPECT and CT pulmonary angiography. Respirology. 2016 Apr 7. doi: 10.1111/resp.12797. [Epub ahead of print] PubMed PMID: 27061739.

Bergmann KC, Heinrich J, Niemann H. Current status of allergy prevalence in Germany: Position paper of the Environmental Medicine Commission of the Robert Koch Institute. Allergo J Int. 2016;25:6-10. Epub 2016 Feb 11. PubMed PMID: 27069844; PubMed Central PMCID: PMC4792334.

Simonneau G, D'Armini AM, Ghofrani HA, Grimminger F, Jansa P, Kim NH, Mayer E, Pulido T, Wang C, Colorado P, Fritsch A, Meier C, Nikkho S, Hoeper MM. Predictors of long-term outcomes in patients treated with riociguat for chronic thromboembolic pulmonary hypertension: data from the CHEST-2 open-label, randomised, long-term extension trial. Lancet Respir Med. 2016 Apr 8. pii: S2213-2600(16)30022-4. doi: 10.1016/S2213-2600(16)30022-4. [Epub ahead of print] PubMed PMID: 27067478.

Watz H, Tetzlaff K, Wouters EF, Kirsten A, Magnussen H, Rodriguez-Roisin R, Vogelmeier C, Fabbri LM, Chanez P, Dahl R, Disse B, Finnigan H, Calverley PM. Blood eosinophil count and exacerbations in severe chronic obstructive pulmonary disease after withdrawal of inhaled corticosteroids: a post-hoc analysis of the WISDOM trial. Lancet Respir Med. 2016 Apr 7. pii: S2213-2600(16)00100-4. doi: 10.1016/S2213-2600(16)00100-4. [Epub ahead of print] PubMed PMID: 27066739.

Schoenfeld N, Haas W, Richter E, Bauer T, Boes L, Castell S, Hauer B, Magdorf K, Matthiessen W, Mauch H, Reuss A, Schenkel K, Ruesch-Gerdes S, Zabel P, Dalhoff K, Schaberg T, Loddenkemper R. Recommendations of the German Central Committee against Tuberculosis (DZK) and the German Respiratory Society (DGP) for the Diagnosis and Treatment of Non-tuberculous Mycobacterioses. Pneumologie. 2016 Apr;70(4):250-276. Epub 2016 Apr 11. PubMed PMID: 27064418.

Hoffmann J, Wilhelm J, Olschewski A, Kwapiszewska G. Microarray analysis in pulmonary hypertension. Eur Respir J. 2016 Apr 13. pii: ERJ-02030-2015. doi: 10.1183/13993003.02030-2015. [Epub ahead of print] Review. PubMed PMID: 27076594.

Mathai SC, Ghofrani HA, Mayer E, Pepke-Zaba J, Nikkho S, Simonneau G. Quality of life in patients with chronic thromboembolic pulmonary hypertension. Eur Respir J. 2016 Apr 13. pii: ERJ-01626-2015. doi: 10.1183/13993003.01626-2015. [Epub ahead of print] Review. PubMed PMID: 27076580.

Wielpütz MO, Eichinger M, Biederer J, Wege S, Stahl M, Sommerburg O, Mall MA, Kauczor HU, Puderbach M. Imaging of Cystic Fibrosis Lung Disease and Clinical Interpretation. Rofo. 2016 Apr 13. [Epub ahead of print] PubMed PMID: 27074425.

Yaroshenko A, Pritzke T, Koschlig M, Kamgari N, Willer K, Gromann L, Auweter S, Hellbach K, Reiser M, Eickelberg O, Pfeiffer F, Hilgendorff A. Visualization of neonatal lung injury associated with mechanical ventilation using x-ray dark-field radiography. Sci Rep. 2016 Apr 13;6:24269. doi: 10.1038/srep24269. PubMed PMID: 27072871.

Bures M, Höffler HK, Friedel G, Kyriss T, Boedeker E, Länger F, Zardo P, Zhang R. Albumin-glutaraldehyde glue for repair of superficial lung defect: an in vitro experiment. J Cardiothorac Surg. 2016 Apr 12;11(1):63. doi: 10.1186/s13019-016-0443-x. PubMed PMID: 27072534; PubMed Central PMCID: PMC4828862.

Guth S, Wiedenroth CB, Kramm T, Mayer E. Pulmonary endarterectomy for the treatment of chronic thromboembolic pulmonary hypertension. Expert Rev Respir Med. 2016 Apr 12. [Epub ahead of print] PubMed PMID: 27070482.

Calverley PM, Könen-Bergmann M, Richard F, Bell S, Hohlfeld JM. Tiotropium Respimat(®) Versus HandiHaler(®): Comparison of Bronchodilator Efficacy of Various Doses in Clinical Trials. Adv Ther. 2016 Mar 28. [Epub ahead of print] PubMed PMID: 27084728.

Welte T. [Ventilation therapy - a success story]. Med Klin Intensivmed Notfmed. 2016 Apr;111(3):184-5. doi: 10.1007/s00063-016-0151-2. German. PubMed PMID: 27084179.

Jenkins DP, Biederman A, D'Armini AM, Dartevelle PG, Gan HL, Klepetko W, Lindner J, Mayer E, Madani MM. Operability assessment in CTEPH: Lessons from the CHEST-1 study. J Thorac Cardiovasc Surg. 2016 Mar 10. pii: S0022-5223(16)00407-4. doi: 10.1016/j.jtcvs.2016.02.062. [Epub ahead of print] PubMed PMID: 27083940.

Funke M, Knudsen L, Lagares D, Ebener S, Probst CK, Fontaine BA, Franklin A, Kellner M, Kühnel M, Matthieu S, Grothausmann R, Chun J, Roberts JD Jr, Ochs M, Tager AM. LPA Signaling Through the LPA(1) Receptor is Required for Alveolarization. Am J Respir Cell Mol Biol. 2016 Jan 21. [Epub ahead of print] PubMed PMID: 27082727.

Gaida A, Holz O, Nell C, Schuchardt S, Lavae-Mokhtari B, Kruse L, Boas U, Langejuergen J, Allers M, Zimmermann S, Vogelmeier C, Koczulla AR, Hohlfeld JM. A dual center study to compare breath volatile organic compounds from smokers and non-smokers with and without COPD. J Breath Res. 2016 Apr 15;10(2):026006. PubMed PMID: 27082437.

Ghofrani HA, Grimminger F, Grünig E, Huang Y, Jansa P, Jing ZC, Kilpatrick D, Langleben D, Rosenkranz S, Menezes F, Fritsch A, Nikkho S, Humbert M. Predictors of long-term outcomes in patients treated with riociguat for pulmonary arterial hypertension: data from the PATENT-2 open-label, randomised, long-term extension trial. Lancet Respir Med. 2016 Apr 8. pii: S2213-2600(16)30019-4. doi: 10.1016/S2213-2600(16)30019-4. [Epub ahead of print] PubMed PMID: 27067479.

Gesierich W, Samitas K, Reichenberger F, Behr J. Collapse phenomenon during Chartis collateral ventilation assessment. Eur Respir J. 2016 Apr 13. pii: ERJ-01973-2015. doi: 10.1183/13993003.01973-2015. [Epub ahead of print] PubMed PMID: 27076587.

New in PubMed from DZL Faculty/ Neu von der DZL-Fakultät in der Woche bis 10. April 2016:

Hoffmann F, Ender F, Schmudde I, Lewkowich IP, Köhl J, König P, Laumonnier Y. Origin, Localization, and Immunoregulatory Properties of Pulmonary Phagocytes in Allergic Asthma. Front Immunol. 2016 Mar 23;7:107. doi: 10.3389/fimmu.2016.00107. eCollection 2016. Review. PubMed PMID: 27047494; PubMed Central PMCID: PMC4803735.

Hoeper MM. Residual Pulmonary Hypertension After Pulmonary Endarterectomy: The Fog is Clearing. Circulation. 2016 Apr 6. pii: CIRCULATIONAHA.116.022595. [Epub ahead of print] PubMed PMID: 27052412.

Kreuter M, Wuyts W, Renzoni E, Koschel D, Maher TM, Kolb M, Weycker D, Spagnolo P, Kirchgaessler KU, Herth FJ, Costabel U. Antacid therapy and disease outcomes in idiopathic pulmonary fibrosis: a pooled analysis. Lancet Respir Med. 2016 Mar 31. pii: S2213-2600(16)00067-9. doi: 10.1016/S2213-2600(16)00067-9. [Epub ahead of print] PubMed PMID: 27050871.

Lamb DJ, Wollin SL, Schnapp A, Bischoff D, Erb KJ, Bouyssou T, Guilliard B, Strasser C, Wex E, Blum S, Thaler E, Nickel H, Radmacher O, Haas H, Swantek JL, Souza D, Canfield M, White D, Panzenbeck M, Kashem MA, Sanville-Ross M, Kono T, Sewald K, Braun A, Obernolte H, Danov O, Schaenzle G, Rast G, Maier GM, Hoffmann M. BI 1002494, a novel potent and selective oral SYK inhibitor displays differential potency in human basophils and B-cells. J Pharmacol Exp Ther. 2016 Apr 5. pii: jpet.116.233155. [Epub ahead of print] PubMed PMID: 27048659.

Grünwald V, Länger F, Raatschen HJ, Beilken A. Proof of principle for bevacizumab activity in desmoid-type fibromatosis. Clin Sarcoma Res. 2016 Apr 4;6:5. doi: 10.1186/s13569-016-0045-3. eCollection 2016. PubMed PMID: 27047656; PubMed Central PMCID: PMC4819267.

Allers M, Langejuergen J, Gaida A, Holz O, Schuchardt S, Hohlfeld JM, Zimmermann S. Measurement of exhaled volatile organic compounds from patients with chronic obstructive pulmonary disease (COPD) using closed gas loop GC-IMS and GC-APCI-MS. J Breath Res. 2016 Apr 8;10(2):026004. PubMed PMID: 27058460.

Gehring U, Wijga AH, Hoek G, Bellander T, Berdel D, Brüske I, Fuertes E, Gruzieva O, Heinrich J, Hoffmann B, de Jongste JC, Klümper C, Koppelman GH, Korek M, Krämer U, Maier D, Melén E, Pershagen G, Postma DS, Standl M, von Berg A, Anto JM, Bousquet J, Keil T, Smit HA, Brunekreef B. Exposure to air pollution and development of asthma and rhinoconjunctivitis throughout childhood and adolescence: a population-based birth cohort study. Lancet Respir Med. 2015 Dec;3(12):933-42. doi: 10.1016/S2213-2600(15)00426-9. PubMed PMID: 27057569.

Hector A, Chotirmall SH, Lavelle GM, Mirković B, Horan D, Eichler L, Mezger M, Singh A, Ralhan A, Berenbrinker S, Mack I, Ensenauer R, Riethmüller J, Graepler-Mainka U, Murray MA, Griese M, McElvaney NG, Hartl D. Chitinase activation in patients with fungus-associated cystic fibrosis lung disease. J Allergy Clin Immunol. 2016 Apr 4. pii: S0091-6749(16)00303-1. doi: 10.1016/j.jaci.2016.01.031. [Epub ahead of print] PubMed PMID: 27056270.

Günther S, Behr J, Knoop H. [Drug-induced Pulmonary Hypertension - a Current Review]. Pneumologie. 2016 Apr 7. [Epub ahead of print] German. PubMed PMID: 27055781.

Hansmann G, Apitz C, Abdul-Khaliq H, Alastalo TP, Beerbaum P, Bonnet D, Dubowy KO, Gorenflo M, Hager A, Hilgendorff A, Kaestner M, Koestenberger M, Koskenvuo JW, Kozlik-Feldmann R, Kuehne T, Lammers AE, Latus H, Michel-Behnke I, Miera O, Moledina S, Muthurangu V, Pattathu J, Schranz D, Warnecke G, Zartner P. Executive summary. Expert consensus statement on the diagnosis and treatment of paediatric pulmonary hypertension. The European Paediatric Pulmonary Vascular Disease Network, endorsed by ISHLT and DGPK. Heart. 2016 May;102 Suppl 2:ii86-ii100. doi: 10.1136/heartjnl-2015-309132. PubMed PMID: 27053701.

Kaestner M, Schranz D, Warnecke G, Apitz C, Hansmann G, Miera O. Pulmonary hypertension in the intensive care unit. Expert consensus statement on the diagnosis and treatment of paediatric pulmonary hypertension. The European Paediatric Pulmonary Vascular Disease Network, endorsed by ISHLT and DGPK. Heart. 2016 May;102 Suppl 2:ii57-ii66. doi: 10.1136/heartjnl-2015-307774. PubMed PMID: 27053699.

Hilgendorff A, Apitz C, Bonnet D, Hansmann G. Pulmonary hypertension associated with acute or chronic lung diseases in the preterm and term neonate and infant. The European Paediatric Pulmonary Vascular Disease Network, endorsed by ISHLT and DGPK. Heart. 2016 May;102 Suppl 2:ii49-ii56. doi: 10.1136/heartjnl-2015-308591. PubMed PMID: 27053698.

Pattathu J, Gorenflo M, Hilgendorff A, Koskenvuo JW, Apitz C, Hansmann G, Alastalo TP. Genetic testing and blood biomarkers in paediatric pulmonary hypertension. Expert consensus statement on the diagnosis and treatment of paediatric pulmonary hypertension. The European Paediatric Pulmonary Vascular Disease Network, endorsed by ISHLT and DGPK. Heart. 2016 May;102 Suppl 2:ii36-ii41. doi: 10.1136/heartjnl-2014-307238. PubMed PMID: 27053696.

New in PubMed from DZL Faculty/ Neu von der DZL-Fakultät in der Woche bis 03. April 2016:

Kreuter M, Ehlers-Tenenbaum S, Palmowski K, Bruhwyler J, Oltmanns U, Muley T, Heussel CP, Warth A, Kolb M, Herth FJ. Impact of Comorbidities on Mortality in Patients with Idiopathic Pulmonary Fibrosis. PLoS One. 2016 Mar 29;11(3):e0151425. doi: 10.1371/journal.pone.0151425. eCollection 2016. PubMed PMID: 27023440.

van Rijt SH, Bölükbas DA, Argyo C, Wipplinger K, Naureen M, Datz S, Eickelberg O, Meiners S, Bein T, Schmid O, Stoeger T. Applicability of avidin protein coated mesoporous silica nanoparticles as drug carriers in the lung. Nanoscale. 2016 Mar 29. [Epub ahead of print] PubMed PMID: 27021247.

Hüttmann EM, Greulich T, Koepke J, Nell C, Hattesohl A, Schmid S, Noeske S, Herr C, John G, Jörres RA, Müller B, Vogelmeier C, Koczulla AR. Correction: Comparison of Two Devices and Two Breathing Patterns for Exhaled Breath Condensate Sampling. PLoS One. 2016 Mar 28;11(3):e0152620. doi: 10.1371/journal.pone.0152620. eCollection 2016. PubMed PMID: 27018972.

Roth A, Glaesener S, Schütz K, Meyer-Bahlburg A. Reduced Number of Transitional and Naive B Cells in Addition to Decreased BAFF Levels in Response to the T Cell Independent Immunogen Pneumovax®23. PLoS One. 2016 Mar 31;11(3):e0152215. doi: 10.1371/journal.pone.0152215. eCollection 2016. PubMed PMID: 27031098.

Lim HJ, Weinheimer O, Wielpütz MO, Dinkel J, Hielscher T, Gompelmann D, Kauczor HU, Heussel CP. Fully Automated Pulmonary Lobar Segmentation: Influence of Different Prototype Software Programs onto Quantitative Evaluation of Chronic Obstructive Lung Disease. PLoS One. 2016 Mar 30;11(3):e0151498. doi: 10.1371/journal.pone.0151498. eCollection 2016. PubMed PMID: 27029047.

Gozdz J, Holbreich M, Metwali N, Thorne PS, Sperling AI, Martinez FD, Ober C, von Mutius E, Vercelli D. Amish and Hutterite Environmental Farm Products Have Opposite Effects on Experimental Models of Asthma. Ann Am Thorac Soc. 2016 Mar;13 Suppl 1:S99. doi: 10.1513/AnnalsATS.201509-581MG. PubMed PMID: 27027969.

Lunding L, Webering S, Vock C, Schröder A, Raedler D, Schaub B, Fehrenbach H, Wegmann M. Effect of IL-37 on Allergic Airway Inflammation. Ann Am Thorac Soc. 2016 Mar;13 Suppl 1:S95-6. doi: 10.1513/AnnalsATS.201506-380MG. PubMed PMID: 27027963.

White ES, Borok Z, Brown KK, Eickelberg O, Guenther A, Jenkins RG, Kolb M, Martinez FJ, Roman J, Sime P; American Thoracic Society Respiratory Cell and Molecular Biology Assembly Working Group on Pulmonary Fibrosis. An American Thoracic Society Official Research Statement: Future Directions in Lung Fibrosis Research. Am J Respir Crit Care Med. 2016 Apr 1;193(7):792-800. doi: 10.1164/rccm.201602-0254ST. PubMed PMID: 27035782.

Watz H. Chronic Obstructive Pulmonary Disease: When Pulmonologists Do Something Good for the Heart. Am J Respir Crit Care Med. 2016 Apr 1;193(7):703-4. doi: 10.1164/rccm.201512-2340ED. PubMed PMID: 27035775.

Hofmann N, Galetskiy D, Rauch D, Wittmann T, Marquardt A, Griese M, Zarbock R. Analysis of the Proteolytic Processing of ABCA3: Identification of Cleavage Site and Involved Proteases. PLoS One. 2016 Mar 31;11(3):e0152594. doi: 10.1371/journal.pone.0152594. eCollection 2016. PubMed PMID: 27031696.

Richter MJ, Milger K, Haase S, Sommer N, Tello K, Seeger W, Mayer E, Wiedenroth CB, Grimminger F, George W, Ghofrani HA, Guth S, Gall H. The Clinical Significance of HbA1c in Operable Chronic Thromboembolic Pulmonary Hypertension. PLoS One. 2016 Mar 31;11(3):e0152580. doi: 10.1371/journal.pone.0152580. eCollection 2016. PubMed PMID: 27031508.

Nold P, Hackstein H, Riedlinger T, Kasper C, Neumann A, Mernberger M, Fölsch C, Schmitt J, Fuchs-Winkelmann S, Barckhausen C, Killer M, Neubauer A, Brendel C. Immunosuppressive capabilities of mesenchymal stromal cells are maintained under hypoxic growth conditions and after gamma irradiation. Cytotherapy. 2015 Feb;17(2):152-62. doi: 10.1016/j.jcyt.2014.10.004. Epub 2014 Nov 21. PubMed PMID: 25453724.

März 2016

New in PubMed from DZL Faculty/ Neu von der DZL-Fakultät in der Woche bis 27. März 2016:

Suhling H, Bollmann B, Gottlieb J. Nintedanib in restrictive chronic lung allograft dysfunction after lung transplantation. J Heart Lung Transplant. 2016 Feb 9. pii: S1053-2498(16)01274-2. doi: 10.1016/j.healun.2016.01.1220. [Epub ahead of print] PubMed PMID: 26996931.

Peteranderl C, Morales-Nebreda L, Selvakumar B, Lecuona E, Vadász I, Morty RE, Schmoldt C, Bespalowa J, Wolff T, Pleschka S, Mayer K, Gattenloehner S, Fink L, Lohmeyer J, Seeger W, Sznajder JI, Mutlu GM, Budinger GR, Herold S. Macrophage-epithelial paracrine crosstalk inhibits lung edema clearance during influenza infection. J Clin Invest. 2016 Mar 21. pii: 83931. doi: 10.1172/JCI83931. [Epub ahead of print] PubMed PMID: 26999599.

Smith MP, von Berg A, Berdel D, Bauer CP, Hoffmann B, Koletzko S, Nowak D, Heinrich J, Schulz H. Physical activity is not associated with spirometric indices in lung-healthy German youth. Eur Respir J. 2016 Mar 23. pii: ERJ-01408-2015. doi: 10.1183/13993003.01408-2015. [Epub ahead of print] PubMed PMID: 27009173.

Pletz MW, Ewig S, Rohde G, Schuette H, Rupp J, Welte T, Suttorp N, Forstner C; CAPNETZ Study Group. Impact of pneumococcal vaccination in children on serotype distribution in adult community-acquired pneumonia using the serotype-specific multiplex urinary antigen detection assay. Vaccine. 2016 Mar 23. pii: S0264-410X(16)30035-4. doi: 10.1016/j.vaccine.2016.03.052. [Epub ahead of print] PubMed PMID: 27016653.

Ehrhardt H, Pritzke T, Oak P, Kossert M, Biebach L, Förster K, Koschlig M, Alvira CM, Hilgendorff A. ABSENCE OF TNF-α ENHANCES INFLAMMATORY RESPONSE IN THE NEWBORN LUNG UNDERGOING MECHANICAL VENTILATION. Am J Physiol Lung Cell Mol Physiol. 2016 Mar 25:ajplung.00367.2015. doi: 10.1152/ajplung.00367.2015. [Epub ahead of print] PubMed PMID: 27016588.

Shi L, Kojonazarov B, Elgheznawy A, Popp R, Dahal BK, Böhm M, Pullamsetti SS, Ghofrani HA, Gödecke A, Jungmann A, Katus HA, Müller OJ, Schermuly RT, Fisslthaler B, Seeger W, Fleming I. miR-223-IGF-IR signaling in hypoxia- and load-induced right ventricular failure: a novel therapeutic approach. Cardiovasc Res. 2016 Mar 24. pii: cvw065. [Epub ahead of print] PubMed PMID: 27013635.

Sarikouch S, Horke A, Tudorache I, Beerbaum P, Westhoff-Bleck M, Boethig D, Repin O, Maniuc L, Ciubotaru A, Haverich A, Cebotari S. Decellularized fresh homografts for pulmonary valve replacement: a decade of clinical experience. Eur J Cardiothorac Surg. 2016 Mar 24. pii: ezw050. [Epub ahead of print] PubMed PMID: 27013071.

Fleischmann C, Thomas-Rueddel DO, Hartmann M, Hartog CS, Welte T, Heublein S, Heublein S, Dennler U, Reinhart K. Hospital Incidence and Mortality Rates of Sepsis. Dtsch Arztebl Int. 2016 Mar 11;113(10):159-66. doi: 10.3238/arztebl.2016.0159. PubMed PMID: 27010950.

Diederich AK, Duda KA, Romero-Saavedra F, Engel R, Holst O, Huebner J. Deletion of fabN in Enterococcus faecalis results in unsaturated fatty acid auxotrophy and decreased release of inflammatory cytokines. Innate Immun. 2016 Mar 22. pii: 1753425916639669. [Epub ahead of print] PubMed PMID: 27009913.

Harzheim D, Sterman D, Shah PL, Eberhardt R, Herth FJ. Bronchoscopic Transparenchymal Nodule Access: Feasibility and Safety in an Endoscopic Unit. Respiration. 2016 Mar 24. [Epub ahead of print] PubMed PMID: 27007334.

Papakonstantinou E, Prasse A, Schacht V, Kapp A, Raap U. Pirfenidone-induced severe phototoxic reaction in a patient with idiopathic lung fibrosis. J Eur Acad Dermatol Venereol. 2016 Mar 23. doi: 10.1111/jdv.13657. [Epub ahead of print] PubMed PMID: 27005406.

Smith MP, von Berg A, Berdel D, Bauer CP, Hoffmann B, Koletzko S, Nowak D, Heinrich J, Schulz H. Physical activity is not associated with spirometric indices in lung-healthy German youth. Eur Respir J. 2016 Mar 23. pii: ERJ-01408-2015. doi: 10.1183/13993003.01408-2015. [Epub ahead of print] PubMed PMID: 27009173.

Smith MP, Berdel D, Nowak D, Heinrich J, Schulz H. Physical Activity Levels and Domains Assessed by Accelerometry in German Adolescents from GINIplus and LISAplus. PLoS One. 2016 Mar 24;11(3):e0152217. doi: 10.1371/journal.pone.0152217. eCollection 2016. PubMed PMID: 27010227; PubMed Central PMCID: PMC4806867.

Bauer T, Trump S, Ishaque N, Thürmann L, Gu L, Bauer M, Bieg M, Gu Z, Weichenhan D, Mallm JP, Röder S, Herberth G, Takada E, Mücke O, Winter M, Junge KM, Grützmann K, Rolle-Kampczyk U, Wang Q, Lawerenz C, Borte M, Polte T, Schlesner M, Schanne M, Wiemann S, Geörg C, Stunnenberg HG, Plass C, Rippe K, Mizuguchi J, Herrmann C, Eils R, Lehmann I. Environment-induced epigenetic reprogramming in genomic regulatory elements in smoking mothers and their children. Mol Syst Biol. 2016 Mar 24;12(3):861. doi: 10.15252/msb.20156520. PubMed PMID: 27013061.

New in PubMed from DZL Faculty/ Neu von der DZL-Fakultät in der Woche bis 20. März 2016:

Fuehner T, Fuge J, Jungen M, Buck A, Suhling H, Welte T, Gottlieb J, Greer M. Topical Nasal Anesthesia in Flexible Bronchoscopy - A Cross-Over Comparison between Two Devices. PLoS One. 2016 Mar 15;11(3):e0150905. doi: 10.1371/journal.pone.0150905. eCollection 2016. PubMed PMID: 26978775.

Biancosino C, Welker L, Krüger M, Bölükbas S, Bittmann I, Kirsten D. Diagnostic Gain from Surgical Biopsy for Interstitial Lung Disease - When is it Worth the Risk? Pneumologie. 2016 Mar;70(3):205-210. Epub 2016 Mar 15. PubMed PMID: 26977754.

Hoeper MM, McLaughlin VV, Dalaan AM, Satoh T, Galiè N. Treatment of pulmonary  hypertension. Lancet Respir Med. 2016 Mar 11. pii: S2213-2600(15)00542-1. doi: 10.1016/S2213-2600(15)00542-1. [Epub ahead of print] Review. PubMed PMID: 26975811.

Hoeper MM, Humbert M, Souza R, Idrees M, Kawut SM, Sliwa-Hahnle K, Jing ZC, Gibbs JS. A global view of pulmonary hypertension. Lancet Respir Med. 2016 Mar 11. pii: S2213-2600(15)00543-3. doi: 10.1016/S2213-2600(15)00543-3. [Epub ahead of print] Review. PubMed PMID: 26975810.

Manapov F, Niyazi M, Gerum S, Roengvoraphoj O, Eze C, Li M, Hildebrandt G, Fietkau R, Klautke G, Belka C. Evaluation of the role of remission status in a heterogeneous limited disease small-cell lung cancer patient cohort treated with definitive chemoradiotherapy. BMC Cancer. 2016 Mar 14;16(1):216. doi: 10.1186/s12885-016-2245-x. PubMed PMID: 26975407; PubMed Central PMCID: PMC4791754.

Kim DW, Mehra R, Tan DS, Felip E, Chow LQ, Camidge DR, Vansteenkiste J, Sharma S, De Pas T, Riely GJ, Solomon BJ, Wolf J, Thomas M, Schuler M, Liu G, Santoro A, Sutradhar S, Li S, Szczudlo T, Yovine A, Shaw AT. Activity and safety of ceritinib in patients with ALK-rearranged non-small-cell lung cancer (ASCEND-1): updated results from the multicentre, open-label, phase 1 trial. Lancet Oncol. 2016 Mar 10. pii: S1470-2045(15)00614-2. doi: 10.1016/S1470-2045(15)00614-2. [Epub ahead of print] PubMed PMID: 26973324.

Mostafa A, Abdelwhab EM, Slanina H, Hussein MA, Kuznetsova I, Schüttler CG, Ziebuhr J, Pleschka S. Phylogenetic analysis of human influenza A/H3N2 viruses isolated in 2015 in Germany indicates significant genetic divergence from vaccine strains. Arch Virol. 2016 Mar 14. [Epub ahead of print] PubMed PMID: 26973232.

Welte T. Pneumococcal Conjugate Vaccine-Equally Effective for Everyone? Dtsch Arztebl Int. 2016 Mar 4;113(9):137-8. doi: 10.3238/arztebl.2016.0137. PubMed PMID: 26987461.

Li A, Ma S, Smith SM, Lee MK, Fischer A, Borok Z, Bellusci S, Li C, Minoo P. Mesodermal ALK5 controls lung myofibroblast versus lipofibroblast cell fate. BMC Biol. 2016 Mar 16;14(1):19. doi: 10.1186/s12915-016-0242-9. PubMed PMID: 26984772; PubMed Central PMCID: PMC4793501.

Suttorp N, Welte T, Marre R, Stenger S, Pletz M, Rupp J, Schütte H, Rohde G; CAPNETZ-Studiengruppe. [CAPNETZ : The competence network for community-acquired pneumonia (CAP)]. Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz. 2016 Mar 16. [Epub ahead of print] German. PubMed PMID: 26984399.

von Laffert M, Schirmacher P, Warth A, Weichert W, Büttner R, Huber RM, Wolf J, Griesinger F, Dietel M, Grohé C. [Statement of the German Society for Pathology and the working group thoracic oncology of the working group oncology/German Cancer Society on ALK testing in NSCLC : Immunohistochemistry and/or FISH?]. Pathologe. 2016 Mar 16. [Epub ahead of print] German. PubMed PMID: 26984297.

Griss K, Bertrams W, Sittka-Stark A, Seidel K, Stielow C, Hippenstiel S, Suttorp N, Eberhardt M, Wilhelm J, Vera J, Schmeck B. microRNAs constitute a negative feedback loop in Streptococcus pneumoniae induced macrophage activation. J Infect Dis. 2016 Mar 16. pii: jiw109. [Epub ahead of print] PubMed PMID: 26984146.

Reck M, Socinski MA, Luft A, Szczęsna A, Dediu M, Ramlau R, Losonczy G, Molinier O, Schumann C, Gralla RJ, Bonomi P, Brown J, Soldatenkova V, Chouaki N, Obasaju C, Peterson P, Thatcher N. The effect of necitumumab in combination with gemcitabine plus cisplatin on tolerability and on quality of life: results from the phase III SQUIRE trial. J Thorac Oncol. 2016 Mar 12. pii: S1556-0864(16)00446-9. doi: 10.1016/j.jtho.2016.03.002. [Epub ahead of print] PubMed PMID: 26980471.

von Laffert M, Schirmacher P, Warth A, Weichert W, Büttner R, Huber RM, Wolf J, Griesinger F, Dietel M, Grohé C. [ALK-Diagnostics in NSCLC - Immunohistochemistry (IHC) and/or Fluorescence-in-situ Hybridisation (FISH)]. Pneumologie. 2016 Mar 16. [Epub ahead of print] German. PubMed PMID: 26984109.

Fernandez IE, Amarie OV, Mutze K, Königshoff M, Yildirim AÖ, Eickelberg O. Systematic phenotyping and correlation of biomarkers with lung function and histology in lung fibrosis. Am J Physiol Lung Cell Mol Physiol. 2016 Mar 18:ajplung.00183.2015. doi: 10.1152/ajplung.00183.2015. [Epub ahead of print] PubMed PMID: 26993522.

Schipke J, Grimm C, Arnstein G, Kockskämper J, Sedej S, Mühlfeld C. Cardiomyocyte loss is not required for the progression of left ventricular hypertrophy induced by pressure overload in female mice. J Anat. 2016 Mar 17. doi: 10.1111/joa.12463. [Epub ahead of print] PubMed PMID: 26990078.

Rank CM, Heußer T, Buzan MT, Wetscherek A, Freitag MT, Dinkel J, Kachelrieß M. 4D respiratory motion-compensated image reconstruction of free-breathing radial MR data with very high undersampling. Magn Reson Med. 2016 Mar 16. doi: 10.1002/mrm.26206. [Epub ahead of print] PubMed PMID: 26991911.

New in PubMed from DZL Faculty/ Neu von der DZL-Fakultät in der Woche bis 13. März 2016:

Beck-Broichsitter M, Samsonova O, Nguyen J, Schmehl T, Seeger W, Kissel T. Influence of amine modified poly(vinyl alcohol)s on vibrating-membrane nebulizer performance and lung toxicity. Eur J Pharm Sci. 2016 Mar 2;86:34-40. doi: 10.1016/j.ejps.2016.02.023. [Epub ahead of print] PubMed PMID: 26946442.

Fuehner T, Kuehn C, Welte T, Gottlieb J. ICU Care Before and After Lung Transplantation. Chest. 2016 Mar 4. pii: S0012-3692(16)41574-6. doi: 10.1016/j.chest.2016.02.656. [Epub ahead of print] Review. PubMed PMID: 26953218.

Gdynia G, Sauer SW, Kopitz J, Fuchs D, Duglova K, Ruppert T, Miller M, Pahl J, Cerwenka A, Enders M, Mairbäurl H, Kamiński MM, Penzel R, Zhang C, Fuller JC, Wade RC, Benner A, Chang-Claude J, Brenner H, Hoffmeister M, Zentgraf H, Schirmacher P, Roth W. The HMGB1 protein induces a metabolic type of tumour cell death by blocking aerobic respiration. Nat Commun. 2016 Mar 7; 7:10764. doi: 10.1038/ncomms10764. PubMed PMID: 26948869.

Smits HH, Hiemstra PS, Prazeres da Costa C, Ege M, Edwards M, Garn H, Howarth PH, Jartti T, de Jong EC, Maizels RM, Marsland BJ, McSorley HJ, Müller A, Pfefferle PI, Savelkoul H, Schwarze J, Unger WW, von Mutius E, Yazdanbakhsh M, Taube C. Microbes and asthma: Opportunities for intervention. J Allergy Clin Immunol. 2016 Mar;137(3):690-7. doi: 10.1016/j.jaci.2016.01.004. PubMed PMID: 26947981.

Solé-Lleonart C, Rouby JJ, Chastre J, Poulakou G, Palmer LB, Blot S, Felton T, Bassetti M, Luyt CE, Pereira JM, Riera J, Welte T, Roberts JA, Rello J. Intratracheal Administration of Antimicrobial Agents in Mechanically Ventilated Adults: An International Survey on Delivery Practices and Safety. Respir Care. 2016 Mar 8. pii: respcare.04519. [Epub ahead of print] PubMed PMID: 26957647.

Vardavas CI, Hohmann C, Patelarou E, Martinez D, Henderson AJ, Granell R, Sunyer J, Torrent M, Fantini MP, Gori D, Annesi-Maesano I, Slama R, Duijts L, de Jongste JC, Aurrekoetxea JJ, Basterrechea M, Morales E, Ballester F, Murcia M, Thijs C, Mommers M, Kuehni CE, Gaillard EA, Tischer C, Heinrich J, Pizzi C, Zugna D, Gehring U, Wijga A, Chatzi L, Vassilaki M, Bergström A, Eller E, Lau S, Keil T, Nieuwenhuijsen M, Kogevinas M. The independent role of prenatal and postnatal exposure to active and passive smoking on the development of early wheeze in children. Eur Respir J. 2016 Mar 10. pii: ERJ-01016-2015. doi: 10.1183/13993003.01016-2015. [Epub ahead of print] PubMed PMID: 26965294.

Bousquet J, Anto JM, Akdis M, Auffray C, Keil T, Momas I, Postma D, Valenta R, Wickman M, Cambon Thomsen A, Haahtela T, Lambrecht BN, Lodrup-Carlsen K, Koppelman GH, Sunyer J, Zuberbier T, Annesi-Maesano I, Arno A, Bindslev-Jensen C, De Carlo G, Forastiere F, Heinrich J, Kowalski ML, Maier D, Melén E, Palkonen S, Smit HA, Standl M, Wright J, Arsanoj A, Benet M, Balardini N, Garcia Aymerich J, Gehring U, Guerra S, Hohman C, Kull I, Lupinek C, Pinart M, Skrindo I, Westman M, Smagghe D, Akdis C, Albang R, Anastasova V, Anderson N, Bachert C, Ballereau S, Ballester F, Basagana X, Bedbrook A, Bergstrom A, von Berg A, Brunekreef B, Burte E, Carlsen KH, Chatzi L, Coquet JM, Curin M, Demoly P, Eller E, Fantini MP, Gerhard B, Hammad H, von Hertzen L, Hovland V, Jacquemin B, Just J, Keller T, Kerkhof M, Kiss R, Kogevinas M, Koletzko S, Lau S, Lehmann I, Lemonnier N, McEachan R, Mäkelä M, Mestres J, Minina E, Mowinckel P, Nadif R, Nawijn M, Oddie S, Pellet J, Pin I, Porta D, Rancière F, Rial-Sebbag A, Saes Y, Schuijs MJ, Siroux V, Tischer CG, Torrent M, Varraso R, De Vocht J, Wenger K, Wieser S, Xu C. Paving the way of systems biology and precision medicine in allergic diseases: The MeDALL success story. Allergy. 2016 Mar 10. doi: 10.1111/all.12880. [Epub ahead of print] Review. PubMed PMID: 26970340.

Baumeler L, Papakonstantinou E, Milenkovic B, Lacoma A, Louis R, Aerts JG, Welte T, Kostikas K, Blasi F, Boersma W, Torres A, Rohde GG, Boeck L, Rakic J, Scherr A, Tamm M, Stolz D. Therapy with proton pump inhibitors for gastroesophageal reflux disease does not reduce the risk for severe exacerbations in COPD. Respirology. 2016 Mar 11. doi: 10.1111/resp.12758. [Epub ahead of print] PubMed PMID: 26970108.

Collins MM, Stainier DY. Organ Function as a Modulator of Organ Formation: Lessons from Zebrafish. Curr Top Dev Biol. 2016;117:417-33. doi: 10.1016/bs.ctdb.2015.10.017. Epub 2016 Jan 7. PubMed PMID: 26969993.

Bahmer T, Watz H, Waschki B, Gramm M, Magnussen H, Rabe KF, Wirtz H, Kirsten D, Kirsten A. Reduced physical activity in lymphangioleiomyomatosis compared with COPD and healthy controls: disease-specific impact and clinical correlates. Thorax. 2016 Mar 11. pii: thoraxjnl-2015-207852. doi: 10.1136/thoraxjnl-2015-207852. [Epub ahead of print] PubMed PMID: 26968971.

Weigel C, Veldwijk MR, Oakes CC, Seibold P, Slynko A, Liesenfeld DB, Rabionet M, Hanke SA, Wenz F, Sperk E, Benner A, Rösli C, Sandhoff R, Assenov Y, Plass C, Herskind C, Chang-Claude J, Schmezer P, Popanda O. Epigenetic regulation of diacylglycerol kinase alpha promotes radiation-induced fibrosis. Nat Commun. 2016 Mar 11;7:10893. doi: 10.1038/ncomms10893. PubMed PMID: 26964756.

New in PubMed from DZL Faculty/ Neu von der DZL-Fakultät in der Woche bis 6. März 2016:

Warth A, Muley T, Harms A, Hoffmann H, Dienemann H, Schirmacher P, Weichert W. Clinical Relevance of Different Papillary Growth Patterns of Pulmonary Adenocarcinoma. Am J Surg Pathol. 2016 Feb 26. [Epub ahead of print] PubMed PMID: 26927890.

Retailleau K, Arhatte M, Demolombe S, Peyronnet R, Baudrie V, Jodar M, Bourreau J, Henrion D, Offermanns S, Nakamura F, Feng Y, Patel A, Duprat F, Honoré E. Arterial Myogenic Activation through Smooth Muscle Filamin A. Cell Rep. 2016 Feb 23. pii: S2211-1247(16)30105-X. doi: 10.1016/j.celrep.2016.02.019. [Epub ahead of print] PubMed PMID: 26923587.

Ewig S, Höffken G, Kern WV, Rohde G, Flick H, Krause R, Ott S, Bauer T, Dalhoff K, Gatermann S, Kolditz M, Krüger S, Lorenz J, Pletz M, de Roux A, Schaaf B, Schaberg T, Schütte H, Welte T. [Management of Adult Community-acquired Pneumonia and Prevention - Update 2016]. Pneumologie. 2016 Feb 29. [Epub ahead of print] German. PubMed PMID: 26926396.

Wujak L, Markart P, Wygrecka M. The low density lipoprotein receptor-related protein (LRP) 1 and its function in lung diseases. Histol Histopathol. 2016 Mar 1:11746. [Epub ahead of print] Review. PubMed PMID: 26926950.

Olsson KM, Olle S, Fuge J, Welte T, Hoeper MM, Lerch C, Maegel L, Haller H, Jonigk D, Schiffer L. CXCL13 in idiopathic pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension. Respir Res. 2016 Feb 29;17(1):21. doi: 10.1186/s12931-016-0336-5. PubMed PMID: 26927848; PubMed Central PMCID: PMC4770535.

Wittmann T, Frixel S, Höppner S, Schindlbeck U, Schams A, Kappler MV, Hegermann J, Wrede C, Liebisch G, Vierzig A, Zacharasiewicz A, Kopp M, Poets CF, Baden W, Hartl D, Van Kaam AH, Lohse P, Aslanidis C, Zarbock R, Griese M. Increased risk of interstitial lung disease in children with a single R288K variant of ABCA3. Mol Med. 2016 Feb 26. doi: 10.2119/molmed.2015.00244. [Epub ahead of print] PubMed PMID: 26928390.

Rafikova O, Rafikov R, Kangath A, Qu N, Aggarwal S, Sharma S, Desai J, Fields T, Ludewig B, Yuan JX, Jonigk D, Black SM. Redox regulation of epidermal growth factor receptor signaling during the development of pulmonary hypertension. Free Radic Biol Med. 2016 Feb 27. pii: S0891 5849(16)00088-5. doi: 10.1016/j.freeradbiomed.2016.02.029. [Epub ahead of print] PubMed PMID: 26928584.

Hoeper MM. Combination or monotherapy for pulmonary arterial hypertension? Lancet Respir Med. 2016 Feb 26. pii: S2213-2600(16)00058-8. doi: 10.1016/S2213-2600(16)00058-8. [Epub ahead of print] PubMed PMID: 26935845.

Weber A, Herr C, Hendrowarsito L, Meyer N, Nennstiel-Ratzel U, von Mutius E, Bolte G, Colon D, Kolb S; GME Study Group. No further increase in the parent reported prevalence of allergies in Bavarian preschool children: Results from three cross-sectional studies. Int J Hyg Environ Health. 2016 Feb 15. pii: S1438-4639(16)30003-7. doi: 10.1016/j.ijheh.2016.02.001. [Epub ahead of print] PubMed PMID: 26944211.

Forstner C, Rohde G, Rupp J, Schuette H, Ott SR, Hagel S, Harrison N, Thalhammer F, von Baum H, Suttorp N, Welte T, Pletz MW; CAPNETZ Study Group. Community-acquired Haemophilus influenza pneumonia - new insights from the CAPNETZ study. J Infect. 2016 Feb 29. pii: S0163-4453(16)00060 8. doi: 10.1016/j.jinf.2016.02.010. [Epub ahead of print] PubMed PMID: 26940505.

Pavord ID, Jones PW, Burgel PR, Rabe KF. Exacerbations of COPD. Int J Chron Obstruct Pulmon Dis. 2016 Feb 19; 11 Spec Iss:21-30. doi: 10.2147/COPD.S85978. eCollection 2016. Review. PubMed PMID: 26937187.

Jones PW, Watz H, Wouters EF, Cazzola M. COPD: the patient perspective. Int J Chron Obstruct Pulmon Dis. 2016 Feb 19; 11 Spec Iss:13-20. doi: 10.2147/COPD.S85977. eCollection 2016. Review. PubMed PMID: 26937186.

Agustí A, Jones PW, Vogelmeier C. Highlights and hot topics in the management of COPD: where are we heading? Int J Chron Obstruct Pulmon Dis. 2016 Feb 18;11 Spec Iss:1-2. doi: 10.2147/ COPD.S85975. eCollection 2016. PubMed PMID: 26937184.

Kreuter M, Nowak D, Rüther T, Hoch E, Thomasius R, Vogelberg C, Brockstedt M, Hellmann A, Gohlke H, Jany B, Loddenkemper R. [Cannabis - Position Paper of the German Respiratory Society (DGP)]. Pneumologie. 2016 Feb; 70(2):87-97. doi:10.1055/s-0042-100040. Epub 2016 Mar 2. German. PubMed PMID: 26935046.

Eigentler TK, Hassel JC, Berking C, Aberle J, Bachmann O, Grünwald V, Kähler KC, Loquai C, Reinmuth N, Steins M, Zimmer L, Sendl A, Gutzmer R. Diagnosis, monitoring and management of immune related adverse drug reactions of anti-PD-1 antibody therapy. Cancer Treat Rev. 2016 Feb 18;45:7-18. doi:10.1016/j.ctrv.2016.02.003. [Epub ahead of print] Review. PubMed PMID: 26922661.

Hollingsworth JW, Leikauf G, Lindsey JY, Schulz H. Comment on Expression of Concern: c-Kit Is Essential for Alveolar Maintenance and Protection from Emphysema-like Disease in Mice. Am J Respir Crit Care Med. 2016 Mar 1; 193(5):581-2. doi: 10.1164/rccm.1935comment. PubMed PMID: 26930438.

Februar 2016

New in PubMed from DZL Faculty/ Neu von der DZL-Fakultät in der Woche bis 28. Feb. 2016:

Forde É, Schütte A, Reeves E, Greene C, Humphreys H, Mall M, Fitzgerald-Hughes D, Devocelle M. Differential in vitro and in vivo toxicities of antimicrobial peptide prodrugs for potential use in cystic fibrosis. Antimicrob Agents Chemother. 2016 Feb 22. pii: AAC.00157-16. [Epub ahead of print] PubMed PMID: 26902766.

Chen Y, Zheng J, Huang Q, Deng F, Huang R, Zhao W, Yin J, Song L, Chen J, Gao X, Liu Z, Petersen F, Yu X. Autoantibodies against the Second Extracellular Loop of M3R Do neither Induce nor Indicate Primary Sjögren's Syndrome. PLoS One. 2016 Feb 22;11(2):e0149485. doi: 10.1371/journal.pone.0149485. eCollection 2016. PubMed PMID: 26901532.

Schulz U, Solidoro P, Müller V, Szabo A, Gottlieb J, Wilkens H, Enseleit F. CMV Immunoglobulins for the Treatment of CMV Infections in Thoracic Transplant Recipients. Transplantation. 2016 Mar; 100 Suppl 3:S5-S10. doi: 10.1097/TP.0000000000001097. PubMed PMID: 26900992.

Pérol M, Ciuleanu TE, Arrieta O, Prabhash K, Syrigos KN, Goksel T, Park K, Kowalyszyn RD, Pikiel J, Lewanski CR, Thomas M, Dakhil S, Kim JH, Karaseva N, Yurasov S, Zimmermann A, Lee P, Carter GC, Reck M, Cappuzzo F, Garon EB. Quality of life results from the phase 3 REVEL randomized clinical trial of ramucirumab-plus-docetaxel versus placebo-plus-docetaxel in advanced/metastatic non-small cell lung cancer patients with progression after platinum-based chemotherapy. Lung Cancer. 2016 Mar; 93:95-103. doi: 10.1016/j.lungcan.2016.01.007. Epub 2016 Jan 19. PubMed PMID: 26898621.

Werner F, Kojonazarov B, Gaßner B, Abeßer M, Schuh K, Völker K, Baba HA, Dahal BK, Schermuly RT, Kuhn M. Endothelial actions of atrial natriuretic peptide prevent pulmonary hypertension in mice. Basic Res Cardiol. 2016 Mar; 111(2):22. doi: 10.1007/s00395-016-0541-x. Epub 2016 Feb 24. PubMed PMID: 26909880.

Schieck M, Schouten JP, Michel S, Suttner K, Toncheva AA, Gaertner VD, Illig T, Lipinski S, Franke A, Klintschar M, Kalayci O, Sahiner UM, Birben E, Melén E, Pershagen G, Freidin MB, Ogorodova LM, Granell R, Henderson J, Brunekreef B, Smit HA, Vogelberg C, von Berg A, Bufe A, Heinzmann A, Laub O, Rietschel E, Simma B, Genuneit J, Jonigk D, Postma DS, Koppelman GH, Vonk JM, Timens W, Boezen HM, Kabesch M. Doublesex and mab-3 related transcription factor 1 (DMRT1) is a sex-specific genetic determinant of childhood-onset asthma and is expressed in testis and macrophages. J Allergy Clin Immunol. 2016 Feb 20. pii: S0091-6749(16)00052-X. doi: 10.1016/j.jaci.2015.12.1305. [Epub ahead of print]PubMed PMID: 26906082.

Hinrichs JB, Renne J, Hoeper MM, Olsson KM, Wacker FK, Meyer BC. Balloon pulmonary angioplasty: applicability of C-Arm CT for procedure guidance. Eur Radiol. 2016 Feb 23. [Epub ahead of print] PubMed PMID: 26905868.

Kang X, Liu H, Onaitis MW, Liu Z, Owzar K, Han Y, Su L, Wei Y, Hung RJ, Brhane Y, McLaughlin J, Brennan P, Bickeböller H, Rosenberger A, Houlston RS, Caporaso N, Landi MT, Heinrich J, Risch A, Wu X, Ye Y, Christiani DC, Amos CI, Wei Q; Transdisciplinary Research in Cancer of the Lung (TRICL) Research Team.Polymorphisms of the centrosomal gene (FGFR1OP) and lung cancer risk: a meta analysis of 14 463 cases and 44 188 controls. Carcinogenesis. 2016 Mar; 37(3):280-9. doi: 10.1093/carcin/bgw014. Epub 2016 Feb 10. PubMed PMID: 26905588.

Heinzelmann K, Noskovičová N, Merl-Pham J, Preissler G, Winter H, Lindner M, Hatz R, Hauck SM, Behr J, Eickelberg O. Surface proteome analysis identifies platelet derived growth factor receptor alpha as a critical mediator of transforming growth factor-beta-induced collagen secretion. Int J Biochem Cell Biol. 2016 Feb 20. pii: S1357-2725(16)30036-X. doi: 10.1016/j.biocel.2016.02.013. [Epub ahead of print] PubMed PMID: 26905437.

Kolditz M, Bauer TT, König T, Rohde G, Ewig S. 3-day mortality in hospitalised community acquired pneumonia: frequency and risk factors. Eur Respir J. 2016 Feb 25. pii: ERJ-00113-2016. doi: 10.1183/13993003.00113-2016. [Epub ahead of print] PubMed PMID: 26917605.

Abdelwhab EM, Hassan MK, Abdel-Moneim AS, Naguib MM, Mostafa A, Hussein IT, Arafa A, Erfan AM, Kilany WH, Agour MG, El-Kanawati Z, Hussein HA, Selim AA, Kholousy S, El-Naggar H, El-Zoghby EF, Samy AS, Iqbal M, Eid A, Ibraheem EM, Pleschka S, Veits J, Nasef SA, Beer M, Mettenleiter TC, Grund C, Ali MM, Harder TC, Hafez HM. Introduction and enzootic of A/H5N1 in Egypt: Virus evolution, pathogenicity and vaccine efficacy ten years on. Infect Genet Evol. 2016 Feb 22. pii: S1567 1348(16)30054-5. doi: 10.1016/j.meegid.2016.02.023. [Epub ahead of print] Review. PubMed PMID: 26917362.

Leidl R, Wacker M, Schwarzkopf L. Better understanding of the health care costs of lung cancer and the implications. Expert Rev Respir Med. 2016 Feb 26:1-3. [Epub ahead of print] PubMed PMID: 26916972.

Bateman ED, Goehring UM, Richard F, Watz H. Roflumilast combined with montelukast versus montelukast alone as add-on treatment in patients with moderate-to-severe asthma. J Allergy Clin Immunol. 2016 Feb 23. pii: S0091-6749(16)00107-X. doi: 10.1016/j.jaci.2015.11.035. [Epub ahead of print] PubMed PMID: 26915674.

Herth FJ, Slebos DJ, Rabe KF, Shah PL. Endoscopic Lung Volume Reduction: An Expert Panel Recommendation. Respiration. 2016 Feb 25. [Epub ahead of print] PubMed PMID: 26910845.

Merkert S, Martin U. Targeted genome engineering using designer nucleases: State of the art and practical guidance for application in human pluripotent stem cells. Stem Cell Res. 2016 Feb 11; 16(2):377-386. doi: 10.1016/j.scr.2016.02.027. [Epub ahead of print] Review. PubMed PMID: 26921872.

Bartmann J, Frankenberger M, Neurohr C, Eickelberg O, Nößner E, von Wulffen W. A novel role of MMP-13 for murine DC function: its inhibition dampens T cell activation. Int Immunol. 2016 Feb 26. pii: dxw008. [Epub ahead of print] PubMedPMID: 26921214.

Bahmer T, Romagnoli M, Girelli F, Claussen M, Rabe KF. The use of auto-antibody testing in the evaluation of interstitial lung disease (ILD) – A practical approach for the pulmonologist. Respir Med. 2016 Feb 1. pii: S0954-6111(16)30015-4. doi: 10.1016/j.rmed.2016.01.019. [Epub ahead of print] Review. PubMed PMID: 26921132.

Kauth M, Heine H. "Allergy protection by cowshed bacteria - recent findings and future prospects". Pediatr Allergy Immunol. 2016 Feb 26. doi: 10.1111/pai.12559. [Epub ahead of print] Review. PubMed PMID: 26919229.

Wiegmann B, von Seggern H, Höffler K, Korossis S, Dipresa D, Pflaum M, Schmeckebier S, Seume J, Haverich A. Developing a biohybrid lung – sufficient endothelialization of poly-4-methly-1 pentene gas exchange hollow-fiber membranes. J Mech Behav Biomed Mater. 2016 Feb 11;60:301 311. doi: 10.1016/j.jmbbm.2016.01.032. [Epub ahead of print] PubMed PMID: 26919566.

Poos AM, Maicher A, Dieckmann AK, Oswald M, Eils R, Kupiec M, Luke B, König R. Mixed Integer Linear Programming based machine learning approach identifies regulators of telomerase in yeast. Nucleic Acids Res. 2016 Feb 22. pii: gkw111. [Epub ahead of print] PubMed PMID: 26908654.

Herth FJ, Eberhardt R. Airway stent: what is new and what should be discarded. Curr Opin Pulm Med. 2016 Feb 22. [Epub ahead of print] PubMed PMID: 26907718.

Herth FJ, Valipour A, Shah PL, Eberhardt R, Grah C, Egan J, Ficker JH, Wagner M, Witt C, Liebers U, Hopkins P, Gesierich W, Phillips M, Stanzel F, McNulty WH, Petermann C, Snell G, Gompelmann D. Segmental volume reduction using thermal vapour ablation in patients with severe emphysema: 6 month results of the multicentre, parallel-group, open-label, randomised controlled STEP-UP trial. Lancet Respir Med. 2016 Feb 15. pii: S2213-2600(16)00045-X. doi: 10.1016/S2213-2600(16)00045-X. [Epub ahead of print] PubMed PMID: 26899390.

New in PubMed from DZL Faculty/ Neu von der DZL-Fakultät in der Woche bis 21. Feb. 2016:

Welte T, Chapman KR, Magnussen H, Miravitlles M. Current thinking and new paradigm for COPD. Respir Med. 2016 Jan 13. pii: S0954-6111(15)30078-0. doi: 10.1016/j.rmed.2015.10.014. [Epub ahead of print] PubMed PMID: 26895809.

Pereira PR, Oliveira-Junior MC, MacKenzie B, Chiovatto JE, Matos Y, Greiffo FR, Rigonato Oliveira NC, Brugemman TR, Delle H, Idzko M, Albertini R, Ligeiro Oliveira AP, Damaceno-Rodrigues NR, Caldini EG, Fernandez IE, Castro-Faria-Neto HC, Dolhnikoff M, Eickelberg O, Vieira RP. Exercise Reduces Lung Fibrosis Involving Serotonin/Akt Signaling. Med Sci Sports Exerc. 2016 Feb 18. [Epub ahead of print] PubMed PMID: 26895395.

Tümmler B. [Treatment of Cystic Fibrosis with CFTR Modulators]. Pneumologie. 2016 Feb 19. [Epub ahead of print] German. PubMed PMID: 26894479.

Kirschbaum A, Beutel B, Rinke A, Rexin P, Fink L, Koczulla R, Bartsch DK. [Multifocal Pulmonary Neuroendocrine Tumours: Genesis, Diagnostics and Treatment]. Pneumologie. 2016 Feb;70(2):123-9. doi: 10.1055/s-0041-110291. Epub 2016 Feb 19. German. PubMed PMID: 26894394.

Hoeper MM, Meyer K, Rademacher J, Fuge J, Welte T, Olsson KM. Diffusion Capacity and Mortality in Patients With Pulmonary Hypertension Due to Heart Failure With Preserved Ejection Fraction. JACC Heart Fail. 2016 Feb 2. pii: S2213-1779(15)00839-2. doi: 10.1016/j.jchf.2015.12.016. [Epub ahead of print] PubMed PMID: 26874383.

Grothaus K, Kanber D, Gellhaus A, Mikat B, Kolarova J, Siebert R, Wieczorek D, Horsthemke B. Genome-wide methylation analysis of retrocopy-associated CpG islands and their genomic environment. Epigenetics. 2016 Feb 18:0. [Epub ahead of print] PubMed PMID: 26890210.

Pillich H, Loose M, Zimmer KP, Chakraborty T. Diverse roles of endoplasmic reticulum stress sensors in bacterial infection. Mol Cell Pediatr. 2016 Dec; 3(1):9. doi: 10.1186/s40348-016-0037-7. Epub 2016 Feb 16. PubMed PMID: 26883353.

Reck M, Heigener D, Reinmuth N. Immunotherapy for small-cell lung cancer: emerging evidence. Future Oncol. 2016 Feb 17. [Epub ahead of print] PubMed PMID: 26882955.

Diel R, Loddenkemper R, Nienhaus A. Consequences of tuberculosis among asylum seekers for health care workers in Germany. J Occup Med Toxicol. 2016 Feb 16; 11:4. doi: 10.1186/s12995-016-0093-x. eCollection 2016. PubMed PMID: 26884805; PubMed Central PMCID: PMC4754836.

Liesche C, Venkatraman L, Aschenbrenner S, Grosse S, Grimm D, Eils R, Beaudouin J. Death receptor based enrichment of Cas9-expressing cells. BMC Biotechnol. 2016 Feb 16;16(1):17. doi: 10.1186/s12896-016-0250-4. PubMed PMID: 26883910; PubMed Central PMCID: PMC4755021.

Hautmann H, Hetzel J, Eberhardt R, Stanzel F, Wagner M, Schneider A, Dirschinger R, Poszler A. Cross Sectional Survey on Bronchoscopy in Germany – The Current Status of Clinical Practice. Pneumologie. 2016 Feb; 70(2):110-116. Epub 2016 Feb 19. PubMed PMID: 26894392.

New in PubMed from DZL Faculty/ Neu von der DZL-Fakultät in der Woche bis 14. Feb. 2016:

Welte T. New antibiotic development: the need versus the costs. Lancet Infect Dis. 2016 Feb 4. pii: S1473-3099(16)00068-2. doi: 10.1016/S1473-3099(16)00068-2. [Epub ahead of print] PubMed PMID: 26852725.

Hector A, Kirn T, Ralhan A, Graepler-Mainka U, Berenbrinker S, Riethmueller J, Hogardt M, Wagner M, Pfleger A, Autenrieth I, Kappler M, Griese M, Eber E, Martus P, Hartl D. Microbial colonization and lung function in adolescents with cystic fibrosis. J Cyst Fibros. 2016 Feb 5. pii: S1569-1993(16)00011 4. doi: 10.1016/j.jcf.2016.01.004. [Epub ahead of print] PubMed PMID: 26856310.

Ambatipudi S, Cuenin C, Hernandez-Vargas H, Ghantous A, Calvez-Kelm FL, Kaaks R, Barrdahl M, Boeing H, Aleksandrova K, Trichopoulou A, Lagiou P, Naska A, Palli D, Krogh V, Polidoro S, Tumino R, Panico S, Bueno-de-Mesquita B, Peeters PH, Quirós JR, Navarro C, Ardanaz E, Dorronsoro M, Key T, Vineis P, Murphy N, Riboli E, Romieu I, Herceg Z. Tobacco smoking-associated genome-wide DNA methylation changes in the EPIC study. Epigenomics. 2016 Feb 11. [Epub ahead of print] PubMed PMID: 26864933.

Marien E, Meister M, Muley T, Gomez Del Pulgar T, Derua R, Spraggins JM, Van de Plas R, Vanderhoydonc F, Machiels J, Binda MM, Dehairs J, Willette Brown J, Hu Y, Dienemann H, Thomas M, Schnabel PA, Caprioli RM, Lacal JC, Waelkens E, Swinnen JV. Phospholipid profiling identifies acyl chain elongation as a ubiquitous trait and potential target for the treatment of lung squamous cell carcinoma. Oncotarget. 2016 Feb 3. doi: 10.18632/oncotarget.7179. [Epub ahead of print] PubMed PMID: 26862848.

Dhami S, Nurmatov U, Agache I, Lau S, Muraro A, Jutel M, Roberts G, Akdis C, Bonini M, Calderon M, Casale T, Cavkaytar O, Cox L, Demoly P, Flood B, Hamelmann E, Izuhara K, Kalayci Ö, Kleine-Tebbe J, Nieto A, Papadopoulos N, Pfaar O, Rosenwasser L, Ryan D, Schmidt-Weber C, Szefler S, Wahn U, van Wijk RG, Wilkinson J, Sheikh A. Allergen immunotherapy for allergic asthma: protocol for a systematic review. Clin Transl Allergy. 2016 Feb 9; 6:5. doi: 10.1186/s13601-016-0094-y. eCollection 2015. PubMed PMID: 26862389; PubMed Central PMCID: PMC4746770.

Prior KK, Wittig I, Leisegang MS, Groenendyk J, Weissmann N, Michalak M, Jansen-Dürr P, Shah AM, Brandes RP. The endoplasmic reticulum chaperone calnexin is a NADPH oxidase Nox4 interacting protein. J Biol Chem. 2016 Feb 9. pii: jbc.M115.710772. [Epub ahead of print] PubMed PMID: 26861875.

Behr J. Guidelines or guidance for better idiopathic pulmonary fibrosis management? BMC Med. 2016 Feb 10; 14(1):24. doi: 10.1186/s12916-016-0567-9. PubMed PMID: 26860906; PubMed Central PMCID: PMC4748484.

Vuckovic A, Herber-Jonat S, Flemmer AW, Strizek B, Engels AC, Jani JC. Antenatal BAY 41-2272 reduces pulmonary hypertension in the rabbit model of congenital diaphragmatic hernia. Am J Physiol Lung Cell Mol Physiol. 2016 Feb 12: ajplung.00178.2015. doi: 10.1152/ajplung.00178.2015. [Epub ahead of print] PubMed PMID: 26873974.

Kenyon JJ, Duda KA, De Felice A, Cunneen MM, Molinaro A, Laitinen J, Skurnik M, Holst O, Reeves PR, De Castro C. Serotype O: 8 isolates in the Yersinia pseudotuberculosis complex have different O antigen gene clusters and produce various forms of rough LPS. Innate Immun. 2016 Feb 11. pii: 1753425916631403. [Epub ahead of print] PubMed PMID: 26873504.

Halle S, Keyser KA, Stahl FR, Busche A, Marquardt A, Zheng X, Galla M, Heissmeyer V, Heller K, Boelter J, Wagner K, Bischoff Y, Martens R, Braun A, Werth K, Uvarovskii A, Kempf H, Meyer Hermann M, Arens R, Kremer M, Sutter G, Messerle M, Förster R. In Vivo Killing Capacity of Cytotoxic T Cells Is Limited and Involves Dynamic Interactions and T Cell Cooperativity. Immunity. 2016 Feb 16; 44(2):233-45. doi: 10.1016/j.immuni.2016.01.010. Epub 2016 Feb 9. PubMed PMID: 26872694.

Huang R, Wei Y, Hung RJ, Liu G, Su L, Zhang R, Zong X, Zhang ZF, Morgenstern H, Brüske I, Heinrich J, Hong YC, Kim JH, Cote M, Wenzlaff A, Schwartz AG, Stucker I, Mclaughlin J, Marcus MW, Davies MP, Liloglou T, Field JK, Matsuo K, Barnett M, Thornquist M, Goodman G, Wang Y, Chen S, Yang P, Duell EJ, Andrew AS, Lazarus P, Muscat J, Woll P, Horsman J, Dawn Teare M, Flugelman A, Rennert G, Zhang Y, Brenner H, Stegmaier C, van der Heijden EH, Aben K, Kiemeney L, Barros-Dios J, Pérez-Ríos M, Ruano-Ravina A, Caporaso NE, Bertazzi PA, Landi MT, Dai J, Shen H, Fernandez-Tardon G, Rodriguez-Suarez M, Tardon A, Christiani DC. Associated Links Among Smoking, Chronic Obstructive Pulmonary Disease, and Small Cell Lung Cancer: A Pooled Analysis in the International Lung Cancer Consortium. EBioMedicine. 2015 Sep 24;2(11):1677-1685. eCollection 2015 Nov. PubMed PMID: 26870794; PubMed Central PMCID: PMC4740296.

Contoli M, Bellini F, Morandi L, Forini G, Bianchi S, Gnesini G, Marku B, Rabe KF, Papi A. Assessing small airway impairment in mild-to-moderate smoking asthmatic patients. Eur Respir J. 2016 Feb 11. pii: ERJ-01708-2015. doi: 10.1183/13993003.01708-2015. [Epub ahead of print] PubMed PMID: 26869674.

Mueller J, Stojkovic M, Berger AK, Rosenberger KD, Schlett CL, Kauczor HU, Junghanss T, Weber TF. How to not miss alveolar echinococcosis in hepatic lesions suspicious for cholangiocellular carcinoma. Abdom Radiol (NY). 2016Feb; 41(2):221-30. doi: 10.1007/s00261-015-0561-2. PubMed PMID: 26867903.

Niopek D, Wehler P, Roensch J, Eils R, Di Ventura B. Optogenetic control of nuclear protein export. Nat Commun. 2016 Feb 8;7:10624. doi: 10.1038/ncomms10624. PubMed PMID: 26853913.

Klee S, Lehmann M, Wagner DE, Baarsma HA, Königshoff M. WISP1 mediates IL-6-dependent proliferation in primary human lung fibroblasts. Sci Rep. 2016 Feb12; 6:20547. doi: 10.1038/srep20547. PubMed PMID: 26867691.

Sabel BO, Buric K, Karara N, Thierfelder KM, Dinkel J, Sommer WH, Meinel FG. High-Pitch CT Pulmonary Angiography in Third Generation Dual-Source CT: Image Quality in an Unselected Patient Population. PLoS One. 2016 Feb 12; 11(2):e0146949. doi: 10.1371/journal.pone.0146949. eCollection 2016. PubMed PMID: 26872262.

New in PubMed from DZL Faculty/ Neu von der DZL-Fakultät in der Woche bis 7. Feb. 2016:

Avsar K, Behr J, Morresi-Hauf A. [Diffuse Pulmonary Ossification]. Pneumologie. 2016 Feb 1. [Epub ahead of print] German. PubMed PMID: 26829606.

Bernemann I, Kersting M, Prokein J, Hummel M, Klopp N, Illig T. [Centralized biobanks: a basis for medical research]. Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz. 2016 Feb 1. [Epub ahead of print] German. PubMed PMID: 26830106.

Naujoks J, Tabeling C, Dill BD, Hoffmann C, Brown AS, Kunze M, Kempa S, Peter A, Mollenkopf HJ, Dorhoi A, Kershaw O, Gruber AD, Sander LE, Witzenrath M, Herold S, Nerlich A, Hocke AC, van Driel I, Suttorp N, Bedoui S, Hilbi H, Trost M, Opitz B. IFNs Modify the Proteome of Legionella-Containing Vacuoles and Restrict Infection Via IRG1-Derived Itaconic Acid. PLoS Pathog. 2016 Feb 1; 12(2):e1005408. doi: 10.1371/journal.ppat.1005408. eCollection 2016 Feb. PubMed PMID: 26829557; PubMed Central PMCID: PMC4734697.

Agusti A, Bel E, Thomas M, Vogelmeier C, Brusselle G, Holgate S, Humbert M, Jones P, Gibson PG, Vestbo J, Beasley R, Pavord ID. Treatable traits: toward precision medicine of chronic airway diseases. Eur Respir J. 2016 Feb; 47(2):410-9. doi: 10.1183/13993003.01359-2015. PubMed PMID: 26828055.

Fiedler J, Thum T. New Insights Into miR-17-92 Cluster Regulation and Angiogenesis. Circ Res. 2016 Jan 8; 118(1):9-11. doi: 10.1161/CIRCRESAHA.115.307935. PubMed PMID: 26837738.

Bergmann O, Braun T. Caught Red-Handed: Cycling Cardiomyocytes. Circ Res. 2016

Jan 8;118(1):3-5. doi: 10.1161/CIRCRESAHA.115.307936. PubMed PMID: 26837736.

Galiè N, Humbert M, Vachiery JL, Gibbs S, Lang I, Torbicki A, Simonneau G, Peacock A, Vonk Noordegraaf A, Beghetti M, Ghofrani A, Sanchez MA, Hansmann G, Klepetko W, Lancellotti P, Matucci M, McDonagh T, Pierard LA, Trindade PT, Zompatori M, Hoeper M. 2015 ESC/ERS Guidelines for the Diagnosis and Treatment of Pulmonary Hypertension. Rev Esp Cardiol (Engl Ed). 2016 Feb; 69(2):177. doi: 10.1016/j.rec.2016.01.002. PubMed PMID: 26837729.

Haag T, Richter AM, Schneider MB, Jiménez AP, Dammann RH. The dual specificity phosphatase 2 gene is hypermethylated in human cancer and regulated by epigenetic mechanisms. BMC Cancer. 2016 Feb 1;16(1):49. doi: 10.1186/s12885-016-2087-6. PubMed PMID: 26833217; PubMed Central PMCID: PMC4736155.

Albrecht C, Ringshausen F, Ott S, Wagner D, Rademacher J, Schneider M, Welte T, Pletz MW. Should all adult cystic fibrosis patients with repeated nontuberculous mycobacteria cultures receive specific treatment? A 10-year case-control study. Eur Respir J. 2016 Feb 4. pii: ERJ-01239-2015. doi: 10.1183/13993003.01239-2015. [Epub ahead of print] PubMed PMID: 26846823.

Zernecke A, Preissner KT. Extracellular Ribonucleic Acids (RNA) Enter the Stage in Cardiovascular Disease. Circ Res. 2016 Feb 5;118(3):469-79. doi: 10.1161/CIRCRESAHA.115.307961. Review. PubMed PMID: 26846641.

Mendler L, Braun T, Müller S. The Ubiquitin-Like SUMO System and Heart Function: From Development to Disease. Circ Res. 2016 Jan 8;118(1):132-44. doi: 10.1161/CIRCRESAHA.115.307730. Review. PubMed PMID: 26837744.

Kuebler WM, Wittenberg C, Lee WL, Reppien E, Goldenberg NM, Lindner K, Gao Y, Winoto Morbach S, Drab M, Mühlfeld C, Dombrowsky H, Ochs M, Schütze S, Uhlig S. Thrombin stimulates albumin transcytosis in lung microvascular endothelial cells via activation of acid sphingomyelinase. Am J Physiol Lung Cell Mol Physiol. 2016 Feb 5:ajplung.00157.2015. doi: 10.1152/ajplung.00157.2015. [Epub ahead of print] PubMed PMID: 26851257.

Beck-Broichsitter M, Stoisiek K, Bohr A, Aragão-Santiago L, Gessler T, Seeger W, Kissel T. Potential of the isolated lung technique for the examination of sildenafil absorption from lung-delivered poly(lactide-co-glycolide) microparticles. J Control Release. 2016 Feb 2. pii: S0168-3659(16)30053-0. doi: 10.1016/j.jconrel.2016.01.057. [Epub ahead of print] PubMed PMID: 26849917.

Stein C, Nötzold RR, Riedl S, Bouchard C, Bauer UM. The Arginine Methyltransferase PRMT6 Cooperates with Polycomb Proteins in Regulating HOXA Gene Expression. PLoS One. 2016 Feb 5; 11(2):e0148892. doi: 10.1371/journal.pone.0148892. eCollection 2016. PubMed PMID: 26848759.

Spanjer AI, Baarsma HA, Oostenbrink LM, Jansen SR, Kuipers CC, Lindner M, Postma DS, Meurs H, Heijink IH, Gosens R, Königshoff M. TGF-β-induced profibrotic signaling is regulated in part by the WNT receptor Frizzled-8. FASEB J. 2016 Feb 5. pii: fj.201500129. [Epub ahead of print] PubMed PMID: 26849959.

Feng M, Yang Z, Pan L, Lai X, Xian M, Huang X, Chen Y, Schröder PC, Roponen M, Schaub B, Wong GW, Li J. Associations of early life exposures and environmental factors with asthma among children in rural and urban areas of Guangdong, China. Chest. 2016 Jan 18. pii: S0012 3692(16)00450-5. doi: 10.1016/j.chest.2015.12.028. [Epub ahead of print]

Januar 2016

New in PubMed from DZL Faculty/ Neu von der DZL-Fakultät in der Woche bis 31. Jan. 2016:

Delcroix M, Lang I, Pepke-Zaba J, Jansa P, D'Armini AM, Snijder R, Bresser P, Torbicki A, Mellemkjaer S, Lewczuk J, Simkova I, Barberà JA, de Perrot M, Hoeper MM, Gaine S, Speich R, Gomez-Sanchez MA, Kovacs G, Jaïs X, Ambroz D, Treacy C, Morsolini M, Jenkins D, Lindner J, Dartevelle P, Mayer E, Simonneau G. Long-Term Outcome of Patients With Chronic Thromboembolic Pulmonary Hypertension (CTEPH): Results From an International Prospective Registry. Circulation. 2016 Jan 29.pii: CIRCULATIONAHA.115.016522. [Epub ahead of print] PubMed PMID: 26826181.

Unkel S, Belka C, Lauber K. On the analysis of clonogenic survival data: Statistical alternatives to the linear-quadratic model. Radiat Oncol. 2016 Jan 28; 11(1):11. doi: 10.1186/s13014-016-0584-z. PubMed PMID: 26822015.

Dumitrescu D, Gerhardt F, Viethen T, Schmidt M, Mayer E, Rosenkranz S. Case report: Subjective loss of performance after pulmonary embolism in an athlete-beyond normal values. BMC Pulm Med. 2016 Jan 28;16(1):21. doi: 10.1186/s12890-016-0180-x. PubMed PMID: 26821715.

Bassetti M, Welte T, Wunderink RG. Treatment of Gram-negative pneumonia in the critical care setting: is the beta-lactam antibiotic backbone broken beyond repair? Crit Care. 2016 Jan 29; 20(1):19. doi: 10.1186/s13054-016-1197-5. PubMed PMID: 26821535.

Bretz AC, Gittler MP, Charles JP, Gremke N, Eckhardt I, Mernberger M, Mandic R, Thomale J, Nist A, Wanzel M, Stiewe T. ΔNp63 activates the Fanconi anemia DNA repair pathway and limits the efficacy of cisplatin treatment in squamous cell carcinoma. Nucleic Acids Res. 2016 Jan 26. pii: gkw036. [Epub ahead of print] PubMed PMID: 26819410.

Kühn T, Floegel A, Sookthai D, Johnson T, Rolle-Kampczyk U, Otto W, von Bergen M, Boeing H, Kaaks R. Higher plasma levels of lysophosphatidylcholine 18:0 are related to a lower risk of common cancers in a prospective metabolomics study. BMC Med. 2016 Jan 28;14(1):13. doi: 10.1186/s12916 016-0552-3. PubMed PMID: 26817443.

von Mutius E, Martinez FD. Inconclusive Results of Randomized Trials of Prenatal Vitamin D for Asthma Prevention in Offspring: Curbing the Enthusiasm. JAMA. 2016 Jan 26;315(4):347-8. doi: 10.1001/jama.2015.18963. PubMed PMID: 26813205.

Dratva J, Zemp E, Dharmage SC, Accordini S, Burdet L, Gislason T, Heinrich J, Janson C, Jarvis D, de Marco R, Norbäck D, Pons M, Real FG, Sunyer J, Villani S, Probst-Hensch N, Svanes C. Early Life Origins of Lung Ageing: Early Life Exposures and Lung Function Decline in Adulthood in Two European Cohorts Aged 28-73 Years. PLoS One. 2016 Jan 26;11(1):e0145127. doi: 10.1371/journal.pone.0145127. eCollection 2016. PubMed PMID: 26811913.

Flentje M, Huber RM, Engel-Riedel W, Andreas S, Kollmeier J, Staar S, Dickgreber N, Vaissiere N, De Almeida C, Edlich B, Fietkau R. GILT-A randomized phase III study of oral vinorelbine and cisplatin with concomitant radiotherapy followed by either consolidation therapy with oral vinorelbine and cisplatin or best supportive care alone in stage III non-small cell lung cancer. Strahlenther Onkol. 2016 Jan 25. [Epub ahead of print] PubMed PMID: 26809652.

Ilhan-Mutlu A, Osswald M, Liao Y, Goemmel M, Reck M, Miles D, Mariani P, Gianni L, Lutiger B, Nendel V, Strock S, Perez-Moreno PD, Thorsen F, von Baumgarten LD, Preusser M, Wick W, Winkler F. Bevacizumab prevents brain metastases formation in lung adenocarcinoma. Mol Cancer Ther. 2016 Jan 25. pii: molcanther.0582.2015. [Epub ahead of print] PubMed PMID: 26809491.

von Mutius E. The microbial environment and its influence on asthma prevention in early life. J Allergy Clin Immunol. 2016 Jan 22. pii: S0091-6749(15)03115-2. doi: 10.1016/j.jaci.2015.12.1301. [Epub ahead of print] PubMed PMID: 26806048.

Boeselt T, Nell C, Kehr K, Holland A, Dresel M, Greulich T, Tackenberg B, Kenn K, Boeder J, Klapdor B, Kirschbaum A, Vogelmeier C, Alter P, Koczulla R. Whole-body vibration therapy in intensive care patients: A feasibility and safety study. J Rehabil Med. 2016 Jan 21. doi: 10.2340/16501977-2052. [Epub ahead of print] PubMed PMID: 26805786.

Hinrichs JB, von Falck C, Hoeper MM, Olsson KM, Wacker FK, Meyer BC, Renne J. Pulmonary Artery Imaging in Patients with Chronic Thromboembolic Pulmonary Hypertension: Comparison of Cone Beam CT and 64-Row Multidetector CT. J Vasc Interv Radiol. 2016 Jan 20. pii:S1051-0443(15)011410. doi: 10.1016/j.jvir.2015.11.046. [Epub ahead of print] PubMed PMID: 26803575.

Ganbat D, Seehase S, Richter E, Vollmer E, Reiling N, Fellenberg K, Gaede KI, Kugler C, Goldmann T. Mycobacteria infect different cell types in the human lung and cause species dependent cellular changes in infected cells. BMC Pulm Med. 2016 Jan 23;16(1):19. doi: 10.1186/s12890-016-0185-5. PubMed PMID: 26803467; PubMed Central PMCID: PMC4724406.

Kampschulte M, Langheinirch AC, Sender J, Litzlbauer HD, Althöhn U, Schwab JD, Alejandre-Lafont E, Martels G, Krombach GA. Nano-Computed Tomography: Techniqueand Applications. Rofo. 2016 Feb; 188(2):146-154. Epub 2016 Jan 27. PubMed PMID:26815120.

Ringshausen FC, Rademacher J. [Nontuberculous mycobacterial pulmonary disease]. Internist (Berl). 2016 Jan 25. [Epub ahead of print] German. PubMed PMID: 26810111.

New in PubMed from DZL Faculty/ Neu von der DZL-Fakultät in der Woche bis 24. Jan. 2016:

Miravitlles M, Vogelmeier C, Roche N, Halpin D, Cardoso J, Chuchalin AG, Kankaanranta H, Sandström T, Śliwiński P, Zatloukal J, Blasi F. A review of national guidelines for management of COPD in Europe. Eur Respir J. 2016 Jan 21. pii: ERJ-01170-2015. doi: 10.1183/13993003.01170-2015. [Epub ahead of print] Review. PubMed PMID: 26797035.

Karnati S, Graulich T, Oruqaj G, Pfreimer S, Seimetz M, Stamme C, Mariani TJ, Weissmann N, Mühlfeld C, Baumgart-Vogt E. Postnatal development of the bronchiolar club cells of distal airways in the mouse lung: stereological and molecular biological studies. Cell Tissue Res. 2016 Jan 21. [Epub ahead of print] PubMed PMID: 26796206.

Welte T, Salzberger B. [Tuberculosis: The return of an almost forgotten disease]. Internist (Berl). 2016 Jan 21. [Epub ahead of print] German. PubMed PMID: 26795947.

Mardare C, Krüger K, Liebisch G, Seimetz M, Couturier A, Ringseis R, Wilhelm J, Weissmann N, Eder K, Mooren FC. Endurance and Resistance Training Affect High Fat Diet-Induced Increase of Ceramides, Inflammasome Expression, and Systemic Inflammation in Mice. J Diabetes Res. 2016;2016:4536470. doi: 10.1155/2016/4536470. Epub 2015 Dec 14. PubMed PMID: 26788518; PubMed Central PMCID: PMC4691630.

Zilz C, Blaas SH, Pfeifer M, Jörres RA, Budweiser S. Mental health, serum biomarkers and survival in severe COPD: a pilot study. Multidiscip Respir Med. 2016 Jan 18;11:3. doi: 10.1186/s40248-016 0041 8. eCollection 2015. PubMed PMID: 26788321; PubMed Central PMCID: PMC4717533.

Falgenhauer L, Waezsada SE, Yao Y, Imirzalioglu C, Käsbohrer A, Roesler U, Michael GB, Schwarz S, Werner G, Kreienbrock L, Chakraborty T; RESET consortium. Colistin resistance gene mcr-1 in extended-spectrum β-lactamase-producing and carbapenemase-producing Gram-negative bacteria in Germany. Lancet Infect Dis. 2016 Jan 7. pii: S1473-3099(16)00009-8. doi: 10.1016/S1473 3099(16)00009-8. [Epub ahead of print] PubMed PMID: 26774242.

Mižíková I, Morty RE. The Extracellular Matrix in Bronchopulmonary Dysplasia: Target and Source. Front Med (Lausanne). 2015 Dec 23;2:91. doi: 10.3389/fmed.2015.00091. eCollection 2015. Review. PubMed PMID: 26779482; PubMed Central PMCID: PMC4688343.

Hess A, Wang-Lauenstein L, Braun A, Kolle SN, Landsiedel R, Liebsch M, Ma-Hock L, Pirow R, Schneider X, Steinfath M, Vogel S, Martin C, Sewald K. Prevalidation of the ex-vivo model PCLS for prediction of respiratory toxicity. Toxicol In Vitro. 2016 Jan 8. pii: S0887-2333(16)30006-6. doi: 10.1016/j.tiv.2016.01.006. [Epub ahead of print] PubMed PMID: 26778741.

Worth H, Buhl R, Criée CP, Kardos P, Mailänder C, Vogelmeier C. The 'real-life' COPD patient in Germany: The DACCORD study. Respir Med. 2015 Dec 30. pii: S0954-6111(15)30101-3. doi: 10.1016/j.rmed.2015.12.010. [Epub ahead of print] PubMed PMID: 26775251.

Suhling H, Gottlieb J, Bara C, Taubert R, Jäckel E, Schiffer M, Bräsen JH. [Chronic rejection : Differences and similarities in various solid organ transplants]. Internist (Berl). 2016 Jan;57(1):25-37. doi: 10.1007/s00108-015-3806-9. German. PubMed PMID: 26782281.

Gottlieb J, Gwinner W, Strassburg CP. [Allocation systems in transplantation medicine: Advantages and disadvantages]. Internist (Berl). 2016 Jan; 57(1):15-24. doi: 10.1007/s00108-015-3805-x. German. PubMed PMID: 26782280.

Haller H, Manns MP, Welte T. [Transplantation : Opportunities and limits]. Internist (Berl). 2016 Jan;57(1):5-6. doi: 10.1007/s00108-015-3804-y. German. PubMed PMID: 26782279.

Weig T, Milger K, Langhans B, Janitza S, Sisic A, Kenn K, Irlbeck T, Pomschar A, Johnson T, Irlbeck M, Behr J, Czerner S, Schramm R, Winter H, Neurohr C, Frey L, Kneidinger N. Core Muscle Size Predicts Postoperative Outcome in Lung Transplant Candidates. Ann Thorac Surg. 2016 Jan 12. pii: S0003 4975(15)01712-9. doi: 10.1016/j.athoracsur.2015.10.041. [Epub ahead of print] PubMed PMID: 26794887.

Wedzicha JA, Calverley PM, Rabe KF. Roflumilast: a review of its use in the treatment of COPD. Int J Chron Obstruct Pulmon Dis. 2016 Jan 6;11:81-90. doi: 10.2147/COPD.S89849. eCollection 2016. Review. PubMed PMID: 26792988; PubMed Central PMCID: PMC4708192.

Brick T, Schober Y, Böcking C, Pekkanen J, Genuneit J, Loss G, Dalphin JC, Riedler J, Lauener R, Nockher WA, Renz H, Vaarala O, Braun-Fahrländer C, von Mutius E, Ege MJ, Pfefferle PI; PASTURE study group. ω-3 fatty acids contribute to the asthma-protective effect of unprocessed cow's milk. J Allergy Clin Immunol. 2016 Jan 11. pii: S0091-6749(15)01731-5. doi: 10.1016/j.jaci.2015.10.042. [Epub ahead of print] PubMed PMID: 26792208.

Schmid-Bindert G, Engel-Riedel W, Reck M, Schuette W, Stöhlmacher J, Fischer JR, Mazières J, Chouaid C, Wolf M, Vinolas N, Soldatenkova V, Ripoche V, Nguyen T, Visseren-Grul C. A randomized Phase 2 study of pemetrexed in combination with cisplatin or carboplatin as adjuvant chemotherapy in patients with completely resected stage IB or II Non-Small-Cell Lung Cancer. Lung Cancer. 2015 Dec; 90(3):397-404. doi: 10.1016/j.lungcan.2015.11.007. Epub 2015 Nov 7. PubMed PMID: 26791798.

Gesierich W, Behr J, Nitschmann S. [Bronchoscopic lung volume reduction: BeLieVeR-HIFi study]. Internist (Berl). 2016 Jan 20. [Epub ahead of print] German. PubMed PMID: 26791736.

Harb H, Amarasekera M, Ashley S, Tulic MK, Pfefferle PI, Potaczek DP, Martino D, Kesper DA, Prescott SL, Renz H. Epigenetic Regulation in Early Childhood: A Miniaturized and Validated Method to Assess Histone Acetylation. Int Arch Allergy Immunol. 2016 Jan 21;168(3):173-181. [Epub ahead of print] PubMed PMID: 26789836.

Salomon JJ, Spahn S, Wang X, Füllekrug J, Bertrand CA, Mall MA. Generation and functional characterization of epithelial cells with stable expression of SLC26A9 Cl- channels. Am J Physiol Lung Cell Mol Physiol. 2016 Jan 22:ajplung.00321.2015. doi: 10.1152/ajplung.00321.2015. [Epub ahead of print] PubMed PMID: 26801567.

Zierer J, Kastenmüller G, Suhre K, Gieger C, Codd V, Tsai PC, Bell J, Peters A, Strauch K, Schulz H, Weidinger S, Mohney RP, Samani NJ, Spector T, Mangino M, Menni C. Metabolomics profiling reveals novel markers for leukocyte telomere length. Aging (Albany NY). 2016 Jan 20. [Epub ahead of print] PubMed PMID: 26797767.

Evans JD, Girerd B, Montani D, Wang XJ, Galiè N, Austin ED, Elliott G, Asano K, Grünig E, Yan Y, Jing ZC, Manes A, Palazzini M, Wheeler LA, Nakayama I, Satoh T, Eichstaedt C, Hinderhofer K, Wolf M, Rosenzweig EB, Chung WK, Soubrier F, Simonneau G, Sitbon O, Gräf S, Kaptoge S, Di Angelantonio E, Humbert M, Morrell NW. BMPR2 mutations and survival in pulmonary arterial hypertension: an individual participant data meta-analysis. Lancet Respir Med. 2016 Jan 18. pii: S2213-2600(15)00544-5. doi: 10.1016/S2213-2600(15)00544-5. [Epub ahead of print] PubMed PMID: 26795434.

Kreuter M, Bonella F, Wijsenbeek M, Maher TM, Spagnolo P. Pharmacological Treatment of Idiopathic Pulmonary Fibrosis: Current Approaches, Unsolved Issues, and Future Perspectives. Biomed Res Int. 2015;2015:329481. doi: 10.1155/2015/329481. Epub 2015 Dec 8. Review. PubMed PMID: 26779535; PubMed Central PMCID: PMC4686637.

New in PubMed from DZL Faculty/ Neu von der DZL-Fakultät in der Woche bis 17. Jan. 2016:

Klughammer B, Brugger W, Cappuzzo F, Ciuleanu T, Mok T, Reck M, Tan EH, Delmar P, Klingelschmitt G, Yin AY, Spleiss O, Wu L, Shames DS. Examining Treatment Outcomes with Erlotinib in Patients with Advanced Non-Small-Cell Lung CancerWhose Tumors Harbor Uncommon Epidermal Growth Factor Receptors Mutations. J Thorac Oncol. 2016 Jan 7. pii: S1556-0864(16)00283-5. doi: 10.1016/j.jtho.2015.12.107. [Epub ahead of print] PubMed PMID: 26773740.

Rohwer N, Bindel F, Grimm C, Lin SJ, Wappler J, Klinger B, Blüthgen N, Du Bois I, Schmeck B, Lehrach H, de Graauw M, Goncalves E, Saez-Rodriguez J, Tan P, Grabsch HI, Prigione A, Kempa S, Cramer T. Annexin A1 sustains tumor metabolism and cellular proliferation upon stable loss of HIF1A. Oncotarget. 2015 Dec 29. doi: 10.18632/oncotarget.6793. [Epub ahead of print] PubMed PMID: 26760764.

Ketel K, Krauss M, Nicot AS, Puchkov D, Wieffer M, Müller R, Subramanian D, Schultz C, Laporte J, Haucke V. A phosphoinositide conversion mechanism for exit from endosomes. Nature. 2016 Jan 13. doi: 10.1038/nature16516. [Epub ahead of print] PubMed PMID: 26760201.

Kammerl IE, Dann A, Mossina A, Brech D, Lukas C, Vosyka O, Nathan P, Conlon TM, Wagner DE, Overkleeft HS, Prasse A, Rosas IO, Straub T, Krauss-Etschmann S, Königshoff M, Preissler G, Winter H, Lindner M, Hatz R, Behr J, Heinzelmann K, Yildirim AÖ, Noessner E, Eickelberg O, Meiners S. Impairment of Immunoproteasome Function by Cigarette Smoke and in COPD. Am J Respir Crit Care Med. 2016 Jan 12. [Epub ahead of print] PubMed PMID: 26756824.

Derlin T, Jonigk D, Bauersachs J, Bengel FM. Molecular Imaging of Chemokine Receptor CXCR4 in Non-Small Cell Lung Cancer Using 68Ga-Pentixafor PET/CT: Comparison With 18F-FDG. Clin Nucl Med. 2016 Jan 11. [Epub ahead of print] PubMed PMID: 26756098.

Gall H, Sommer N, Milger K, Richter MJ, Voswinckel R, Bandorski D, Seeger W, Grimminger F, Ghofrani HA. Survival with sildenafil and inhaled iloprost in a cohort with pulmonary hypertension: an observational study. BMC Pulm Med. 2016 Jan 12;16(1):5. doi: 10.1186/s12890-015-0164-2. PubMed PMID: 26753921; PubMed Central PMCID: PMC4709958.

Schedel M, Jia Y, Michel S, Takeda K, Domenico J, Joetham A, Ning F, Strand M, Han J, Wang M, Lucas JJ, Vogelberg C, Kabesch M, O'Connor BP, Gelfand EW. 1,25D3 prevents CD8(+)Tc2 skewing and asthma development through VDR binding changes to the Cyp11a1 promoter. Nat Commun. 2016 Jan 11;7:10213. doi: 10.1038/ncomms10213. PubMed PMID: 26750596; PubMed Central PMCID: PMC4712703.

Busley D, Ochs M, Hoeltig D, Ganter M, Acevedo C, Schmiedl A, Hennig-Pauka I. Characterization of surfactant alterations in pigs infected with Actinobacillus pleuropneumoniae. Exp Lung Res. 2016 Jan 14:1-13. [Epub ahead of print] PubMed PMID: 26765785.

Olivieri M, Heinrich J, Schlünssen V, Antó JM, Forsberg B, Janson C, Leynaert B, Norback D, Sigsgaard T, Svanes C, Tischer C, Villani S, Jarvis D, Verlato G. The risk of respiratory symptoms on allergen exposure increases with increasing specific IgE levels. Allergy. 2016 Jan 14. doi: 10.1111/all.12841. [Epub ahead of print] PubMed PMID: 26764559.

Kreuter M, Vansteenkiste J, Fischer JR, Eberhardt WE, Zabeck H, Kollmeier J, Serke M, Frickhofen N, Reck M, Engel-Riedel W, Neumann S, Thomeer M, Schumann C, De Leyn P, Graeter T, Stamatis G, Griesinger F, Thomas M; TREAT investigators. Three-Year Follow-Up of a Randomized Phase II Trial on Refinement of Early-Stage NSCLC Adjuvant Chemotherapy with Cisplatin and Pemetrexed versus Cisplatin and Vinorelbine (the TREAT Study). J Thorac Oncol. 2016 Jan;11(1):85-93. doi: 10.1016/j.jtho.2015.09.014. PubMed PMID: 26762743.

Steinhauser S, Kurzawa N, Eils R, Herrmann C. A comprehensive comparison of tools for differential ChIP-seq analysis. Brief Bioinform. 2016 Jan 13. pii: bbv110. [Epub ahead of print] PubMed PMID: 26764273.

New in PubMed from DZL Faculty/ Neu von der DZL-Fakultät in der Woche bis 10. Jan. 2016:

Wacker ME, Jörres RA, Schulz H, Heinrich J, Karrasch S, Karch A, Koch A, Peters A, Leidl R, Vogelmeier C, Holle R; COSYCONET-Consortium. Direct and indirect costs of COPD and its comorbidities: Results from the German COSYCONETstudy. Respir Med. 2015 Dec 10. pii: S0954-6111(15)30092-5. doi: 10.1016/j.rmed.2015.12.001. [Epub ahead of print] PubMed PMID: 26725462.

Schoenfeld C, Cebotari S, Hinrichs J, Renne J, Kaireit T, Olsson KM, Voskrebenzev A, Gutberlet M, Hoeper MM, Welte T, Haverich A, Wacker F, Vogel-Claussen J. MR Imaging-derived Regional Pulmonary Parenchymal Perfusion and Cardiac Function for Monitoring Patients with Chronic Thromboembolic Pulmonary Hypertension before and after Pulmonary Endarterectomy.Radiology. 2015 Dec 28:150765. [Epub ahead of print] PubMed PMID: 26727392.

Krawinkel J, Richter U, Torres-Mapa ML, Westermann M, Gamrad L, Rehbock C, Barcikowski S, Heisterkamp A. Optical and electron microscopy study of laser-based intracellular molecule delivery using peptide-conjugated photodispersible gold nanoparticle agglomerates. J Nanobiotechnology. 2016 Jan 8; 14(1):2. PubMed PMID: 26745990.

Voskrebenzev A, Gutberlet M, Becker L, Wacker F, Vogel-Claussen J. Reproducibility of fractional ventilation derived by Fourier decomposition after adjusting for tidal volume with and without an MRI compatible spirometer. Magn Reson Med. 2015 Nov 24. doi: 10.1002/mrm.26047. [Epub ahead of print] PubMed PMID: 26745750.

Klawitter S, Fuchs NV, Upton KR, Muñoz-Lopez M, Shukla R, Wang J, Garcia-Cañadas M, Lopez-Ruiz C, Gerhardt DJ, Sebe A, Grabundzija I, Merkert S, Gerdes P, Pulgarin JA, Bock A, Held U, Witthuhn A, Haase A, Sarkadi B, Löwer J, Wolvetang EJ, Martin U, Ivics Z, Izsvák Z, Garcia-Perez JL, Faulkner GJ, Schumann GG. Reprogramming triggers endogenous L1 and Alu retrotransposition in human induced pluripotent stem cells. Nat Commun. 2016 Jan 8;7:10286. doi: 10.1038/ncomms10286. PubMed PMID: 26743714.

Schmidt A, Hammerbacher AS, Bastian M, Nieken KJ, Klockgether J, Merighi M, Lapouge K, Poschgan C, Kölle J, Acharya KR, Ulrich M, Tümmler B, Unden G, Kaever V, Lory S, Haas D, Schwarz S, Döring G. Oxygen-dependent regulation of c-di-GMP synthesis by SadC controls alginate production in Pseudomonas aeruginosa. Environ Microbiol. 2016 Jan 6. doi: 10.1111/1462-2920.13208. [Epub ahead of print] PubMed PMID: 26743546.

Short KR, Kasper J, van der Aa S, Andeweg AC, Zaaraoui-Boutahar F, Goeijenbier M, Richard M, Herold S, Becker C, Scott DP, Limpens RW, Koster AJ, Bárcena M, Fouchier RA, Kirkpatrick CJ, Kuiken T. Influenza virus damages the alveolar barrier by disrupting epithelial cell tight junctions. Eur Respir J. 2016 Jan 7. pii: ERJ-01282-2015. doi: 10.1183/13993003.01282-2015. [Epub ahead of print] PubMed PMID: 26743480.

Mostafa A, Kanrai P, Ziebuhr J, Pleschka S. The PB1 segment of an influenza A virus H1N1 2009pdm isolate enhances the replication efficiency of specific influenza vaccine strains in cell culture and embryonated eggs. J Gen Virol. 2016 Jan 7. doi: 10.1099/jgv.0.000390. [Epub ahead of print] PubMed PMID: 26743314.

Piepho T, Cavus E, Noppens R, Byhahn C, Dörges V, Zwissler B, Timmermann A. S1 guidelines on airway management : Guideline of the German Society of Anesthesiology and Intensive Care Medicine. Anaesthesist. 2016 Jan 4. [Epub ahead of print] PubMed PMID: 26727936.

Reiser MF. 25 years of European Radiology. Eur Radiol. 2016 Jan 4. [Epub ahead of print] PubMed PMID: 26727934.

Galiè N, Humbert M, Vachiery JL, Gibbs S, Lang I, Torbicki A, Simonneau G, Peacock A, Vonk Noordegraaf A, Beghetti M, Ghofrani A, Sanchez MA, Hansmann G, Klepetko W, Lancellotti P, Matucci M, McDonagh T, Pierard LA, Trindade PT, Zompatori M, Hoeper M. [2015 ESC/ERS Guidelines for the diagnosis and treatment of pulmonary hypertension]. Kardiol Pol. 2015;73(12):1127-206. doi: 10.5603/KP.2015.0242. Polish. PubMed PMID: 26727670.

New in PubMed from DZL Faculty/ Neu von der DZL-Fakultät in der Woche bis 3. Jan. 2016:

Schmitz ML, Kracht M. Cyclin-Dependent Kinases as Coregulators of Inflammatory Gene Expression. Trends Pharmacol Sci. 2015 Dec 21. pii: S0165-6147(15)00223-0. doi: 10.1016/j.tips.2015.10.004. [Epub ahead of print] Review. PubMed PMID: 26719217.

Ahuja S, Knudsen L, Chillappagari S, Henneke I, Ruppert C, Korfei M, Gochuico BR, Bellusci S, Seeger W, Ochs M, Guenther A, Mahavadi P. MAP1LC3B overexpression protects against Hermansky-Pudlak syndrome type - 1 induced defective autophagy in vitro. Am J Physiol Lung Cell Mol Physiol. 2015 Dec 30:ajplung.00213.2015. doi: 10.1152/ajplung.00213.2015. [Epub ahead of print] PubMed PMID: 26719147.

Kirchner B, Pfaffl MW, Dumpler J, von Mutius E, Ege MJ. microRNA in native and processed cow's milk and its implication for the farm milk effect on asthma. J Allergy Clin Immunol. 2015 Dec 18. pii: S0091-6749(15)01634-6. doi: 10.1016/j.jaci.2015.10.028. [Epub ahead of print] PubMed PMID: 26707195.

Bianconi I, Jeukens J, Freschi L, Alcalá-Franco B, Facchini M, Boyle B, Molinaro A, Kukavica-Ibrulj I, Tümmler B, Levesque RC, Bragonzi A. Comparative genomics and biological characterization of sequential Pseudomonas aeruginosa isolates from persistent airways infection. BMC Genomics. 2015 Dec 29; 16(1):1105. doi: 10.1186/s12864-015-2276-8. PubMed PMID: 26714629; PubMed Central PMCID: PMC4696338.

Solé-Lleonart C, Roberts JA, Chastre J, Poulakou G, Palmer LB, Blot S, Felton T, Bassetti M, Luyt CE, Pereira JM, Riera J, Welte T, Qiu H, Rouby JJ, Rello J; ESGCIP Investigators. Global survey on nebulization of antimicrobial agents in mechanically ventilated patients: A call for international guidelines. Clin Microbiol Infect. 2015 Dec 23. pii: S1198-743X(15)01042-3. doi: 10.1016/j.cmi.2015.12.016. [Epub ahead of print] PubMed PMID: 26723563.

Welte T. Acute exacerbation in COPD: we must do more. Eur Respir J. 2016 Jan;47(1):14-5. doi: 10.1183/13993003.01981-2015. PubMed PMID: 26721956.

Langleben D, Galiè N, He J, Huang Y, Humbert M, Keogh A, Rubin LJ, Zhou D, Curram J, Davie N, Ghofrani HA. Use of clinically relevant responder threshold criteria to evaluate the response to treatment in the phase III PATENT-1 study. J Heart Lung Transplant. 2015 Mar;34(3):338-47. doi: 10.1016/j.healun.2014.12.001. Epub 2014 Dec 12. PubMed PMID: 25703961.

Rolf A, Rixe J, Kim WK, Guth S, Körlings N, Möllmann H, Nef HM, Liebetrau C, Krombach G, Kramm T, Mayer E, Hamm CW.Pulmonary vascular remodeling before and after pulmonary endarterectomy in patients with chronic thromboembolic pulmonary hypertension: a cardiac magnetic resonance study. Int J Cardiovasc Imaging. 2015 Mar; 31(3):613-9. doi: 10.1007/s10554-014-0580-z. Epub 2014 Dec 18. PubMed PMID: 25519191.

Ius F, Sommer W, Kieneke D, Tudorache I, Kühn C, Avsar M, Siemeni T, Salman J, Erdfelder C, Verboom M, Kielstein J, Tecklenburg A, Greer M, Hallensleben M, Blasczyk R, Schwerk N, Gottlieb J, Welte T, Haverich A, Warnecke G. IgM-Enriched Human Intravenous Immunoglobulin-Based Treatment of Patients With Early Donor Specific Anti-HLA Antibodies After Lung Transplantation. Transplantation. 2015 Dec 28. [Epub ahead of print] PubMed PMID: 26714123.

Rieber J, Deeg A, Ullrich E, Foerster R, Bischof M, Warth A, Schnabel PA, Muley T, Kappes J, Heussel CP, Welzel T, Thomas M, Steins M, Dienemann H, Debus J, Hoffmann H, Rieken S. Outcome and prognostic factors of postoperative radiation therapy (PORT) after incomplete resection of non-small cell lung cancer (NSCLC). Lung Cancer. 2016 Jan;91:41-7. doi: 10.1016/j.lungcan.2015.11.014. Epub 2015 Nov 25. PubMed PMID: 26711933.

Dezember 2015

New in PubMed from DZL Faculty/ Neu von der DZL-Fakultät in der Woche bis 28. Dez. 2015:

Plecitá-Hlavatá L, Tauber J, Li M, Zhang H, Flockton AR, Pullamsetti SS, Chelladurai P, D'alessandro A, El Kasmi KC, Ježek P, Stenmark KR. Constitutive Reprogramming of Fibroblast Mitochondrial Metabolism in Pulmonary Hypertension. Am J Respir Cell Mol Biol. 2015 Dec 23. [Epub ahead of print] PubMed PMID:26699943.

Saboor F, Reckmann AN, Tomczyk CU, Peters DM, Weissmann N, Kaschtanow A, Schermuly RT, Michurina TV, Enikolopov G, Müller D, Mietens A, Middendorff R. Nestin-expressing vascular wall cells drive development of pulmonary hypertension. Eur Respir J. 2015 Dec 23. pii: ERJ-00574-2015. doi: 10.1183/13993003.00574-2015. [Epub ahead of print] PubMed PMID: 26699726.

Sitbon O, Channick R, Chin KM, Frey A, Gaine S, Galiè N, Ghofrani HA, Hoeper MM, Lang IM, Preiss R, Rubin LJ, Di Scala L, Tapson V, Adzerikho I, Liu J, Moiseeva O, Zeng X, Simonneau G, McLaughlin VV; GRIPHON Investigators. Selexipag for the Treatment of Pulmonary Arterial Hypertension. N Engl J Med. 2015 Dec 24; 373(26):2522-33. doi: 10.1056/NEJMoa1503184. PubMed PMID: 26699168.

Nadler A, Yushchenko DA, Müller R, Stein F, Feng S, Mulle C, Carta M, Schultz C. Exclusive photorelease of signalling lipids at the plasma membrane. NatCommun. 2015 Dec 21;6:10056. doi: 10.1038/ncomms10056. PubMed PMID: 26686736.

Safi S, Beckhove P, Warth A, Benner A, Roeder F, Rieken S, Debus J, Dienemann H, Hoffmann H, Huber PE. A randomized phase II study of radiation induced immune boost in operable non-small cell lung cancer (RadImmune trial). BMC Cancer. 2015 Dec 19; 15:988. doi: 10.1186/s12885-015-2006-2. PubMed PMID: 26686362; PubMed Central PMCID: PMC4684916.

Zissler UM, Bieren JE, Jakwerth CA, Chaker AM, Schmidt-Weber CB. Current and future biomarkers in allergic asthma. Allergy. 2015 Dec 25. doi:10.1111/all.12828. [Epub ahead of print] Review. PubMed PMID: 26706728.

Klotz LV, Morresi-Hauf A, Hatz RA, Lindner M. Vascular Leiomyoma of the Pulmonary Artery. Ann Thorac Surg. 2016 Jan;101(1):342-4. doi: 10.1016/j.athoracsur.2015.02.113. PubMed PMID: 26694272.

Bradley P, Gordon NC, Walker TM, Dunn L, Heys S, Huang B, Earle S, Pankhurst LJ, Anson L, de Cesare M, Piazza P, Votintseva AA, Golubchik T, Wilson DJ, Wyllie DH, Diel R, Niemann S, Feuerriegel S, Kohl TA, Ismail N, Omar SV, Smith EG, Buck D, McVean G, Walker AS, Peto TE, Crook DW, Iqbal Z. Rapid antibiotic-resistance predictions from genome sequence data for Staphylococcus aureus and Mycobacterium tuberculosis. Nat Commun. 2015 Dec 21;6:10063. doi: 10.1038/ncomms10063. PubMedPMID: 26686880.

New in PubMed from DZL Faculty/ Neu von der DZL-Fakultät in der Woche bis 21. Dez. 2015:

Lingner H, Großhennig A, Flunkert K, Buhr-Schinner H, Heitmann R, Tönnesmann U, van der Meyden J, Schultz K. ProKaSaRe Study Protocol: A Prospective Multicenter Study of Pulmonary Rehabilitation of Patients With Sarcoidosis. JMIR Res Protoc. 2015 Dec 4;4(4):e134. doi: 10.2196/resprot.4948. PubMed PMID: 26679102.

Schmidt K, Damm K, Prenzler A, Golpon H, Welte T. Preferences of lung cancer patients for treatment and decision-making: a systematic literature review. Eur J Cancer Care (Engl). 2015 Dec 17. doi: 10.1111/ecc.12425. [Epub ahead of print] PubMed PMID: 26676876.

Tiwari S, Ammerpohl O, Kalthoff H. Target Gene Discovery for Novel Therapeutic Agents in Cancer Treatment. Methods Mol Biol. 2016;1381:181-200. doi: 10.1007/978-1-4939-3204-7_10. PubMed PMID: 26667461.

Ammerpohl O, Haake A, Kolarova J, Siebert R. Quantitative DNA Methylation Profiling in Cancer. Methods Mol Biol. 2016;1381:75-92. doi: 10.1007/978-1-4939-3204-7_5. PubMed PMID: 26667456.

Fasanelli F, Baglietto L, Ponzi E, Guida F, Campanella G, Johansson M, Grankvist K, Johansson M, Assumma MB, Naccarati A, Chadeau-Hyam M, Ala U, Faltus C, Kaaks R, Risch A, De Stavola B, Hodge A, Giles GG, Southey MC, Relton CL, Haycock PC, Lund E, Polidoro S, Sandanger TM, Severi G, Vineis P. Hypomethylation of smoking-related genes is associated with future lung cancer in four prospective cohorts. Nat Commun. 2015 Dec 15;6:10192. doi: 10.1038/ncomms10192. PubMed PMID: 26667048.

Martin U. Pluripotent stem cells for disease modeling and drug screening: new perspectives for treatment of cystic fibrosis? Mol Cell Pediatr. 2015 Dec;2(1):15. doi: 10.1186/s40348-015-0023-5. Epub 2015 Dec 14. PubMed PMID: 26666881; PubMed Central PMCID: PMC4678132.

Daniel JM, Prock A, Dutzmann J, Sonnenschein K, Thum T, Bauersachs J, Sedding DG. Regulator of G Protein Signaling 5 Prevents Smooth Muscle Cell Proliferation and Attenuates Neointima Formation. Arterioscler Thromb Vasc Biol. 2015 Dec 10. pii: ATVBAHA.115.305974. [Epub ahead of print] PubMed PMID: 26663397.

Gupta SK, Thum T. Non-coding RNAs as orchestrators of autophagic processes. J Mol Cell Cardiol. 2015 Dec 2. pii: S0022-2828(15)30116-4. doi: 10.1016/j.yjmcc.2015.11.012. [Epub ahead of print] Review. PubMed PMID: 26654780.

Kulkarni U, Karsten CM, Kohler T, Hammerschmidt S, Bommert K, Tiburzy B, Meng L, Thieme L, Recke A, Ludwig RJ, Pollok K, Kalies K, Bogen B, Boettcher M, Kamradt T, Hauser AE, Langer C, Huber-Lang M, Finkelman FD, Köhl J, Wong DM, Manz RA. IL-10 mediates plasmacytosis-associated immunodeficiency by inhibiting complement-mediated neutrophil migration. J Allergy Clin Immunol. 2015 Dec 1. pii: S0091-6749(15)01564-X. doi: 10.1016/j.jaci.2015.10.018. [Epub ahead of print] PubMed PMID: 26653800.

Rojas M, Mora AL, Kapetanaki M, Weathington N, Gladwin M, Eickelberg O. Aging and Lung Disease. Clinical Impact and Cellular and Molecular Pathways. Ann Am Thorac Soc. 2015 Dec;12(12):S222-7. doi: 10.1513/AnnalsATS.201508-484PL. PubMed PMID: 26653202.

Rivera NV, Ronninger M, Shchetynsky K, Franke A, Nöthen MM, Müller-Quernheim J, Schreiber S, Adrianto I, Karakaya B, van Moorsel CH, Navratilova Z, Kolek V, Rybicki BA, Iannuzzi MC, Petrek M, Grutters JC, Montgomery C, Fischer A, Eklund A, Padyukov L, Grunewald J. High-density Genetic Mapping Identifies New Susceptibility Variants in Sarcoidosis Phenotypes and Shows Genomic-driven Phenotypic Differences. Am J Respir Crit Care Med. 2015 Dec 10. [Epub ahead of print] PubMed PMID: 26651848.

Kiermaier E, Moussion C, Veldkamp CT, Gerardy-Schahn R, de Vries I, Williams LG, Chaffee GR, Phillips AJ, Freiberger F, Imre R, Taleski D, Payne RJ, Braun A, Förster R, Mechtler K, Mühlenhoff M, Volkman BF, Sixt M. Polysialylation controls dendritic cell trafficking by regulating chemokine recognition. Science. 2015 Dec 10. pii: aad0512. [Epub ahead of print] PubMed PMID: 26657283.

Aragão-Santiago L, Bohr A, Delaval M, Dalla-Bona AC, Gessler T, Seeger W, Beck-Broichsitter M. Innovative formulations for controlled drug delivery to the lungs and the technical and toxicological challenges to overcome. Curr Pharm Des. 2015 Dec 16. [Epub ahead of print] PubMed PMID: 26675224.

Boonsanay V, Zhang T, Georgieva A, Kostin S, Qi H, Yuan X, Zhou Y, Braun T. Regulation of Skeletal Muscle Stem Cell Quiescence by Suv4-20h1-Dependent Facultative Heterochromatin Formation. Cell Stem Cell. 2015 Dec 5. pii: S1934-5909(15)00500-7. doi: 10.1016/j.stem.2015.11.002. [Epub ahead of print] PubMed PMID: 26669898.

Schäfer S, Ferioli S, Hofmann T, Zierler S, Gudermann T, Chubanov V. Mibefradil represents a new class of benzimidazole TRPM7 channel agonists. Pflugers Arch. 2015 Dec 16. [Epub ahead of print] PubMed PMID: 26669310.

Kobold S, Duewell P, Schnurr M, Subklewe M, Rothenfusser S, Endres S. Immunotherapy in Tumors. Dtsch Arztebl Int. 2015 Nov 27;112(48):809-15. doi: 10.3238/arztebl.2015.0809. PubMed PMID: 26667979.

Heigener DF, Reck M. Immunotherapy: the third wave in lung cancer treatment. Lancet Respir Med. 2015 Dec; 3(12):923-4. doi: 10.1016/S2213-2600(15)00429-4. PubMed PMID: 26679022.

Haverich A, Haller H. [Organ transplantation in Germany : Critical examination in times of scarce resources]. Internist (Berl). 2015 Dec 19. [Epub ahead of print] German. PubMed PMID: 26678283.

Liu Y, deSouza NM, Shankar LK, Kauczor HU, Trattnig S, Collette S, Chiti A. A risk management approach for imaging biomarker-driven clinical trials in oncology. Lancet Oncol. 2015 Dec; 16(16):e622-8. doi: 10.1016/S1470-2045(15)00164-3. Review. PubMed PMID: 26678215.

Eberhardt M, Lai X, Tomar N, Gupta S, Schmeck B, Steinkasserer A, Schuler G, Vera J. Third-Kind Encounters in Biomedicine: Immunology Meets Mathematics and Informatics to Become Quantitative and Predictive. Methods Mol Biol. 2016;1386:135-79. doi: 10.1007/978-1-4939-3283 2_9. PubMed PMID: 26677184.

Schmeck B, Bertrams W, Lai X, Vera J. Systems Medicine for Lung Diseases: Phenotypes and Precision Medicine in Cancer, Infection, and Allergy. Methods Mol Biol. 2016;1386:119-33. doi: 10.1007/978 1-4939-3283-2_8. PubMed PMID: 26677183.

Rozman D, Acimovic J, Schmeck B. Training in Systems Approaches for the Next Generation of Life Scientists and Medical Doctors. Methods Mol Biol. 2016;1386:73-86. doi: 10.1007/978-1-4939-3283-2_5. PubMed PMID: 26677180.

Mandal J, Malla B, Steffensen R, Costa L, Egli A, Trendelenburg M, Blasi F, Kostikas K, Welte T, Torres A, Louis R, Boersma W, Milenkovic B, Aerts J, Rohde GG, Lacoma A, Rentsch K, Roth M, Tamm M, Stolz D. Mannose-binding lectin protein and its association to clinical outcomes in COPD: a longitudinal study. Respir Res. 2015 Dec 18;16:150. doi: 10.1186/s12931-015-0306-3. PubMed PMID: 26684757.

Koch C, Schramm R, Roller FC, Hecker A, Henrich M, Schneck E, Krombach G, Weigand MA, Lichtenstern C. Impact of unsuspected subsegmental pulmonary embolism in ICU patients. Anaesthesist. 2015 Dec 11. [Epub ahead of print] PubMed PMID:26661080.

New in PubMed from DZL Faculty/ Neu von der DZL-Fakultät in der Woche bis 13. Dez. 2015:

Wegmann M, Fehrenbach H, Krauss-Etschmann S. [Asthma Update 2015 - What Cell Biology in Basic Pulmonary Research Can Offer to the Pneumologist]. Pneumologie. 2015 Dec 7. [Epub ahead of print] German. PubMed PMID: 26640964.

Kreuter M, Herth FJ, Wacker M, Leidl R, Hellmann A, Pfeifer M, Behr J, Witt S, Kauschka D, Mall M, Günther A, Markart P.Exploring Clinical and Epidemiological Characteristics of Interstitial Lung Diseases: Rationale, Aims, and Design of a Nationwide Prospective Registry-The EXCITING-ILD Registry. Biomed Res Int. 2015;2015:123876. doi: 10.1155/2015/123876. Epub 2015 Nov 10. PubMed PMID: 26640781; PubMed Central PMCID: PMC4657073.

Weinmann T, Gerlich J, Heinrich S, Nowak D, Gerdes J, Schlichtiger J, von Mutius E, Schaub B, Vogelberg C, Roller D, Radon K.Establishing a birth cohort to investigate the course and aetiology of asthma and allergies across three generations - rationale, design, and methods of the ACROSSOLAR study. BMC Public Health. 2015 Dec 4;15(1):1210. doi: 10.1186/s12889-015-2555-y. PubMed PMID: 26637409; PubMed Central PMCID: PMC4670515.

Warth A, Körner S, Penzel R, Muley T, Dienemann H, Schirmacher P, von Knebel-Doeberitz M, Weichert W, Kloor M.Microsatellite instability in pulmonary adenocarcinomas: a comprehensive study of 480 cases. Virchows Arch. 2015 Dec 4. [Epub ahead of print] PubMed PMID: 26637197.

Gren ST, Rasmussen TB, Janciauskiene S, Håkansson K, Gerwien JG, Grip O. A Single-Cell Gene Expression Profile Reveals Inter-Cellular Heterogeneity within Human Monocyte Subsets. PLoS One. 2015 Dec 9; 10(12):e0144351. doi: 10.1371/journal.pone.0144351. eCollection 2015. PubMed PMID: 26650546.

Schmeck B, Jerrentrup L, Bals R. [COPD Update 2015: Cell Biology goes Clinic? - Important Research Findings for Clinicians]. Pneumologie. 2015Dec;69(12):704-710. Epub 2015 Dec 9. German. PubMed PMID: 26649596.

Huber R, Panterodt T, Welz B, Christmann M, Friesenhagen J, Westphal A, Pietsch D, Brand K. C/EBPβ-LAP*/LAP Expression Is Mediated by RSK/eIF4B-Dependent Signalling and Boosted by Increased Protein Stability in Models of Monocytic Differentiation. PLoS One. 2015 Dec 8; 10(12):e0144338. doi: 10.1371/journal.pone.0144338. eCollection 2015. PubMed PMID: 26646662.

Szatmári V, Teske E, Nikkels PG, Griese M, de Jong PA, Grinwis G, Theegarten D, Veraa S, van Steenbeek FG, Drent M, Bonella F. Pulmonary alveolar proteinosis in a cat. BMC Vet Res. 2015 Dec 9;11(1):302. doi: 10.1186/s12917-015-0613-4. PubMed PMID: 26646313.

Sun N, Fernandez IE, Wei M, Wu Y, Aichler M, Eickelberg O, Walch A. Pharmacokinetic and pharmacometabolomic study of pirfenidone in normal mouse tissues using high mass resolution MALDI-FTICR-mass spectrometry imaging. Histochem Cell Biol. 2015 Dec 8. [Epub ahead of print] PubMed PMID: 26645566.

Alioto TS, Buchhalter I, Derdak S, Hutter B, Eldridge MD, Hovig E, Heisler LE, Beck TA, Simpson JT, Tonon L, Sertier AS, Patch AM, Jäger N, Ginsbach P, Drews R, Paramasivam N, Kabbe R, Chotewutmontri S, Diessl N, Previti C, Schmidt S, Brors B, Feuerbach L, Heinold M, Gröbner S, Korshunov A, Tarpey PS, Butler AP, Hinton J, Jones D, Menzies A, Raine K, Shepherd R, Stebbings L, Teague JW, Ribeca P, Giner FC, Beltran S, Raineri E, Dabad M, Heath SC, Gut M, Denroche RE, Harding NJ, Yamaguchi TN, Fujimoto A, Nakagawa H, Quesada V, Valdés-Mas R, Nakken S, Vodák D, Bower L, Lynch AG, Anderson CL, Waddell N, Pearson JV, Grimmond SM, Peto M, Spellman P, He M, Kandoth C, Lee S, Zhang J, Létourneau L, Ma S, Seth S, Torrents D, Xi L, Wheeler DA, López-Otín C, Campo E, Campbell PJ, Boutros PC, Puente XS, Gerhard DS, Pfister SM, McPherson JD, Hudson TJ, Schlesner M, Lichter P, Eils R, Jones DT, Gut IG. A comprehensive assessment of somatic mutation detection in cancer using whole-genome sequencing. Nat Commun. 2015 Dec 9; 6:10001. doi: 10.1038/ ncomms10001. PubMed PMID: 26647970.

Kriegsmann M, Muley T, Harms A, Tavernar L, Goldmann T, Dienemann H, Herpel E, Warth A. Differential diagnostic value of CD5 and CD117 expression in thoracic tumors: A large scale study of 1465 non-small cell lung cancer cases. Diagn Pathol. 2015 Dec 8;10(1):210. doi: 10.1186/s13000-015 0441-7. PubMed PMID: 26643918.

Kreuter M, Kirsten D, Bahmer T, Penzel R, Claussen M, Ehlers-Tenenbaum S, Muley T, Palmowski K, Eichinger M, Leider M, Herth FJ, Rabe KF, Bittmann I, Warth A. Screening for Helicobacter pylori in Idiopathic Pulmonary Fibrosis Lung Biopsies.Respiration. 2015 Dec 9. [Epub ahead of print] PubMed PMID: 26645213.

Diel R, Nienhaus A, Hillemann D, Richter E. Cost-benefit analysis of Xpert® MTB/RIF for tuberculosis suspects in German hospitals. Eur Respir J. 2015 Dec 2. pii: ERJ-01333-2015. doi: 10.1183/13993003.01333-2015. [Epub ahead of print] PubMed PMID: 26647440.

New in PubMed from DZL Faculty/ Neu von der DZL-Fakultät in der Woche bis 6. Dez. 2015:

Hecker M, Sommer N, Hecker A, Bandorski D, Weigand MA, Krombach GA, Mayer E, Walmrath D. [Pulmonary embolism]. Med Klin Intensivmed Notfmed. 2015 Nov 30. [Epub ahead of print] German. PubMed PMID: 26621816.

Yaroshenko A, Hellbach K, Yildirim AÖ, Conlon TM, Fernandez IE, Bech M, Velroyen A, Meinel FG, Auweter S, Reiser M, Eickelberg O, Pfeiffer F. Improved In vivo Assessment of Pulmonary Fibrosis in Mice using X-Ray Dark-Field Radiography.Sci Rep. 2015 Dec 1;5:17492. doi: 10.1038/srep17492. PubMed PMID: 26619958; PubMed Central PMCID: PMC4664921.

Artigas MS, Wain LV, Miller S, Kheirallah AK, Huffman JE, Ntalla I, Shrine N, Obeidat M, Trochet H, McArdle WL, Alves AC, Hui J, Zhao JH, Joshi PK, Teumer A, Albrecht E, Imboden M, Rawal R, Lopez LM, Marten J, Enroth S, Surakka I, Polasek O, Lyytikäinen LP, Granell R, Hysi PG, Flexeder C, Mahajan A, Beilby J, Bossé Y, Brandsma CA, Campbell H, Gieger C, Gläser S, González JR, Grallert H, Hammond CJ, Harris SE, Hartikainen AL, Heliövaara M, Henderson J, Hocking L, Horikoshi M, Hutri-Kähönen N, Ingelsson E, Johansson Å, Kemp JP, Kolcic I, Kumar A, Lind L, Melén E, Musk AW, Navarro P, Nickle DC, Padmanabhan S, Raitakari OT, Ried JS, Ripatti S, Schulz H, Scott RA, Sin DD, Starr JM; UK BiLEVE, Viñuela A, Völzke H, Wild SH, Wright AF, Zemunik T, Jarvis DL, Spector TD, Evans DM, Lehtimäki T, Vitart V, Kähönen M, Gyllensten U, Rudan I, Deary IJ, Karrasch S, Probst-Hensch NM, Heinrich J, Stubbe B, Wilson JF, Wareham NJ, James AL, Morris AP, Jarvelin MR, Hayward C, Sayers I, Strachan DP, Hall IP, Tobin MD. Sixteen new lung function signals identified through 1000 Genomes Project reference panel imputation. Nat Commun. 2015 Dec 4;6:8658. doi: 10.1038/ncomms9658. PubMed PMID: 26635082.

Chung JH, Huitt G, Yagihashi K, Hobbs SB, Faino AV, Bolster BD Jr, Biederer J, Puderbach M, Lynch DA. Proton MRI for Initial Assessment of Isolated Mycobacterium avium Complex (MAC) Pneumonia. Ann Am Thorac Soc. 2015 Dec 3. [Epub ahead of print] PubMed PMID: 26633593.

Hoeper MM, Behr J, Held M, Grunig E, Vizza CD, Vonk-Noordegraaf A, Lange TJ, Claussen M, Grohé C, Klose H, Olsson KM, Zelniker T, Neurohr C, Distler O, Wirtz H, Opitz C, Huscher D, Pittrow D, Gibbs JS. Pulmonary Hypertension in Patients with Chronic Fibrosing Idiopathic Interstitial Pneumonias. PLoS One. 2015 Dec 2;10(12):e0141911. doi: 10.1371/journal.pone.0141911. eCollection 2015. PubMed PMID: 26630396.

Velroyen A, Yaroshenko A, Hahn D, Fehringer A, Tapfer A, Müller M, Noël PB, Pauwels B, Sasov A, Yildirim AÖ, Eickelberg O, Hellbach K, Auweter SD, Meinel FG, Reiser MF, Bech M, Pfeiffer F. Grating-based X-ray Dark-field Computed Tomography of Living Mice. EBioMedicine. 2015 Aug 13; 2(10): 1500-6. doi: 10.1016/j.ebiom.2015.08.014. eCollection 2015 Oct. PubMed PMID: 26629545; PubMed Central PMCID: PMC4634200.

Samsa LA, Givens C, Tzima E, Stainier DY, Qian L, Liu J. Cardiac contraction activates endocardial Notch signaling to modulate chamber maturation in zebrafish. Development. 2015 Dec 1; 142(23): 4080-91. doi: 10.1242/dev.125724. PubMed PMID: 26628092.

Fink C, Hoffmann J, Knop M, Li Y, Isermann K, Roeder T. Intestinal FoxO signaling is required to survive oral infection in Drosophila. Mucosal Immunol. 2015 Dec 2. doi: 10.1038/mi.2015.112. [Epub ahead of print] PubMed PMID: 26627459.

Liesche C, Grußmayer KS, Ludwig M, Wörz S, Rohr K, Herten DP, Beaudouin J, Eils R. Automated Analysis of Single-Molecule Photobleaching Data by Statistical Modeling of Spot Populations. Biophys J. 2015 Dec 1;109(11):2352-2362. doi: 10.1016/j.bpj.2015.10.035. PubMed PMID: 26636946.

Weitnauer M, Mijošek V, Dalpke AH. Control of local immunity by airway epithelial cells. Mucosal Immunol. 2015 Dec 2. doi: 10.1038/mi.2015.126. [Epub ahead of print] Review. PubMed PMID: 26627458.

Schloß M, Heckrodt J, Schneider C, Discher T, Krombach GA. Magnetic Resonance Imaging of the Lung as an Alternative for a Pregnant Woman with Pulmonary Tuberculosis. J Radiol Case Rep. 2015 May 31;9(5):7-13. doi: 10.3941/jrcr.v9i5.2256. eCollection 2015 May. PubMed PMID: 26622928; PubMed Central PMCID: PMC4638373.

Grünig E, Peacock AJ. Imaging the heart in pulmonary hypertension: an update. Eur Respir Rev. 2015 Dec;24(138):653-64. doi: 10.1183/16000617.0058-2015. Review. PubMed PMID: 26621979.

Katsirntaki K(1), Mauritz C, Olmer R, Schmeckebier S, Sgodda M, Puppe V, Eggenschwiler R, Duerr J, Schubert SC, Schmiedl A, Ochs M, Cantz T, Salwig I, Szibor M, Braun T, Rathert C, Martens A, Mall MA, Martin U. Bronchoalveolar sublineage specification of pluripotent stem cells: effect of dexamethasone plus cAMP-elevating agents and keratinocyte growth factor Tissue Eng Part A. 2015 Feb; 21(3-4):669-82. doi: 10.1089/ten.TEA.2014.0097. Epub 2014 Dec 1.

Matsuda R, Hosono C, Samakovlis C, Saigo K. Multipotent versus differentiated cell fate selection in the developing Drosophila airways. Elife. 2015 Dec 3; 4. pii: e09646. doi: 10.7554/eLife.09646. [Epub ahead of print] PubMed PMID: 26633813.

Lotz J, Olesch J, Muller B, Polzin T, Galuschka P, Lotz J, Heldmann S, Breuhahn K, Gonzalez M, Lahrmann B, Grabe N, Laue H, Sedlaczek O, Warth A, Modersitzki J. Patch-Based Nonlinear Image Registration for Gigapixel Whole Slide Images. IEEE Trans Biomed Eng. 2015 Nov 23. [Epub ahead of print] PubMed PMID: 26625400.

November 2015

New in PubMed from DZL Faculty/ Neu von der DZL-Fakultät in der Woche bis 29. Nov. 2015:

Diehl J, Gries B, Pfeil U, Goldenberg A, Mermer P, Kummer W, Paddenberg R. Expression and localization of GPR91 and GPR99 in murine organs. Cell Tissue Res. 2015 Nov 21. [Epub ahead of print] PubMed PMID: 26590824.

Mori Y, Takahashi N, Ogawa N, Gudermann T. Oxygen physiology: sensors and ion channels. Pflugers Arch. 2015 Nov 21. [Epub ahead of print] PubMed PMID: 26590926.

Hoegl S, Zwissler B, Eltzschig HK, Vohwinkel C. Acute respiratory distress syndrome following cardiovascular surgery: current concepts and novel therapeutic approaches. Curr Opin Anaesthesiol. 2015 Nov 23. [Epub ahead of print] PubMed PMID: 26598954.

Li YQ, Shrestha Y, Pandey M, Chen M, Kablan A, Gavrilova O, Offermanns S, Weinstein LS. Gq/11α and Gsα mediate distinct physiological responses to central melanocortins. J Clin Invest. 2015 Nov 23. pii: 76348. doi: 10.1172/JCI76348. [Epub ahead of print] PubMed PMID: 26595811.

Wanzel M, Vischedyk JB, Gittler MP, Gremke N, Seiz JR, Hefter M, Noack M, Savai R, Mernberger M, Charles JP, Schneikert J, Bretz AC, Nist A, Stiewe T. CRISPR-Cas9-based target validation for p53 reactivating model compounds. Nat Chem Biol. 2015 Nov 23. doi: 10.1038/nchembio.1965. [Epub ahead of print] PubMed PMID: 26595461.

Blanco I, Lipsker D, Lara B, Janciauskiene S. Neutrophilic Panniculitis Associated with Alpha-1 Antitrypsin Deficiency: an Update. Br J Dermatol. 2015 Nov 23. doi: 10.1111/bjd.14309. [Epub ahead of print] Review. PubMed PMID: 26595240.

Schneider A, Wagenpfeil G, Jörres RA, Wagenpfeil S. Influence of the practice setting on diagnostic prediction rules using FENO measurement in combination with clinical signs and symptoms of asthma. BMJ Open. 2015 Nov 24;5(11):e009676. doi: 10.1136/bmjopen-2015-009676. PubMed PMID: 26603255.

Avsar M, Jansson K, Sommer W, Kruse B, Thissen S, Dreckmann K, Knoefel AK, Salman J, Hafer C, Hecker J, Buechler G, Karstens JH, Jonigk D, Länger F, Kaever V, Falk CS, Hewicker-Trautwein M, Ungefroren H, Haverich A, Strüber M, Warnecke G. Augmentation of Transient Donor Cell Chimerism and Alloantigen-Specific Regulation of Lung Transplants in Miniature Swine. Am J Transplant. 2015 Nov 25. doi: 10.1111/ajt.13629. [Epub ahead of print] PubMed PMID: 26602894.

Aalbers R, Vogelmeier C, Kuna P. Achieving asthma control with ICS/LABA: A review of strategies for asthma management and prevention. Respir Med. 2015 Nov 6. pii: S0954-6111(15)30083-4. doi: 10.1016/j.rmed.2015.11.002. [Epub ahead of print] Review. PubMed PMID: 26614594.

Wiedenroth CB, Liebetrau C, Breithecker A, Guth S, Lautze HF, Ortmann E, Arlt M, Krombach GA, Bandorski D, Hamm CW, Möllmann H, Mayer E. Combined pulmonary endarterectomy and balloon pulmonary angioplasty in patients with chronic thromboembolic pulmonary hypertension. J Heart Lung Transplant. 2015 Oct 30. pii: S1053-2498(15)01491-6. doi: 10.1016/j.healun.2015.10.030. [Epub ahead of print] PubMed PMID: 26612053.

Flechsig P, Choyke P, Kratochwil C, Warth A, Antoch G, Holland-Letz T, Rath D, Eichwald V, Huber PE, Kauczor HU, Haberkorn U, Giesel FL. Increased x-ray attenuation in malignant vs. benign mediastinal nodes in an orthotopic model of lung cancer. Diagn Interv Radiol. 2015 Nov 25. doi: 10.5152/dir.2015.15220. [Epub ahead of print] PubMed PMID: 26611258.

Leuchte HH, Mernitz P, Baezner C, Baumgartner RA, von Wulffen W, Neurohr C, Behr J. Self-Report Daily Life Activity as a Prognostic Marker of Idiopathic Pulmonary Fibrosis. Respiration. 2015 Nov 27; 90(6). [Epub ahead of print] PubMed PMID: 26610049.

Hegermann J, Lünsdorf H, Ochs M, Haller H. Visualization of the glomerular endothelial glycocalyx by electron microscopy using cationic colloidal thorium dioxide. Histochem Cell Biol. 2015 Nov 25. [Epub ahead of print] PubMed PMID: 26608651.

Napp LC, Kühn C, Hoeper MM, Vogel-Claussen J, Haverich A, Schäfer A, Bauersachs J. Cannulation strategies for percutaneous extracorporeal membrane oxygenation in adults. Clin Res Cardiol. 2015 Nov 25. [Epub ahead of print] PubMed PMID: 26608160.

Hadem J, Gottlieb J, Seifert D, Fegbeutel C, Sommer W, Greer M, Wiesner O, Kielstein JT, Schneider AS, Ius F, Fuge J, Kühn C, Tudorache I, Haverich A, Welte T, Warnecke G, Hoeper MM. Prolonged Mechanical Ventilation following Lung Transplantation - A Single-Center Study. Am J Transplant. 2015 Nov 26. doi:10.1111/ajt.13632. [Epub ahead of print] PubMed PMID: 26607844.

Hamon Y, Legowska M, Fergelot P, Dallet-Choisy S, Newell L, Vanderlynden L, Kord Valeshabad A, Acrich K, Kord H, Charalampos T, Morice-Picard F, Surplice I, Zoidakis J, David K, Vlahou A, Ragunatha S, Nagy N, Farkas K, Széll M, Goizet C, Schacher B, Battino M, Al Farraj Aldosari A, Wang X, Liu Y, Marchand-Adam S, Lesner A, Kara E, Korkmaz-Icöz S, Moss C, Eickholz P, Taieb A, Kavukcu S, Jenne DE, Gauthier F, Korkmaz B. Analysis of urinary cathepsin C for diagnosing Papillon-Lefèvre syndrome. FEBS J. 2015 Nov 26. doi: 10.1111/febs.13605. [Epub ahead of print] PubMed PMID: 26607765.

Bardou O, Menou A, François C, Duitman JW, von der Thüsen JH, Borie R, Sales KU, Mutze K, Castier Y, Sage E, Liu L, Bugge TH, Fairlie DP, Königshoff M, Crestani B, Borensztajn KS. Membrane-anchored Serine Protease Matriptase is a Trigger of Pulmonary Fibrogenesis. Am J Respir Crit Care Med. 2015 Nov 24. [Epub ahead of print] PubMed PMID: 26599507.

New in PubMed from DZL Faculty/ Neu von der DZL-Fakultät in der Woche bis 22. Nov. 2015:

Amaral AF, Newson RB, Abramson MJ, Antó JM, Bono R, Corsico AG, de Marco R, Demoly P, Forsberg B, Gislason T, Heinrich J, Huerta I, Janson C, Jõgi R, Kim JL, Maldonado J, Martinez-Moratalla Rovira J, Neukirch C, Nowak D, Pin I, Probst-Hensch N, Raherison-Semjen C, Svanes C, Urrutia Landa I, van Ree R, Versteeg SA, Weyler J, Zock JP, Burney PG, Jarvis DL. Changes in IgE sensitization and total IgE levels over 20 years of follow-up. J Allergy Clin Immunol. 2015 Nov 13. pii: S0091-6749(15)01430-X. doi: 10.1016/j.jaci.2015.09.037. [Epub ahead of print] PubMed PMID: 26586040.

Brunner S, Brunner D, Winter H, Kneidinger N. Feasibility of whole body vibration as an early inpatient rehabilitation tool after lung transplantation - a pilot study. Clin Transplant. 2015 Nov 21. doi: 10.1111/ctr.12669. [Epub ahead of print] PubMed PMID: 26589261.

Einarsdóttir H, Yaroshenko A, Velroyen A, Bech M, Hellbach K, Auweter S, Yildirim Ö, Meinel FG, Eickelberg O, Reiser M, Larsen R, Ersbøll BK, Pfeiffer F. Computer-aided diagnosis of pulmonary diseases using x-ray darkfield radiography. Phys Med Biol. 2015 Nov 18; 60(24):9253-9268. [Epub ahead of print] PubMed PMID: 26577057.

Enderle Y, Meid AD, Friedrich J, Grünig E, Wilkens H, Haefeli WE, Burhenne J. Dried blood spot technique for the monitoring of ambrisentan, bosentan, sildenafil, and tadalafil in patients with pulmonary arterial hypertension. Anal Chem. 2015 Nov 19. [Epub ahead of print] PubMed PMID: 26583764.

Gisch N, Schwudke D, Thomsen S, Heß N, Hakenbeck R, Denapaite D. Lipoteichoic acid of Streptococcus oralis Uo5: a novel biochemical structure comprising an unusual phosphorylcholine substitution pattern compared to Streptococcus pneumoniae. Sci Rep. 2015 Nov 18; 5:16718. doi: 10.1038/srep16718. PubMed PMID: 26577602.

Graeber SY, Hug MJ, Sommerburg O, Hirtz S, Hentschel J, Heinzmann A, Dopfer C, Schulz A, Mainz JG, Tümmler B, Mall MA. Intestinal Current Measurements Detect Activation of Mutant CFTR in Patients with Cystic Fibrosis with the G551D Mutation Treated with Ivacaftor. Am J Respir Crit Care Med. 2015 Nov 15;192(10):1252-5. doi: 10.1164/rccm.201507-1271LE. PubMed PMID: 26568242.

Hoeper MM, Huscher D, Pittrow D. Incidence and prevalence of pulmonary arterial hypertension in Germany. Int J Cardiol. 2015 Nov 9;203:612-613. doi: 10.1016/j.ijcard.2015.11.001. [Epub ahead of print] PubMed PMID: 26580339.

Loss GJ, Depner M, Hose AJ, Genuneit J, Karvonen AM, Hyvärinen A, Roduit C, Kabesch M, Lauener R, Pfefferle PI, Pekkanen J, Dalphin JC, Riedler J, Braun-Fahrländer C, von Mutius E, Ege MJ; PASTURE study group. The Early Development of Wheeze: Environmental Determinants and Genetic Susceptibility at 17q21. Am J Respir Crit Care Med. 2015 Nov 17. [Epub ahead of print] PubMed PMID: 26575599.

Magnussen H, Tetzlaff K, Bateman ED, Watz H, Kirsten AM, Wouters EF, Disse B, Finnigan H, Rodriguez-Roisin R, Calverley PM. Lung-function changes over time following withdrawal of inhaled corticosteroids in patients with severe COPD. Eur Respir J. 2015 Nov 19. pii: ERJ-01644-2015. doi: 10.1183/13993003.01644-2015. [Epub ahead of print] PubMed PMID: 26585433.

Michel C, Neubauer A, Burchert A. [Molecular tumour therapy]. Internist (Berl). 2015 Nov 21. [Epub ahead of print] German. PubMed PMID: 26585240.

Pak O, Bakr AG, Gierhardt M, Albus J, Strielkov I, Kroschel F, Hoeres T, Hecker M, Ghofrani HA, Seeger W, Weissmann N, Sommer N. Effects of carbon monoxide releasing molecules (CO-RMs) on pulmonary vasoreactivity in isolated perfused lungs. J Appl Physiol (1985). 2015 Nov 19:jap.00726.2015. doi: 10.1152/japplphysiol.00726.2015. [Epub ahead of print] PubMed PMID: 26586910.

Pugatsch T, Shoseyov D, Cohen-Cymberknoh M, Hayut B, Armoni S, Griese M, Kerem E. Adherence pattern to study drugs in clinical trials by patients with cystic fibrosis. Pediatr Pulmonol. 2015 Nov 19. doi: 10.1002/ppul.23344. [Epub ahead of print] PubMed PMID: 26583331.

Rosenkranz E, Hilgers RD, Uciechowski P, Petersen A, Plümäkers B, Rink L. Zinc enhances the number of regulatory T cells in allergen-stimulated cells from atopic subjects. Eur J Nutr. 2015 Nov 20. [Epub ahead of print] PubMed PMID: 26589301.

Schultze T, Hilker R, Mannala GK, Gentil K, Weigel M, Farmani N, Windhorst AC, Goesmann A, Chakraborty T, Hain T. A detailed view of the intracellular transcriptome of Listeria monocytogenes in murine macrophages using RNA-seq. Front Microbiol. 2015 Oct 30; 6:1199. eCollection 2015. PubMed PMID: 26579105; PubMed Central PMCID: PMC4627465.

Zepeda-Mendoza CJ, Mukhopadhyay S, Wong ES, Harder N, Splinter E, de Wit E, Eckersley-Maslin MA, Ried T, Eils R, Rohr K, Mills A, de Laat W, Flicek P, Sengupta AM, Spector DL. Quantitative analysis of chromatin interaction changes upon a 4.3 Mb deletion at mouse 4E2. BMC Genomics. 2015 Nov 21; 16(1):982. PubMed PMID: 26589460.

Zissler UM, Chaker AM, Effner R, Ulrich M, Guerth F, Piontek G, Dietz K, Regn M, Knapp B, Theis FJ, Heine H, Suttner K, Schmidt-Weber CB. Interleukin-4 and interferon-γ orchestrate an epithelial polarization in the airways. MucosalImmunol. 2015 Nov 18. doi: 10.1038/mi.2015.110. [Epub ahead of print] PubMedPMID: 26577568.

New in PubMed from DZL Faculty/ Neu von der DZL-Fakultät, 16. Nov. 2015

Babu KR, Muckenthaler MU. miR-20a regulates expression of the iron exporter ferroportin in lung cancer. J Mol Med (Berl). 2015 Nov 12. [Epub ahead of print] PubMed PMID: 26560875.

Conlon TM, Bartel J, Ballweg K, Günter S, Prehn C, Krumsiek J, Meiners S, Theiss FJ, Adamski J, Eickelberg O, Yildirim AO. Metabolomics screening identifies reduced L-carnitine to be associated with progressive emphysema. Clin  Sci (Lond). 2015 Nov 12. pii: CS20150438. [Epub ahead of print] PubMed PMID: 26564208.

den Dekker HT, Sonnenschein-van der Voort AM, de Jongste JC, Anessi-Maesano I, Arshad SH, Barros H, Beardsmore CS, Bisgaard H, Phar SC, Craig L, Devereux G, van der Ent CK, Esplugues A, Fantini MP, Flexeder C, Frey U, Forastiere F, Gehring U, Gori D, van der Gugten AC, Henderson AJ, Heude B, Ibarluzea J, Inskip HM, Keil T, Kogevinas M, Kreiner-Møller E, Kuehni CE, Lau S, Mélen E, Mommers M, Morales E, Penders J, Pike KC, Porta D, Reiss IK, Roberts G, Schmidt A, Schultz ES, Schulz H, Sunyer J, Torrent M, Vassilaki M, Wijga AH, Zabaleta C, Jaddoe VW, Duijts L. Early growth characteristics and the risk of reduced lung function and asthma: A meta-analysis of 25,000 children. J Allergy Clin Immunol. 2015 Nov 5. pii: S0091-6749(15)01361-5. doi: 10.1016/j.jaci.2015.08.050. [Epub ahead of print] PubMed PMID: 26548843.

Heidegger S, Jarosch A, Schmickl M, Endres S, Bourquin C, Hotz C. Mycoplasma hyorhinis Contaminated Cell Lines Activate Primary Innate Immune Cells via a Protease-Sensitive Factor. PloS One. 2015 Nov 13;10(11):e0142523. doi: 10.1371/journal.pone.0142523. eCollection 2015. PubMed PMID: 26565413.

Hosono C, Matsuda R, Adryan B, Samakovlis C. Transient junction anisotropies orient annular cell polarization in the Drosophila airway tubes. Nat Cell Biol. 2015 Nov 9. doi: 10.1038/ncb3267. [Epub ahead of print] PubMed PMID: 26551273.

Kircher P, Hermanns C, Nossek M, Drexler MK, Grosse R, Fischer M, Sarikas A, Penkava J, Lewis T, Prywes R, Gudermann T, Muehlich S. Filamin A interacts with the coactivator MKL1 to promote the activity of the transcription factor SRF and  cell migration. Sci Signal. 2015 Nov 10;8(402):ra112. doi: 10.1126/scisignal.aad2959. PubMed PMID: 26554816.

Lunding L, Schröder A, Wegmann M. Allergic airway inflammation: unravelling the relationship between IL-37, IL-18Rα and Tir8/SIGIRR. Expert Rev Respir Med. 2015 Nov 11:1-12. [Epub ahead of print] PubMed PMID: 26561030.

Manali ED, Papadaki G, Konstantonis D, Tsangaris I, Papaioannou AI, Kolilekas  L, Schams A, Kagouridis K, Karakatsani A, Orfanos S, Griese M, Papiris SA. CARDIOVASCULAR RISK IN PULMONARY ALVEOLAR PROTEINOSIS. Expert Rev Respir Med. 2015 Nov 11. [Epub ahead of print] PubMed PMID: 26558331.

Purath U, Ibrahim R, Zeitvogel J, Renz H, Runkel F, Schmidts T, Dobler D, Werfel T, Müller A, Garn H. Efficacy of T-cell transcription factor-specific DNAzymes in murine skin inflammation models. J Allergy Clin Immunol. 2015 Nov 9.  pii: S0091-6749(15)01362-7. doi: 10.1016/j.jaci.2015.09.022. [Epub ahead of print] PubMed PMID: 26560045.

Schlosser A, Pilecki B, Hemstra LE, Kejling K, Kristmannsdottir GB, Wulf-Johansson H, Moeller JB, Füchtbauer EM, Nielsen O, Kirketerp-Møller K, Dubey LK, Hansen PB, Stubbe J, Wrede C, Hegermann J, Ochs M, Rathkolb B, Schrewe A, Bekeredjian R, Wolf E, Gailus-Durner V, Fuchs H, de Angelis MH, Lindholt JS, Holmskov U, Sorensen GL. MFAP4 Promotes Vascular Smooth Muscle Migration, Proliferation and Accelerates Neointima Formation. Arterioscler Thromb Vasc Biol. 2015 Nov 12. pii: ATVBAHA.115.306672. [Epub ahead of print] PubMed PMID: 26564819. 

Schneider JP, Pedersen L, Mühlfeld C, Ochs M. Staining histological lung sections with Sudan Black B or Sudan III for automated identification of alveolar epithelial type II cells. Acta Histochem. 2015 Nov 7. pii: S0065-1281(15)30016-7. doi: 10.1016/j.acthis.2015.10.005. [Epub ahead of print] PubMed PMID: 26558990.

von Laffert M, Stenzinger A, Hummel M, Weichert W, Lenze D, Warth A, Penzel R, Herbst H, Kellner U, Jurmeister P, Schirmacher P, Dietel M, Klauschen F. ALK-FISH borderline cases in non-small cell lung cancer: Implications for diagnostics and  clinical decision making. Lung Cancer. 2015 Oct 23. pii: S0169-5002(15)30066-0. doi: 10.1016/j.lungcan.2015.09.022. [Epub ahead of print] PubMed PMID: 26547803.

von Mutius E. No Risk of Asthma in Late-Preterm Infants: Confounding or Misclassification? J Allergy Clin Immunol Pract. 2015 Nov-Dec; 3 (6):911-2. doi: 10.1016/j.jaip.2015.09.005. PubMed PMID: 26553617.

New in PubMed from DZL Faculty/ Neu von der DZL-Fakultät, 9. Nov. 2015

Brandenberger C, Ochs M, Mühlfeld C. Assessing particle and fiber toxicology in the respiratory system: the stereology toolbox. Part Fibre Toxicol. 2015 Oct 31;12(1):35. doi: 10.1186/s12989-015 0110-8. PubMed PMID: 26521139; PubMed Central PMCID: PMC4628359.

Caniard A, Ballweg K, Lukas C, Yildirim AÖ, Eickelberg O, Meiners S. Proteasome function is not impaired in healthy aging of the lung. Aging (Albany NY). 2015 Oct;7(10):776-92. PubMed PMID: 26540298.

Dalhoff K. [Pneumococcal Vaccination for Adults - starting before 60? Con]. Dtsch Med Wochenschr. 2015 Nov 3. [Epub ahead of print] German. PubMed PMID: 26529671.

Eberhardt WE, Pöttgen C, Gauler TC, Friedel G, Veit S, Heinrich V, Welter S, Budach W, Spengler W, Kimmich M, Fischer B, Schmidberger H, De Ruysscher D, Belka C, Cordes S, Hepp R, Lütke-Brintrup D, Lehmann N, Schuler M, Jöckel KH, Stamatis G, Stuschke M. Phase III Study of Surgery Versus Definitive Concurrent Chemoradiotherapy Boost in Patients With Resectable Stage IIIA(N2) and Selected IIIB Non-Small-Cell Lung Cancer After Induction Chemotherapy and Concurrent Chemoradiotherapy (ESPATUE). J Clin Oncol. 2015 Nov 2. pii: JCO.2015.62.6812. [Epub ahead of print] PubMed PMID: 26527789.

Holz O, Tan L, Schaumann F, Müller M, Scholl D, Hidi R, McLeod A, Krug N, Hohlfeld JM. Inter- and intrasubject variability of the inflammatory response to segmental endotoxin challenge in healthy volunteers. Pulm Pharmacol Ther. 2015 Nov 3. pii: S1094-5539(15)30010-9. doi: 10.1016/j.pupt.2015.10.011. [Epub ahead of print] PubMed PMID: 26545873.

Hoogendoorn M, Feenstra T, Asukai Y, Briggs A, Borg S, Dal Negro R, Hansen RN, Jansson S, Wacker M, Risebrough N, Samyshkin Y, Leidl R, Rutten van-Mölken M. Patient Heterogeneity In Cost Effectiveness Models for Chronic Obstructive Pulmonary Disease (Copd): are Current Models Suitable to Evaluate Personalized Medicine. Value Health. 2015 Nov;18(7):A694. doi: 10.1016/j.jval.2015.09.2586. Epub 2015 Oct 20. PubMed PMID: 26533890.

Istvánffy R, Vilne B, Schreck C, Ruf F, Pagel C, Grziwok S, Henkel L, Prazeres da Costa O, Berndt J, Stümpflen V, Götze KS, Schiemann M, Peschel C, Mewes HW, Oostendorp RA. Stroma-Derived Connective Tissue Growth Factor Maintains Cell Cycle Progression and Repopulation Activity of Hematopoietic Stem Cells In Vitro. Stem Cell Reports. 2015 Oct 28. pii: S2213-6711(15)00280-5. doi: 10.1016/j.stemcr.2015.09.018. [Epub ahead of print] PubMed PMID: 26527384.

Kauczor HU, Bonomo L, Gaga M, Nackaerts K, Peled N, Prokop M, Remy-Jardin M, von Stackelberg O, Sculier JP; European Society of Radiology (ESR) and the European Respiratory Society (ERS). Lung cancer screening white paper: a slippery step forward? Eur Respir J. 2015 Nov;46(5):1521-2. doi: 10.1183/13993003.01103-2015. PubMed PMID: 26521283.

Kuhlmann A, Treskova M, Ultsch B, Weidemann F, Wichmann O, Falkenhorst G, Graf von der Schulenburg J. Cost-Effectiveness of Pneumococcal Vaccination of Elderly In Germany. Value Health. 2015 Nov;18(7):A584. doi: 10.1016/j.jval.2015.09.1957. Epub 2015 Oct 20. PubMed PMID: 26533280.

Mack I, Hector A, Ballbach M, Kohlhäufl J, Fuchs KJ, Weber A, Mall MA, Hartl D. The role of chitin, chitinases, and chitinase-like proteins in pediatric lung diseases. Mol Cell Pediatr. 2015 Dec;2(1):3. doi: 10.1186/s40348-015-0014-6. Epub 2015 Feb 27. PubMed PMID: 26542293.

Marenholz I, Esparza-Gordillo J, Rüschendorf F, Bauerfeind A, Strachan DP, Spycher BD, Baurecht H, Margaritte-Jeannin P, Sääf A, Kerkhof M, Ege M, Baltic S, Matheson MC, Li J, Michel S, Ang WQ, McArdle W, Arnold A, Homuth G, Demenais F, Bouzigon E, Söderhäll C, Pershagen G, de Jongste JC, Postma DS, Braun-Fahrländer C, Horak E, Ogorodova LM, Puzyrev VP, Bragina EY, Hudson TJ, Morin C, Duffy DL, Marks GB, Robertson CF, Montgomery GW, Musk B, Thompson PJ, Martin NG, James A, Sleiman P, Toskala E, Rodriguez E, Fölster-Holst R, Franke A, Lieb W, Gieger C, Heinzmann A, Rietschel E, Keil T, Cichon S, Nöthen MM, Pennell CE, Sly PD, Schmidt CO, Matanovic A, Schneider V, Heinig M, Hübner N, Holt PG, Lau S, Kabesch M, Weidinger S, Hakonarson H, Ferreira MA, Laprise C, Freidin MB, Genuneit J, Koppelman GH, Melén E, Dizier MH, Henderson AJ, Lee YA. Meta-analysis identifies seven susceptibility loci involved in the atopic march. Nat Commun. 2015 Nov 6;6:8804. doi: 10.1038/ncomms9804. PubMed PMID: 26542096.

Niedermaier S, Hilgendorff A. Bronchopulmonary dysplasia - an overview about pathophysiologic concepts. Mol Cell Pediatr. 2015 Dec;2(1):2. doi: 10.1186/s40348-015-0013-7. Epub 2015 Feb 26. PubMed PMID: 26542292.

Oglesby IK, Agrawal R, Mall MA, McElvaney NG, Greene CM. miRNA-221 is elevated in cystic fibrosis airway epithelial cells and regulates expression of ATF6. Mol Cell Pediatr. 2015 Dec;2(1):1. doi: 10.1186/s40348-014-0012-0. Epub 2015 Jan 7. PubMed PMID: 26542291.

Olsson KM, Frank A, Fuge J, Welte T, Hoeper MM, Bitter T. Acute hemodynamic effects of adaptive servoventilation in patients with pre-capillary and post-capillary pulmonary hypertension. Respir Res. 2015 Nov 4;16(1):137. doi: 10.1186/s12931-015-0298-z. PubMed PMID: 26538143.

Pletz MW, Ewig S, Heppner HJ, Welte T. [Position Paper on Adult Pneumococcal Vaccination]. Pneumologie. 2015 Nov;69(11):633-7. doi: 10.1055/s-0034-1393413. Epub 2015 Nov 2. German. PubMed PMID: 26523835.

Pletz MW, Welte T. Pneumococcal conjugate vaccine for adults: "It's tough to make predictions, …". Eur Respir J. 2015 Nov;46(5):1265-8. doi: 10.1183/13993003.01038-2015. PubMed PMID: 26521280.

Pahn G, Skornitzke S, Schlemmer HP, Kauczor HU, Stiller W. Toward standardized quantitative image quality (IQ) assessment in computed tomography (CT): A comprehensive framework for automated and comparative IQ analysis based on ICRU Report 87. Phys Med. 2015 Oct 28. pii: S1120 1797(15)01003-0. doi: 10.1016/j.ejmp.2015.09.017. [Epub ahead of print] PubMed PMID: 26520485.

Schulz A, Tümmler B. Non-allergic asthma as a CFTR-related disorder. J Cyst Fibros. 2015 Oct 30. pii: S1569-1993(15)00253-2. doi: 10.1016/j.jcf.2015.10.011. [Epub ahead of print] PubMed PMID: 26526220.

Sharifpanah F, Jayarathne SW, Bekhite MM, Hurtado-Oliveros J, Preissner KT, Wartenberg M, Sauer H. Stimulation of vasculogenesis and leukopoiesis of embryonic stem cells by extracellular transfer RNA and ribosomal RNA. Free Radic Biol Med. 2015 Oct 31. pii: S0891-5849(15)01094-1. doi: 10.1016/j.freeradbiomed.2015.10.423. [Epub ahead of print] PubMed PMID: 26524400.

Thijs W, Janssen K, van Schadewijk AM, Papapoulos SE, le Cessie S, Middeldorp S, Melissant CF, Rabe KF, Hiemstra PS. Nasal Levels of Antimicrobial Peptides in Allergic Asthma Patients and Healthy Controls: Differences and Effect of a Short 1, 25(OH)2 Vitamin D3 Treatment. PLoS One. 2015 Nov 6; 10(11):e0140986. doi: 10.1371/journal.pone.0140986. eCollection 2015. PubMed PMID: 26545199.

Weichert W, Kossakowski C, Harms A, Schirmacher P, Muley T, Dienemann H, Warth A. Proposal of a prognostically relevant grading scheme for pulmonary squamous cell carcinoma. Eur Respir J. 2015 Nov 5. pii: ERJ-00937-2015. doi: 10.1183/13993003.00937-2015. [Epub ahead of print] PubMed PMID: 26541540.

Wirth A, Wang S, Takefuji M, Tang C, Althoff TF, Schweda F, Wettschureck N, Offermanns S. Age dependent blood pressure elevation is due to increased vascular smooth muscle tone mediated by G protein signaling. Cardiovasc Res. 2015 Nov 3. pii: cvv249. [Epub ahead of print] PubMed PMID: 26531127.

New in PubMed from DZL Faculty/ Neu von der DZL-Fakultät, 2. Nov. 2015

Afshar K, David S, Fuehner T, Gottlieb J, Gutzmer R. BRAF Inhibition in a Lung Transplant Recipient With Metastatic Melanoma. JAMA Dermatol. 2015 Oct 21:1-3. doi: 10.1001/ jamadermatol.2015.2910. [Epub ahead of print] PubMed PMID: 26502378.

Al Alam D, El Agha E, Sakurai R, Kheirollahi V, Moiseenko A, Danopoulos S, Shrestha A, Schmoldt C, Quantius J, Herold S, Chao CM, Tiozzo C, De Langhe S, Plikus MV, Thornton M, Grubbs B, Minoo P, Rehan VK, Bellusci S. Evidence for the involvement of Fibroblast Growth Factor 10 in lipofibroblast formation during embryonic lung development. Development. 2015 Oct 28. pii: dev.109173. [Epub ahead of print] PubMed PMID: 26511927.

Boch T, Reinwald M, Postina P, Cornely OA, Vehreschild JJ, Heußel CP, Heinz WJ, Hoenigl M, Eigl S, Lehrnbecher T, Hahn J, Claus B, Lauten M, Egerer G, Müller MC, Will S, Merker N, Hofmann WK, Buchheidt D, Spiess B. Identification of invasive fungal diseases in immunocompromised patients by combining an Aspergillus specific PCR with a multifungal DNA-microarray from primary clinical samples. Mycoses. 2015 Oct 26. doi: 10.1111/myc.12424. [Epub ahead of print] PubMed PMID: 26497302.

Burtin C, Ter Riet G, Puhan MA, Waschki B, Garcia-Aymerich J, Pinto-Plata V, Celli B, Watz H, Spruit MA. Handgrip weakness and mortality risk in COPD: a multicentre analysis. Thorax. 2015 Oct 29. pii: thoraxjnl-2015-207451. doi: 10.1136/thoraxjnl-2015-207451. [Epub ahead of print] PubMed PMID: 26514408.

Channick RN, Delcroix M, Ghofrani HA, Hunsche E, Jansa P, Le Brun FO, Mehta S, Pulido T, Rubin LJ, Sastry BK, Simonneau G, Sitbon O, Souza R, Torbicki A, Galiè N. Effect of macitentan on hospitalizations: results from the SERAPHIN trial. JACC Heart Fail. 2015 Jan;3(1):1-8. doi: 10.1016/j.jchf.2014.07.013. Epub 2014 Nov 11. PubMed PMID: 25457902.

Dempke WC, Edvardsen K, Lu S, Reinmuth N, Reck M, Inoue A. Brain Metastases in NSCLC - are TKIs Changing the Treatment Strategy? Anticancer Res. 2015 Nov; 35(11):5797-806. Review. PubMed PMID: 26504000.

Eberhardt R, Gompelmann D, Herth FJ, Schuhmann M. Endoscopic bronchial valve treatment: patient selection and special considerations. Int J Chron Obstruct Pulmon Dis. 2015 Oct 8;10:2147-57. doi: 10.2147/COPD.S63473. eCollection 2015. Review. PubMed PMID: 26504379; PubMed Central PMCID: PMC4603713.

Homann A, Röckendorf N, Kromminga A, Frey A, Jappe U. B cell epitopes on infliximab identified by oligopeptide microarray with unprocessed patient sera. J Transl Med. 2015 Oct 29;13(1):339. doi: 10.1186/s12967-015-0706-7. PubMed PMID: 26511203; PubMed Central PMCID: PMC4625721.

Ius F, Sommer W, Tudorache I, Avsar M, Siemeni T, Salman J, Molitoris U, Gras C, Juettner B, Puntigam J, Optenhoefel J, Greer M, Schwerk N, Gottlieb J, Welte T, Hoeper MM, Haverich A, Kuehn C, Warnecke G. Five-year experience with intraoperative extracorporeal membrane oxygenation in lung transplantation: Indications and midterm results. J Heart Lung Transplant. 2015 Sep 5. pii: S1053-2498(15)01391-1. doi: 10.1016/j.healun.2015.08.016. [Epub ahead of print] PubMed PMID: 26496786.

Paprottka PM, Zengel P, Cyran CC, Ingrisch M, Nikolaou K, Reiser MF, Clevert DA. Evaluation of multimodality imaging using image fusion with MRI and CEUS in an experimental animal model. Clin Hemorheol Microcirc. 2015 Sep 5. [Epub ahead of print] PubMed PMID: 26519228.

Piepho T, Cavus E, Noppens R, Byhahn C, Dörges V, Zwissler B, Timmermann A. [S1 guidelines on airway management]. Anaesthesist. 2015 Oct 30. [Epub ahead ofprint] German. PubMed PMID: 26519189.

Rosenberger A, Friedrichs S, Amos CI, Brennan P, Fehringer G, Heinrich J, Hung RJ, Muley T, Müller Nurasyid M, Risch A, Bickeböller H. META-GSA: Combining Findings from Gene-Set Analyses across Several Genome-Wide Association Studies. PLoS One. 2015 Oct 26;10(10):e0140179. doi: 10.1371/journal.pone.0140179. eCollection 2015. PubMed PMID: 26501144; PubMed Central PMCID: PMC4621033.

Stammler D, Eigenbrod T, Menz S, Frick JS, Sweet MJ, Shakespear MR, Jantsch J, Siegert I, Wölfle S, Langer JD, Oehme I, Schaefer L, Fischer A, Knievel J, Heeg K, Dalpke AH, Bode KA. Inhibition of Histone Deacetylases Permits Lipopolysaccharide-Mediated Secretion of Bioactive IL-1β via a Caspase-1-Independent Mechanism. J Immunol. 2015 Oct 30. pii: 1501195. [Epub ahead of print] PubMed PMID: 26519528.

Salzberger B, Welte T. [Antimicrobial resistance]. Internist (Berl). 2015 Nov; 56(11):1231-2. doi: 10.1007/s00108-015-3709-9. German. PubMed PMID: 26507817.

Strunk AK, Ciesek S, Schmidt JJ, Kühn C, Hoeper MM, Welte T, Kielstein JT. Single and multiple dose pharmacokinetics of ethambutol and rifampin in a tuberculosis patient with acute respiratory distress syndrome undergoing extended daily dialysis and ECMO treatment. Int J Infect Dis. 2015 Oct 27. pii: S1201-9712(15)00252-0. doi: 10.1016/j.ijid.2015.10.018. [Epub ahead of print] PubMed PMID: 26518065.

Tudorache I, Theodoridis K, Baraki H, Sarikouch S, Bara C, Meyer T, Höffler K, Hartung D, Hilfiker A, Haverich A, Cebotari S. Decellularized aortic allografts versus pulmonary autografts for aortic valve replacement in the growing sheep model: haemodynamic and morphological results at 20 months after implantation. Eur J Cardiothorac Surg. 2015 Oct 24. pii: ezv362. [Epub ahead of print] PubMed PMID: 26503725.

Zhang T, Braun T, Zhou Y. Prmt5 differentiates developmental vs regenerative myogenesis. Oncotarget. 2015 Oct 21. doi: 10.18632/oncotarget.6207. [Epub ahead of print] PubMed PMID: 26506593.

Oktober 2015

New in PubMed from DZL Faculty/ Neu von der DZL-Fakultät, 26. Okt. 2015

Gaass T, Bauman G, Biederer J, Hintze C, Schneider M, Dinkel J. Pulmonary perfusion imaging: Qualitative comparison of TCIR MRI and SPECT/CT in porcine lung. Eur J Radiol. 2015 Sep 2. pii: S0720-048X(15)30089-9. doi: 10.1016/j.ejrad.2015.08.017. [Epub ahead of print] PubMed PMID: 26481482.

Goldmann T, Kugler C, Reinmuth N, Vollmer E, Reck M. PD-L1 copy number gain in Non Small Cell Lung Cancer defines a new subset of patients for anti PD-L1 therapy. Ann Oncol. 2015 Oct 20. pii: mdv510. [Epub ahead of print] PubMed PMID: 26487587.

Harms A, Herpel E, Pfarr N, Penzel R, Heussel CP, Herth FJ, Dienemann H, Weichert W, Warth A. NUT carcinoma of the thorax: Case report and review of the literature. Lung Cancer. 2015 Oct 9. pii: S0169-5002(15)30070-2. doi: 10.1016/j.lungcan.2015.10.001. [Epub ahead of print] Review. PubMed PMID: 26490121.

Kuenne C, Guenther S, Looso M, Zhang T, Krueger M, Zhou Y, Braun T, Kim J. RNA-Seq analysis of isolated satellite cells in Prmt5 deficient mice. Genom Data. 2015 Jun 3;5:122-5. doi: 10.1016/j.gdata.2015.05.013. eCollection 2015 Sep. PubMed PMID: 26484239; PubMed Central PMCID: PMC4583631.

Qian DC, Byun J, Han Y, Greene CS, Field JK, Hung RJ, Brhane Y, Mclaughlin JR, Fehringer G, Landi MT, Rosenberger A, Bickeböller H, Malhotra J, Risch A, Heinrich J, Hunter DJ, Henderson BE, Haiman CA, Schumacher FR, Eeles RA, Easton DF, Seminara D, Amos CI. Identification of shared and unique susceptibility pathways among cancers of the lung, breast, and prostate from genome-wide association studies and tissue-specific protein interactions. Hum Mol Genet. 2015 Oct 19. pii: ddv440. [Epub ahead of print] PubMed PMID: 26483192.

Reimann S, Fink L, Wilhelm J, Hoffmann J, Bednorz M, Seimetz M, Dessureault I, Troesser R, Ghanim B, Klepetko W, Seeger W, Weissmann N, Kwapiszewska G. Increased S100A4 expression in the vasculature of human COPD lungs and murine model of smoke-induced emphysema. Respir Res. 2015 Oct 20;16:127. doi: 10.1186/s12931-015-0284-5. PubMed PMID: 26483185; PubMed Central PMCID: PMC4612429.

Simonneau G, Channick RN, Delcroix M, Galiè N, Ghofrani HA, Jansa P, Le Brun FO, Mehta S, Perchenet L, Pulido T, Sastry BK, Sitbon O, Souza R, Torbicki A, Rubin LJ. Incident and prevalent cohorts with pulmonary arterial hypertension: insight from SERAPHIN. Eur Respir J. 2015 Oct 22. pii: ERJ-00364-2015. doi: 10.1183/13993003.00364-2015. [Epub ahead of print] PubMed PMID: 26493786.13:

Sommer N, Strielkov I, Pak O, Weissmann N. Oxygen sensing and signal transduction in hypoxic pulmonary vasoconstriction. Eur Respir J. 2015 Oct 22. pii: ERJ-00945-2015. doi: 10.1183/13993003.00945-2015. [Epub ahead of print] Review. PubMed PMID: 26493804.

Wolfson LJ, Gibbert J, Wirth D, Diel R. Cost-effectiveness of incorporating bedaquiline into a treatment regimen for multidrug-resistant/extensively drug-resistant tuberculosis in Germany. Eur Respir J. 2015 Oct 22. pii: ERJ-00811-2015. doi: 10.1183/13993003.00811-2015. [Epub ahead of print] PubMed PMID: 26493796.

New in PubMed from DZL Faculty/ Neu von der DZL-Fakultät, 19. Okt. 2015

Agha EE, Kosanovic D, Schermuly RT, Bellusci S. Role of fibroblast growth factors in organ regeneration and repair. Semin Cell Dev Biol. 2015 Oct 13. pii: S1084-9521(15)00206-2. doi: 10.1016/j.semcdb.2015.10.009. [Epub ahead of print] Review. PubMed PMID: 26459973.

Aper T, Wilhelmi M, Gebhardt C, Hoeffler K, Benecke N, Hilfiker A, Haverich A. Novel method for the generation of tissue-engineered vascular grafts based on a highly compacted fibrin matrix. Acta Biomater. 2015 Oct 12. pii: S1742-7061(15)30142-2. doi: 10.1016/j.actbio.2015.10.012. [Epub ahead of print] PubMed PMID: 26472610.

Aumann I, Kreis K, Damm K, Golpon H, Welte T, Graf von der Schulenburg JM. Treatment-related experiences and preferences of patients with lung cancer: a qualitative analysis. Health Expect. 2015 Oct 15. doi: 10.1111/hex.12417. [Epub ahead of print] PubMed PMID: 26468689.

Baroke E, Heussel CP, Warth A, Eichinger M, Oltmanns U, Palmowski K, Herth FJ, Kreuter M. Pleuroparenchymal fibroelastosis in association with carcinomas. Respirology. 2015 Oct 13. doi: 10.1111/resp.12654. [Epub ahead of print] PubMed PMID: 26464176.

Bölükbas DA, Meiners S. Lung cancer nanomedicine: potentials and pitfalls. Nanomedicine (Lond). 2015 Oct 16. [Epub ahead of print] PubMed PMID: 26472521.

Homuth G, Wahl S, Müller C, Schurmann C, Mäder U, Blankenberg S, Carstensen M, Dörr M, Endlich K, Englbrecht C, Felix SB, Gieger C, Grallert H, Herder C, Illig T, Kruppa J, Marzi CS, Mayerle J, Meitinger T, Metspalu A, Nauck M, Peters A, Rathmann W, Reinmaa E, Rettig R, Roden M, Schillert A, Schramm K, Steil L, Strauch K, Teumer A, Völzke H, Wallaschofski H, Wild PS, Ziegler A, Völker U, Prokisch H, Zeller T. Extensive alterations of the whole-blood transcriptome are associated with body mass index: results of an mRNA profiling study involving two large population-based cohorts. BMC Med Genomics. 2015 Oct 15;8(1):65. doi: 10.1186/s12920-015-0141-x. PubMed PMID: 26470795.

Jonigk D, Izykowski N, Rische J, Braubach P, Kühnel M, Warnecke G, Lippmann T, Kreipe H, Haverich A, Welte T, Gottlieb J, Laenger F. Molecular Profiling in Lung Biopsies of Human Pulmonary Allografts to Predict Chronic Lung Allograft Dysfunction. Am J Pathol. 2015 Oct 14. pii: S0002-9440(15)00533-7. doi: 10.1016/j.ajpath.2015.08.016. [Epub ahead of print] PubMed PMID: 26476349.

Rauch D, Wetzke M, Reu S, Wesselak W, Schams A, Hengst M, Kammer B, Ley-Zaporozhan J, Kappler M, Proesmans M, Lange J, Escribano A, Eitan K, Ahrens F, Brasch F, Schwerk N, Griese M; PTI study group of the kids-lung-register. Persistent Tachypnea of Infancy - Usual and Aberrant. Am J Respir Crit Care Med. 2015 Oct 16. [Epub ahead of print] PubMed PMID: 26474448.

Richter MJ, Pader P, Gall H, Reichenberger F, Seeger W, Mayer E, Guth S, Kramm T, Grimminger F, Ghofrani HA, Voswinckel R. The prognostic relevance of oxygen uptake in inoperable chronic thromboembolic pulmonary hypertension. Clin Respir J. 2015 Oct 16. doi: 10.1111/crj.12399. [Epub ahead of print] PubMed PMID: 26470843.

V Berg A, Filipiak-Pittroff B, Schulz H, Hoffmann U, Link E, Sußmann M, Schnappinger M, Brüske I, Standl M, Krämer U, Hoffmann B, Heinrich J, Bauer CP, Koletzko S, Berdel D; GINIplus study group. Allergic manifestation 15 years after early intervention with hydrolyzed formulas - the GINI Study. Allergy. 2015 Oct 14. doi: 10.1111/all.12790. [Epub ahead of print] PubMed PMID: 26465137.

Verjans E, Ohl K, Reiss LK, van Wijk F, Toncheva AA, Wiener A, Yu Y, Rieg AD, Gaertner VD, Roth J, Knol E, Kabesch M, Wagner N, Uhlig S, Martin C, Tenbrock K. The cAMP response element modulator (CREM) regulates TH2 mediated inflammation. Oncotarget. 2015 Oct 8. doi: 10.18632/oncotarget.6041. [Epub ahead of print] PubMed PMID: 26459392.

Verkman AS, Edelman A, Amaral M, Mall MA, Beekman JM, Meiners T, Galietta LJ, Bear CE. Finding new drugs to enhance anion secretion in cystic fibrosis: Toward suitable systems for better drug screening. Report on the pre-conference meeting to the 12th ECFS Basic Science Conference, Albufeira, 25-28 March 2014. J Cyst Fibros. 2015 Oct 13. pii: S1569-1993(15)00218-0. doi: 10.1016/j.jcf.2015.10.001. [Epub ahead of print] PubMed PMID: 26474804.

New in PubMed from DZL Faculty/ Neu von der DZL-Fakultät: 12. Okt. 2015

Bossone E, Ferrara F, Grünig E. Echocardiography in pulmonary hypertension. Curr Opin Cardiol. 2015 Nov;30(6):574-86. doi: 10.1097/HCO.0000000000000217. PubMed PMID: 26447500.

Elborn JS, Bell SC, Madge SL, Burgel PR, Castellani C, Conway S, De Rijcke K, Dembski B, Drevinek P, Heijerman HG, Innes JA, Lindblad A, Marshall B, Olesen HV, Reimann AL, Solé A, Viviani L, Wagner TO, Welte T, Blasi F. Report of the European Respiratory Society/European Cystic Fibrosis Society task force on the care of adults with cystic fibrosis. Eur Respir J. 2015 Oct 9. pii: ERJ-00592-2015. doi: 10.1183/13993003.00592-2015. [Epub ahead of print] PubMed PMID: 26453627.

Gottlieb J, Zamora MR, Hodges T, Musk AW, Sommerwerk U, Dilling D, Arcasoy S, DeVincenzo J, Karsten V, Shah S, Bettencourt BR, Cehelsky J, Nochur S, Gollob J, Vaishnaw A, Simon AR, Glanville AR. ALN-RSV01 for prevention of bronchiolitis obliterans syndrome after respiratory syncytial virus infection in lung transplant recipients. J Heart Lung Transplant. 2015 Sep 3. pii: S1053 2498(15)01387-X. doi: 10.1016/j.healun.2015.08.012. [Epub ahead of print] PubMed PMID: 26452996.

Griese M. Pushing chILD Forward: The Bright Future of Children's Interstitial Lung Diseases. Ann Am Thorac Soc. 2015 Oct;12(10):1428-9. doi: 10.1513/AnnalsATS.201508-550ED. PubMed PMID: 26448346.

Hackstein H, Lippitsch A, Krug P, Schevtschenko I, Kranz S, Hecker M, Dietert K, Gruber AD, Bein G, Brendel C, Baal N. Prospectively defined murine mesenchymal stem cells inhibit Klebsiella pneumoniae-induced acute lung injury and improve pneumonia survival. Respir Res. 2015 Oct 6;16:123. doi: 10.1186/s12931-015-0288-1. PubMed PMID: 26438075; PubMed Central PMCID:

PMC4594670.

Harms A, Fuehner T, Warnecke G, Haverich A, Gottlieb J, Trummer A. Epithelial and Erythrocyte Microvesicles From Bronchoalveolar Lavage Fluid Are Elevated and Associated With Outcome in Chronic Lung Allograft Dysfunction. Transplantation. 2015 Oct 8. [Epub ahead of print] PubMed PMID: 26451527.

Husain-Syed F, Muciño-Bermejo MJ, Ronco C, Seeger W, Birk HW. Peritoneal ultrafiltration for refractory fluid overload and ascites due to pulmonary arterial hypertension. Ann Hepatol. 2015 Nov Dec;14(6):929-32. doi: 10.5604/16652681.1171786. PubMed PMID: 26436367.

Le DD, Funck U, Wronski S, Heck S, Tschernig T, Bischoff M, Sester M, Herr C, Bals R, Welte T, Braun A, Dinh QT. Steroid Treatment Reduces Allergic Airway Inflammation and Does Not Alter the Increased Numbers of Dendritic Cells and Calcitonin Gene-Related Peptide-Expressing Neurons in Airway Sensory Ganglia. Neuroimmunomodulation. 2015 Oct 8. [Epub ahead of print] PubMed PMID: 26444004.

Manuel O, López-Medrano F, Keiser L, Welte T, Cordero E, Hirsch HH. Influenza and other respiratory virus infections in solid organ transplant recipients. Clin Microbiol Infect. 2014 Sep;20 Suppl 7:102-8. Review. PubMed PMID: 26451405.

Prasse A. [Idiopathic Pulmonary Fibrosis]. Pneumologie. 2015 Oct;69(10):608-15. doi: 10.1055/s 0034-1393036. Epub 2015 Oct 7. German. PubMedPMID: 26444136.

Rademacher J, Schulz A, Hedtfeld S, Stanke F, Ringshausen F, Welte T, Tümmler B. Nasal potential difference of carriers of the W493R ENaC variant with non-cystic fibrosis bronchiectasis. Eur Respir J. 2015 Oct 9. pii: ERJ-01128-2015. doi: 10.1183/13993003.01128-2015. [Epub ahead of print] PubMed PMID: 26453628.

Wagner C, Goldmann T, Rohmann K, Rupp J, Marwitz S, Rotta Detto Loria J, Limmer S, Zabel P, Dalhoff K, Drömann D. Budesonide Inhibits Intracellular Infection with Non-Typeable Haemophilus influenzae despite Its Anti-Inflammatory Effects in Respiratory Cells and Human Lung Tissue: A Role for p38 MAP Kinase. Respiration. 2015 Oct 10. [Epub ahead of print] PubMed PMID: 26452008.

New in PubMed from DZL Faculty/ Neu von der DZL-Fakultät: 5. Okt. 2015

André PA, Prêle CM, Vierkotten S, Carnesecchi S, Donati Y, Chambers RC, Pache JC, Crestani B, Barazzone-Argiroffo C, Königshoff M, Laurent GJ, Irminger-Finger I. BARD1 mediates TGF-β signaling in pulmonary fibrosis. Respir Res. 2015 Sep 29;16:118. doi: 10.1186/s12931-015-0278-3. PubMed PMID: 26415510; PubMed Central PMCID: PMC4587901.

Anz D, Rapp M, Eiber S, Koelzer VH, Thaler R, Haubner S, Knott M, Nagel S, Golic M, Wiedemann GM, Bauernfeind F, Wurzenberger C, Hornung Prof V, Scholz C, Mayr D, Rothenfusser S, Endres S, Bourquin C. Suppression of intratumoral CCL22 by type I interferon inhibits migration of regulatory T cells and blocks cancer progression. Cancer Res. 2015 Oct 2. pii: canres.3499.2014. [Epub ahead of print] PubMed PMID: 26432403.

Banat GA, Tretyn A, Pullamsetti SS, Wilhelm J, Weigert A, Olesch C, Ebel K, Stiewe T, Grimminger F, Seeger W, Fink L, Savai R. Immune and Inflammatory Cell Composition of Human Lung Cancer Stroma. PLoS One. 2015 Sep 28;10(9):e0139073. doi: 10.1371/journal.pone.0139073. eCollection 2015. PubMed PMID: 26413839; PubMed Central PMCID: PMC4587668.

Dietert K, Mundhenk L, Erickson NA, Reppe K, Hocke AC, Kummer W, Witzenrath M, Gruber AD. Murine CLCA5 is uniquely expressed in distinct niches of airway epithelial cells. Histochem Cell Biol. 2015 Mar; 143(3):277-87. doi: 10.1007/s00418-014-1279-x. Epub 2014 Sep 12. PubMed PMID: 25212661; PubMed Central PMCID: PMC4317516.

Goldman JW, Shi P, Reck M, Paz-Ares L, Koustenis A, Hurt KC. Treatment Rationale and Study Design for the JUNIPER Study: A Randomized Phase III Study of Abemaciclib With Best Supportive Care Versus Erlotinib With Best Supportive Care in Patients With Stage IV Non-Small-Cell Lung Cancer With a Detectable KRAS Mutation Whose Disease Has Progressed After Platinum-Based Chemotherapy. Clin Lung Cancer. 2015 Aug 18. pii: S1525-7304(15)00190-4. doi: 10.1016/j.cllc.2015.08.003. [Epub ahead of print] PubMed PMID: 26432508.

Koegelenberg CF, Theron J, Dheda K, Bruwer W, Allwood B, Vorster M, Von Groote-Bidlingmaier F, Slebos DJ, Shah P, Herth F. Recommendations for the use of endoscopic lung volume reduction in South Africa: Role in the treatment of emphysema. S Afr Med J. 2015 Sep 19;105(10):810-5. doi: 10.7196/SAMJnew.8147. PubMed PMID: 26428583.

Malczyk M, Veith C, Schermuly RT, Gudermann T, Dietrich A, Sommer N, Weissmann N, Pak O. NADPH oxidases-do they play a role in TRPC regulation under hypoxia? Pflugers Arch. 2015 Oct 1. [Epub ahead of print] PubMed PMID: 26424109.

Raghu G, Amatto VC, Behr J, Stowasser S. Comorbidities in idiopathic pulmonary fibrosis patients: a systematic literature review. Eur Respir J. 2015 Oct;46(4):1113-30. doi: 10.1183/13993003.02316-2014. PubMed PMID: 26424523.

Reck M, Mellemgaard A, von Pawel J, Gottfried M, Bondarenko I, Cheng Y, Zarogoulidis K, Luft A, Bennouna J, Barrueco J, Aboshady H, Hocke J, Kaiser R, Douillard JY; LUME-Lung 1 Study Group. Anti-angiogenic-specific adverse events in patients with non-small cell lung cancer treated with nintedanib and docetaxel. Lung Cancer. 2015 Aug 12. pii: S0169-5002(15)30027-1. doi: 10.1016/j.lungcan.2015.08.003. [Epub ahead of print] PubMed PMID: 26415992.

Scheiermann P, Czerner S, Kaspar M, Schramm R, Winter H, Wimmer CD, Guba M, Stangl M, Faltenbacher V, Ripperger M, Frey L, Neurohr C, Behr J, Meiser B, Hagl C, Zwissler B, Dossow VV. Combined Lung and Liver Transplantation With Extracorporeal Membrane Oxygenation Instead of Cardiopulmonary Bypass. J Cardiothorac Vasc Anesth. 2015 Jun 30. pii: S1053-0770(15)00672-2. doi: 10.1053/j.jvca.2015.06.034. [Epub ahead of print] PubMed PMID: 26432697.

Sogkas G, Stegner D, Syed SN, Vögtle T, Rau E, Gewecke B, Schmidt RE, Nieswandt B, Gessner JE. Cooperative and alternate functions for STIM1 and STIM2 in macrophage activation and in the context of inflammation.Immun Inflamm Dis. 2015 Sep;3(3):154-70. doi: 10.1002/iid3.56. Epub 2015 May 12. PubMed PMID: 26417434; PubMed Central PMCID: PMC4578517.

Solyanik O, Hollmann P, Dettmer S, Kaireit T, Schaefer-Prokop C, Wacker F, Vogel-Claussen J, Shin HO. Quantification of Pathologic Air Trapping in Lung Transplant Patients Using CT Density Mapping: Comparison with Other CT Air Trapping Measures. PLoS One. 2015 Oct 2;10(10):e0139102. doi: 10.1371/journal.pone.0139102. eCollection 2015. PubMed PMID: 26430890.

Valipour A, Shah PL, Gesierich W, Eberhardt R, Snell G, Strange C, Barry R, Gupta A, Henne E, Bandyopadhyay S, Raffy P, Yin Y, Tschirren J, Herth FJ. Patterns of Emphysema Heterogeneity. Respiration. 2015 Oct 3. [Epub ahead of print] PubMed PMID: 26430783.

Willführ A, Brandenberger C, Piatkowski T, Grothausmann R, Nyengaard JR, Ochs M, Mühlfeld C. Estimation of the number of alveolar capillaries by the Euler number (Euler-Poincaré characteristic). Am J Physiol Lung Cell Mol Physiol. 2015 Oct 2:ajplung.00410.2014. doi: 10.1152/ajplung.00410.2014. [Epub ahead of print] PubMed PMID: 26432874.

Wujak ŁA, Blume A, Baloğlu E, Wygrecka M, Wygowski J, Herold S, Mayer K, Vadász I, Besuch P, Mairbäurl H, Seeger W, Morty RE. FXYD1 negatively regulates Na(+)/K(+)-ATPase activity in lung alveolar epithelial cells. Respir Physiol Neurobiol. 2015 Sep 24. pii: S1569-9048(15)30045-8. doi: 10.1016/j.resp.2015.09.008. [Epub ahead of print] PubMed PMID: 26410457.

Yamauchi Y, Muley T, Safi S, Rieken S, Bischoff H, Kappes J, Warth A, Herth FJ, Dienemann H, Hoffmann H. The dynamic pattern of recurrence in curatively resected non-small cell lung cancer patients: Experiences at a single institution. Lung Cancer. 2015 Sep 15. pii: S0169-5002(15)30054-4. doi: 10.1016/j.lungcan.2015.09.010. [Epub ahead of print] PubMed PMID: 26415991.

September 2015

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August 2015

New in PubMed from DZL Faculty/ Neu von der DZL-Fakultät: 31. Aug. 2015

Asselbergs IC, Eikenboom HC, Wartna JB, Koes BW, Casas L, Sunyer J, Tischer C, Gehring U, Wickman M, Garcia-Esteban R, Lehmann I, Kull I, Reich A, Lau S, Wijga A, Antó JM, Nawrot TS, Heinrich J, Keil T, Torrent M. Early-life house dust mite allergens, childhood mite sensitization, and respiratory outcomes. Allergy. 2015 Sep;70(9):1189-91. doi: 10.1111/all.12665. PubMed PMID: 26311615.

Balta S, Demırer Z, Aparci M, Yildirim AO, Ozturk C. The lymphocyte-monocyte ratio in clinical practice. J Clin Pathol. 2015 Aug 25. pii: jclinpath-2015-203233. doi: 10.1136/jclinpath-2015-203233. [Epub ahead of print] PubMed PMID: 26307075.

Bardin P, Kanniess F, Gauvreau G, Bredenbröker D, Rabe KF. Roflumilast for asthma: Efficacy findings in mechanism of action studies. Pulm Pharmacol Ther. 2015 Aug 18. pii: S1094-5539(15)00091-7. doi: 10.1016/j.pupt.2015.08.006. [Epub ahead of print] PubMed PMID: 26296794.

Barth SD, Schulze JJ, Kühn T, Raschke E, Hüsing A, Johnson T, Kaaks R, Olek S. Treg-Mediated Immune Tolerance and the Risk of Solid Cancers: Findings From EPIC-Heidelberg. J Natl Cancer Inst. 2015 Aug 22;107(11). pii: djv224. doi: 10.1093/jnci/djv224. Print 2015 Nov. PubMed PMID: 26298011.

Deng L, Blanco FJ, Stevens H, Lu R, Caudrillier A, McBride MW, McClure JD, Grant JS, Thomas M, Frid MG, Stenmark KR, White K, Seto AG, Morrell NW, Bradshaw AC, MacLean MR, Baker AH. miR-143 Activation Regulates Smooth Muscle and Endothelial Cell Crosstalk in Pulmonary Arterial Hypertension. Circ Res. 2015 Aug 26. pii: CIRCRESAHA.115.306806. [Epub ahead of print] PubMed PMID: 26311719.

Galiè N, Barberà JA, Frost AE, Ghofrani HA, Hoeper MM, McLaughlin VV, Peacock AJ, Simonneau G, Vachiery JL, Grünig E, Oudiz RJ, Vonk-Noordegraaf A, White RJ, Blair C, Gillies H, Miller KL, Harris JH, Langley J, Rubin LJ; AMBITION Investigators. Initial Use of Ambrisentan plus Tadalafil in Pulmonary Arterial Hypertension. N Engl J Med. 2015 Aug 27;373(9):834-44. doi: 10.1056/NEJMoa1413687. PubMed PMID: 26308684.

Gatidis S, Schmidt H, Gücke B, Bezrukov I, Seitz G, Ebinger M, Reimold M, Pfannenberg CA, Nikolaou K, Schwenzer NF, Schäfer JF. Comprehensive Oncologic Imaging in Infants and Preschool Children With Substantially Reduced Radiation Exposure Using Combined Simultaneous 18F-Fluorodeoxyglucose Positron Emission Tomography/Magnetic Resonance Imaging: A Direct Comparison to 18F-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography. Invest Radiol. 2015 Aug 24. [Epub ahead of print] PubMed PMID: 26309185.

Lunding L, Wegmann M. NK cells in asthma exacerbation. Oncotarget. 2015 Jul 13. [Epub ahead of print] PubMed PMID: 26296976.

Mairbäurl H, Baloglu E. Rebuttal to the PRO Statement: Corticosteroids Are Useful in the Management of HAPE. High Alt Med Biol. 2015 Aug 25. [Epub ahead of print] PubMed PMID: 26305427.

Mairbäurl H, Baloglu E. Con: Corticosteroids Are Useful in the Management of HAPE. High Alt Med Biol. 2015 Aug 25. [Epub ahead of print] PubMed PMID: 26305280.

Oteros J, Pusch G, Weichenmeier I, Heimann U, Möller R, Röseler S, Traidl-Hoffmann C, Schmidt-Weber C, Buters JT. Automatic and Online Pollen Monitoring. Int Arch Allergy Immunol. 2015 Aug 19;167(3):158-166. [Epub ahead of print] PubMed PMID: 26302820.

Pujol JL, Vansteenkiste JF, De Pas TM, Atanackovic D, Reck M, Thomeer M, Douillard JY, Fasola G, Potter V, Taylor P, Bosquée L, Scheubel R, Jarnjak S, Debois M, de Sousa Alves P, Louahed J, Brichard VG, Lehmann FF. Safety and Immunogenicity of MAGE-A3 Cancer Immunotherapeutic with or without Adjuvant Chemotherapy in Patients with Resected Stage IB to III MAGE-A3-Positive NSCLC. J Thorac Oncol. 2015 Aug 25. [Epub ahead of print] PubMed PMID: 26309191.

Ramm R, Hartmann T, Tudorache I, Haverich A, Hilfiker A. No evidence for αGal epitope transfer from media containing FCS onto human endothelial cells in culture. Xenotransplantation. 2015 Aug 24. doi: 10.1111/xen.12183. [Epub ahead of print] PubMed PMID: 26301779.

Yang BH, Hagemann S, Mamareli P, Lauer U, Hoffmann U, Beckstette M, Föhse L, Prinz I, Pezoldt J, Suerbaum S, Sparwasser T, Hamann A, Floess S, Huehn J, Lochner M. Foxp3(+) T cells expressing RORγt represent a stable regulatory T-cell effector lineage with enhanced suppressive capacity during intestinal inflammation. Mucosal Immunol. 2015 Aug 26. doi: 10.1038/mi.2015.74. [Epub ahead of print] PubMed PMID: 26307665.

Yadav P, Freitag-Wolf S, Lieb W, Dempfle A, Krawczak M. Allowing for population stratification in case-only studies of gene-environment interaction, using genomic control. Hum Genet. 2015 Aug 22. [Epub ahead of print] PubMed PMID: 26297539.

New in PubMed from DZL Faculty/ Neu von der DZL-Fakultät: 24. Aug. 2015

Alter P, Glück T, Figiel JH, Koczulla AR, Vogelmeier CF, Rupp H. From Heart Failure to Highly Unsaturated Fatty Acid Deficiency and Vice Versa: Bidirectional Heart and Liver Interactions. Can J Cardiol. 2015 May 30. pii: S0828-282X(15)00401-8. doi: 10.1016/j.cjca.2015.05.019. [Epub ahead of print] PubMed PMID: 26277086.

Bateman ED, O'Byrne PM, Buhl R, Rabe KF. Roflumilast for asthma: Weighing the evidence. Pulm Pharmacol Ther. 2015 Aug 13. pii: S1094-5539(15)00086-3. doi: 10.1016/j.pupt.2015.08.001. [Epub ahead of print] PubMed PMID: 26278190.

Dalpke AH, Hofko M, Hamilton F, Mackenzie L, Zimmermann S, Templeton K. Evaluation of the BD MAX™ StaphSR assay for rapid identification of Staphylococcus aureus and methicillin-resistant S. aureus in positive blood culture broths. J Clin Microbiol. 2015 Aug 19. pii: JCM.01922-15. [Epub ahead of print] PubMed PMID: 26292311.

Dittrich NP, Kummer W, Clauss WG, Fronius M. Luminal acetylcholine does not affect the activity of the CFTR in tracheal epithelia of pigs. Int Immunopharmacol. 2015 Aug 15. pii: S1567 5769(15)30068-0. doi: 10.1016/j.intimp.2015.08.010. [Epub ahead of print] PubMed PMID: 26286842.

Gramolelli S, Weidner-Glunde M, Abere B, Viejo-Borbolla A, Bala K, Rückert J, Kremmer E, Schulz TF. Inhibiting the Recruitment of PLCγ1 to Kaposi's Sarcoma Herpesvirus K15 Protein Reduces the Invasiveness and Angiogenesis of Infected Endothelial Cells. PLoS Pathog. 2015 Aug 21; 11(8):e1005105. doi: 10.1371/journal.ppat.1005105. eCollection 2015 Aug. PubMed PMID: 26295810.

Gudermann T, Bader M. Receptors, G proteins, and integration of calcium signalling. J Mol Med (Berl). 2015 Aug 21. [Epub ahead of print] PubMed PMID: 26293356.

Hoechter DJ, von Dossow V, Winter H, Müller HH, Meiser B, Neurohr C, Behr J, Guenther S, Hagl C, Schramm R. The Munich Lung Transplant Group: Intraoperative Extracorporeal Circulation in Lung Transplantation. Thorac Cardiovasc Surg. 2015 Aug 20. [Epub ahead of print] PubMed PMID: 26291747.

Hoffmann JE, Plass T, Nikić I, Aramburu IV, Koehler C, Gillandt H, Lemke EA, Schultz C. Frontispiece: Highly Stable trans-Cyclooctene Amino Acids for Live-Cell Labeling. Chemistry. 2015 Aug 24;21(35). doi: 10.1002/chem.201583561. PubMed PMID: 26284950.

John-Schuster G, Günter S, Hager K, Conlon TM, Eickelberg O, Yildirim AÖ. Inflammaging increases susceptibility to cigarette smoke-induced COPD. Oncotarget. 2015 May 29. [Epub ahead of print] PubMed PMID: 26284585.

Junge KM, Bauer T, Geissler S, Hirche F, Thürmann L, Bauer M, Trump S, Bieg M, Weichenhan D, Gu L, Mallm JP, Ishaque N, Mücke O, Röder S, Herberth G, Diez U, Borte M, Rippe K, Plass C, Hermann C, Stangl GI, Eils R, Lehmann I. Increased vitamin D levels at birth and in early infancy increase offspring allergy risk-evidence for involvement of epigenetic mechanisms. J Allergy Clin Immunol. 2015 Aug 15. pii: S0091-6749(15)00941-0. doi: 10.1016/j.jaci.2015.06.040. [Epub ahead of print] PubMed PMID: 26282283.

Khaiboullina SF, Gumerova AR, Khafizova IF, Martynova EV, Lombardi VC, Bellusci S, Rizvanov AA. CCL27: Novel Cytokine with Potential Role in Pathogenesis of Multiple Sclerosis. Biomed Res Int. 2015; 2015:189638. doi: 10.1155/2015/189638. Epub 2015 Jul 29. PubMed PMID: 26295034; PubMed Central PMCID: PMC4532821.

Koch C, Hecker A, Grau V, Padberg W, Wolff M, Henrich M. Intravenous immunoglobulin in necrotizing fasciitis - A case report and review of recent literature. Ann Med Surg (Lond). 2015 Aug 1;4(3):260-3. doi: 10.1016/j.amsu.2015.07.017. eCollection 2015 Sep. PubMed PMID: 26288730; PubMed Central PMCID: PMC4539184.

Kunz JB, Rausch T, Bandapalli OR, Eilers J, Pechanska P, Schuessele S, Assenov Y, Stütz AM, Kirschner-Schwabe R, Hof J, Eckert C, von Stackelberg A, Schrappe M, Stanulla M, Koehler R, Avigad S, Elitzur S, Handgretinger R, Benes V, Weischenfeldt J, Korbel JO, Muckenthaler MU, Kulozik AE. Pediatric T-lymphoblastic leukemia evolves into relapse by clonal selection, acquisition of mutations and promoter hypomethylation. Haematologica. 2015 Aug 20. pii: haematol.2015.129692. [Epub ahead of print] PubMed PMID: 26294725.

Merches K, Khairnar V, Knuschke T, Shaabani N, Honke N, Duhan V, Recher M, Navarini AA, Hardt C, Häussinger D, Tümmler B, Gulbins E, Futerman AH, Hoffmann D, Lang F, Lang PA, Westendorf AM, Lang KS. Virus-Induced Type I Interferon Deteriorates Control of Systemic Pseudomonas Aeruginosa Infection. Cell Physiol Biochem. 2015;36(6):2379-92. doi: 10.1159/000430200. Epub 2015 Jul 27. PubMed PMID: 26279441.

Nassenstein C, Wiegand S, Lips KS, Li G, Klein J, Kummer W. Cholinergic activation of the murine trachealis muscle via non-vesicular acetylcholine release involving low-affinity choline transporters. Int Immunopharmacol. 2015 Aug 13. pii: S1567-5769(15)30065-5. doi: 10.1016/j.intimp.2015.08.007. [Epub ahead of print] PubMed PMID: 26278668.

Ringshausen FC, de Roux A, Diel R, Hohmann D, Welte T, Rademacher J. Bronchiectasis in Germany: a population-based estimation of disease prevalence. Eur Respir J. 2015 Aug 20. pii: ERJ-00954-2015. doi: 10.1183/13993003.00954-2015. [Epub ahead of print] PubMed PMID: 26293498.

Thum T. Antiageing concepts and cardiovascular disease. Eur Heart J. 2015 Aug 20. pii: ehv412. [Epub ahead of print] PubMed PMID: 26294791.

New in PubMed from DZL Faculty/ Neu von der DZL-Fakultät: 17. Aug. 2015

Badorrek P, Hohlfeld JM, Krug N, Joshi A, Raut A. Efficacy and safety of a novel nasal steroid, S0597, in patients with seasonal allergic rhinitis. Ann Allergy Asthma Immunol. 2015 Aug 10. pii: S1081-1206(15)00485-8. doi: 10.1016/j.anai.2015.07.016. [Epub ahead of print] PubMed PMID: 26272281.

Becker S, Steinmeyer J, Avsar M, Höffler K, Salman J, Haverich A, Warnecke G, Ochs M, Schnapper A. Evaluating acellular versus cellular perfusate composition during prolonged ex vivo lung perfusion after initial cold ischemia for 24 hours. Transpl Int. 2015 Aug 12. doi: 10.1111/tri.12649. [Epub ahead of print] PubMed PMID: 26264867.

Berger MM, Köhne H, Hotz L, Hammer M, Schommer K, Bärtsch P, Mairbäurl H. Response to the letter: role of remote ischemic preconditioning against acute mountain sickness during early phase by Sikri and Chawla. Physiol Rep. 2015 Aug; 3(8). pii: e12498. doi: 10.14814/phy2.12498. PubMed PMID: 26265757.

Betz T, Dehnert C, Bärtsch P, Schommer K, Mairbäurl H. Does High Alveolar Fluid Reabsorption Prevent HAPE in Individuals with Exaggerated Pulmonary Hypertension in Hypoxia? High Alt Med Biol. 2015 Aug 10. [Epub ahead of print] PubMed PMID: 26258866.

Derlin T, Baumann U, Bengel FM. Molecular imaging of glutamate-carboxypeptidase II (prostate specific membrane antigen) in malignant epithelioid hemangioendothelioma. Eur J Nucl Med Mol Imaging. 2015 Aug 12. [Epub ahead of print] PubMed PMID: 26260651.

Ferrarotti I, Poplawska-Wisniewska B, Trevisan MT, Koepke J, Dresel M, Koczulla R, Ottaviani S, Baldo R, Gorrini M, Sala G, Cavallon L, Welte T, Chorostowska-Wynimko J, Luisetti M, Janciauskiene S. How Can We Improve the Detection of Alpha1-Antitrypsin Deficiency? PLoS One. 2015 Aug 13; 10(8):e0135316. doi: 10.1371/journal.pone.0135316. eCollection 2015. PubMed PMID: 26270547.

Griese M, Zarbock R, Costabel U, Hildebrandt J, Theegarten D, Albert M, Thiel A, Schams A, Lange J, Krenke K, Wesselak T, Schön C, Kappler M, Blum H, Krebs S, Jung A, Kröner C, Klein C, Campo I, Luisetti M, Bonella F. GATA2 deficiency in children and adults with severe pulmonary alveolar proteinosis and hematologic disorders. BMC Pulm Med. 2015 Aug 12; 15:87. doi: 10.1186/s12890 015-0083-2. PubMed PMID: 26264606.

Holz O, Biller H, Mueller M, Kane K, Rosano M, Hanrahan J, Hava DL, Hohlfeld JM. Efficacy and safety of inhaled calcium lactate PUR118 in the ozone challenge model - a clinical trial. BMC Pharmacol Toxicol. 2015 Aug 12; 16:21. doi: 10.1186/s40360-015-0021-1. PubMed PMID: 26265479; PubMed Central PMCID: PMC4533952.

Horsch M, Aguilar-Pimentel JA, Bönisch C, Côme C, Kolster-Fog C, Jensen KT, Lund AH, Lee I, Grossman LI, Sinkler C, Hüttemann M, Bohn E, Fuchs H, Ollert M, Gailus-Durner V, Hrabĕ de Angelis M, Beckers J. Cox4i2, Ifit2, and Prdm11 Mutant Mice: Effective Selection of Genes Predisposing to an Altered Airway Inflammatory Response from a Large Compendium of Mutant Mouse Lines. PLoS One. 2015 Aug 11; 10(8):e0134503. doi: 10.1371/journal.pone.0134503. eCollection 2015. PubMed PMID: 26263558.

Kempf H, Kropp C, Olmer R, Martin U, Zweigerdt R. Cardiac differentiation of human pluripotent stem cells in scalable suspension culture. Nat Protoc. 2015 Sep;10(9):1345-61. doi: 10.1038/nprot.2015.089. Epub 2015 Aug 13. PubMed PMID: 26270394.

Li C, Bellusci S, Borok Z, Minoo P. Noncanonical WNT Signaling in the Lung. J Biochem. 2015 Aug 10. pii: mvv081. [Epub ahead of print] Review. PubMed PMID: 26261051.

Mena-Romano P, Cheng C, Glowa C, Peschke P, Pan L, Haberkorn U, Dimitrakopoulou-Strauss A, Karger CP. Measurement of hypoxia-related parameters in three sublines of a rat prostate carcinoma using dynamic (18)F-FMISO-Pet-Ct and quantitative histology. Am J Nucl Med Mol Imaging. 2015 Jun 15;5(4):348-62. eCollection 2015. PubMed PMID: 26269773; PubMed Central PMCID: PMC4529589.

Michael Frei D, Hodneland E, Rios-Mondragon I, Burtey A, Neumann B, Bulkescher J, Schölermann J, Pepperkok R, Gerdes HH, Kögel T. Novel microscopy-based screening method reveals regulators of contact-dependent intercellular transfer. Sci Rep. 2015 Aug 14;5:12879. doi: 10.1038/srep12879. PubMed PMID: 26271723.

Rauš K, Pleschka S, Klein P, Schoop R, Fisher P. Effect of an Echinacea-Based Hot Drink Versus Oseltamivir in Influenza Treatment: A Randomized, Double-Blind, Double-Dummy, Multicenter, Noninferiority Clinical Trial. Curr Ther Res Clin Exp. 2015 Apr 20; 77:66-72. doi: 10.1016/j.curtheres.2015.04.001. eCollection 2015 Dec. PubMed PMID: 26265958; PubMed Central PMCID: PMC4528044.

Richter M, Lautze HJ, Walther T, Braun T, Kostin S, Kubin T. The failing heart is a major source of circulating FGF23 via oncostatin M receptor activation. J Heart Lung Transplant. 2015 Sep; 34(9): 1211 4. doi: 10.1016/j.healun.2015.06.007. Epub 2015 Jun 17. PubMed PMID: 26267742.

Rieber J, Schmitt J, Warth A, Muley T, Kappes J, Eichhorn F, Hoffmann H, Heussel CP, Welzel T, Debus J, Thomas M, Steins M, Rieken S. Outcome and prognostic factors of multimodal therapy for pulmonary large-cell neuroendocrine carcinomas. Eur J Med Res. 2015 Aug 14;20(1):64. doi: 10.1186/s40001-015-0158-9. PubMed PMID: 26272455; PubMed Central PMCID: PMC4536693.

Schweighöfer H, Rummel C, Mayer K, Rosengarten B. Brain function in iNOS knock out or iNOS inhibited (l-NIL) mice under endotoxic shock. Intensive Care Med Exp. 2014 Dec;2(1):24. doi: 10.1186/s40635-014-0024-z. Epub 2014 Sep 20. PubMed PMID: 26266921; PubMed Central PMCID: PMC4513038.

Sivaraj KK, Li R, Albarran-Juarez J, Wang S, Tischner D, Grimm M, Swiercz JM, Offermanns S, Wettschureck N. Endothelial Gαq/11 is required for VEGF-induced vascular permeability and angiogenesis. Cardiovasc Res. 2015 Aug 13. pii: cvv216. [Epub ahead of print] PubMed PMID: 26272756.

Thomas MN, Kalnins A, Andrassy M, Wagner A, Klussmann S, Rentsch M, Habicht A, Pratschke S, Stangl M, Bazhin AV, Meiser B, Fischereder M, Werner J, Guba M, Andrassy J. SDF-1/CXCR4/CXCR7 is pivotal for vascular smooth muscle cell proliferation and chronic allograft vasculopathy. Transpl Int. 2015 Aug 12. doi: 10.1111/tri.12651. [Epub ahead of print] PubMed PMID: 26265085.

Walser SM, Gerstner DG, Brenner B, Bünger J, Eikmann T, Janssen B, Kolb S, Kolk A, Nowak D, Raulf M, Sagunski H, Sedlmaier N, Suchenwirth R, Wiesmüller G, Wollin KM, Tesseraux I, Herr CE. Evaluation of exposure-response relationships for health effects of microbial bioaerosols – A systematic review. Int J Hyg Environ Health. 2015 Jul 18. pii: S1438-4639(15)00100-5. doi: 10.1016/j.ijheh.2015.07.004. [Epub ahead of print] Review. PubMed PMID: 26272513.

Warth A, Weichert W, Reck M, Reinmuth N. [ROS1-Translocations in Non-Small Cell Lung Cancer]. Pneumologie. 2015 Aug; 69(8):477-82. doi: 10.1055/s-0034-1392446. Epub 2015 Aug 10. German. PubMed PMID: 26258422.

Zimmermann A, Zissel G, Müller-Quernheim J, Hofmann S, Schreiber S, Fischer A. Are bronchoalveolar lavages a good source for microbial profiling? Differences between throat and bronchoalveolar lavage microbiomes. J Med Microbiol. 2015 Aug; 64(8):948-51. doi: 10.1099/jmm.0.000112. PubMed PMID: 26271248.

New in PubMed from DZL Faculty/ Neu von der DZL-Fakultät: 10. Aug. 2015

Eigenbrod T, Keller P, Kaiser S, Rimbach K, Dalpke AH, Helm M. Recognition of Specified RNA Modifications by the Innate Immune System. Methods Enzymol. 2015;560:73-89. doi: 10.1016/bs.mie.2015.03.006. Epub 2015 Jul 22. PubMed PMID: 26253966.

Gompelmann D, Eberhardt R, Herth FJ. Novel Endoscopic Approaches to Treating Chronic Obstructive Pulmonary Disease and Emphysema. Semin Respir Crit Care Med. 2015 Aug;36(4):609-15. doi: 10.1055/s-0035-1555614. Epub 2015 Aug 3. PubMed PMID: 26238645.

Hou Y, Adrian-Segarra JM, Richter M, Kubin N, Shin J, Werner I, Walther T, Schönburg M, Pöling J, Warnecke H, Braun T, Kostin S, Kubin T. Animal Models and "Omics" Technologies for Identification of Novel Biomarkers and Drug Targets to Prevent Heart Failure. Biomed Res Int. 2015;2015:212910. doi: 10.1155/2015/212910. Epub 2015 Jul 7. Review. PubMed PMID: 26236717; PubMed Central PMCID: PMC4508378.

Kahn N, Riedlinger J, Roeßler M, Rabe C, Lindner M, Koch I, Schott-Hildebrand S, Herth FJ, Schneider MA, Meister M, Muley TR. Blood-sampling collection prior to surgery may have a significant influence upon biomarker concentrations measured. Clin Proteomics. 2015 Jul 31;12(1):19. doi: 10.1186/s12014-015-9093-6. eCollection 2015. PubMed PMID: 26236175; PubMed Central PMCID: PMC4521486.

Kovacs L, Han W, Rafikov R, Bagi Z, Offermanns S, Saido TC, Black SM, Su Y. Activation of Calpain-2 by Mediators in Pulmonary Vascular Remodeling of Pulmonary Arterial Hypertension. Am J Respir Cell Mol Biol. 2015 Aug 6. [Epub ahead of print] PubMed PMID: 26248159.

Kreuter M. IPF, comorbidities and management implications: Patient case 1. Sarcoidosis Vasc Diffuse Lung Dis. 2015 Aug 3;32(1 Suppl):24-5. PubMed PMID: 26237440.

Oehrle B, Burgstaller G, Irmler M, Dehmel S, Grün J, Hwang T, Krauss-Etschmann S, Beckers J, Meiners S, Eickelberg O. Validated prediction of pro-invasive growth factors using a transcriptome wide invasion signature derived from a complex 3D invasion assay. Sci Rep. 2015 Aug 5;5:12673. doi: 10.1038/srep12673. PubMed PMID: 26243655; PubMed Central PMCID: PMC4525140.

Rabe KF. Elastic Recoil Revisited. Chest. 2015 Aug 1;148(2):297-8. doi: 10.1378/chest.15-0786. PubMed PMID: 26238824.

Raghu G, Nathan SD, Behr J, Brown KK, Egan JJ, Kawut SM, Flaherty KR, Martinez FJ, Wells AU, Shao L, Zhou H, Henig N, Szwarcberg J, Gillies H, Montgomery AB, O'Riordan TG. Pulmonary hypertension in idiopathic pulmonary fibrosis with mild-to-moderate restriction. Eur Respir J. 2015 Aug 6. pii: ERJ 01537-2014. doi: 10.1183/13993003.01537-2014. [Epub ahead of print] PubMed PMID: 26250495.

Tiede SL, Gall H, Dörr O, Troidl C, Liebetrau C, Voss S, Voswinckel R, Schermuly RT, Seeger W, Grimminger F, Zeiher AM, Dimmeler S, Möllmann H, Hamm CW, Ghofrani HA, Nef HM. New potential diagnostic biomarkers for pulmonary hypertension. Eur Respir J. 2015 Aug 6. pii: ERJ-00187-2015. doi: 10.1183/13993003.00187-2015. [Epub ahead of print] PubMed PMID: 26250494.

Vancheri C, Cottin V, Kreuter M, Hilberg O. IPF, comorbidities and management implications. Sarcoidosis Vasc Diffuse Lung Dis. 2015 Aug 3;32(1 Suppl):17-23. PubMed PMID: 26237439.

New in PubMed from DZL Faculty/ Neu von der DZL-Fakultät: 3. Aug. 2015

Kahn N, Riedlinger J, Roeßler M, Rabe C, Lindner M, Koch I, Schott-Hildebrand S, Herth FJ, Schneider MA, Meister M and Muley TR. Blood-sampling collection prior to surgery may have a significant influence upon biomarker concentrations measured. Clinical Proteomics. 2015 Jul 31; 12:19  doi:10.1186/s12014-015-9093-6.

Frost AE, Barst RJ, Hoeper MM, Chang HJ, Frantz RP, Fukumoto Y, Galié N, Hassoun PM, Klose H, Matsubara H, Morrell NW, Peacock AJ, Pfeifer M, Simonneau G, Tapson VF, Torres F, Dario Vizza C, Lawrence D, Yang W, Felser JM, Quinn DA, Ghofrani HA. Long-term safety and efficacy of imatinib in pulmonary arterial hypertension. J Heart Lung Transplant. 2015 Jun 11. pii: S1053-2498(15)01299-1. doi: 10.1016/j.healun.2015.05.025. [Epub ahead of print] PubMed PMID: 26210752.

Latus H, Bandorski D, Rink F, Tiede H, Siaplaouras J, Ghofrani A, Seeger W, Schranz D, Apitz C. Heart Rate Variability is Related to Disease Severity in Children and Young Adults with Pulmonary Hypertension. Front Pediatr. 2015 Jul 7;3:63. doi: 10.3389/fped.2015.00063. eCollection 2015. PubMed PMID: 26217650; PubMed Central PMCID: PMC4493387.

Watermann I, Schmitt B, Stellmacher F, Müller J, Gaber R, Kugler Ch, Reinmuth N, Huber RM, Thomas M, Zabel P, Rabe KF, Jonigk D, Warth A, Vollmer E, Reck M, Goldmann T. Improved diagnostics targeting c-MET in non-small cell lung cancer: expression, amplification and activation? Diagn Pathol. 2015 Jul 28;10(1):130. doi: 10.1186/s13000-015-0362-5. PubMed PMID: 26215852; PubMed Central PMCID: PMC4517562.

Brinker TJ, Seeger W. Photoaging Mobile Apps: A Novel Opportunity for Smoking Cessation? J Med Internet Res. 2015 Jul 27;17(7):e186. doi: 10.2196/jmir.4792. PubMed PMID: 26215210.

Oeder S, Alessandrini F, Wirz OF, Braun A, Wimmer M, Frank U, Hauser M, Durner J, Ferreira F, Ernst D, Mempel M, Gilles S, Buters JT, Behrendt H, Traidl-Hoffmann C, Schmidt-Weber C, Akdis M, Gutermuth J. Pollen-derived non-allergenic substances enhance Th2-induced IgE production in B cells. Allergy. 2015 Jul 27. doi: 10.1111/all.12707. [Epub ahead of print] PubMed PMID: 26214762.

Tomasi R, Prueckner S, Czerner S, Schramm R, Preissler G, Zwißler B, von Dossow-Hanfstingl V. Comparison of an advanced minimally invasive cardiac output monitoring with a continuous invasive cardiac output monitoring during lung transplantation. J Clin Monit Comput. 2015 Jul 30. [Epub ahead of print] PubMed PMID: 26223864.

Palaniyar N, Mall MA, Taube C, Worgall S, Grasemann H. New Developments in Cystic Fibrosis Airway Inflammation. Mediators Inflamm. 2015;2015:769425. doi: 10.1155/2015/769425. Epub 2015 Jun 29. PubMed PMID: 26221065; PubMed Central PMCID: PMC4499624.

Fuertes E, Bracher J, Flexeder C, Markevych I, Klümper C, Hoffmann B, Krämer U, von Berg A, Bauer CP, Koletzko S, Berdel D, Heinrich J, Schulz H. Long-term air pollution exposure and lung function in 15 year-old adolescents living in an urban and rural area in Germany: The GINIplus and LISAplus cohorts. Int J Hyg Environ Health. 2015 Jul 17. pii: S1438-4639(15)00099-1. doi: 10.1016/j.ijheh.2015.07.003. [Epub ahead of print] PubMed PMID: 26220828.

Schellong SM, Welte T. [Dyspnea : The most common chief complaints and their differential diagnosis]. Internist (Berl). 2015 Aug;56(8):864. doi: 10.1007/s00108-015-3685-0. German. PubMed PMID: 26219617.

Madurga A, Golec A, Pozarska A, Ishii I, Mižíková I, Nardiello C, Vadász I, Herold S, Mayer K, Reichenberger F, Fehrenbach H, Seeger W, Morty RE. The H2S-generating enzymes cystathionine β-synthase and cystathionine γ-lyase play a role in vascular development during normal lung alveolarization. Am J Physiol Lung Cell Mol Physiol. 2015 Jul 31:ajplung.00134.2015. doi: 10.1152/ajplung.00134.2015. [Epub ahead of print] PubMed PMID: 26232299.

Alter P, van de Sand K, Nell C, Figiel JH, Greulich T, Vogelmeier CF, Koczulla AR. Airflow limitation in COPD is associated with increased left ventricular wall stress in coincident heart failure. Respir Med. 2015 Jul 17. pii: S0954-6111(15)30027-5. doi: 10.1016/j.rmed.2015.07.012. [Epub ahead of print] PubMed PMID: 26231928.

Ehlken N, Lichtblau M, Klose H, Weidenhammer J, Fischer C, Nechwatal R, Uiker S, Halank M, Olsson K, Seeger W, Gall H, Rosenkranz S, Wilkens H, Mertens D, Seyfarth HJ, Opitz C, Ulrich S, Egenlauf B, Grünig E. Exercise training improves peak oxygen consumption and haemodynamics in patients with severe pulmonary arterial hypertension and inoperable chronic thrombo-embolic pulmonary hypertension: a prospective, randomized, controlled trial. Eur Heart J. 2015 Jul 31. pii: ehv337. [Epub ahead of print] PubMed PMID: 26231884.

Holz O, Roepcke S, Watz H, Tegtbur U, Lahu G, Hohlfeld JM. Constant-load exercise decreases the serum concentration of myeloperoxidase in healthy smokers and smokers with COPD. Int J Chron Obstruct Pulmon Dis. 2015 Jul 21;10:1393-1402. eCollection 2015. PubMed PMID: 26229458; PubMed Central PMCID: PMC4516189.

Veith C, Schermuly RT, Brandes R, Weissmann N. Molecular mechanisms of HIF-induced pulmonary arterial smooth muscle cell alterations in pulmonary hypertension. J Physiol. 2015 Jul 30. doi: 10.1113/JP270689. [Epub ahead of print] PubMed PMID: 26228924.

Behr J, Bonella F, Bonnet R, Gläser S, Grohé C, Günther A, Koschel D, Kreuter M, Kirsten D, Krögel C, Markart P, Müller-Quernheim J, Neurohr C, Pfeifer M, Prasse A, Schönfeld N, Schreiber J, Wirtz H, Witt C, Costabel U. [Position Paper: Significance of the Forced Vital Capacity in Idiopathic Pulmonary Fibrosis]. Pneumologie. 2015 Jul 30. [Epub ahead of print] German. PubMed PMID: 26227628.

de Angelis MH, […] Eickelberg O, […], Schulz H, […], Yildirim AÖ, […], et al. Analysis of mammalian gene function through broad-based phenotypic screens across a consortium of mouse clinics. Nat Genet. 2015 Jul 27. doi: 10.1038/ng.3360. [Epub ahead of print] PubMed PMID: 26214591.

Klose H, Harbaum L, Oqueka T, Simon M, Grünig E. [Therapy of Pulmonary Arterial Hypertension]. Pneumologie. 2015 Jul 28. [Epub ahead of print] German. PubMed PMID: 26220551.

Schaub B, Vercelli D. Environmental protection from allergic diseases: From humans to mice and back. Curr Opin Immunol. 2015 Jul 23;36:88-93. doi: 10.1016/j.coi.2015.07.004. [Epub ahead of print] Review. PubMed PMID: 26210896.

Juli 2015

New in PubMed from DZL Faculty/ Neu von der DZL-Fakultät: 27. Juli 2015

Oksala N, Pärssinen J, Seppälä I, Klopp N, Illig T, Laaksonen R, Levula M, Raitoharju E, Kholova I, Sioris T, Kähönen M, Lehtimäki T, Hytönen VP. Kindlin 3 (FERMT3) is associated with unstable atherosclerotic plaques, anti-inflammatory type II macrophages and upregulation of beta-2 integrins in all major arterial beds. Atherosclerosis. 2015 Jul 13;242(1):145-154. doi:10.1016/j.atherosclerosis.2015.06.058. [Epub ahead of print] PubMed PMID: 26188538.

di Giuseppe R, Kühn T, Hirche F, Buijsse B, Dierkes J, Fritsche A, Kaaks R, Boeing H, Stangl GI, Weikert C. Potential Predictors of Plasma Fibroblast Growth Factor 23 Concentrations: Cross-Sectional Analysis in the EPIC-Germany Study. PLoS One. 2015 Jul 20;10(7):e0133580. doi: 10.1371/journal.pone.0133580. eCollection 2015. PubMed PMID: 26193703.

Micek ST, Kollef MH, Torres A, Chen C, Rello J, Chastre J, Antonelli M, Welte T, Clair B, Ostermann H, Calbo E, Wunderink R, Menichetti F, Schramm G, Menon V. Pseudomonas aeruginosa Nosocomial Pneumonia: Impact of Pneumonia Classification. Infect Control Hosp Epidemiol. 2015 Jul 20:1-8. [Epub ahead of print] PubMed PMID: 26190444.

Luzak A, Flexeder C, von Berg A, Berdel D, Klümper C, Koletzko S, Bauer CP, Heinrich J, Nowak D, Schulz H. Relation of lung function and current inhalant allergen-specific immunoglobulin E concentrations in adolescents (GINIplus cohort). Ann Allergy Asthma Immunol. 2015 Jul 17. pii: S1081-1206(15)00407-X. doi: 10.1016/j.anai.2015.06.016. [Epub ahead of print] PubMed PMID: 26195441.

Semren N, Welk V, Korfei M, Keller IE, Fernandez IE, Adler H, Günther A, Eickelberg O, Meiners S. Regulation of 26S Proteasome Activity in Pulmonary Fibrosis. Am J Respir Crit Care Med. 2015 Jul 24. [Epub ahead of print] PubMed PMID: 26207697.

Kauke T, Kneidinger N, Martin B, Dick A, Schneider C, Schramm R, Meimarakis G, Preissler G, Eickelberg O, von Dossow V, Behr J, Hatz R, Neurohr C, Winter H. Bronchiolitis obliterans syndrome due to donor-specific HLA-antibodies. Tissue Antigens. 2015 Jul 23. doi: 10.1111/tan.12626. [Epub ahead of print] PubMed PMID: 26204790.

Zhang R, Bures M, Höffler HK, Jonigk D, Haverich A, Krüger M. In Vitro Lung Model Assessing the Efficacy of Surgical Sealants in Treating Alveolar Air Leaks. J Invest Surg. 2015 Jul 23. [Epub ahead of print] PubMed PMID: 26204492.

Esser RW, Stoeckel MC, Kirsten A, Watz H, Taube K, Lehmann K, Petersen S, Magnussen H, von Leupoldt A. Structural Brain Changes in Patients with Chronic Obstructive Pulmonary Disease. Chest. 2015 Jul 23. doi: 10.1378/chest.15-0027. [Epub ahead of print] PubMed PMID: 26203911.

Neuberger M, Hapfelmeier A, Schmidt M, Gesierich W, Reichenberger F, Morresi-Hauf A, Hatz RA, Lindner M. Carcinoid tumours of the lung and the 'PEPPS' approach: evaluation of preoperative bronchoscopic tumour debulking as preparation for subsequent parenchyma-sparing surgery. BMJ Open Respir Res. 2015 Jul 15;2(1):e000090. doi: 10.1136/bmjresp-2015-000090. eCollection 2015. PubMed PMID: 26203359.

Hecker A, Küllmar M, Wilker S, Richter K, Zakrzewicz A, Atanasova S, Mathes V, Timm T, Lerner S, Klein J, Kaufmann A, Bauer S, Padberg W, Kummer W, Janciauskiene S, Fronius M, Schweda EK, Lochnit G, Grau V. Phosphocholine-Modified Macromolecules and Canonical Nicotinic Agonists Inhibit ATP-Induced IL-1β Release. J Immunol. 2015 Jul 22. pii: 1400974. [Epub ahead of print] PubMed PMID: 26202987.

Araki S, Izumiya Y, Rokutanda T, Ianni A, Hanatani S, Kimura Y, Onoue Y, Senokuchi T, Yoshizawa T, Yasuda O, Koitabashi N, Kurabayashi M, Braun T, Bober E, Yamagata K, Ogawa H. Sirt7 Contributes to Myocardial Tissue Repair by Maintaining TGF-β Signaling Pathway. Circulation. 2015 Jul 22. pii: CIRCULATIONAHA.114.014821. [Epub ahead of print] PubMed PMID: 26202810.

Heinbockel L, Marwitz S, Barcena Varela S, Ferrer-Espada R, Reiling N, Goldmann T, Gutsmann T, Mier W, Schürholz T, Drömann D, Brandenburg K, Martinez de Tejada G. Therapeutical Administration of Peptide Pep19-2.5 and Ibuprofen Reduces Inflammation and Prevents Lethal Sepsis. PLoS One. 2015 Jul 21;10(7):e0133291. doi: 10.1371/journal.pone.0133291. eCollection 2015. PubMed PMID: 26197109.

Jaiswal A, Godinez W, Eils R, Lehmann M, Rohr K. Tracking Virus Particles in Fluorescence Microscopy Images Using Multi-Scale Detection and Multi-Frame Association. IEEE Trans Image Process. 2015 Jul 17. [Epub ahead of print] PubMed PMID: 26208342.

Schupp JC, Tchaptchet S, Lützen N, Engelhard P, Müller-Quernheim J, Freudenberg MA, Prasse A. Immune response to Propionibacterium acnes in patients with sarcoidosis - in vivo and in vitro. BMC Pulm Med. 2015 Jul 24;15(1):75. PubMed PMID: 26204953.

Varagnolo L, Lin Q, Obier N, Plass C, Dietl J, Zenke M, Claus R, Müller AM. PRC2 inhibition counteracts the culture-associated loss of engraftment potential  of human cord blood-derived hematopoietic stem and progenitor cells. Sci Rep. 2015 Jul 22;5:12319. doi: 10.1038/srep12319. PubMed PMID: 26198814.

Petersen I, Warth A. Lung cancer: developments, concepts, and specific aspects of the new WHO classification. J Cancer Res Clin Oncol. 2015 Jul 22. [Epub ahead of print] PubMed PMID: 26197868.

New in PubMed from DZL Faculty/ Neu von der DZL-Fakultät: 20. Juli 20 2015

George J, […],Muley T, […],Schnabel PA,[…], Lindner M, […], et al. Comprehensive genomic profiles of small cell lung cancer. Nature. 2015 Jul 13. doi: 10.1038/nature14664. [Epub ahead of print] PMID: 26168399 [PubMed - as supplied by publisher]

Stentzel S, Sundaramoorthy N, Michalik S, Nordengrün M, Schulz S, Kolata J, Kloppot P, Engelmann S, Steil L, Hecker M, Schmidt F, Völker U, Roghmann MC, Bröker BM. Specific serum IgG at diagnosis of Staphylococcus aureus bloodstream invasion is correlated with disease progression. J Proteomics. 2015 Jul 5. pii: S1874-3919(15)30056-7. doi: 10.1016/j.jprot.2015.06.018. [Epub ahead of print] PubMed PMID: 26155744.

Rossi A, Kontarakis Z, Gerri C, Nolte H, Hölper S, Krüger M, Stainier DY. Genetic compensation induced by deleterious mutations but not gene knockdowns. Nature. 2015 Jul 13. doi: 10.1038/nature14580. [Epub ahead of print] PubMed PMID: 26168398.


Wang S, Iring A, Strilic B, Albarrán Juárez J, Kaur H, Troidl K, Tonack S, Burbiel JC, Müller CE, Fleming I, Lundberg JO, Wettschureck N, Offermanns S. P2Y2
and Gq/G11 control blood pressure by mediating endothelial mechanotransduction. J Clin Invest. 2015 Jul 13. pii: 81067. doi: 10.1172/JCI81067. [Epub ahead of print] PubMed PMID: 26168216.

Huber MB, Wacker ME, Vogelmeier CF, Leidl R. Comorbid Influences on Generic Health-Related Quality of Life in COPD: A Systematic Review. PLoS One. 2015 Jul 13;10(7):e0132670. doi: 10.1371/journal.pone.0132670. eCollection 2015. PubMed PMID: 26168154.

Lam E, Ramke M, Warnecke G, Schrepfer S, Kopfnagel V, Dobner T, Heim A. Effective Apical Infection of Differentiated Human Bronchial Epithelial Cells and Induction of Proinflammatory Chemokines by the Highly Pneumotropic Human Adenovirus Type 14p1. PLoS One. 2015 Jul 13;10(7):e0131201. doi: 10.1371/journal.pone.0131201. eCollection 2015. PubMed PMID: 26168049.


Heinrich J. Can prenatal maternal stress increase the risk of asthma? Expert Rev Respir Med. 2015 Jul 11:1-3. [Epub ahead of print] PubMed PMID: 26165207.

Reck M, Mellemgaard A. Emerging treatments and combinations in the management of NSCLC: clinical potential of nintedanib. Biologics. 2015 Jul 1;9:47-56. doi: 10.2147/BTT.S57356. eCollection 2015. Review. PubMed PMID: 26170616.


Chillappagari S, Preuss J, Licht S, Müller C, Mahavadi P, Sarode G,
Vogelmeier C, Guenther A, Nahrlich L, Rubin BK, Henke MO. Altered protease and antiprotease balance during a COPD exacerbation contributes to mucus obstruction. Respir Res. 2015 Jul 15;16(1):85. doi: 10.1186/s12931-015-0247-x. PubMed PMID: 26169056.

Gassmann M, Muckenthaler MU. Adaptation of iron requirement to hypoxic conditions at high altitude. J Appl Physiol (1985). 2015 Jul 16:jap.00248.2015. doi: 10.1152/japplphysiol.00248.2015. [Epub ahead of print] PubMed PMID: 26183475.

Müller B, Bovet M, Yin Y, Stichel D, Malz M, González-Vallinas M, Middleton A, Ehemann V, Schmitt J, Muley T, Meister M, Herpel E, Singer S, Warth A, Schirmacher P, Drasdo D, Matthäus F, Breuhahn K. Concomitant expression of far upstream element (FUSE) binding protein (FBP) interacting repressor (FIR) and its splice variants induce migration and invasion of non-small cell lung cancer (NSCLC) cells. J Pathol. 2015 Jul 14. doi: 10.1002/path.4588. [Epub ahead of print] PubMed PMID: 26177862.

Raghu G, Rochwerg B, Zhang Y, Garcia CA, Azuma A, Behr J, Brozek JL, Collard HR, Cunningham W, Homma S, Johkoh T, Martinez FJ, Myers J, Protzko SL, Richeldi L, Rind D, Selman M, Theodore A, Wells AU, Hoogsteden H, Schünemann HJ; ATS, ERS, JRS, and ALAT. An Official ATS/ERS/JRS/ALAT Clinical Practice Guideline: Treatment of Idiopathic Pulmonary Fibrosis. An Update of the 2011 Clinical Practice Guideline. Am J Respir Crit Care Med. 2015 Jul 15;192(2):e3-e19. doi: 10.1164/rccm.201506-1063ST. PubMed PMID: 26177183.


Hoegl S, Brodsky KS, Blackburn MR, Karmouty-Quintana H, Zwissler B, Eltzschig
HK. Alveolar Epithelial A2B Adenosine Receptors in Pulmonary Protection during Acute Lung Injury. J Immunol. 2015 Jul 17. pii: 1401957. [Epub ahead of print]

Dittrich A, Hessenkemper W, Schaper F. Systems biology of IL-6, IL-12 family cytokines. Cytokine Growth Factor Rev. 2015 Jul 4. pii: S1359-6101(15)00050-7. doi: 10.1016/j.cytogfr.2015.07.002. [Epub ahead of print] PubMed PMID: 26187858.


Mühlfeld C, Hegermann J, Wrede C, Ochs M. A review of recent developments and
applications of morphometry/stereology in lung research. Am J Physiol Lung Cell Mol Physiol. 2015 Jul 17:ajplung.00047.2015. doi: 10.1152/ajplung.00047.2015. [Epub ahead of print] PubMed PMID: 26186944.

Sommer W, Ius F, Salman J, Avsar M, Tudorache I, Kühn C, Wiegmann B, Marsch G, Kaufeld T, Zinne N, Fuehner T, Greer M, Gottlieb J, Boethig D, Haverich A, Welte T, Warnecke G. Survival and spirometry outcomes after lung transplantation from donors aged 70 years and older. J Heart Lung Transplant. 2015 Jun 10. pii: S1053-2498(15)01289-9. doi: 10.1016/j.healun.2015.06.002. [Epub ahead of print] PubMed PMID: 26186805.

Galluzzo M, Ciraolo E, Lucattelli M, Hoxha E, Ulrich M, Campa CC, Lungarella G, Doring G, Zhou-Suckow Z, Mall M, Hirsch E, De Rose V. Genetic Deletion and Pharmacological Inhibition of PI3K γ Reduces Neutrophilic Airway Inflammation and Lung Damage in Mice with Cystic Fibrosis-Like Lung Disease. Mediators Inflamm. 2015;2015:545417. Epub 2015 Jun 21. PubMed PMID: 26185363.

Stanke F. The Contribution of the Airway Epithelial Cell to Host Defense. Mediators Inflamm. 2015;2015:463016. Epub 2015 Jun 21. Review. PubMed PMID: 26185361.

van Koningsbruggen-Rietschel S, Naehrlich L. Cystic fibrosis transmembrane conductance regulator biomarkers in 'real life': can we evaluate individual efficacy of cystic fibrosis transmembrane conductance regulator therapy? Ther Adv Respir Dis. 2015 Aug;9(4):198-200. doi: 10.1177/1753465815579364. PubMed PMID: 26175480.

Rademacher J, de Roux A, Ringshausen FC. [PROGNOSIS - The PROspective German
NOn-CF BronchiectaSIS Patient Registry]. Pneumologie. 2015 Jul;69(7):391-3. doi: 10.1055/s-0034-1392254. Epub 2015 Jul 14. German. PubMed PMID: 26171712.

Viales RR, Eichstaedt CA, Ehlken N, Fischer C, Lichtblau M, Grünig E, Hinderhofer K. Mutation in BMPR2 Promoter: A 'Second Hit' for Manifestation of Pulmonary Arterial Hypertension? PLoS One. 2015 Jul 13;10(7):e0133042. doi: 10.1371/journal.pone.0133042. eCollection 2015. PubMed PMID: 26167679.


Keubler LM, Buettner M, Häger C, Bleich A. A Multihit Model: Colitis Lessons
from the Interleukin-10-deficient Mouse. Inflamm Bowel Dis. 2015 Jul 7. [Epub ahead of print] PubMed PMID: 26164667.

Meyer NH, Mayerhofer H, Tripsianes K, Blindow S, Barths D, Mewes A, Weimar T, Köhli T, Bade S, Madl T, Frey A, Haas H, Mueller-Dieckmann J, Sattler M, Schramm G. A crystallin fold in the interleukin-4-inducing principle of Schistosoma mansoni eggs (IPSE/alpha-1) mediates IgE binding for antigen-independent basophil activation. J Biol Chem. 2015 Jul 10. pii: jbc.M115.675066. [Epub ahead of print] PubMed PMID: 26163514.

Ma CS, Wong N, Rao G, Avery DT, Torpy J, Hambridge T, Bustamante J, Okada S, Stoddard JL, Deenick EK, Pelham SJ, Payne K, Boisson-Dupuis S, Puel A, Kobayashi M, Arkwright PD, Kilic SS, El Baghdadi J, Nonoyama S, Minegishi Y, Mahdaviani SA, Mansouri D, Bousfiha A, Blincoe AK, French MA, Hsu P, Campbell DE, Stormon MO, Wong M, Adelstein S, Smart JM, Fulcher DA, Cook MC, Phan TG, Stepensky P, Boztug K, Kansu A, İkincioğullari A, Baumann U, Beier R, Roscioli T, Ziegler JB, Gray P, Picard C, Grimbacher B, Warnatz K, Holland SM, Casanova JL, Uzel G, Tangye SG. Monogenic mutations differentially affect the quantity and quality of T follicular helper cells in patients with human primary immunodeficiencies. J Allergy Clin Immunol. 2015 Jul 7. pii: S0091-6749(15)00787-3. doi: 10.1016/j.jaci.2015.05.036. [Epub ahead of print] PubMed PMID: 26162572.

Schiller HB, Fernandez IE, Burgstaller G, Schaab C, Scheltema RA, Schwarzmayr T, Strom TM, Eickelberg O, Mann M. Time- and compartment-resolved proteome profiling of the extracellular niche in lung injury and repair. Mol Syst Biol. 2015 Jul 14;11(7):819. doi: 10.15252/msb.20156123. PubMed PMID: 26174933.

New in PubMed from DZL Faculty/ Neu von der DZL-Fakultät: 13. Juli 2015 

Al-Furoukh N, Ianni A, Nolte H, Hölper S, Krüger M, Wanrooij S, Braun T. ClpX stimulates the mitochondrial unfolded protein response (UPR(mt)) in mammalian cells. Biochim Biophys Acta. 2015 Jul 2. pii: S0167-4889(15)00206-2. doi: 10.1016/j.bbamcr.2015.06.016. [Epub ahead of print] PubMed PMID: 26142927.

Lindner C, Thomsen I, Wahl B, Ugur M, Sethi MK, Friedrichsen M, Smoczek A, Ott S, Baumann U, Suerbaum S, Schreiber S, Bleich A, Gaboriau-Routhiau V, Cerf-Bensussan N, Hazanov H, Mehr R, Boysen P, Rosenstiel P, Pabst O. Diversification of memory B cells drives the continuous adaptation of secretory antibodies to gut microbiota. Nat Immunol. 2015 Jun 29. doi: 10.1038/ni.3213. [Epub ahead of print] PubMed PMID: 26147688.

Anlauf M, Hein L, Hense HW, Köbberling J, Lasek R, Leidl R, Schöne-Seifert B. Complementary and alternative drug therapy versus science-oriented medicine. Ger  Med Sci. 2015 Jun 23;13:Doc05. eCollection 2015. PubMed PMID: 26161049.

Oglesby IK, Vencken SF, Agrawal R, Gaughan K, Molloy K, Higgins G, McNally P,  McElvaney NG, Mall MA, Greene CM. miR-17 overexpression in cystic fibrosis airway epithelial cells decreases interleukin-8 production. Eur Respir J. 2015 Jul 9. pii: ERJ-01634-2014. doi: 10.1183/09031936.00163414. [Epub ahead of print] PubMed PMID: 26160865.

Henne E, Ferguson JS, Mest R, Herth FJ. Thermal Vapor Ablation for Lung Lesions in a Porcine Model. Respiration. 2015 Jul 8. [Epub ahead of print] PubMed PMID: 26160498.

Schneider A, Schwarzbach J, Faderl B, Hautmann H, Jörres RA. Whole-Body Plethysmography in Suspected Asthma. Dtsch Arztebl Int. 2015 Jun 12;112(24):405-411. doi: 10.3238/arztebl.2015.0405. PubMed PMID: 26159217.

Karo-Atar D, Bordowitz A, Wand O, Pasmanik-Chor M, Fernandez IE, Itan M, Frenkel R, Herbert DR, Finkelman FD, Eickelberg O, Munitz A. A protective role for IL-13 receptor α 1 in bleomycin-induced pulmonary injury and repair. Mucosal Immunol. 2015 Jul 8. doi: 10.1038/mi.2015.56. [Epub ahead of print] PubMed PMID: 26153764.

Ridder K, Sevko A, Heide J, Dams M, Rupp AK, Macas J, Starmann J, Tjwa M, Plate KH, Sültmann H, Altevogt P, Umansky V, Momma S. Extracellular vesicle-mediated transfer of functional RNA in the tumor microenvironment. Oncoimmunology. 2015 Mar 19;4(6):e1008371. eCollection 2015 Jun. PubMed PMID: 26155418.

Oumouna M, Weitnauer M, Mijošek V, Schmidt LM, Eigenbrod T, Dalpke AH. Cell-contact dependent inhibition of monocytes by airway epithelial cells and reversion by infection with Respiratory Syncytial Virus. Immunobiology. 2015 Jun 27. pii: S0171-2985(15)30015-2. doi: 10.1016/j.imbio.2015.06.017. [Epub ahead of print] PubMed PMID: 26153873.

Hecker M, Behnk A, Morty RE, Sommer N, Vadász I, Herold S, Seeger W, Mayer K. PPAR-α activation reduced LPS-induced inflammation in alveolar epithelial cells. Exp Lung Res. 2015 Jul 7:1-11. [Epub ahead of print] PubMed PMID: 26151160.

Dengler V, Westphalen K, Koeppen M. Disruption of circadian rhythms and sleep in critical illness and its impact on innate immunity. Curr Pharm Des. 2015 Jul 5. [Epub ahead of print] PubMed PMID: 26144943.

New in PubMed from DZL Faculty: 6. Juli 2015  (DZL PIs underlined)

Valkonen M, Wouters IM, Täubel M, Rintala H, Lenters V, Vasara R, Genuneit J, Braun-Fahrländer C, Piarroux R, von Mutius E, Heederik D, Hyvärinen A. Bacterial Exposures and Associations with Atopy and Asthma in Children. PLoS One. 2015 Jun 29;10(6):e0131594. doi: 10.1371/journal.pone.0131594. eCollection 2015. PubMed PMID: 26121165; PubMed Central PMCID: PMC4488145.

Martikainen MV, Kääriö H, Karvonen A, Schröder PC, Renz H, Kaulek V, Dalphin JC, von Mutius E, Schaub B, Pekkanen J, Hirvonen MR, Roponen M. Farm exposures are associated with lower percentage of circulating myeloid dendritic cell subtype 2 at age 6. Allergy. 2015 Jun 27. doi: 10.1111/all.12682. [Epub ahead of print] PubMed PMID: 26119336.

Watz H. The Lungs and the Heart. Am J Respir Crit Care Med. 2015 Jul 1;192(1):7-8. doi: 10.1164/rccm.201505-0888ED. PubMed PMID: 26131988.

Bush A, Cunningham S, de Blic J, Barbato A, Clement A, Epaud R, Hengst M, Kiper N, Nicholson AG, Wetzke M, Snijders D, Schwerk N, Griese M; chILD-EU collaboration. European protocols for the diagnosis and initial treatment of interstitial lung disease in children. Thorax. 2015 Jul 1. pii: thoraxjnl-2015-207349. doi: 10.1136/thoraxjnl-2015-207349. [Epub ahead of print] Review. PubMed PMID: 26135832.

Kramer R, Sauer-Heilborn A, Welte T, Guzman CA, Abraham WR, Höfle MG. A cohort study of the airway mycobiome in adult cystic fibrosis patients: differences in community structure of fungi compared to bacteria reveal predominance of transient fungal elements. J Clin Microbiol. 2015 Jul 1. pii: JCM.01094-15. [Epub ahead of print] PubMed PMID: 26135861.

Fuehner T, Clajus C, Fuge J, Jonigk D, Welte T, Haverich A, Greer M, Gottlieb J. Lung Transplantation after Endoscopic Lung Volume Reduction. Respiration. 2015 Jul 2. [Epub ahead of print] PubMed PMID: 26138023. (BREATH)

Zhang C, Doherty JA, Burgess S, Hung RJ, Lindström S, Kraft P, Gong J, Amos C, Sellers TA, Monteiro AN, Chenevix-Trench G, Bickeböller H, Risch A, Brennan P, McKay J, Houlston R, Landi MT, Timofeeva M, Wang Y, Heinrich J, Kote-Jarai Z, Eeles RA, Muir K, Wiklund F, Grönberg H, Berndt SI, Chanock SJ, Schumacher F, Haiman CA, Henderson BE, Amin Al Olama A, Andrulis IL, Hopper JL, Chang-Claude J, John EM, Malone KE, Gammon MD, Ursin G, Whittemore AS, Hunter DJ, Gruber SB, Knight JA, Hou L, Le Marchand L, Newcomb PA, Hudson TJ, Chan AT, Li L, Woods MO, Ahsan H, Pierce BL; GECCO and the GAME-ON Network: CORECT, DRIVE, ELLIPSE, FOCI, and TRICL. Genetic determinants of telomere length and risk of common cancers: a Mendelian randomization study. Hum Mol Genet. 2015 Jul 2. pii: ddv252. [Epub ahead of print] PubMed PMID: 26138067.

MacKenzie B, Korfei M, Henneke I, Sibinska Z, Tian X, Hezel S, Dilai S, Wasnick R, Schneider B, Wilhelm J, El Agha E, Klepetko W, Seeger W, Schermuly R, Günther A, Bellusci S. Increased FGF1-FGFRc expression in idiopathic pulmonary fibrosis. Respir Res. 2015 Jul 3;16(1):83. [Epub ahead of print] PubMed PMID: 26138239. (UGMLC) Matamala N, Martínez MT, Lara B, Pérez L, Vázquez I, Jimenez A, Barquín M, Ferrarotti I, Blanco I, Janciauskiene S, Martinez-Delgado B. Alternative transcripts of the SERPINA1 gene in alpha-1 antitrypsin deficiency. J Transl Med. 2015 Jul 4;13(1):211. PubMed PMID: 26141700.

Eigenbrod T, Dalpke AH. Bacterial RNA: An Underestimated Stimulus for Innate Immune Responses. J Immunol. 2015 Jul 15;195(2):411-8. doi: 10.4049/jimmunol.1500530. Review. PubMed PMID: 26138638.

Harzheim D, Eberhardt R, Hoffmann H, Herth FJ. The Solitary Pulmonary Nodule. Respiration. 2015 Jun 26. [Epub ahead of print] PubMed PMID: 26138915.

Juni 2015

New in PubMed from DZL Faculty: 29. Juni 2015

Heinz C, Reiner M, Belka C, Walter F, Söhn M. Technical evaluation of different respiratory monitoring systems used for 4D CT acquisition under free breathing. J Appl Clin Med Phys. 2015 Mar 8;16(2):4917. doi:10.1120/jacmp.v16i2.4917. PubMed PMID: 26103168.

Vogelmeier CF, Asijee GM, Kupas K, Beeh KM. Tiotropium and Salmeterol in COPD Patients at Risk of Exacerbations: A Post Hoc Analysis from POET-COPD(®). Adv Ther. 2015 Jun 23. [Epub ahead of print] PubMed PMID: 26100349.

Regan EA, Lynch DA, Curran-Everett D, Curtis JL, Austin JH, Grenier PA, Kauczor HU, Bailey WC, DeMeo DL, Casaburi RH, Friedman P, Van Beek EJ, Hokanson JE, Bowler RP, Beaty TH, Washko GR, Han MK, Kim V, Kim SS, Yagihashi K, Washington L, McEvoy CE, Tanner C, Mannino DM, Make BJ, Silverman EK, Crapo JD; Genetic Epidemiology of COPD (COPDGene) Investigators. Clinical and Radiologic Disease in Smokers With Normal Spirometry. JAMA Intern Med. 2015 Jun 22. doi: 10.1001/jamainternmed.2015.2735. [Epub ahead of print] PubMed PMID: 26098755.

Vansteenkiste JF, Canon JL, De Braud F, Grossi F, De Pas T, Gray JE, Su WC, Felip E, Yoshioka H, Gridelli C, Dy GK, Thongprasert S, Reck M, Aimone P, Vidam GA, Roussou P, Wang YA, Di Tomaso E, Soria JC. Safety and Efficacy of Buparlisib (BKM120) in Patients With PI3K Pathway-Activated Non-Small Cell Lung Cancer (NSCLC): Results From the Phase II BASALT-1 Study. J Thorac Oncol. 2015 Jun 19. [Epub ahead of print] PubMed PMID: 26098748.

Kellner M, Wehling J, Warnecke G, Heidrich M, Izykowski N, Vogel-Claussen J, Lorbeer RA, Antonopoulos G, Janciauskiene S, Grothausmann R, Knudsen L, Ripken T, Meyer H, Kreipe H, Ochs M, Jonigk D, Kühnel MP. Correlating 3D morphology with molecular pathology: fibrotic remodelling in human lung biopsies. Thorax. 2015 Jun 24. pii: thoraxjnl-2015-207131. doi: 10.1136/thoraxjnl-2015-207131. [Epub ahead of print] PubMed PMID: 26108569.

Arif R, Eichhorn F, Kallenbach K, Seppelt P, Ruhparwar A, Dienemann H, Karck Resection of thoracic malignancies infiltrating cardiac structures with use of cardiopulmonary bypass. J Cardiothorac Surg. 2015 Jun 25;10(1):87. doi: 10.1186/s13019-015-0296-8. PubMed PMID: 26109311; PubMed Central PMCID: PMC4479230.

Colombi D, Dinkel J, Weinheimer O, Obermayer B, Buzan T, Nabers D, Bauer C, Oltmanns U, Palmowski K, Herth F, Kauczor HU, Sverzellati N, Kreuter M, Heussel CP. Visual vs Fully Automatic Histogram-Based Assessment of Idiopathic Pulmonary Fibrosis (IPF) Progression Using Sequential Multidetector Computed Tomography (MDCT). PLoS One. 2015 Jun 25;10(6):e0130653. doi: 10.1371/journal.pone.0130653. eCollection 2015. PubMed PMID: 26110421.

Slebos DJ, Hartman JE, Klooster K, Blaas S, Deslee G, Gesierich W, Hetzel J, Hetzel M, McNulty W, Kemp SV, Kessler R, Leroy S, Stanzel F, Witt C, Zoumot Z, Herth FJ, Shah PL. Bronchoscopic Coil Treatment for Patients with Severe Emphysema: A Meta-Analysis. Respiration. 2015 Jun 25. [Epub ahead of print] PubMed PMID: 26112380.

Bartsch DK, Albers MB, Lopez CL, Apitzsch JC, Walthers EM, Fink L, Fendrich V, Slater EP, Waldmann J, Anlauf M. Bronchopulmonary Neuroendocrine Neoplasms and their Precursor Lesions in Multiple Endocrine Neoplasia Type 1. Neuroendocrinology. 2015 Jun 18. [Epub ahead of print] PubMed PMID: 26113081.

Kosanovic D, Luitel H, Dahal BK, Cornitescu T, Janssen W, Danser AH, Garrelds IM, De Mey JG, Fazzi G, Schiffers P, Iglarz M, Fischli W, Ghofrani HA, Weissmann N, Grimminger F, Seeger W, Reiss I, Schermuly RT. Chymase: a multifunctional player in pulmonary hypertension associated with lung fibrosis. Eur Respir J. 2015 Jun 25. pii: ERJ-00182-2015. doi: 10.1183/09031936.00018215. [Epub ahead of print] PubMed PMID: 26113671.

de Marco R, Marcon A, Rossi A, Antó JM, Cerveri I, Gislason T, Heinrich J, Janson C, Jarvis D, Kuenzli N, Leynaert B, Probst-Hensch N, Svanes C, Wjst M, Burney P. Asthma, COPD and overlap syndrome: a longitudinal study in young European adults. Eur Respir J. 2015 Jun 25. pii: ERJ-00086-2015. doi: 10.1183/09031936.00008615. [Epub ahead of print] PubMed PMID: 26113674.

McLaughlin V, N Channick R, Ghofrani HA, Lemarié JC, Naeije R, Packer M, Souza R, Tapson VF, Tolson J, Al Hiti H, Meyer G, Hoeper MM. Bosentan added to sildenafil therapy in patients with pulmonary arterial hypertension. Eur Respir 2015 Jun 25. pii: ERJ-02044-2014. doi: 10.1183/13993003.02044-2014. [Epub ahead of print] PubMed PMID: 26113687.

Mall MA, Galietta LJ. Targeting ion channels in cystic fibrosis. J Cyst Fibros. 2015 Jun 23. pii: S1569-1993(15)00150-2. doi: 10.1016/j.jcf.2015.06.002. [Epub ahead of print] Review. PubMed PMID: 26115565.

Conrad E, Polonio-Vallon T, Meister M, Matt S, Bitomsky N, Herbel C, Liebl M, Greiner V, Kriznik B, Schumacher S, Krieghoff-Henning E, Hofmann TG. HIPK2 restricts SIRT1 activity upon severe DNA damage by a phosphorylation-controlled mechanism. Cell Death Differ. 2015 Jun 26. doi: 10.1038/cdd.2015.75. [Epub ahead of print] PubMed PMID: 26113041.

Walker TM, Kohl TA, Omar SV, Hedge J, Del Ojo Elias C, Bradley P, Iqbal Z, Feuerriegel S, Niehaus KE, Wilson DJ, Clifton DA, Kapatai G, Ip CL, Bowden R, Drobniewski FA, Allix-Béguec C, Gaudin C, Parkhill J, Diel R, Supply P, Crook DW, Smith EG, Walker AS, Ismail N, Niemann S, Peto TE; Modernizing Medical Microbiology (MMM) Informatics Group. Whole-genome sequencing for prediction of Mycobacterium tuberculosis drug susceptibility and resistance: a retrospective cohort study. Lancet Infect Dis. 2015 Jun 23. pii: S1473-3099(15)00062-6. doi: 10.1016/S1473-3099(15)00062-6. [Epub ahead of print] PubMed PMID: 26116186.

Guenther SP, Brunner S, Born F, Fischer M, Schramm R, Pichlmaier M, Massberg S, Hagl C, Khaladj N. When all else fails: extracorporeal life support in therapy-refractory cardiogenic shock. Eur J Cardiothorac Surg. 2015 Jun 23. pii: ezv212. [Epub ahead of print] PubMed PMID: 26104533.

New in PubMed from DZL Faculty: 22. Juni 2015

1: Burgstaller G, Vierkotten S, Lindner M, Königshoff M, Eickelberg OMultidimensional immunolabeling and 4D time-lapse imaging of vital ex-vivo lung tissue. Am J Physiol Lung Cell Mol Physiol. 2015 Jun 19:ajplung.00061.2015. doi:  10.1152/ajplung.00061.2015. [Epub ahead of print] PubMed PMID: 26092995. 

2: Luo Y, El Agha E, Turcatel G, Chen H, Chiu J, Warburton D, Bellusci S, Qian BP, Menke DB, Shi W. Mesenchymal Adenomatous Polyposis Coli plays critical and diverse roles in regulating lung development. BMC Biol. 2015 Jun 20;13(1):42. [Epub ahead of print] PubMed PMID: 26092405. 

3: Schmier S, Mostafa A, Haarmann T, Bannert N, Ziebuhr J, Veljkovic V, Dietrich  U, Pleschka S. In Silico Prediction and Experimental Confirmation of HA Residues  Conferring Enhanced Human Receptor Specificity of H5N1 Influenza A Viruses. Sci Rep. 2015 Jun 19;5:11434. doi: 10.1038/srep11434. PubMed PMID: 26091504. 

4: Berger MM, Macholz F, Mairbäurl H, Bartsch P. Remote Ischemic Preconditioning for Prevention of High Altitude Diseases: Fact or Fiction? J Appl Physiol (1985). 2015 Jun 18:jap.00156.2015. doi: 10.1152/japplphysiol.00156.2015. [Epub ahead of  print] PubMed PMID: 26089545. 

5: Thome UH, Genzel-Boroviczeny O, Bohnhorst B, Schmid M, Fuchs H, Rohde O, Avenarius S, Topf HG, Zimmermann A, Faas D, Timme K, Kleinlein B, Buxmann H, Schenk W, Segerer H, Teig N, Gebauer C, Hentschel R, Heckmann M, Schlösser R, Peters J, Rossi R, Rascher W, Böttger R, Seidenberg J, Hansen G, Zernickel M, Alzen G, Dreyhaupt J, Muche R, Hummler HD; PHELBI Study Group. Permissive hypercapnia in extremely low birthweight infants (PHELBI): a randomised controlled multicentre trial. Lancet Respir Med. 2015 Jun 15. pii: S2213-2600(15)00204-0. doi: 10.1016/S2213-2600(15)00204-0. [Epub ahead of print]  PubMed PMID: 26088180. 

6: Schremser K, Rogowski WH, Adler-Reichel S, Tufman AL, Huber RM, Stollenwerk B. Cost-Effectiveness of an Individualized First-Line Treatment Strategy Offering Erlotinib Based on EGFR Mutation Testing in Advanced Lung Adenocarcinoma Patients in Germany. Pharmacoeconomics. 2015 Jun 17. [Epub ahead of print] PubMed PMID: 26081300. 

7: Li K, Hüsing A, Sookthai D, Bergmann M, Boeing H, Becker N, Kaaks RSelecting high-risk individuals for lung cancer screening - a prospective evaluation of existing risk models and eligibility criteria in the German EPIC cohort. Cancer Prev Res (Phila). 2015 Jun 15. pii: canprevres.0424.2014. [Epub ahead of print] PubMed PMID: 26076698. 

8: Claudia F, Thiering E, von Berg A, Berdel D, Hoffmann B, Koletzko S, Bauer CP, Koletzko B, Heinrich J, Schulz H. Peak weight velocity in infancy is negatively associated with lung function in adolescence. Pediatr Pulmonol. 2015 Jun 14. doi: 10.1002/ppul.23216. [Epub ahead of print] PubMed PMID: 26073174. 

9: Dupuis A, Keenan K, Ooi CY, Dorfman R, Sontag MK, Naehrlich L, Castellani C, Strug LJ, Rommens JM, Gonska T. Prevalence of meconium ileus marks the severity of mutations of the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) gene. Genet Med. 2015 Jun 18. doi: 10.1038/gim.2015.79. [Epub ahead of print] PubMed PMID: 26087176. 

10: Nagel C, Henn P, Ehlken N, D'Andrea A, Blank N, Bossone E, Böttger A, Fiehn C, Fischer C, Lorenz HM, Stöckl F, Grünig E, Egenlauf B. Stress-Doppler-Echocardiography for early detection of systemic sclerosis associated pulmonary arterial hypertension. Arthritis Res Ther. 2015 Jun 19;17(1):165. [Epub ahead of print] PubMed PMID: 26084934.

New in PubMed from DZL Faculty: June 15, 2015

1: Schuette W, Schirmacher P, Eberhardt WE, Fischer JR, Graf von der Schulenburg  JM, Mezger J, Schumann C, Serke M, Zaun S, Dietel M, Thomas M. EGFR Mutation Status and First-line Treatment in Patients with Stage III/IV Non-small cell Lung Cancer in Germany: An Observational Study. Cancer Epidemiol Biomarkers Prev. 2015 Jun 12. pii: cebp.1149.2014. [Epub ahead of print] PubMed PMID: 26070531.

2: Nussbaumer-Ochsner Y, Stolk J, Ferraz da Silva LF, van Schadewijk A, de Jeu RC, Prins FA, Mauad T, Rabe KF, Hiemstra PS. Association of Lung Inflammatory Cells with Small Airways Function and Exhaled Breath Markers in Smokers - Is There a Specific Role for Mast Cells? PLoS One. 2015 Jun 12;10(6):e0129426. doi:  10.1371/journal.pone.0129426. eCollection 2015. PubMed PMID: 26069967. 

3: Reuther P, Göpfert K, Dudek AH, Heiner M, Herold S, Schwemmle M. Generation of a variety of stable Influenza A reporter viruses by genetic engineering of the NS gene segment. Sci Rep. 2015 Jun 12;5:11346. doi: 10.1038/srep11346. PubMed PMID: 26068081. 

4: Hueper K, Vogel-Claussen J, Parikh MA, Austin JH, Bluemke DA, Carr J, Choi J, Goldstein TA, Gomes AS, Hoffman EA, Kawut SM, Lima J, Michos ED, Post WS, Po MJ,  Prince MA, Liu K, Rabinowitz D, Skrok J, Smith BM, Watson K, Yin Y, Zambeli-Ljepovic AM, Barr RG. Pulmonary Microvascular Blood Flow in Mild Chronic  Obstructive Pulmonary Disease and Emphysema. The MESA COPD Study. Am J Respir Crit Care Med. 2015 Jun 11. [Epub ahead of print] PubMed PMID: 26067761. 

5: Nerlich A, Ruangkiattikul N, Laarmann K, Janze N, Dittrich-Breiholz O, Kracht M, Goethe R. C/EBPβ is a transcriptional key regulator of IL-36α in murine macrophages. Biochim Biophys Acta. 2015 Jun 8. pii: S1874-9399(15)00120-0. doi: 10.1016/j.bbagrm.2015.06.002. [Epub ahead of print] PubMed PMID: 26066982. 

6: Seys LJ, Verhamme FM, Dupont LL, Desauter E, Duerr J, Seyhan Agircan A, Conickx G, Joos GF, Brusselle GG, Mall MA, Bracke KR. Airway Surface Dehydration  Aggravates Cigarette Smoke-Induced Hallmarks of COPD in Mice. PLoS One. 2015 Jun  12;10(6):e0129897. doi: 10.1371/journal.pone.0129897. eCollection 2015. PubMed PMID: 26066648. 

7: Vogelmeier CF, Vestbo J, Hurd SS, Decramer M. Changes in GOLD: today and tomorrow. Lancet Respir Med. 2015 Jun;3(6):424-6. doi: 10.1016/S2213-2600(15)00191-5. PubMed PMID: 26065970. 

8: Milger K, Felix JF, Voswinckel R, Sommer N, Franco OH, Grimminger FReichenberger F, Seeger W, Ghofrani HA, Gall H. Sildenafil versus nitric oxide for acute vasodilator testing in pulmonary arterial hypertension. Pulm Circ. 2015 Jun;5(2):305-12. doi: 10.1086/680355. PubMed PMID: 26064455; PubMed Central PMCID: PMC4449241. 

9: Ghofrani HA, Staehler G, Grünig E, Halank M, Mitrovic V, Unger S, Mueck W, Frey R, Grimminger F, Schermuly RT, Behr J. Acute effects of riociguat in borderline or manifest pulmonary hypertension associated with chronic obstructive pulmonary disease. Pulm Circ. 2015 Jun;5(2):296-304. doi: 10.1086/680214. PubMed  PMID: 26064454; PubMed Central PMCID: PMC4449240. 

10: Vilmann P, Clementsen PF, Colella S, Siemsen M, De Leyn P, Dumonceau JM, Herth FJ, Larghi A, Vazquez-Sequeiros E, Hassan C, Crombag L, Korevaar DA, Konge  L, Annema JT. Combined endobronchial and esophageal endosonography for the diagnosis and staging of lung cancer: European Society of Gastrointestinal Endoscopy (ESGE) Guideline, in cooperation with the European Respiratory Society  (ERS) and the European Society of Thoracic Surgeons (ESTS). Endoscopy. 2015 Jun;47(6):c1. doi: 10.1055/s-0034-1392453. Epub 2015 Jun 10. PubMed PMID: 26062074. (

11: Meyer-Bahlburg A. B-1 cells as a source of IgA. Ann N Y Acad Sci. 2015 Jun 9. doi: 10.1111/nyas.12801. [Epub ahead of print] PubMed PMID: 26062045. 

12: Seimetz M, Parajuli N, Pichl A, Bednorz M, Ghofrani HA, Schermuly RT, Seeger  W, Grimminger F, Weissmann N. Cigarette Smoke-Induced Emphysema and Pulmonary Hypertension Can Be Prevented by Phosphodiesterase 4 and 5 Inhibition in Mice. PLoS One. 2015 Jun 9;10(6):e0129327. doi: 10.1371/journal.pone.0129327. eCollection 2015. PubMed PMID: 26058042. 

13: Kulis M, Merkel A, Heath S, Queirós AC, Schuyler RP, Castellano G, Beekman R, Raineri E, Esteve A, Clot G, Verdaguer-Dot N, Duran-Ferrer M, Russiñol N, Vilarrasa-Blasi R, Ecker S, Pancaldi V, Rico D, Agueda L, Blanc J, Richardson D,  Clarke L, Datta A, Pascual M, Agirre X, Prosper F, Alignani D, Paiva B, Caron G,  Fest T, Muench MO, Fomin ME, Lee ST, Wiemels JL, Valencia A, Gut M, Flicek P, Stunnenberg HG, Siebert R, Küppers R, Gut IG, Campo E, Martín-Subero JI. Whole-genome fingerprint of the DNA methylome during human B cell differentiation. Nat Genet. 2015 Jun 8. doi: 10.1038/ng.3291. [Epub ahead of print] PubMed PMID: 26053498. 

14: Diddens-Tschoeke HC, Hüttmann G, Gruber AD, Pottier RH, Hanken H. Localized thermal tumor destruction using dye-enhanced photothermal tumor therapy. Lasers Surg Med. 2015 Jun 5. doi: 10.1002/lsm.22356. [Epub ahead of print] PubMed PMID:  26052931. 

15: Krauss-Etschmann S, Meyer KF, Dehmel S, Hylkema MN. Inter- and transgenerational epigenetic inheritance: evidence in asthma and COPD? Clin Epigenetics. 2015 May 1;7(1):53. doi: 10.1186/s13148-015-0085-1. eCollection 2015. PubMed PMID: 26052354; PubMed Central PMCID: PMC4456695. 

16: Fischer A, Ellinghaus D, Nutsua M, Hofmann S, Montgomery CG, Iannuzzi MC, Rybicki BA, Petrek M, Mrazek F, Pabst S, Grohé C, Grunewald J, Ronninger M, Eklund A, Padyukov L, Mihailovic-Vucinic V, Jovanovic D, Sterclova M, Homolka J,  Nöthen MM, Herms S, Gieger C, Strauch K, Winkelmann J, Boehm BO, Brand S, Büning  C, Schürmann M, Ellinghaus E, Baurecht H, Lieb W, Nebel A, Müller-Quernheim J, Franke A, Schreiber S; GenPhenReSa Consortium. Identification of Immune-relevant  Factors Conferring Sarcoidosis Genetic Risk. Am J Respir Crit Care Med. 2015 Jun  6. [Epub ahead of print] PubMed PMID: 26051272. 

17: Flechsig P, Mehndiratta A, Haberkorn U, Kratochwil C, Giesel FL. PET/MRI and  PET/CT in Lung Lesions and Thoracic Malignancies. Semin Nucl Med. 2015 Jul;45(4):268-281. doi: 10.1053/j.semnuclmed.2015.03.004. Review. PubMed PMID: 26050655. 

New in PubMed from DZL Faculty:  June 8, 2015

1: Husain-Syed F, McCullough PA, Birk HW, Renker M, Brocca A, Seeger W, Ronco C.  Cardio-Pulmonary-Renal Interactions: A Multidisciplinary Approach. J Am Coll Cardiol. 2015 Jun 9;65(22):2433-2448. doi: 10.1016/j.jacc.2015.04.024. Review. PubMed PMID: 26046738.  

2: Thatcher N, Hirsch FR, Luft AV, Szczesna A, Ciuleanu TE, Dediu M, Ramlau R, Galiulin RK, Bálint B, Losonczy G, Kazarnowicz A, Park K, Schumann C, Reck M, Depenbrock H, Nanda S, Kruljac-Letunic A, Kurek R, Paz-Ares L, Socinski MA; SQUIRE investigators. Necitumumab plus gemcitabine and cisplatin versus gemcitabine and cisplatin alone as first-line therapy in patients with stage IV squamous non-small-cell lung cancer (SQUIRE): an open-label, randomised, controlled phase 3 trial. Lancet Oncol. 2015 Jun 1. pii: S1470-2045(15)00021-2. doi: 10.1016/S1470-2045(15)00021-2. [Epub ahead of print] PubMed PMID: 26045340.  

3: Singh I, Ozturk N, Cordero J, Mehta A, Hasan D, Cosentino C, Sebastian C, Krüger M, Looso M, Carraro G, Bellusci S, Seeger W, Braun T, Mostoslavsky R, Barreto G. High mobility group protein-mediated transcription requires DNA damage marker γ-H2AX. Cell Res. 2015 Jun 5. doi: 10.1038/cr.2015.67. [Epub ahead of print] PubMed PMID: 26045162.  

4: Ernst A, Anders H, Kapfhammer H, Orth M, Hennel R, Seidl K, Winssinger N, Belka C, Unkel S, Lauber K. HSP90 inhibition as a means of radiosensitizing resistant, aggressive soft tissue sarcomas. Cancer Lett. 2015 Jun 1. pii: S0304-3835(15)00374-2. doi: 10.1016/j.canlet.2015.05.024. [Epub ahead of print] PubMed PMID: 26044951.  

5: Werfel T, Heratizadeh A, Niebuhr M, Kapp A, Roesner LM, Karch A, Erpenbeck VJ, Lösche C, Jung T, Krug N, Badorrek P, Hohlfeld JM. Exacerbation of atopic dermatitis on grass pollen exposure in an environmental challenge chamber. J Allergy Clin Immunol. 2015 Jun 1. pii: S0091-6749(15)00575-8. doi: 10.1016/j.jaci.2015.04.015. [Epub ahead of print] PubMed PMID: 26044854.  

6: Richter MJ, Sommer N, Gall H, Voswinckel R, Seeger W, Mayer E, Wiedenroth CB, Rieth A, Grimminger F, Guth S, Ghofrani HA. Pulmonary Hemodynamic Response to Exercise in Chronic Thromboembolic Pulmonary Hypertension before and after Pulmonary Endarterectomy. Respiration. 2015 Jun 3. [Epub ahead of print] PubMed PMID: 26044754.  

7: Deckmann K, Krasteva-Christ G, Rafiq A, Herden C, Wichmann J, Knauf S, Nassenstein C, Grevelding CG, Dorresteijn A, Chubanov V, Gudermann T, Bschleipfer T, Kummer W. Cholinergic urethral brush cells are widespread throughout placental mammals. Int Immunopharmacol. 2015 Jun 1. pii: S1567-5769(15)00267-2. doi: 10.1016/j.intimp.2015.05.038. [Epub ahead of print] PubMed PMID: 26044348.

8: Casale TB, Cole J, Beck E, Vogelmeier CF, Willers J, Lassen C, Hammann-Haenni A, Trokan L, Saudan P, Wechsler ME. CYT003, a TLR9 Agonist, in Persistent Allergic Asthma - A Randomized Placebo-controlled Phase 2b Study. Allergy. 2015 Jun 4. doi: 10.1111/all.12663. [Epub ahead of print] PubMed PMID: 26042362.

9: Oeder S, Kanashova T, Sippula O, Sapcariu SC, Streibel T, Arteaga-Salas JM, Passig J, Dilger M, Paur HR, Schlager C, Mülhopt S, Diabaté S, Weiss C, Stengel B, Rabe R, Harndorf H, Torvela T, Jokiniemi JK, Hirvonen MR, Schmidt-Weber C, Traidl-Hoffmann C, BéruBé KA, Wlodarczyk AJ, Prytherch Z, Michalke B, Krebs T, Prévôt AS, Kelbg M, Tiggesbäumker J, Karg E, Jakobi G, Scholtes S, Schnelle-Kreis J, Lintelmann J, Matuschek G, Sklorz M, Klingbeil S, Orasche J, Richthammer P, Müller L, Elsasser M, Reda A, Gröger T, Weggler B, Schwemer T, Czech H, Rüger CP, Abbaszade G, Radischat C, Hiller K, Buters JT, Dittmar G, Zimmermann R. Particulate matter from both heavy fuel oil and diesel fuel shipping emissions show strong biological effects on human lung cells at realistic and comparable in vitro exposure conditions. PLoS One. 2015 Jun 3;10(6):e0126536. doi: 10.1371/journal.pone.0126536. eCollection 2015. PubMed PMID: 26039251.  

10: Staab-Weijnitz CA, Fernandez IE, Knüppel L, Maul J, Heinzelmann K, Juan-Guardela BM, Hennen E, Preissler G, Winter H, Neurohr C, Hatz R, Lindner M,  Behr J, Kaminski N, Eickelberg O. FK506-binding Protein 10 is a Potential Novel Drug Target for Idiopathic Pulmonary Fibrosis. Am J Respir Crit Care Med. 2015 Jun 3. [Epub ahead of print] PubMed PMID: 26039104.

11: Buzan MT, Eichinger M, Kreuter M, Kauczor HU, Herth FJ, Warth A, Pop CM, Heussel CP, Dinkel J. T2 mapping of CT remodelling patterns in interstitial lung  disease. Eur Radiol. 2015 Jun 3. [Epub ahead of print] PubMed PMID: 26037715.  

12: Petersen A, Kull S, Rennert S, Becker WM, Krause S, Ernst M, Gutsmann T, Bauer J, Lindner B, Jappe U. Peanut defensins: Novel allergens isolated from lipophilic peanut extract. J Allergy Clin Immunol. 2015 May 30. pii: S0091-6749(15)00570-9. doi: 10.1016/j.jaci.2015.04.010. [Epub ahead of print] PubMed PMID: 26037551.  

13: Mutze K, Vierkotten S, Milosevic J, Eickelberg O, Königshoff M. Enolase 1 and protein disulfide isomerase associated 3 regulate Wnt/β-catenin driven alveolar epithelial cell trans-differentiation. Dis Model Mech. 2015 May 14. pii: dmm.019117. [Epub ahead of print] PubMed PMID: 26035385.  

14: Vilmann P, Clementsen PF, Colella S, Siemsen M, De Leyn P, Dumonceau JM, Herth FJ, Larghi A, Vasquez-Sequeiros E, Hassan C, Crombag L, Korevaar DA, Konge  L, Annema JT. Combined endobronchial and oesophageal endosonography for the diagnosis and staging of lung cancer. Eur Respir J. 2015 Jun 1. pii: ERJ-00645-2015. [Epub ahead of print] PubMed PMID: 26034128.  

15: Vilmann P, Frost Clementsen P, Colella S, Siemsen M, De Leyn P, Dumonceau JM, Herth FJ, Larghi A, Vasquez-Sequeiros E, Hassan C, Crombag L, Korevaar DA, Konge  L, Annema JT. Combined endobronchial and esophageal endosonography for the diagnosis and staging of lung cancer: European Society of Gastrointestinal Endoscopy (ESGE) Guideline, in cooperation with the European Respiratory Society  (ERS) and the European Society of Thoracic Surgeons (ESTS). Eur J Cardiothorac Surg. 2015 Jun 1. pii: ezv194. [Epub ahead of print] PubMed PMID: 26034060.  

16: Krasteva-Christ G, Soultanova A, Schütz B, Papadakis T, Weiss C, Deckmann K,  Chubanov V, Gudermann T, Voigt A, Meyerhof W, Boehm U, Weihe E, Kummer WIdentification of cholinergic chemosensory cells in mouse tracheal and laryngeal  glandular ducts. Int Immunopharmacol. 2015 May 29. pii: S1567-5769(15)00257-X. doi: 10.1016/j.intimp.2015.05.028. [Epub ahead of print] PubMed PMID: 26033492.

17: Holm AT, Wulf-Johansson H, Hvidsten S, Jorgensen PT, Schlosser A, Pilecki B,  Ormhøj M, Moeller JB, Johannsen C, Baun C, Andersen T, Schneider JP, Hegermann J, Ochs M, Götz AA, Schulz H, de Angelis MH, Vestbo J, Holmskov U, Sorensen GL. Characterization of spontaneous air space enlargement in mice lacking microfibrillar-associated protein 4. Am J Physiol Lung Cell Mol Physiol. 2015 Jun 1;308(11):L1114-24. doi: 10.1152/ajplung.00351.2014. Epub 2015 Apr 10. PubMed PMID: 26033354.

18: Vogl M, Leidl R. Informing management on the future structure of hospital care: an extrapolation of trends in demand and costs in lung diseases. Eur J Health Econ. 2015 Jun 2. [Epub ahead of print] PubMed PMID: 26032899.  (CPC-M)

19: Bandorski D, Erkapic D, Stempfl J, Höltgen R, Grünig E, Schmitt J, Chasan R,  Grimminger J, Neumann T, Hamm CW, Seeger W, Ghofrani HA, Gall H. Ventricular tachycardias in patients with pulmonary hypertension: an underestimated prevalence? A prospective clinical study. Herzschrittmacherther Elektrophysiol. 2015 Jun 2. [Epub ahead of print] PubMed PMID: 26031512.  

20: Vilmann P, Clementsen PF, Colella S, Siemsen M, De Leyn P, Dumonceau JM, Herth FJ, Larghi A, Vasquez-Sequeiros E, Hassan C, Crombag L, Korevaar DA, Konge  L, Annema JT. Combined endobronchial and esophageal endosonography for the diagnosis and staging of lung cancer: European Society of Gastrointestinal Endoscopy (ESGE) Guideline, in cooperation with the European Respiratory Society  (ERS) and the European Society of Thoracic Surgeons (ESTS). Endoscopy. 2015 Jun;47(6):545-59. doi: 10.1055/s-0034-1392040. Epub 2015 Jun 1. PubMed PMID: 26030890.  

21: Hoeper MM. Pharmacological therapy for patients with chronic thromboembolic pulmonary hypertension. Eur Respir Rev. 2015 Jun;24(136):272-282. Review. PubMed  PMID: 26028639.

22: Kim NH, Mayer E. Chronic thromboembolic pulmonary hypertension: the evolving  treatment landscape. Eur Respir Rev. 2015 Jun;24(136):173-7. doi: 10.1183/16000617.00001515. PubMed PMID: 26028629.  

23: Celli BR, Decramer M, Wedzicha JA, Wilson KC, Agustí AA, Criner GJ, MacNee W, Make BJ, Rennard SI, Stockley RA, Vogelmeier C, Anzueto A, Au DH, Barnes PJ, Burgel PR, Calverley PM, Casanova C, Clini EM, Cooper CB, Coxson HO, Dusser DJ, Fabbri LM, Fahy B, Ferguson GT, Fisher A, Fletcher MJ, Hayot M, Hurst JR, Jones PW, Mahler DA, Maltais F, Mannino DM, Martinez FJ, Miravitlles M, Meek PM, Papi A, Rabe KF, Roche N, Sciurba FC, Sethi S, Siafakas N, Sin DD, Soriano JB, Stoller JK, Tashkin DP, Troosters T, Verleden GM, Verschakelen J, Vestbo J, Walsh JW, Washko GR, Wise RA, Wouters EF, ZuWallack RL; ATS/ERS Task Force for COPD Research. An official American Thoracic Society/European Respiratory Society statement: research questions in COPD. Eur Respir Rev. 2015 Jun;24(136):159-72. doi: 10.1183/16000617.00000315. PubMed PMID: 26028628.  

24: Postma DS, Brightling C, Fabbri L, van der Molen T, Nicolini G, Papi A, Rabe  KF, Siddiqui S, Singh D, van den Berge M, Kraft M. Unmet needs for the assessment of small airways dysfunction in asthma: introduction to the ATLANTIS study. Eur Respir J. 2015 Jun;45(6):1534-8. doi: 10.1183/09031936.00214314. PubMed PMID: 26028618.  

25: Welte T. Prevention is better than cure: time to change the focus of community-acquired pneumonia management. Eur Respir J. 2015 Jun;45(6):1524-5. doi: 10.1183/09031936.00064015. PubMed PMID: 26028615.  

26: Brahmer J, Reckamp KL, Baas P, Crinò L, Eberhardt WE, Poddubskaya E, Antonia  S, Pluzanski A, Vokes EE, Holgado E, Waterhouse D, Ready N, Gainor J, Arén Frontera O, Havel L, Steins M, Garassino MC, Aerts JG, Domine M, Paz-Ares L, Reck M, Baudelet C, Harbison CT, Lestini B, Spigel DR. Nivolumab versus Docetaxel in Advanced Squamous-Cell Non-Small-Cell Lung Cancer. N Engl J Med. 2015 May 31. [Epub ahead of print] PubMed PMID: 26028407.  

New in PubMed from DZL Faculty:  June 1, 2015

1: Voss M, Wolf L, Kamyschnikow A, Wonnenberg B, Honecker A, Herr C, Lepper PM, Wegmann M, Menger MD, Bals R, Beisswenger C. IL-17A contributes to maintenance of pulmonary homeostasis in a murine model of cigarette smoke-induced emphysema. Am  J Physiol Lung Cell Mol Physiol. 2015 May 29:ajplung.00388.2014. doi: 10.1152/ajplung.00388.2014. [Epub ahead of print] PubMed PMID: 26024895.  

2: Sommerburg O, Schenk JP, Mall MA. [Lung diseases in children]. Radiologe. 2015 May 30. [Epub ahead of print] German. PubMed PMID: 26023006.  

3: Waschki B, Kirsten AM, Holz O, Mueller KC, Schaper M, Sack AL, Meyer T, Rabe  KF, Magnussen H, Watz H. Disease Progression and Changes in Physical Activity in  Patients with COPD. Am J Respir Crit Care Med. 2015 May 28. [Epub ahead of print] PubMed PMID: 26020495.  

4: Leuchte HH, Baezner C, Baumgartner RA, Muehling O, Neurohr C, Behr JResidual pulmonary vasodilative reserve predicts outcome in idiopathic pulmonary  hypertension. Heart. 2015 Jun 15;101(12):972-6. doi: 10.1136/heartjnl-2015-307529. PubMed PMID: 26015441.

5: Burns J, Mason C, Mueller N, Ohlander J, Zock JP, Drobnic F, Wolfarth B, Heinrich J, Omenaas E, Stensrud T, Nowak D, Radon K; GA2LEN-Olympic Study-Team; European Community Respiratory Health Survey. Asthma prevalence in Olympic summer athletes and the general population: An analysis of three European countries. Respir Med. 2015 May 14. pii: S0954-6111(15)00156-0. doi: 10.1016/j.rmed.2015.05.002. [Epub ahead of print] PubMed PMID: 26013359.  

6: Toncheva AA, Potaczek DP, Schedel M, Gersting SW, Michel S, Krajnov N, Gaertner VD, Klingbeil JM, Illig T, Franke A, Winkler C, Hohlfeld JM, Vogelberg C, von Berg A, Bufe A, Heinzmann A, Laub O, Rietschel E, Simma B, Genuneit J, Muntau AC, Kabesch M. Childhood asthma is associated with mutations and gene expression differences of ORMDL genes which can interact. Allergy. 2015 May 22. doi: 10.1111/all.12652. [Epub ahead of print] PubMed PMID: 26011647.  

7: Neurohr C, Behr J. Changes in the current classification of IIP: A critical review. Respirology. 2015 May 26. doi: 10.1111/resp.12553. [Epub ahead of print]  PubMed PMID: 26011188.

8: Milger K, Holdt LM, Teupser D, Huber RM, Behr J, Kneidinger N. Identification of a novel SERPINA-1 mutation causing alpha-1 antitrypsin deficiency in a patient with severe bronchiectasis and pulmonary embolism. Int J Chron Obstruct Pulmon Dis. 2015 May 7;10:891-7. doi: 10.2147/COPD.S80173. eCollection 2015. PubMed PMID: 26005342; PubMed Central PMCID: PMC4428364.

9: Wei J, Gerlich J, Genuneit J, Nowak D, Vogelberg C, von Mutius E, Radon K. Hormonal factors and incident asthma and allergic rhinitis during puberty in girls. Ann Allergy Asthma Immunol. 2015 May 21. pii: S1081-1206(15)00271-9. doi:  10.1016/j.anai.2015.04.019. [Epub ahead of print] PubMed PMID: 26003905.  

10: Marra AM, Egenlauf B, Ehlken N, Fischer C, Eichstaedt C, Nagel C, Bossone E, Cittadini A, Halank M, Gall H, Olsson KM, Lange TJ, Grünig E. Change of right heart size and function by long-term therapy with riociguat in patients with pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension. Int J Cardiol. 2015 May 19;195:19-26. doi: 10.1016/j.ijcard.2015.05.105. [Epub ahead of print] PubMed PMID: 26011408.  


Ältere Publikationen (Mai 2015 und vorhergehende) finden Sie in den Ordnern unter "Forschung -> "Publikationen" -> "Archiv".

May 2015 and older: For older publications please check the "New in PubMed Archive" folders. 

 

Babu KR, Muckenthaler MU. miR-20a regulates expression of the iron exporter ferroportin in lung cancer. J Mol Med (Berl). 2015 Nov 12. [Epub ahead of print] PubMed PMID: 26560875.

 

Conlon TM, Bartel J, Ballweg K, Günter S, Prehn C, Krumsiek J, Meiners S, Theiss FJ, Adamski J, Eickelberg O, Yildirim AO. Metabolomics screening identifies reduced L-carnitine to be associated with progressive emphysema. Clin  Sci (Lond). 2015 Nov 12. pii: CS20150438. [Epub ahead of print] PubMed PMID: 26564208.

 

den Dekker HT, Sonnenschein-van der Voort AM, de Jongste JC, Anessi-Maesano I, Arshad SH, Barros H, Beardsmore CS, Bisgaard H, Phar SC, Craig L, Devereux G, van der Ent CK, Esplugues A, Fantini MP, Flexeder C, Frey U, Forastiere F, Gehring U, Gori D, van der Gugten AC, Henderson AJ, Heude B, Ibarluzea J, Inskip HM, Keil T, Kogevinas M, Kreiner-Møller E, Kuehni CE, Lau S, Mélen E, Mommers M, Morales E, Penders J, Pike KC, Porta D, Reiss IK, Roberts G, Schmidt A, Schultz ES, Schulz H, Sunyer J, Torrent M, Vassilaki M, Wijga AH, Zabaleta C, Jaddoe VW, Duijts L. Early growth characteristics and the risk of reduced lung function and asthma: A meta-analysis of 25,000 children. J Allergy Clin Immunol. 2015 Nov 5. pii: S0091-6749(15)01361-5. doi: 10.1016/j.jaci.2015.08.050. [Epub ahead of print] PubMed PMID: 26548843.

 

Heidegger S, Jarosch A, Schmickl M, Endres S, Bourquin C, Hotz C. Mycoplasma hyorhinis Contaminated Cell Lines Activate Primary Innate Immune Cells via a Protease-Sensitive Factor. PloS One. 2015 Nov 13;10(11):e0142523. doi: 10.1371/journal.pone.0142523. eCollection 2015. PubMed PMID: 26565413.

 

Hosono C, Matsuda R, Adryan B, Samakovlis C. Transient junction anisotropies orient annular cell polarization in the Drosophila airway tubes. Nat Cell Biol. 2015 Nov 9. doi: 10.1038/ncb3267. [Epub ahead of print] PubMed PMID: 26551273.

 

Kircher P, Hermanns C, Nossek M, Drexler MK, Grosse R, Fischer M, Sarikas A, Penkava J, Lewis T, Prywes R, Gudermann T, Muehlich S. Filamin A interacts with the coactivator MKL1 to promote the activity of the transcription factor SRF and  cell migration. Sci Signal. 2015 Nov 10;8(402):ra112. doi: 10.1126/scisignal.aad2959. PubMed PMID: 26554816.

 

Lunding L, Schröder A, Wegmann M. Allergic airway inflammation: unravelling the relationship between IL-37, IL-18Rα and Tir8/SIGIRR. Expert Rev Respir Med. 2015 Nov 11:1-12. [Epub ahead of print] PubMed PMID: 26561030.

 

Manali ED, Papadaki G, Konstantonis D, Tsangaris I, Papaioannou AI, Kolilekas  L, Schams A, Kagouridis K, Karakatsani A, Orfanos S, Griese M, Papiris SA. CARDIOVASCULAR RISK IN PULMONARY ALVEOLAR PROTEINOSIS. Expert Rev Respir Med. 2015 Nov 11. [Epub ahead of print] PubMed PMID: 26558331.

 

Purath U, Ibrahim R, Zeitvogel J, Renz H, Runkel F, Schmidts T, Dobler D, Werfel T, Müller A, Garn H. Efficacy of T-cell transcription factor-specific DNAzymes in murine skin inflammation models. J Allergy Clin Immunol. 2015 Nov 9.  pii: S0091-6749(15)01362-7. doi: 10.1016/j.jaci.2015.09.022. [Epub ahead of print] PubMed PMID: 26560045.

 

Schlosser A, Pilecki B, Hemstra LE, Kejling K, Kristmannsdottir GB, Wulf-Johansson H, Moeller JB, Füchtbauer EM, Nielsen O, Kirketerp-Møller K, Dubey LK, Hansen PB, Stubbe J, Wrede C, Hegermann J, Ochs M, Rathkolb B, Schrewe A, Bekeredjian R, Wolf E, Gailus-Durner V, Fuchs H, de Angelis MH, Lindholt JS, Holmskov U, Sorensen GL. MFAP4 Promotes Vascular Smooth Muscle Migration, Proliferation and Accelerates Neointima Formation. Arterioscler Thromb Vasc Biol. 2015 Nov 12. pii: ATVBAHA.115.306672. [Epub ahead of print] PubMed PMID: 26564819.

 

Schneider JP, Pedersen L, Mühlfeld C, Ochs M. Staining histological lung sections with Sudan Black B or Sudan III for automated identification of alveolar epithelial type II cells. Acta Histochem. 2015 Nov 7. pii: S0065-1281(15)30016-7. doi: 10.1016/j.acthis.2015.10.005. [Epub ahead of print] PubMed PMID: 26558990.

 

von Laffert M, Stenzinger A, Hummel M, Weichert W, Lenze D, Warth A, Penzel R, Herbst H, Kellner U, Jurmeister P, Schirmacher P, Dietel M, Klauschen F. ALK-FISH borderline cases in non-small cell lung cancer: Implications for diagnostics and  clinical decision making. Lung Cancer. 2015 Oct 23. pii: S0169-5002(15)30066-0. doi: 10.1016/j.lungcan.2015.09.022. [Epub ahead of print] PubMed PMID: 26547803.

 

von Mutius E. No Risk of Asthma in Late-Preterm Infants: Confounding or Misclassification? J Allergy Clin Immunol Pract. 2015 Nov-Dec; 3 (6):911-2. doi: 10.1016/j.jaip.2015.09.005. PubMed PMID: 26553617.

 

 

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